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Increased end-stage renal disease risk in patients with inflammatory bowel disease:A nationwide populationbased study

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World Journal of Gastroenterology 2018年第42期24卷 4798-4808页

作者： Seona Park Jaeyoung Chun Kyung-Do Han Hosim Soh Kookhwan Choi Ji Hye kim Jooyoung Lee Changhyun Lee Jong pil Im Joo Sung kim Department of Internal Medicine Liver Research InstituteSeoul National University College of Medicine Department of Biostatistics College of MedicineThe Catholic University of Korea Department of Internal Medicine CHA Gangnam Medical CenterCHA University Department of Internal Medicine and Healthcare Research Institute Healthcare System Gangnam CenterSeoul National University Hospital

AIM To estimate the risk of end-stage renal disease(ESRD)in patients with inflammatory bowel disease(IBD).METHODS From January 2010 to December 2013, patients with Crohn's disease(CD) and ulcerative colitis(UC) were identified, based on both the International Classification of Diseases, 10 th revision(ICD-10) and the rare,intractable disease registration program codes from the National Health Insurance(NHI) database in South Korea. We compared 38812 patients with IBD to ageand sex-matched non-IBD controls with a ratio of 1:*** newly diagnosed with ESRD were identified with the ICD-10 *** During a mean follow-up of 4.9 years, ESRD was detected in 79(0.2%) patients with IBD and 166(0.1%)controls. The incidence of ESRD in patients with IBD was0.42 per 1000 person-years. Patients with IBD had a significantly higher risk of ESRD than controls [adjusted hazard ratio(HR) = 3.03; 95% confidence interval(CI):1.77-5.20; P < 0.001]. The incidences(per 1000 personyears)of ESRD were 0.51 in patients with CD and 0.13 in controls, respectively(adjusted HR = 6.33; 95%CI:2.75-14.56; P < 0.001). In contrast, the incidence of ESRD was similar between the UC and control groups(0.37 vs 0.37 per 1000 person-years; adjusted HR = 2.01;95%CI: 0.90-4.51; P = 0.089).CONCLUSION The risk of ESRD was elevated in patients with CD, but not UC. Patients with CD should be monitored carefully for signs of renal insufficiency.

关键词： Claims data Inflammatory bowel disease Crohn’s disease End-stage renal disease Ulcerative colitis

Rapid determination of lithium-ion battery degradation: High C-rate LAM and calculated limiting LLI

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Journal of Energy Chemistry 2022年第4期31卷 663-671页

作者： Gyuwon Seo Jaeyun Ha Moonsu kim Jihyeon Park Jaewon Lee Eunoak Park Sungyool Bong Kiyoung Lee Soon Jong Kwon Seung-pil Moon Jinsub Choi Jaeyoung Lee Electrochemical Reaction and Technology Laboratory School of Earth Sciences and Environmental EngineeringGwangju Institute of Science and Technology(GIST)Gwangju 61005South Korea Department of Chemistry and Chemical Engineering Inha UniversityIncheon 22212South Korea Ertl Center for Electrochemistry and Catalysis GISTGwangju 61005South Korea Korea Electric Power Corporation Research Institute Daejeon 34056South Korea International Future Research Center of Chemical Energy Storage and Conversion Processes(ifRC-CHESS) GISTGwangju 61005South Korea

Herein,incremental capacity-differential voltage (IC-DV) at a high C-rate (HC) is used as a non-invasive diagnostic tool in lithium-ion batteries,which inevitably exhibit capacity fading caused by multiple mechanisms during charge/discharge *** battery degradation modes are complex,the simple output of capacity fading does not yield any useful data in that *** IC and DV curves obtained under restricted conditions (<0.1C,25℃) were applied in non-invasive analysis for accurate observation of degradation symptoms,a facile,rapid diagnostic approach without intricate,complex calculations is critical in on-board ***,Li Ni_(0.5)Mn_(0.3)Co_(0.2)O_(2)(NMC532)/graphite pouch cells were cycled at 4 and 6C and the degradation characteristics,i.e.,loss of active materials (LAM) and loss of lithium inventory (LLI),were parameterized using the IC-DV *** the incremental current cycling,the initial steep LAM and LLI slopes underwent gradual transitions to gentle states and revealed the gap between low-and high-current measurements.A quantitative comparison of LAM at high and low C-rate showed that a IC;revealed the relative amount of available reaction region limited by cell ***,this did not provide a direct relationship for estimating the LAM at a low ***,the limiting LLI,which is calculated at a C-rate approaching 0,was obtained by extrapolating the LLI through more than two points measured at high C-rate,and therefore,the LLI at 0.1C was accurately determined using rapid cycling.

