检索结果-南通市图书馆

Identifying more reliable parameters for the detection of change during the follow-up of mild to moderate keratoconus patients

引用

Eye and Vision 2017年第1期4卷 143-149页

作者： Ivo Guber Colm McAlinden françois Majo Ciara Bergin Department of Ophthalmology University of GenevaGenevaSwitzerland Department of Ophthalmology Glangwili HospitalHywel Dda University Health BoardCarmarthenUK School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhouZhejiangChina Jules-Gonin Eye Hospital University of LausanneFondation Asile des AveuglesLausanneSwitzerland

Background:Reaching a consensus on which parameters are most reliable at detecting progressive keratoconus patients with serial topography imaging is not *** aim of the study was to isolate the parameters best positioned to detect keratoconus progression using the Pentacam HR^(®)measures based on the respective limits of repeatability and range of ***:Using the Pentacam HR^(®),a tolerance index was calculated on anterior segment parameters in healthy and keratoconic *** tolerance index provides a scale from least to most affected parameters in terms of measurement noise relative to that observed in healthy ***,based on the“number of increments”from no disease to advanced disease,a relative utility(RU)score was also *** values close to 1 indicate parameters best positioned to detect a change in keratoconic ***:The tolerance index values indicated that 36%of ocular parameters for keratoconic eyes had repeatability limits which were wider than normative limits(worse),but 28%of the ocular parameters were narrower than normative limits(better).Considering only those parameters with a RU greater than 0.95,a small number of parameters were within this range,such as corneal curvature and asphericity ***:This study demonstrates that measurement error in keratoconic eyes is significantly greater than healthy *** implemented here provide guidance on the levels of expected precision in keratoconic eyes relative to healthy eyes to aid clinicians in distinguishing real change from *** maximal keratometry(Kmax),central corneal thickness(CCT)and thinnest corneal thickness(TCT)were highlighted as problematic indices for the follow-up of keratoconus in terms of repeatability.

关键词： Pentacam Keratoconus Progression Repeatability Precision Corneal crosslinking

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cycloadditions of 1-iminylphosphirane complexes with allenes

引用

Chinese Chemical Letters 2021年第1期32卷 449-452页

作者： Juan Li Mingyue Cui Rongqiang Tian Zheng Duan françois Mathey College of Chemistry Green Catalysis CenterInternational Phosphorus LaboratoryInternational Joint Research Laboratory for Functional Organophosphorus Materials of Henan ProvinceZhengzhou UniversityZhengzhou 450001China

A cascade carbonylative ring expansion and [2+2]/[4+2] cycloaddition of strained 1-iminylphosphirane complexes with aryl allenes were *** carbonylative ring expansion of 1-iminylphosphirane complexes provides an azaphosphacyclohexone complex intermediate with a C=P double *** following [2+2] or dearomatic [4+2] cycloaddition of this intermediate with allenes is modulated by the aryl substituents on the imino *** regioselective [2+2] cycloaddition with 1,1-diarylallene provides an entry to bicyclo[4.2.0]octan-4-one skeletons featuring a four-membered phosphacyclobutane *** dearomatic [4+2] cycloaddition was preferred with less aromatic naphthalene and yielded octahydrochrysene skeleton containing heteroatoms.

关键词： Phosphirane Allene Ring expansion Cycloaddition Carbonylative Heterocycle

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Fate of undigested proteins in the pig large intestine:What impact on the colon epithelium?

引用

Animal Nutrition 2022年第2期9卷 110-118页

作者： françois Blachier Mireille Andriamihaja Xiang-Feng Kong UMR PNCA Nutrition Physiology and Alimentary BehaviorUniversite Paris-SaclayAgroParisTechINRAEParisFrance Key Laboratory of Agro-Ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesChangshaChina

