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Dipyridyl Azo Compound 4,4'-Azopyridine as a Potential Coating Material for Toilet Sanitizer

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Chemical Research in Chinese Universities 2023年第6期39卷 864-869页

作者： WANG Qiwei JIANG Lu lam pik-ling CHUI Chung-Hin WONG Wai-Yeung Antibiotics Research and Reevaluation Key Laboratory of Sichuan Province Sichuan Industrial Institute of AntibioticsChengdu UniversityChengdu 610052P.R.China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomHong KongP.R.China Research and Development Division One Health International LimitedHong KongP.R.China

Good toilet hygiene can reduce the risk of pathogenic *** flushing,pathogenic bacteria can be spread by the water droplets,especially in the toilet *** coli(***)is one of the frequently occurring Gram-negative bacterial pathogens found in the toilet *** this study,we investigated the potential *** activity of some azobenzene *** them,compound 2,with the heterocyclic nitrogen in both phenyl rings,showed the strongest antibacterial effect on ***,with the minimum inhibitory concentration of 80μg/mL and the minimum bactericidal concentration of 320μg/*** 2 displayed a comparative zone of clearance[(14.50±2.29)mm]to that of ampicillin[(13.17±1.76)mm].The reactive oxygen species(ROS)assay suggested that compound 2 might induce the loss of bacteria via the oxidative stress by eliciting the generation of intracellular *** further examined the potential cytotoxicity of compound 2 to the human skin HaCaT *** 2-treated skin cells showed a good maintenance of cellular morphology and a clear definition of cell nuclei,with a satisfactory cell viability(ca.90%)at 80μg/***,compound 2 would be a possible antibacterial coating agent for the surface sanitizer of the toilet seats to inhibit the growth of ***.

关键词： Antibacterial Azobenzene Escherichia coli Skin cytotoxicity Toilet seat

TRMT6 and TRMT61A facilitated acute pancreatitis severity via regulation of neutrophil function

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Science China Life Sciences 2025年

作者： Yuan Dong Li Su Sin Man lam Cen Yan Yalan Deng Guotao Lu Jinkui Yang Guanghou Shui Yingmei Feng Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Department of Science and Development Beijing Youan HospitalCapital Medical University Laboratory for Clinical Medicine Capital Medical University Neuroscience Research Institute Peking University Center of Medical and Health AnalysisPeking University State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences Pancreatic Center Department of GastroenterologyAffiliated Hospital of Yangzhou UniversityYangzhou University Beijing Key Laboratory of Diabetes Research and Care Department of EndocrinologyBeijing Tongren HospitalCapital Medical University

Dear Editor,Type 2 diabetes mellitus (T2DM) has been identified as a risk factor for increased severity in acute pancreatitis (AP)(Mikóet al,2018).However,to date,no studies have simultaneously included healthy individuals,T2DM patients,and AP patients to investigate which diabetes-associated metabolites are linked to AP severity.

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Answering Reachability Queries on Incrementally Updated Graphs by Hierarchical Labeling Schema

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Journal of Computer Science & Technology 2016年第2期31卷 381-399页

作者： Tak-lam Wong Department of Mathematics and Information Technology The Hong Kong Institute of Education Hong Kong China

We proposed a novel solution schema called the Hierarchical Labeling Schema （HLS） to answer reachability queries in directed graphs. Different from many existing approaches that focus on static directed acyclic graphs （DAGs）, our schema focuses on directed cyclic graphs （DCGs） where vertices or arcs could be added to a graph incrementally. Unlike many of the traditional approaches, HLS does not require the graph to be acyclic in constructing its index. Therefore, it could, in fact, be applied to both DAGs and DCGs. When vertices or arcs are added to a graph, the HLS is capable of updating the index incrementally instead of re-computing the index from the scratch each time, making it more efficient than many other approaches in the practice. The basic idea of HLS is to create a tree for each vertex in a graph and link the trees together so that whenever two vertices are given, we can immediately know whether there is a path between them by referring to the appropriate trees. We conducted extensive experiments on both real-world datasets and synthesized datasets. We compared the performance of HLS, in terms of index construction time, query processing time and space consumption, with two state-of-the-art methodologies, the path-tree method and the 3-hop method. We also conducted simulations to model the situation when a graph is updated incrementally. The performance comparison of different algorithms against HLS on static graphs has also been studied. Our results show that HLS is highly competitive in the practice and is particularly useful in the cases where the graphs are updated frequently.