关键词： Battery degradation Rapid degradation diagnosis Loss of active materials(LAM) Loss of lithium inventory(LLI) Incremental capacity(IC) Differential voltage(DV)

Clinical and endoscopic characteristics of drug-induced esophagitis

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World Journal of Gastroenterology 2014年第31期20卷 10994-10999页

作者： Su Hwan kim Ji Bong Jeong Ji Won kim Seong-Joon Koh Byeong Gwan kim Kook Lae Lee Mee Soo Chang Jong pil Im Hyoun Woo Kang Cheol Min Shin Department of Internal Medicine Seoul National University Boramae Hospital Seoul National University College of Medicine Department of Pathology Seoul National University Boramae Hospital Seoul National University College of Medicine Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Department of Internal Medicine Dongguk University Ilsan Hospital Goyang 410-773 Gyeonggi-do South Korea Department of Internal Medicine Seoul National University Bundang Hospital Seongnam 463-707 Gyeonggido South Korea

AIM: To investigate clinical, endoscopic and pathological characteristics of drug-induced esophagitis.

关键词： Drug Esophagitis Endoscopy Pathology Symptoms Kissing ulcers

Genetic variation of the PSCA gene(rs2294008) is not associated with the risk of prostate cancer

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The Journal of Biomedical Research 2017年第3期31卷 226-231页

作者： II-Seok Lee Sung pil Seo Yun Sok Ha pildu Jeong Ho Won Kang Won Tae kim Yong-June kim Seok Joong Yun Sang Cheol Lee Wun-Jae kim Department of Urology Chungbuk National University College of Medicine Department of Urology School of MedicineKyungpook National University

Prostate stem cell antigen（PSCA） is a cell-membrane glycoprotein consisting of 123 amino acids and highly expressed in the prostate,but there have been few reports on the relationship between rs2294008 of PSCA and prostate cancer in the ***,we evaluated the association between rs2294008 and the risk of prostate cancer.A total of 240 prostate cancer patients and 306 controls（patients with benign prostatic hyperplasia） were *** analysis of rs2294008 of PSCA was performed using *** regression analysis was performed according to the genotype of PSCA *** found that CT and TT genotypes were associated with an insignificant risk of prostate cancer compared with the CC genotype（P= 0.627 and 0.397,respectively）.In addition,there was no significant difference in rs2294008 according to clinicopathological parameters,such as age,Gleason score,prostate-specific antigen（PSA）,stage,and metastasis in prostate cancer（P 〉 0.05 for each）.Age,Gleason score,PSA,pathologic stage,and metastasis did not modify the association between PSCA and the risk of prostate cancer（each P 〉 0.05 for each）.Taken together,the genetic polymorphism of PSCA rs2294008 was not associated with the risk of prostate *** results suggest that rs2294008 may not play a role in prostate carcinogenesis.

关键词： prostatic neoplasms polymorphism genetic risk prostate polymorphism single nucleotide

Anethole improves the developmental competence of porcine embryos by reducing oxidative stress via the sonic hedgehog signaling pathway

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1395-1407页

作者： Ye Eun Joo pil-Soo Jeong Sanghoon Lee Se-Been Jeon Min-Ah Gwon Min Ju kim Hyo-Gu Kang Bong-Seok Song Sun-Uk kim Seong-Keun Cho Bo-Woong Sim Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyCheongjuSouth Korea Department of Animal Science College of Natural Resources and Life SciencePusan National UniversityMiryangSouth Korea Laboratory of Theriogenology College of Veterinary MedicineChungnam National UniversityDaejeonSouth Korea Department of Biotechnology College of EngineeringDaegu UniversityGyeongsanSouth Korea Department of Animal Science and Biotechnology College of Agriculture and Life ScienceChungnam National UniversityDaejeonSouth Korea Department of Functional Genomics University of Science and TechnologyDaejeonSouth Korea Department of Animal Science College of Natural Resources and Life ScienceLife and Industry Convergence Research InstitutePusan National UniversityMiryangSouth Korea

