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Recent advances in the management of rectal cancer: No surgery, minimal surgery or minimally invasive surgery

World Journal of Gastrointestinal Surgery 2017年第6期9卷 139-148页

作者： Joseph M Plummer pierre-anthony leake Matthew R Albert Department of Surgery Radiology Anaesthesia and Intensive Care University of the West Indies Center for Colon and Rectal Surgery De-partment of Colon and Rectal Surgery Florida Hospital

Over the last decade,with the acceptance of the need for improvements in the outcome of patients affected with rectal cancer,there has been a significant increase in the literature regarding treatment options available to patients affected by this *** treatment related decisions should be made at a high volume multidisciplinary tumor board,after pre-operative rectal magnetic resonance imaging and the importance of total mesorectal excision(TME)are accepted standard of *** controversial is the emerging role for watchful waiting rather than radical surgery in complete pathologic responders,which may be appropriate in 20%of *** with early T1 rectal cancers and favorable pathologic features can be cured with local excision only,with transanal minimal invasive surgery(TAMIS)because of its versatility and almost universal availability of the necessary equipment and skillset in the average laparoscopic surgeon,emerging as the leading *** trials have raised concerns about the oncologic outcomes of the standard"top-down"TME hence transanal TME(Ta TME"bottom-up")approach has gained popularity as an *** challenges are many,with a dearth of evidence of the oncologic superiority in the long-term for any given ***,this review highlights recent advances in the role of chemoradiation only for complete pathologic responders,TAMIS for highly selected early rectal cancer patients and Ta TME as options to improve cure rates whilst maintaining quality of life in these patients,while we await the results of further definitive trials being currently conducted.

关键词：直肠的癌症警惕等待 Transanal 最小的侵略外科 Transanal 全部的 mesorectal 切除

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Pathological factors affecting gastric adenocarcinoma survival in a Caribbean population from 2000-2010

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World Journal of Gastrointestinal Surgery 2014年第6期6卷 94-100页

作者： Patrick O Roberts Joseph Plummer pierre-anthony leake Shane Scott Tamara G de Souza Ayesha Johnson Tracey N Gibson Barrie Hanchard Marvin Reid The Department of Surgery Radiology Anaesthesia and Intensive Care The University of the West IndiesJamaica 999172 West Indies College of Public Health University of South Florida Tampa FL 33620-9951 United States The Department of Pathol-ogy The University of the West Indies Jamaica 999172 West Indies Tropical Medicine Research Institute The Univer-sity of the West Indies Jamaica 999172 West Indies

AIM: To investigate pathological factors related to long term patient survival post surgical management of gas-tric adenocarcinoma in a Caribbean ***: This is a retrospective, observational study of all patients treated surgically for gastric adenocarci-noma from January 1st 2000 to December 31 st 2010 at The University Hospital of the West Indies, an urban Jamaican hospital. Pathological reports of all gastrecto-my specimens post gastric cancer resection during the specified interval were accessed. Patients with a final diagnosis other than adenocarcinoma, as well as pa-tients having undergone surgery at an external institu-tion were excluded. The clinical records of the selected cohort were reviewed. The following variables were analysed; patient gender, patient age, the number of gastrectomies previous performed by the lead surgeon, the gross anatomical location and appearance of the tumour, the histological appearance of the tumour, infil-tration of the tumour into stomach wall and surround-ing structures, presence of Helicobacter pylori and the presence of gastritis. Patient status as dead vs alive was documented for the end of the interval. The effect of the aforementioned factors on patient survival were analysed using Logrank tests, Cox regression models, Ranksum tests, Kruskal-Wallis tests and Kaplan-Meier ***: A total of 79 patients, 36 males and 43 fe-males, were included. Their median age was 67 years(range 36-86 years). Median survival time from surgery was 70 mo with 40.5% of patients dying before the termination date of the study. Tumours ranged from 0.8 cm in size to encompassing the entire stomach speci-men, with a median tumour size of 6 cm. The median number of nodes removed at surgery was 8 with a maximum of 28. The median number of positive lymph nodes found was 2, with a range of 0 to 22. Patients' median survival time was approximately 70 mo, with 40.5% of the patients in this cohort dying before the terminal date. An