Apart from its obvious agronomic interest in feeding billions of people worldwide,the porcine species represents an irreplaceable experimental model for intestinal physiologists and *** this review,we give an overview on the fate of proteins that are not fully digested in the pig small intestine,and thus are transferred into the large *** the large intestine,dietary and endogenous proteins are converted to peptides and amino acids(AA)by the action of bacterial proteases and ***,which cannot,except in the neonatal period,be absorbed to any significant level by the colonocytes,are used by the intestinal microbes for protein synthesis and for the production of numerous *** note,the production of the AA-derived metabolites greatly depends on the amount of undigested polysaccharides in the pig's *** effects of these AA-derived bacterial metabolites on the pig colonic epithelium have not yet been largely ***,the available data,performed on colonic mucosa,isolated colonic crypts and colonocytes,indicate that some of them,like ammonia,butyrate,acetate,hydrogen sulfide(H_(2)S),and p-cresol are active either directly or indirectly on energy metabolism in colonic epithelial *** studies in that area will certainly gain from the utilization of the pig colonic organoid model,which allows for disposal of functional epithelial *** studies will contribute to a better understanding of the potential causal links between diet-induced changes in the luminal concentrations of these AA-derived bacterial metabolites and effects on the colon epithelial barrier function and water/electrolyte absorption.

关键词： Gut microbiota Amino acids Bacterial metabolites Pig Large intestine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Metabolic syndrome,levels of androgens,and changes of erectile dysfunction and quality of life impairment 1 year after radical prostatectomy

引用

Asian Journal of Andrology 2021年第4期23卷 370-375页

作者： Yann Neuzillet Mathieu Rouanne Jean-françois Dreyfus Jean-pierre Raynaud Marc Schneider Morgan Roupret Sarah Drouin Marc Galiano Xavier Cathelinau Thierry Lebret Henry Botto Department of Urology Hospital FochUVSQ-Paris-Saclay UniversitySuresnes 92150France Department of Clinical Research and Innovation Hospital FochUVSQ-Paris-Saclay UniversitySuresnes 92150France Sorbonne University Paris 75013France Department of Urology Hospital Louis PasteurColmar 68000France Department of Urology Hôpital Pitié-SalpêtrièreAssistance Publique-Hôpitaux de ParisSorbonne UniversityParis 75013France Department of Urology Montsouris InstituteParis-Descartes UniversityParis 75014France

Robust data evaluating the association of preoperative parameters of the patients with quality of life after radical prostatectomy are *** investigated whether clinical and biological preoperative characteristics of the patients were associated with impaired patient-reported quality of life(QoL)and sexual outcomes 1 year after radical *** evaluated patient-reported outcomes among the 1343 men participating in the AndroCan trial(NCT02235142).QoL and erectile dysfunction(ED)were assessed before and 1 year after radical prostatectomy using validated self-assessment questionnaires(Aging Male's Symptoms[AMS]and the 5-item abridged version of the International Index of Erectile Function[IIEF5]).At baseline,1194 patients(88.9%)accepted to participate.A total of 750(55.8%)patients answered the 1-year postoperative *** of them,only 378(50.4%of responders)provided answers that could be used for *** year after prostatectomy,ED had worsened by 8.0(95%confidence interval[CI]:7.3–8.7;P<0.0001)out of a maximum of *** global AMS score has worsened by 2.8(95%CI:1.7–3.8;P<0.0001).ED scores 1 year postsurgery were positively correlated with preoperative age and percentage of fat mass,and negatively correlated with total cholesterol,dehydroepiandrosterone(DHEA),and androstenediol(D5);AMS were poorly correlated with preoperative *** and sexual symptoms significantly worsened after radical *** bioavailable testosterone levels were significantly correlated with smaller changes on AMS somatic subscores *** findings may be used to inform patients with newly diagnosed prostate cancer.

关键词： metabolic syndrome quality of life radical prostatectomy sexual outcomes testosterone deficiency

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Performance optimization of grid aggregation in spatial data warehouses

引用

International Journal of Digital Earth 2015年第12期8卷 970-988页

作者： Myoung-Ah Kang Mehdi Zaamoune françois Pinet Sandro Bimonte Philippe Beaune LIMOS-CNRS UMR 6158 ISIMAUniversitéBlaise PascalAubièreFrance Irstea UR TSCFClermont-FerrandFrance Agaetis Clermont-FerrandFrance

The problem of storage and querying of large volumes of spatial grids is an issue to *** this paper,we propose a method to optimize queries to aggregate raster grids stored in *** our approach,we propose to estimate the exact result rather than calculate the exact *** approach reduces query execution *** advantage of our method is that it does not require implementing or modifying functionalities of database management *** approach is based on a new data structure and a specific model of SQL *** work is applied here to relational data warehouses.

