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Microengineering double layer hydrogel structures towards the recapitulation of the hematopoietic stem cell niche

Science Bulletin 2018年第20期63卷 1319-1323页

作者： pilar carreras Rodrigo Cortrim Chaves Miguel Gallardo Alejandra Ortiz Joaquin Martinez Lopez Samuel K.Sia Department of Biomedical Engineering Columbia UniversityNew YorkNY 10032USA Hematology Department Research Institute i+12Hospital 12 OctubreMadrid 2804Spain Hematological Malignancies Clinical Research Unit H120 CNIOMadrid 28029Spain

Adult stem cells,especially from bone marrow,have a tremendous therapeutic potential,and its application in regenerative medicine has been increasingly studied [1,2].It is well known that three-dimensional (3D)cell culture matrix promotes many biological relevant functions not observed in two-dimensional (2D) monolayer cell culture [3]and therefore,engineering 3D cell culture platforms to mimic the native in vivo biological systems represents a realistic approach for studies of bone marrow stem cells. High-throughput microfluidics constitutes a promising technology to generate hydrogel three dimensional constructs [4,5],however, its application to host adult stem cells remains still a challenge.

关键词： hydrogel hematopoietic stem cell

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Non-alcoholic fatty liver disease in patients with intestinal, pulmonary or skin diseases: Inflammatory cross-talk that needs a multidisciplinary approach

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World Journal of Gastroenterology 2021年第41期27卷 7113-7124页

作者： Mercedes Perez-carreras Begoña Casis-Herce Raquel Rivera Inmaculada Fernandez pilar Martinez-Montiel Victoria Villena Gastroenterology and Hepatology Unit 12 de Octubre Universitary HospitalMadrid 28041Spain Faculty of Medicine Complutense UniversityMadrid 28040Spain Dermatology Department 12 de Octubre Universitary HospitalMadrid 28041Spain Pneumology Service 12 de Octubre Universitary HospitalMadrid 28041Spain

Non-alcoholic fatty liver disease(NAFLD)is currently considered the most common cause of liver *** prevalence is increasing in parallel with the obesity and type 2 diabetes mellitus(DM2)epidemics in developed *** recent studies have suggested that NAFLD may be the hepatic manifestation of a systemic inflammatory metabolic disease that also affects other organs,such as intestine,lungs,skin and vascular *** appears that local and systemic proinflammatory/anti-inflammatory cytokine imbalance,together with insulin resistance and changes in the intestinal microbiota,are pathogenic mechanisms shared by NAFLD and other *** is more common in patients with extrahepatic diseases such as inflammatory bowel disease(IBD),obstructive syndrome apnea(OSA)and psoriasis than in the general ***,there is evidence that this association has a negative impact on the severity of liver *** risk characteristics for NAFLD have been identified in populations with IBD(***,obesity,DM2,previous bowel surgery,IBD evolution time,methotrexate treatment),OSA(***,DM2,OSA severity,increased transaminases)and psoriasis(***,metabolic factors,severe psoriasis,arthropathy,elevated transaminases,methotrexate treatment).These specific phenotypes might be used by gastroenterologists,pneumologists and dermatologists to create screening algorithms for *** algorithms should include non-invasive markers of fibrosis used in NAFLD to select subjects for referral to the ***,controlled studies in NAFLD patients with extrahepatic comorbidities are required to demonstrate a causal relationship and also that appropriate multidisciplinary management improves these patients’prognosis and survival.

关键词： Non-alcoholic fatty liver disease Liver fibrosis Psoriasis Obstructive sleep apnea Metabolic syndrome Inflammatory bowel disease

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