关键词：胃的腺癌加勒比海牙买加病理学幸存 Gastrectomy 胃炎 Helicobacter pylori 贲门环绕的切除术边缘

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Comparative analysis of open and laparoscopic colectomy for malignancy in a developing country

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World Journal of Gastrointestinal Surgery 2013年第11期5卷 294-299页

作者： pierre-anthony leake Kristen Pitzul Patrick O Roberts Joseph M Plummer Department of Surgery RadiologyAnaesthesia and Intensive CareFaculty of Medical SciencesUniversity of the WestIndiesKingston 7Jamaica Institute of Health Policy Management and Evaluation University of TorontoTorontoOntario M5T 3M6Canada

AIM: To compare the short-term, including oncologic, outcomes of open vs laparoscopic colectomy for cancer in a developing country. METHODS: The records of patients who underwent elective open and laparoscopic colectomies for cancer at the University Hospital of the West Indies between January 2005 and December 2010 were retrospectively reviewed. Demographic(age, gender, Charlson comorbidity index score), peri-operative, post-operative and oncologic data were collected for each patient. Specific oncologic variables included lymph node yield, pathologic stage, grade, proximal, distal and circumferential margin involvement. Fisher's exact, Mann-Whitney, and binary logistic regression tests were used for analysis. Significance level was set atP < 0.05. RESULTS: There were 87 cases for open colectomy(OC) and 17 cases for laparoscopic colectomy(LC). Demographics did not significantly differ between OC and LC groups. Intra-operative blood loss and postoperative analgesic requirements did not significantly differ between groups. There was a trend towards longer operating times in OC group and shorter hospital stay in the LC group. Lymph node yield(14 vs 14, P = 0.619), proximal(10 cm vs 7 cm, P = 0.353) and distal(8 cm vs 8 cm, P = 0.57) resection margin distance and circumferential margin involvement(9 vs 0, P = 0.348) did not significantly differ between groups. Thirty-day morbidity was equivalent between groups(22 vs 6, P = 0.774). There were 6 deaths within 30 d of initial procedure, all in the OC group(6.9%). CONCLUSION: Laparoscopic colectomy in a developing country is oncologically safe and represents a option for colonic malignancies in these regions. Such data encourage the continued laparoscopic development.

关键词： Laparoscopy Colectomy Cancer Developing country Colorectal Oncology Short-term Outcomes

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Electrically pumped quantum-dot lasersgrownon 300 mm patterned Si photonic wafers

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Light(Science & Applications) 2022年第11期11卷 2698-2705页

作者： Chen Shang Kaiyin Feng Eamonn THughes Andrew Clark Mukul Debnath Rosalyn Koscica Gerald leake Joshua Herman David Harame Peter Ludewig Yating Wan John E.Bowers Materials Department University of California Santa BarbaraSanta BarbaraCA 93106USA Department of Electrical and Computer Engineering University of California Santa BarbaraSanta BarbaraCA 93106USA OQE IncGreensboroNC 27409USA RF SUNY Polytechnic Institute AlbanyNY 12203USA NAsPIII/NV GmbH MarburgGermany

Monolithic integration of quantum dot(QD)gain materials onto Si photonic platforms via direct epitaxial growth is a promising solution for on-chip light *** developments have demonstrated superior device reliability in blanket hetero-epitaxy ofⅡ-Ⅴdevices on Si at elevated ***,thick,defect management epi designs prevent vertical light coupling from the gain region to the Si-on-lnsulator ***,we demonstrate the frst electrically pumped QD lasers grown by molecular beam epitaxy on a 300 mm patterned(001)Si wafer with a buttcoupled *** growth and fabrication challenges imposed by the template architecture have been resolved,contributing to continuous wave lasing to 60℃and a maximum double-side output power of 126.6 mW at 20℃with a double-side wall-plug efficiency of 8.6%.The potential for robust on-chip laser operation and effcient lowloss light coupling to Si photonic circuits makes this heteroepitaxial integration platform on Si promising for scalable and low-cost mass production.

