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Impact of pre-existing cardiometabolic diseases on metastatic cancer stage at diagnosis:a prospective multinational cohort study

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Cancer Communications 2024年第5期44卷 593-597页

作者： Anna Jansana Aviane Auguste Marina Kvaskoff Agnès Fournier Emma Fontvieille Laia Peruchet-Noray Carine Biessy Reynalda Cordova Kristina Elin Nielsen Petersen Anne Tjoneland Verena Katzke Rudolf Kaaks Fulvio Ricceri Salvatore Panico Paolo Contiero Maria-Jose Sánchez Jesus Castilla Marta Crous-Bou Alicia Heath Elom Kouassivi Aglago Elisabete Weiderpass Marc James Gunter pietro ferrari Elio Riboli Vivian Viallon Heinz Freisling International Agency for Research on Cancer(IARC-WHO) LyonFrance Paris-Saclay University University of Versailles-Saint-Quentin-en-YvelineUniversity Paris-SudFrench National Institute for Health and Medical Research(Inserm)Gustave Roussy“Exposome and Heredity”TeamCESPVillejuifFrance Department of Nutritional Sciences University of ViennaViennaAustria Danish Cancer Society Research Center CopenhagenDenmark Department of Public Health University of CopenhagenCopenhagenDenmark Division of Cancer Epidemiology German Cancer Research CentreHeidelbergGermany Department of Clinical and Biological Sciences University of TurinTurinItaly Unit of Epidemiology Regional Health Service ASL TO3GrugliascoTurinItaly Department of Clinical Medicine and Surgery Federico II UniversityNaplesItaly Environmental Epidemiology Unit Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)-Istituto Nazionale dei TumoriMilanItaly Cancer Registry of Granada Institute for Biosanitary Research of Granada(ibs.GRANADA)GranadaSpain Epidemiology and Control of Chronic Diseases Group Epidemiology and Public Health Networking Biomedical Research CentreMadridSpain Navarra Public Health Institute PamplonaSpain Unit of Nutrition and Cancer Cancer Epidemiology Research ProgramCatalan Institute of Oncology(ICO)-Bellvitge Biomedical Research Institute(IDIBELL)L’Hospitalet de LlobregatBarcelonaSpain Department of Epidemiology Harvard Tseng-Hsi Chan School of Public HealthBostonMassachusettsUSA Department of Epidemiology and Biostatistics School of Public HealthImperial College LondonSt Mary’s CampusNorfolk PlaceLondonUK

Owing to shared risk factors between cardiometabolic diseases(CMDs)and cancer,coupled with population aging,the lifetime risk of an individual developing cancer after a CMD is ***,biological mechanisms such as insulin resistance or inflammation may not only predispose individuals withCMDto an elevated risk of certain types of cancer but also to a diagnosis of cancer at an advanced stage[1,2].

关键词： diagnosis diseases cancer

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Access control technologies for Big Data management systems:literature review and future trends

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Cybersecurity 2019年第1期2卷 63-75页

作者： pietro Colombo Elena ferrari DiSTA University of InsubriaVia Mazzini 521100 VareseItaly

Data security and privacy issues are magnified by the volume,the variety,and the velocity of Big Data and by the lack,up to now,of a reference data model and related data manipulation *** this paper,we focus on one of the key data security services,that is,access control,by highlighting the differences with traditional data management systems and describing a set of requirements that any access control solution for Big Data platforms may *** then describe the state of the art and discuss open research issues.

关键词： Big Data Access control Privacy NoSQL data management systems

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A slug capturing method in unconventional scenarios: The 5ESCARGOTS code applied to non-Newtonian fluids, high viscous oils and complex geometries

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Petroleum 2019年第2期5卷 171-177页

作者： Marco ferrari Arianna Bonzanini pietro Poesio Department of Mathematics Politecnico di MilanoP.zza Leonardo Da Vinci 3220133 MilanItaly Department of Mechanical and Industrial Engineering Universita degli Studi di Bresciavia Branze 3825123 BresciaItaly

Previous work showed that a one-dimensional,hyperbolic,transient five-equation two-fluid model can predict automatically the formation,growth,and subsequent development of slugs in horizontal and near-horizontal *** method was implemented in a finite volume numerical scheme e called 5ESCARGOTS *** with experimental data showed that it can be used to predict the flow pattern and statistical characteristics(slug velocity,length,and frequency).However,the capabilities of this approach have been tested only for water-air flows in a straight horizontal *** this work,we validate the application of the code to some unconventional ***,we test the possibility of slug capturing approach to describe and predict the relevant features of air/high viscosity oils or air/non-Newtonian fluids *** between some slug characteristics and empirical correlations,available in literature,are ***,we move from simple geometries toward more complex conditions that may be representative of actual application cases,also employing high viscous oils as liquid *** against experimental data shows results in reasonable agreement.

