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Targeting menin: a promising therapeutic strategy for susceptible acute leukemia subtypes

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5141-5142页

作者： pietro Di Fazio Department of Visceral Thoracic and Vascular SurgeryPhilipps University of MarburgBaldingerstrasse35043MarburgGermany

Two recent studies published in Nature focused on the clinical efficacy of the menin inhibitor revumenib(SNDX-5613)in KMT2A(histone-lysine N-methyltransferase 2A)-rearranged or NPM1(Nucleophosmin1)-mutant acute myeloid leukemia.1,2 These studies indicate that menin inhibition and its acquired resistance to long-term exposure to revuminib are key points for future treatment,emphasizing the role of menin as a challenging and promising target for the current treatment of leukemia.

关键词： acute clinical therapeutic

Comparison Between Deep Learning Models and Traditional Machine Learning Approaches for Facial Expression Recognition in Ageing Adults

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Journal of Computer Science & Technology 2020年第5期35卷 1127-1146页

作者： Andrea Caroppo Alessandro Leone pietro Siciliano Institute for Microelectronics and Microsystems National Research Council of ItalyLecce 73100Italy

Facial expression recognition is one'of the most active areas of research in computer vision since one of the non-verbal communication methods by which one understands the lnood/mental state of a person is the expression of ***,it has been used in various fields such as human-robot interaction,security,computer graphics animation,and ambient ***,it remains a challenging task since existing approaches lack generalizability and almost all studies ignore the effects of facial attributes,such as *** expression recognition even though the research indicates that facial expression inanifestation varies with ***,a lot of progress has been made in this topic and great improvements in classification task were achieved with the emergence of deep learning *** approaches have sliown how hierarchies of features can be directly learned from original data,thus avoiding classical hand designed feature extraction methods that generally rely on manual operations witli labelled ***,research papers systematically exploring tlu4 performance of existing deep architectures for the task of classifying expression of ageing adults are absent in the *** the present work a tentative to try this gap is done considering the performance of three recent deep convolutiorial neural networks models(VGG-16,AlexNet and GoogLeNet/Inception V1)and evaluating it on four different benchmark datcisets(FACES,Lifespan,CIFE,and FER2013)which also contain facial expressions performed by elderly *** the baseline,and with the aim of making a comparison,two traditional inacliine learning approaches based on handcrafted features extraction process are evaluated on the same *** out an exhaustive and rigorous experimentation focused on the concept of "transfer learning",which consists of replacing the output level of the deep architectures considered with new output levels appropriate to the number of classes(facial expressions),

关键词： computer vision deep learning facial expression machine learning ageing adult

Messages from Powdery Mildew DNA:How the Interplay with a Host Moulds Pathogen Genomes

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Journal of Integrative Agriculture 2014年第2期13卷 233-236页

作者： pietro D Spanu Department of Life Sciences Imperial College LondonLondon SW7 2AZUnited Kingdom

The genomes of the barley, Arabidopsis and pea powdery mildew are significantly larger than those of related fungi. This is due to an extraordinary expansion of retro-trasposons that are evident as repetitive elements in the sequence. The protein coding genes are fewer than expected due to an overall reduction in the size of gene families, a reduction in the number of paralogs and because of the loss of certain metabolic pathways. Many of these changes have also been observed in the genomes of other taxonomically unrelated obligate biotrophic pathogens. The only group of genes that bucks the trend of gene loss, are those encoding small secreted proteins that bear the hall marks of effectors.

关键词： barley powdery mildew genome effectors

Unsteady Inflow Effects on the Wake Shed from a High-Lift LPT Blade Subjected to Boundary Layer Laminar Separation

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Journal of Thermal Science 2012年第2期21卷 97-108页

作者： Francesca Satta Marina Ubaldi pietro Zunino Università degli Studi di Genova

An experimental investigation on the near and far wake of a cascade of high-lift low-pressure turbine blades subjected to boundary layer separation over the suction side surface has been carried out, under steady and unsteady inflows. Two Reynolds number conditions, representative of take-off/landing and cruise operating conditions of the real engine, have been tested. The effect of upstream wake-boundary layer interaction on the wake shed from the profile has been investigated in a three-blade large-scale linear turbine cascade. The comparison between the wakes shed under steady and unsteady inflows has been performed through the analysis of mean velocity and Reynolds stress components measured at midspan of the central blade by means of a two-component crossed miniature hot-wire probe. The wake development has been analyzed in the region between 2% and 100% of the blade chord from the central blade trailing edge, aligned with the blade exit direction. Wake integral parameters, half-width and maximum velocity defects have been evaluated from the mean velocity distributions to quantify the modifications induced on the vane wake by the upstream wake. Moreover the thicknesses of the two wake shear layers have been considered separately in order to identify the effects of Reynolds number and incoming flow on the wake shape. The self-preserving state of the wake has been looked at, taking into account the different thicknesses of the two shear layers. The evaluation of the power density spectra of the velocity fluctuations allowed the study of the wake unsteady behavior, and the detection of the effects induced by the different operating conditions on the trailing edge vortex shedding.

关键词： Wake-wake unsteady interaction high-lift blade profiles low-pressure turbine blade wake.

Adult neurogenesis and regeneration in zebrafish brain: are the neurotrophins involved in?