关键词： graph indexing reachability query Hierarchical Labeling Schema (HLS) incremental update directed cyclic graph

Design and mathematical analysis of activating transcriptional amplifiers that enable modular temporal control in synthetic juxtacrine circuits

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Synthetic and Systems Biotechnology 2023年第4期8卷 654-672页

作者： Calvin lam Department of Biochemistry and Molecular Biology University of Nebraska Medical CenterOmahaNE68198USA.

The ability to control mammalian cells such that they self-organize or enact therapeutic effects as desired has incredible *** only would it further our understanding of native processes such as development and the immune response,but it would also have powerful applications in medical fields such as regenerative medicine and *** control is typically obtained by synthetic circuits that use synthetic receptors,but control remains *** synthetic juxtacrine receptors(SJRs)are widely used as they are fully modular and enable spatial control,but they have limited gene expression amplification and temporal *** these are integral facets to cell control,I therefore designed transcription factor based amplifiers that amplify gene expression and enable unidirectional temporal control by prolonging duration of target gene *** a validated in silico framework for SJR signaling,I combined these amplifiers with SJRs and show that these SJR amplifier circuits can direct spatiotemporal patterning and improve the quality of self-organization.I then show that these circuits can improve chimeric antigen receptor(CAR)T cell tumor killing against various heterogenous antigen expression *** amplifiers are flexible tools that improve control over SJR based circuits with both basic and therapeutic applications.

关键词： Synthetic biology Synthetic development Synthetic immunotherapy synNotch SNIPR Amplifiers Self-organization Temporal control Spatiotemporal control CAR T cell Synthetic receptors

Interactions Between Arbuscular Mycorrhizae and Plants in Phytoremediation of Metal-Contaminated Soils: A Review

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Pedosphere 2013年第5期23卷 549-563页

作者： LEUNG Ho-Man WANG Zhen-Wen YE Zhi-Hong YUNG Kin-lam PENG Xiao-ling CHEUNG Kwai-Chung Department of Biology Hong Kong Baptist University School of Biological Science and Technology Yangzhou University State Key Laboratory for Bio-control and School of Life Sciences Sun Yat-sen University Division of Science and Technology BNU-HKBU United International College Department of Applied Sciences Hong Kong Institute of Vocational Education (Chai Wan)

Metal contamination in the environment is a global concern due to its high toxicity to living organisms and its worldwide distribution. The principal goal of this review is to examine the current strategies and technologies for the remediation of metal- contaminated soils by metal-accumulating plants and assess the roles of arbnscular mycorrhizal （AM） fungi in remediation of soils under hyperaccumulator or non-accumulator plants. The use of plants to remove metals from the environment or reduce the toxicity, known as phytoremediation, is an environmentally sustainable and low cost remediation technology. The mechanisms of the use of hyperaccumulator plants for phytoremediation included solubilization of the metal in the soil matrix, the plant uptake of the metal, detoxification/chelation and sequestration, and volatilization. Recently, some ecologists have found that phytoremediation with the aids of mycorrhizae can enhance efficiency in the removal of toxic metals. AM fungi can facilitate the survival of their host plants growing on metal-contaminated land by enhancing their nutrient acquisition, protecting them from the metal toxicity, absorbing metals, and also enhancing phytostabilization and phytoextraction. Such information may be useful for developing phytoremediation program at metal-contaminated sites.

关键词： AM fungi heavy metals hyperaccumulator plant phytoextraction phytostabilization

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Phase change memory

Science China(Information Sciences) 2011年第5期54卷 1061-1072页

作者： lam Chung IBM Research T.J. Watson Research Center Yorktown Heights New York 10598 USA

Phase change memory (PCM) is a non-volatile solid-state memory technology based on the large resistivity contrast between the amorphous and crystalline states in phase change materials. We present the physics behind this large resistivity contrast and describe how it is being exploited to create high density PCM. We address the challenges facing this technology, including the design of PCM cells, fabrication, device variability, thermal cross-talk and write disturb. We discuss the scalability, assess the performance, and examine the reliability of PCM including data retention, multi-bit storage and endurance.