Background Anethole(AN)is an organic antioxidant compound with a benzene ring and is expected to have a positive impact on early embryogenesis in ***,no study has examined the effect of AN on porcine embryonic ***,we investigated the effect of AN on the development of porcine embryos and the underlying *** We cultured porcine in vitro-fertilized embryos in medium with AN(0,0.3,0.5,and 1 mg/mL)for 6 *** at 0.5 mg/mL significantly increased the blastocyst formation rate,trophectoderm cell number,and cellular survival rate compared to the ***-supplemented embryos exhibited significantly lower reactive oxygen species levels and higher glutathione levels than the ***,AN significantly improved the quantity of mitochondria and mitochondrial membrane potential,and increased the lipid droplet,fatty acid,and ATP ***,the levels of proteins and genes related to the sonic hedgehog(SHH)signaling pathway were significantly increased by *** These results revealed that AN improved the developmental competence of porcine preimplantation embryos by activating SHH signaling against oxidative stress and could be used for large-scale production of high-quality porcine embryos.

关键词： Anethole Lipid metabolism Mitochondrial function Porcine embryo development Sonic hedgehog signaling pathway

Mechanical properties of Cu matrix composite fabricated by extrusion process

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Transactions of Nonferrous Metals Society of China 2016年第10期26卷 2679-2686页

作者： Ji-Hun PAK Gwi-Nam kim Sung-Gu HWANG Beom-Su kim Jung-pil NOH Sun-Chul HUH Department of Mechanical and Precision Engineering Gyeongsang National University Department of Mechanical System Engineering Gyeongsang National University Department of Mechanical and Energy Engineering Gyeongsang National University

Carbon nanotube （CNT）was applied in various fields for itssuperior electrical, mechanical and thermal characteristics. After composites were fabricated by extrusion processusing ball-milledCu-CNT powders, mechanicalpropertiesofCu-CNT composites according to CNT fraction were reviewed. CNT （1%, 5% and 10%）,Cu （d=100 nm）, zirconia balls （90 g） and ethanol （20mL） were mixed and dispersed for5h at a speed of 500 r/minusing a planetary ball mill. A billet （d=50 mm, length=100 mm） was made with Cu, and the composite powderswerefilled up into billet using the uni-axial press. In the extrusion process, after the billet was heated at 880℃for1h, specimens were produced in the shape of a round bar using the billet by applying a load of 200 t. The composite powdersweremeasured for particle size byparticlesize distributionequipment. Then the specimen surface fabricated by extrusion was observed by SEM. Mechanicalpropertiesmeasured by the indentation equipment increased with increasing CNT content. The yield strength, tensile strength and hardness of theCu–CNTs composites canbeobviously improved.

关键词： extrusion milling indentation matrix mechanical properties microstructure

Adenosine monophosphate enhances callus regeneration competence for de novo plant organogenesis

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Molecular Plant 2023年第12期16卷 1867-1870页

作者： Hong Gil Lee Seo Young Jang Eun Yee Jie Seung Hee Choi Ok-Sun Park Soon Hyung Bae Hyun-Soon kim Suk Weon kim Geum-Sook Hwang pil Joon Seo Department of Chemistry Seoul National UniversitySeoul 08826Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Korea Integrated Metabolomics Research Group Western Seoul CenterKorea Basic Science InstituteSeoul 03759Korea Biological Resource Center Korea Research Institute of Bioscience and BiotechnologyJeongeup56212Korea Plant Systems Engineering Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Korea College of Pharmacy Chung-Ang UniversitySeoul 06974Korea