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Neural Regeneration Research 2019年第12期14卷 2067-2068页

作者： pietro Cacialli Carla Lucini Department of Veterinary Medicine University of Naples Federico Ⅱ

Neurotrophins (NTs) are implicated in the maintenance and survival of the peripheral and central nervous systems and mediate several forms of synaptic plasticity. Members of the family include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), NT3, and NT4. NTs were first identified as survival factors for developing neurons, but are pleiotropic molecules that can exert a variety of functions, including the regulation of neuronal differentiation, axonal and dendritic growth, and synaptic plasticity (Bothwell, 2014). NTs interact with two distinct types of receptors: the common p75 neurotrophin receptor, which belongs to the tumor necrosis factor receptor superfamily of death receptors and the Trk receptor tyrosine kinase family.

关键词： Adult neurogenesis regeneration neurotrophins

Therapeutic potential of curcumin in digestive diseases

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World Journal of Gastroenterology 2013年第48期19卷 9256-9270页

作者： pietro Dulbecco Vincenzo Savarino Department of Internal Medicine and Medical Specialties University of Genoa 16132 Genoa Italy

Curcumin is a low-molecular-weight hydrophobic polyphenol that is extracted from turmeric,which possesses a wide range of biological properties including anti-inflammatory,anti-oxidant,anti-proliferative and anti-microbial *** its diverse targets and substantial safety,clinical applications of this molecule for digestive disorders have been largely limited to case series or small clinical *** poor bioavailability of curcumin is likely the major hurdle for its more widespread use in ***,complexation of curcumin into phytosomes has recently helped to bypass this problem,as it has been demonstrated that this new lecithin formulation enables increased absorption to a level 29-fold higher than that of traditional curcuminoid *** allows us to achieve much greater tissue substance delivery using significantly lower doses of curcumin than have been used in past clinical *** curcumin has already been shown to provide good therapeutic results in some small studies of both inflammatory and neoplastic bowel disorders,it is reasonable to anticipate an even greater efficacy with the advent of this new technology,which remarkably improves its *** features are very promising and may represent a novel and effective therapeutic approach to both functional and organic digestive diseases.

关键词： Curcumin Curcumin-phythosome Curcumin bioavailability Digestive disorders

Time Complexity of Evolutionary Algorithms for Combinatorial Optimization:A Decade of Results

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International Journal of Automation and computing 2007年第3期4卷 281-293页

作者： pietro S.Oliveto The Center of Excellence for Research in Computational Intelligence and Applications (CERCIA) School of Computer Science University of BirminghamEdgbastonBirmingham B15 2TTUK

Computational time complexity analyzes of evolutionary algorithms （EAs） have been performed since the mid-nineties. The first results were related to very simple algorithms, such as the （1＋1）-EA, on toy problems. These efforts produced a deeper understanding of how EAs perform on different kinds of fitness landscapes and general mathematical tools that may be extended to the analysis of more complicated EAs on more realistic problems. In fact, in recent years, it has been possible to analyze the （1＋1）-EA on combinatorial optimization problems with practical applications and more realistic population-based EAs on structured toy problems. This paper presents a survey of the results obtained in the last decade along these two research lines. The most common mathematical techniques are introduced, the basic ideas behind them are discussed and their elective applications are highlighted. Solved problems that were still open are enumerated as are those still awaiting for a solution. New questions and problems arisen in the meantime are also considered.

关键词： Evolutionary algorithms computational complexity combinatorial optimization evolutionary computation theory.

Endo-hepatology: Why should we do endoscopic ultrasound-guided interventions to the liver that we could do through the skin?

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World Journal of Gastroenterology 2024年第40期30卷 4333-4338页

作者： Claudio Calvanese pietro Fusaroli Gastroenterology Unit Hospital of ImolaUniversity of BolognaImola 40026BolognaItaly

Endoscopic ultrasound(EUS)-guided interventions on the liver such as diffuse biopsy and portal pressure gradient measurement are emerging as potential alternatives to percutaneous *** purpose of this editorial was to address all the indications that could potentially make an EUS-guided approach a possible alternative to the percutaneous procedures with respect to the proce-dures that could join the EUS examination such as upper endoscopy for gastro-esophageal varices,pancreaticobiliary investigation with EUS,and other potential advantages in terms of patient *** issue of a holistic gastroenterologist approach was also discussed along with the potential for developing clinical research.

关键词： Endo-hepatology Endoscopic ultrasound Endosonography Liver disease Liver biopsy Portal hypertension

An adaptive directional MAC protocol for ad hoc networks using directional antennas

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Science China(Information Sciences) 2012年第6期55卷 1360-1371页

作者： TOWSLEY Don LIO pietro Deptartment of Computer Science University of MassachusettsAmherst 01003USA

A directional antenna can bring benefits in terms of power consumption,spatial reuse,*** exploit the advantage of directional antennas and improve the transmission throughput highest,this paper proposes an adaptive directional MAC protocol(ADMAC).By varying the transmission strategy according to the usage of the channel,nodes can send RTS and CTS packets omni-directionally or ***,this paper proposes a calculation method of virtual carrier sensing with collision *** the method,ADMAC protocol makes more pairs of nodes transmit and receive data simultaneously without interferences than other MAC protocols for directional *** paper compares the simultaneous delivering nodes and network throughput of ADMAC with DMAC,DVCS and SDMAC under different experiment *** simulation results show that the throughput of ADMAC is higher than the throughput of DMAC,DVCS and SDMAC protocols.

关键词： medium access control directional MAC directional antennas MANETs