关键词： pumped quantum coupling

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AGRONOMIC AND ENVIRONMENTAL BENEFITS OF REINTRODUCING HERB-AND LEGUME-RICH MULTISPECIES LEYS INTO ARABLE ROTATIONS:A REVIEW

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Frontiers of Agricultural Science and Engineering 2022年第2期9卷 245-271页

作者： Emily C.COOLEDGE David R.CHADWICK Lydia M.J.SMITH Jonathan R.leake Davey L.JONES School of Natural Sciences Bangor UniversityGwyneddLL572UWUK National Institute of Agricultural Botany Huntingdon RoadCambridgeCB 3 OLEUK Plants Photosynthesis and SoilUniversity of SheffieldSheffieldS102TNUK Centre for Sustainable Farming Systems Food Futures InstituteMurdochWA 6150Australia

Agricultural intensification and the subsequent decline of mixed farming systems has led to an increase in continuous cropping with only a few fallow or break years,undermining global soil ***-ley rotations incorporating temporary pastures(leys) lasting 1–4 years may alleviate soil degradation by building soil fertility and improving soil ***,the majority of previous research on arable-ley rotations has utilized either grass or grassclover leys within ungrazed *** leys,containing a mix of grasses,legumes,and herbs,are rapidly gaining popularity due to their promotion in agri-environment schemes and potential to deliver greater ecosystem services than conventional grass or grass-clover *** grazing in arable-ley rotations may increase the economic resilience of these systems,despite limited research of the effects of multispecies leys on ruminant health and greenhouse gas *** review aims to evaluate previous research on multispecies leys,highlighting areas for future research and the potential benefits and disbenefits on soil quality and livestock *** botanical composition of multispecies leys is crucial,as legumes,deep rooted perennial plants(e.g.,Onobrychis viciifolia and Cichorium intybus) and herbs(e.g.,Plantago lanceolata) can increase soil carbon,improve soil structure,reduce nitrogen fertilizer requirements,and promote the recovery of soil fauna(e.g.,earthworms) in degraded arable soils while delivering additional environmental benefits(e.g.,biological nitrification inhibition and enteric methane reduction).Multispecies leys have the potential to deliver biologically driven regenerative agriculture,but more long-term research is needed to underpin evidence-based policy and farmer guidance.

关键词： bioactive forages integrated crop-livestock systems nitrogen cycling plant secondary metabolites soil carbon soil quality

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Microseismic monitoring and analysis of induced seismicity source mechanisms in a retreating room and pillar coal mine in the Eastern United States

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Underground Space 2017年第2期2卷 115-124页

作者： Morgen R.leake William J.Conrad Erik C.Westman Setareh Ghaychi Afrouz Ryan J.Molka Mining and Minerals Engineering Department Virginia Polytechnic Institute and State University445 Old Turner Street100 Holden HallBlacksburgVA 24060USA

A microseismic monitoring system was installed in an underground room and pillar coal mine in the Eastern United States to analyze the occurrence and characteristics of induced seismicity during the retreat of two panels in the *** study is the first microseismic monitoring effort at an underground coal mine in nearly 30 *** the retreat of the first panel,an array of eight uniaxial geophones,installed 10 *** the roof,recorded events and their *** second panel was monitored using an array of twelve uniaxial geophones and two triaxial geophones,also installed 10 *** the *** the results of these studies,it has been found that the magnitude of seismic events is minimally affected by immediate roof geology or depth of ***,it was observed in both studies that the rate at which seismic events occurred did vary with changing roof geology and depth of *** the seismic data from the second panel retreat,focal mechanism solutions were generated for 50 hand-picked events in order to determine if the failure was in compression,tension,or *** of the focal mechanism solutions show that stress relief resulting in dilational events occurs at significant depths,150-200 m in this case,beneath the active mining face.