关键词： Newtonian viscous slug

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Velocity profiles description and shape factors inclusion in a hyperbolic,one-dimensional,transient two-fluid model for stratified and slug flow simulations in pipes

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Petroleum 2019年第2期5卷 191-198页

作者： Arianna Bonzanini Davide Picchi Marco ferrari pietro Poesio Dipartimento di Ingegneria Meccanica ed Industriale Universita degli Studi di BresciaVia Branze3825123BresciaItaly Energy Resources Engineering Stanford UniversityStanford94305CAUnited States Department of Mathematics Politecnico di Milanop.zza Leonardo da Vinci3220133MilanItaly

In a previous work it has been shown that a one-dimensional,hyperbolic,transient five equations twofluid model is able to numerically describe stratified,wavy,and slug flow in horizontal and nearhorizontal *** statistical characteristics can be numerically predicted with results in good agreement with experimental data and well-known empirical *** this model some approximated and simplified assumptions are adopted to describe shear stresses at wall and at phase *** this paper,we focus on the possibility to account for the cross sectional flow by inserting shape factors into the momentum balance equations of the aforementioned *** profiles are obtained by a pre-integrated model and they are computed at each time step and at each computational *** that the velocity profiles are known,the obtained shape factors are inserted in the numerical *** this way it is possible to recover part of the information lost due to the one-dimensional flow *** profiles computed in stratified conditions are compared against experimental profiles measured by PIV technique;a method to compute the velocity profile during slug initiation and growth has been developed and the computed velocity distribution in the liquid phase was compared against the one-seventh power law.

关键词： Multi-phase pipeline transport Oil&gas Hyperbolic two-fluid model Velocity profiles Shape factors

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Measuring 3D face deformations from RGB images of expression rehabilitation exercises

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Virtual Reality & Intelligent Hardware 2022年第4期4卷 306-323页

作者： Claudio ferrari Stefano BERRETTI pietro PALA Alberto Del BIMBO Department of Engineering and Architecture University of ParmaParma 43124Italy Department of Information Engineering University of FlorenceFlorence 50139Italy

Background The accurate(quantitative)analysis of 3D face deformation is a problem of increasing interest in many *** particular,defining a 3D model of the face deformation into a 2D target image to capture local and asymmetric deformations remains a challenge in existing literature.A measure of such local deformations may be a relevant index for monitoring the rehabilitation exercises of patients suffering from Par-kinson’s or Alzheimer’s disease or those recovering from a *** In this paper,a complete framework that allows the construction of a 3D morphable shape model(3DMM)of the face is presented for fitting to a target RGB *** model has the specific characteristic of being based on localized components of *** fitting transformation is performed from 3D to 2D and guided by the correspondence between landmarks detected in the target image and those manually annotated on the average *** fitting also has the distinction of being performed in two steps to disentangle face deformations related to the identity of the target subject from those induced by facial *** The method was experimentally validated using the MICC-3D dataset,which includes 11 *** subject was imaged in one neutral pose and while performing 18 facial actions that deform the face in localized and asymmetric *** each acquisition,3DMM was fit to an RGB frame whereby,from the apex facial action and the neutral frame,the extent of the deformation was *** results indicate that the proposed approach can accurately capture face deformation,even localized and asymmetric *** The proposed framework demonstrated that it is possible to measure deformations of a reconstructed 3D face model to monitor facial actions performed in response to a set of ***,these results were obtained using only RGB targets,without the need for 3D scans captured with costly *** paves the way for the use of the

关键词： 3D morphable face model Sparse and locally coherent 3DMM components Local and asymmetric Face deformations Face rehabilitation Face deformation measure

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Targeting menin: a promising therapeutic strategy for susceptible acute leukemia subtypes

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5141-5142页

作者： pietro Di Fazio Department of Visceral Thoracic and Vascular SurgeryPhilipps University of MarburgBaldingerstrasse35043MarburgGermany

Two recent studies published in Nature focused on the clinical efficacy of the menin inhibitor revumenib(SNDX-5613)in KMT2A(histone-lysine N-methyltransferase 2A)-rearranged or NPM1(Nucleophosmin1)-mutant acute myeloid leukemia.1,2 These studies indicate that menin inhibition and its acquired resistance to long-term exposure to revuminib are key points for future treatment,emphasizing the role of menin as a challenging and promising target for the current treatment of leukemia.