关键词： solid state memory non-volatile DRAM flash phase change resistive memory data retention write endurance solid-state drive computer memory

Schistosomal appendicitis:A serious and often misdiagnosed condition

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World Journal of Clinical Cases 2025年第10期13卷 62-64页

作者： Phi Duong Nguyen Thanh Kien lam Orthopaedic-Burn-Plastic Surgery City Children’s HospitalHo Chi Minh City 71815Viet Nam The Faculty of Medical Technology Van Lang UniversityHo Chi Minh City 700000Viet Nam

Schistosomal appendicitis(SA)is a rare but serious complication of schistosomiasis,a parasitic disease affecting over 250 million people worldwide.A recent retrospective study by Wang et al provides important insights into the clinicopathological characteristics of *** study compared 136 cases of SA to 5418 cases of non-SA over a ten-year *** findings include a higher average age of SA patients(61.73 years vs 35.8 years for non-SA),a higher proportion of acute on chronic appendicitis(33.1%vs 16%),and a significantly higher incidence of colorectal cancer(11.7%vs 2.2%).Despite these differences,SA remains a diagnostic challenge due to its nonspecific clinical presentation and lack of specific laboratory *** study also highlights the persistent prevalence of SA,accounting for 1.6%-3.4%of all appendicitis cases each year from 2013 to *** findings underscore the need for enhanced awareness,early detection,and prompt treatment of SA in endemic *** the association with colorectal cancer,patients with SA require thorough screening and *** research into the pathogenesis and diagnostic markers of SA is *** the global battle against schistosomiasis continues,targeted efforts to diagnose and manage SA can significantly improve patient outcomes.

关键词： Schistosomal appendicitis Schistosomiasis Colorectal cancer Misdiagnosis Clinicopathological characteristics

Conditional Coverage Estimation for High-Quality Prediction Intervals

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Journal of Systems Science and Systems Engineering 2023年第3期32卷 289-319页

作者： Ziyi Huang Henry lam Haofeng Zhang School of Engineering and Applied Science Columbia UniversityNew YorkNY 10027USA

Deep learning has been recently studied to generate high-quality prediction intervals(PIs)for uncertainty quantification in regression tasks,including recent applications in simulation *** high-quality criterion requires PIs to be as narrow as possible,whilst maintaining a pre-specified level of data(marginal)***,most existing works for high-quality PIs lack accurate information on conditional coverage,which may cause unreliable predictions if it is significantly smaller than the marginal *** address this problem,we propose an end-to-end framework which could output high-quality PIs and simultaneously provide their conditional coverage *** doing so,we design a new loss function that is both easy-to-implement and theoretically justified via an exponential concentration *** evaluation on real-world benchmark datasets and synthetic examples shows that our approach not only achieves competitive results on high-quality PIs in terms of average PI width,but also accurately estimates conditional coverage information that is useful in assessing model uncertainty.

关键词： Uncertainty quantification prediction intervals conditional coverage neural networks calibrationerror

Complete characterization of ultrashort optical pulses with a phase-shifting wedged reversal shearing interferometer

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Light(Science & Applications) 2018年第1期7卷 755-765页

作者： Billy lam Chunlei Guo The Institute of Optics University of RochesterRochesterNY 14627USA Changchun Institute of Optics Fine Mechanics and PhysicsChinese Academy of Sciences130033 ChangchunChina

The ability of an interferometer to characterize the spatial information of a light beam is often limited by the temporal profile of the beam,with femtosecond pulse characterization being particularly *** this study,we developed a simple,stable,controllable shearing and vectorial phase-shifting wedged reversal shearing interferometer that is able to characterize all types of coherent and partially coherent light *** proposed interferometer consists of only a single beam splitter cube with one wedged entrance face and is insensitive to environmental vibration due to its common path configuration.A near zero-path length difference of the proposed interferometer ensures its operation for ultrashort pulses,providing,for the first time,a simple and stable interferometric tool to fully characterize sub-100 fs laser *** common beam characterization can be carried out with the interferometer,such as the amplitude,phase,polarization,wavelength,and pulse ***,this technique is sensitive to the wavefront tilt and can be used for precise beam ***,this interferometer can be an essential tool for beam characterization,optical imaging,and the testing required for a wide range of applications,including astronomy,biomedicine,ophthalmology,optical testing and imaging systems,and adaptive optics.

关键词： interferometer ultrashort shearing