Dear Editor,Plant tissue culture involves callus formation and de novo shoot ***,explants from differentiated tissues are used to generate a pluripotent cell mass,called callus,on auxin-rich callus-inducing medium(CIM),followed by shoot regeneration on cytokinin-rich shoot-inducing medium(SiM).Callus results from division of pericycle-like cells(Atta et al.,2009;Sugimoto et al.,2010);its cellular identity resembles that of lateral root primordia(Atta et al.,2009;Sugimoto et al.,2010).Callus acquires cellular pluripotency by forming root stem cell niches on CIM(Sugimoto et al.,2010)。

关键词： Adenosine callus

Colorectal stenting:An advanced approach to malignant colorectal obstruction

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World Journal of Gastroenterology 2014年第43期20卷 16020-16028页

作者： Sung pil Hong Tae Il kim Division of Gastroenterology Department of Internal MedicineYonsei University College of MedicineSeoul 120-752South Korea

Some colorectal cancer(CRC)patients present symptoms of bowel obstruction,which is considered a surgical *** of poor medical condition and high incidence of post-surgical complications,there has been increasing use of self-expanding metal stents(SEMS)for the purpose of palliation or as a bridge to surgery with some benefits,including shorter hospital stays,lower rates of adverse events,and one-stage ***,with increasing survival of CRC patients,there have been controversial data on clinical outcomes and complications,compared between SEMS use and surgery for treatment of malignant bowel *** review recent clinical data on clinical outcomes of SEMS use compared to surgery,including complications.

关键词： Colon Cancer Obstruction Stent Palliation

Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study

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World Journal of Gastroenterology 2020年第37期26卷 5661-5672页

作者： Eun Ae Kang Jaeyoung Chun Jee Hyun kim Kyungdo Han Hosim Soh Seona Park Seung Wook Hong Jung Min Moon Jooyoung Lee Hyun Jung Lee Jun-Beom Park Jong pil Im Joo Sung kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of MedicineSeoul 03722South Korea Department of Internal Medicine Gangnam Severance HospitalYonsei University College of MedicineSeoul 06229South Korea Department of Internal Medicine Bundang CHA Medical CenterCHA University School of MedicineSeoul 13496South Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoul 06978South Korea Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 03080South Korea Department of Periodontics the Catholic University of Korea College of MedicineSeoul 06591South Korea

BACKGROUND Periodontitis is a chronic inflammation of periodontal *** effect of periodontitis on the development of inflammatory bowel disease(IBD)remains *** To assessed the risk of IBD among patients with periodontitis,and the risk factors for IBD related to *** A nationwide population-based cohort study was performed using claims data from the Korean National Healthcare Insurance *** total,9950548 individuals aged≥20 years who underwent national health screening in 2009 were *** diagnosed IBD[Crohn’s disease(CD),ulcerative colitis(UC)]using the International Classification of Disease 10th revision and rare intractable disease codes,was compared between the periodontitis and nonperiodontitis groups until *** A total of 1092825 individuals(11.0%)had *** was significantly associated with older age,male gender,higher body mass index,quitting smoking,not drinking alcohol,and regular *** mean age was 51.4±12.9 years in the periodontitis group and 46.6±14.2 years in the nonperiodontitis group(P<0.01),*** mean body mass index was 23.9±3.1 and 23.7±3.2 in the periodontitis and non-periodontitis groups,respectively(P<0.01).Men were 604307(55.3%)and 4844383(54.7%)in the periodontitis and non-periodontitis groups,*** mean follow-up duration was 7.26 *** with periodontitis had a significantly higher risk of UC than those without periodontitis[adjusted hazard ratio:1.091;95%confidence interval(CI):1.008-1.182],but not CD(adjusted hazard ratio:0.879;95%confidence interval:0.731-1.057).The risks for UC were significant in the subgroups of age≥65 years,male gender,alcohol drinker,current smoker,and reduced physical *** smokers aged≥65 years with periodontitis were at a 1.9-fold increased risk of UC than non-smokers aged≥65 years without *** Periodontitis was significantly associated with the risk of developing UC,b

关键词： Inflammatory bowel disease Periodontitis Smoking Ulcerative colitis Crohn’s disease