关键词： acute clinical therapeutic

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Comparison Between Deep Learning Models and Traditional Machine Learning Approaches for Facial Expression Recognition in Ageing Adults

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Journal of Computer Science & Technology 2020年第5期35卷 1127-1146页

作者： Andrea Caroppo Alessandro Leone pietro Siciliano Institute for Microelectronics and Microsystems National Research Council of ItalyLecce 73100Italy

Facial expression recognition is one'of the most active areas of research in computer vision since one of the non-verbal communication methods by which one understands the lnood/mental state of a person is the expression of ***,it has been used in various fields such as human-robot interaction,security,computer graphics animation,and ambient ***,it remains a challenging task since existing approaches lack generalizability and almost all studies ignore the effects of facial attributes,such as *** expression recognition even though the research indicates that facial expression inanifestation varies with ***,a lot of progress has been made in this topic and great improvements in classification task were achieved with the emergence of deep learning *** approaches have sliown how hierarchies of features can be directly learned from original data,thus avoiding classical hand designed feature extraction methods that generally rely on manual operations witli labelled ***,research papers systematically exploring tlu4 performance of existing deep architectures for the task of classifying expression of ageing adults are absent in the *** the present work a tentative to try this gap is done considering the performance of three recent deep convolutiorial neural networks models(VGG-16,AlexNet and GoogLeNet/Inception V1)and evaluating it on four different benchmark datcisets(FACES,Lifespan,CIFE,and FER2013)which also contain facial expressions performed by elderly *** the baseline,and with the aim of making a comparison,two traditional inacliine learning approaches based on handcrafted features extraction process are evaluated on the same *** out an exhaustive and rigorous experimentation focused on the concept of "transfer learning",which consists of replacing the output level of the deep architectures considered with new output levels appropriate to the number of classes(facial expressions),

关键词： computer vision deep learning facial expression machine learning ageing adult

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Messages from Powdery Mildew DNA:How the Interplay with a Host Moulds Pathogen Genomes

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Journal of Integrative Agriculture 2014年第2期13卷 233-236页

作者： pietro D Spanu Department of Life Sciences Imperial College LondonLondon SW7 2AZUnited Kingdom

The genomes of the barley, Arabidopsis and pea powdery mildew are significantly larger than those of related fungi. This is due to an extraordinary expansion of retro-trasposons that are evident as repetitive elements in the sequence. The protein coding genes are fewer than expected due to an overall reduction in the size of gene families, a reduction in the number of paralogs and because of the loss of certain metabolic pathways. Many of these changes have also been observed in the genomes of other taxonomically unrelated obligate biotrophic pathogens. The only group of genes that bucks the trend of gene loss, are those encoding small secreted proteins that bear the hall marks of effectors.

关键词： barley powdery mildew genome effectors

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Unsteady Inflow Effects on the Wake Shed from a High-Lift LPT Blade Subjected to Boundary Layer Laminar Separation

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Journal of Thermal Science 2012年第2期21卷 97-108页

作者： Francesca Satta Marina Ubaldi pietro Zunino Università degli Studi di Genova

An experimental investigation on the near and far wake of a cascade of high-lift low-pressure turbine blades subjected to boundary layer separation over the suction side surface has been carried out, under steady and unsteady inflows. Two Reynolds number conditions, representative of take-off/landing and cruise operating conditions of the real engine, have been tested. The effect of upstream wake-boundary layer interaction on the wake shed from the profile has been investigated in a three-blade large-scale linear turbine cascade. The comparison between the wakes shed under steady and unsteady inflows has been performed through the analysis of mean velocity and Reynolds stress components measured at midspan of the central blade by means of a two-component crossed miniature hot-wire probe. The wake development has been analyzed in the region between 2% and 100% of the blade chord from the central blade trailing edge, aligned with the blade exit direction. Wake integral parameters, half-width and maximum velocity defects have been evaluated from the mean velocity distributions to quantify the modifications induced on the vane wake by the upstream wake. Moreover the thicknesses of the two wake shear layers have been considered separately in order to identify the effects of Reynolds number and incoming flow on the wake shape. The self-preserving state of the wake has been looked at, taking into account the different thicknesses of the two shear layers. The evaluation of the power density spectra of the velocity fluctuations allowed the study of the wake unsteady behavior, and the detection of the effects induced by the different operating conditions on the trailing edge vortex shedding.

关键词： Wake-wake unsteady interaction high-lift blade profiles low-pressure turbine blade wake.

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Adult neurogenesis and regeneration in zebrafish brain: are the neurotrophins involved in?

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Neural Regeneration Research 2019年第12期14卷 2067-2068页

作者： pietro Cacialli Carla Lucini Department of Veterinary Medicine University of Naples Federico Ⅱ

Neurotrophins (NTs) are implicated in the maintenance and survival of the peripheral and central nervous systems and mediate several forms of synaptic plasticity. Members of the family include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT3, and NT4. NTs were first identified as survival factors for developing neurons, but are pleiotropic molecules that can exert a variety of functions, including the regulation of neuronal differentiation, axonal and dendritic growth, and synaptic plasticity (Bothwell, 2014). NTs interact with two distinct types of receptors: the common p75 neurotrophin receptor, which belongs to the tumor necrosis factor receptor superfamily of death receptors and the Trk receptor tyrosine kinase family.

关键词： Adult neurogenesis regeneration neurotrophins

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