关键词： Deep mining Induced seismicity Coal mining Rock mechanics Source mechanisms Subsidence

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A convolutional neural network for defect classification in Bragg coherent X-ray diffraction

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npj Computational Materials 2021年第1期7卷 1026-1033页

作者： Bruce Lim Ewen Bellec Maxime Dupraz Steven leake Andrea Resta Alessandro Coati Michael Sprung Ehud Almog Eugen Rabkin Tobias Schulli Marie-Ingrid Richard Grenoble INP-Phelma Univ.Grenoble AlpesGrenobleFrance ESRF-The European Synchrotron GrenobleFrance CEA Grenoble IRIGMEMNRSUniv.Grenoble AlpesGrenobleFrance Synchrotron SOLEIL L’Orme des MerisiersGif-sur-YvetteFrance Deutsches Elektronen-Synchrotron(DESY) HamburgGermany Department of Materials Science and Engineering Technion-Israel Institute of TechnologyHaifaIsrael

Coherent diffraction imaging enables the imaging of individual defects,such as dislocations or stacking faults,in *** defects and their surrounding elastic strain fields have a critical influence on the macroscopic properties and functionality of ***,their identification in Bragg coherent diffraction imaging remains a challenge and requires significant data *** ability to identify defects from the diffraction pattern alone would be a significant advantage when targeting specific defect types and accelerates experiment design and ***,we exploit a computational tool based on a three-dimensional(3D)parametric atomistic model and a convolutional neural network to predict dislocations in a crystal from its 3D coherent diffraction *** diffraction patterns from several thousands of relaxed atomistic configurations of nanocrystals are used to train the neural network and to predict the presence or absence of dislocations as well as their type(screw or edge).Our study paves the way for defect-recognition in 3D coherent diffraction patterns for material science.

关键词： materials coherent defect

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Cost Estimation of Voltage Dips in Small Industries Based on Equipment Sensitivity Analysis

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Smart Grid and Renewable Energy 2016年第11期7卷 271-292页

作者： leake Enquay Weldemariam Vladimir Cuk Joseph Fraciscus Gerardus Cobben Department of Electrical Engineering Eindhoven University of Technology Eindhoven The Netherlands Dutch Electric Utility Arnhem The Netherlands

Voltage dip is one of the detrimental power quality problems that can lead to huge financial losses in industries. Its economic impact is not only associated with the quality of the supply but also with sensitivity of electronic controls and equipment of the industry which are susceptible to voltage dips. Mitigating solutions are available but the choice depends on the careful assessment of the economic impact of voltage dips and economic gains of solutions. This paper presents an approach for estimating the economic cost of voltage dips based on sensitivity analysis. The voltage-tolerance curves of the sensitive equipment are obtained from experimental tests under different conditions. From the behavior and interaction of process equipment, different failure modes and economic sensitivity density are determined for different types of voltage dips. Voltage events monitored in the MV-network for several years are assessed to determine the frequency and severity of voltage dips at the customer terminal. The economic values of equipment and processes are assessed to get insight into alternative solutions with more rewarding measures. Then, cost-benefit analysis is performed to compare the economic gains of solutions protecting equipment or processes showing more rewarding economic values.

关键词： Economic Impact Equipment Sensitivity Power Quality Voltage Dip

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Autodesk Inventor

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1000年

作者： leake James M.

来源：畅想之星图书光盘版（南... 评论

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不同聚氨酯Dacron材料抗血栓性能的比较

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北京生物医学工程 1992年第1期11卷 60-63页

作者： D.L.leake 朱明华

运用不同编织Dacron和不同氨基甲酸酯涂层的Dacron血管修补物进行试验.整个材料置于富血小板血浆中,与血小板接触,随后分析三种血小板的释放物质,即β—血栓球蛋白,血小板4因子和血栓烷B_2,还有血小板停滞数.这些常用来确定材料本身形... 详细信息

运用不同编织Dacron和不同氨基甲酸酯涂层的Dacron血管修补物进行试验.整个材料置于富血小板血浆中,与血小板接触,随后分析三种血小板的释放物质,即β—血栓球蛋白,血小板4因子和血栓烷B_2,还有血小板停滞数.这些常用来确定材料本身形成血栓的程度.在某些实验中Dacron—氨基甲酸酯复合物显示具有比其它任何常用的血管外科材料更好的抗血栓性.虽然在血管外科和病人的处理中有不断改进,但是在临床上移植物的血栓形成仍是一个重要问题,在有利于这种现象(即血液流动、血液的特性、周围阻力)的条件下,移植材料仍起着重要的作用.

关键词： Dacron 抗血栓性能聚氨酯

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