关键词： data warehouse database modelling geographical information system

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electrochemical treatment of olive mill wastewater:Treatment extent and effluent phenolic compounds monitoring using some uncommon analytical tools

引用

Journal of Environmental Sciences 2013年第1期25卷 220-230页

作者： Chokri Belaid Moncef Khadraoui Salma Mseddi Monem Kallel Boubaker Elleuch Jean franois Fauvarque Laboratory of Water Energy and Environment Sfax UniversityENIS BP "1173" 3038 Sfax Tunisia Laboratory of Industrial Electrochemistry CNAM 2 Rue Conté 75003 Paris France

Problems related with industrials effluents can be divided in two parts：（1） their toxicity associated to their chemical content which should be removed before discharging the wastewater into the receptor media; （2） and the second part is linked to the difficulties of pollution characterisation and monitoring caused by the complexity of these matrixes. This investigation deals with these two aspects, an electrochemical treatment method of an olive mill wastewater （OMW） under platinized expanded titanium electrodes using a modified Gl＂ignard reactor for toxicity removal as well as the exploration of the use of some specific analytical tools to monitor effluent phenolic compounds elimination. The results showed that electrochemical oxidation is able to remove/mitigate the OMW pollution. Indeed, 87% of OMW color was removed and all aromatic compounds were disappeared from the solution by anodic oxidation. Moreover, 55% of the chemical oxygen demand （COD） and the total organic carbon （TOC） were reduced. On the other hand, UV- Visible spectrophotometry, Gaz chromatography/mass spectrometry, cyclic voltammetry and 13C Nuclear Magnetic Resonance （NMR） showed that the used treatment seems efficaciously to eliminate phenolic compounds from OMW. It was concluded that electrochemical oxidation in a modified Grignard reactor is a promising process for the destruction of all phenolic compounds present in OMW. Among the monitoring analytical tools applied, cyclic voltammetry and 13C NMR are among the techniques that are introduced for the first time to control the advancement of the OMW treatment and gave a close insight on polyphenols disappearance.

关键词： olive mill wastewater electro-oxidation polyphenols cyclic voltammetry GC/MS 13C NMR

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain

引用

Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 132-142页

作者： Samuele Iesari Milton Eduardo Inostroza Nú?ez Juan Manuel Rico Juri Olga Ciccarelli Eliano Bonaccorsi-Riani Laurent Coubeau pierre-fran?ois Laterre pierre Goffette Chantal De Reyck Beno?t Lengelé pierre Gianello Jan Lerut Starzl Abdominal Transplant Unit Cliniques Universitaires Saint-Luc Institut de Recherche Expérimentale et Clinique Université catholique de Louvain Department of Biotechnological and Applied Clinical Sciences University of L’Aquila Hepatobiliopancreatic Unit Las Higueras Hospital Cirugía de Trasplantes Centro Médico Imbanaco Department of Intensive Care Cliniques Universitaires Saint-Luc Université catholique de Louvain Department of Radiology Cliniques Universitaires Saint-Luc Université catholique de Louvain Department of Plastic and Reconstructive Surgery Cliniques Universitaires Saint-Luc Université catholique de Louvain P?le de Chirurgie Expérimentale et Transplantation Institut de Recherche Expérimentale et Clinique Université catholique de Louvain

Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely

关键词： Liver transplantation Living-donor Hepatocellular cancer Secondary liver tumor Small-for-size syndrome Small-for-size graft

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

On Some Properties of the Curl Operator and Their Consequences for the Navier-Stokes System

引用

Communications in Mathematical Research 2022年第4期38卷 449-497页

作者： Nicolas Lerner françois Vigneron Sorbonne Universite Institut de Mathématiques de JussieuUMR 7586Campus Pierre et Marie Curie4 Place Jussieu75252 Paris cedex 05France Universitéde Reims Champagne-Ardenne Laboratoire de Mathématiques de ReimsUMR 9008Moulin de la HousseBP 103951687 Reims cedex 2France

We investigate some geometric properties of the curl operator,based on its diagonalization and its expression as a non-local symmetry of the pseudoderivative(-△)^(1/2) among divergence-free vector fields with finite *** this context,we introduce the notion of spin-definite fields,*** of(-△)^(-1/2)*** two spin-definite components of a general 3D incompressible flow untangle the right-handed motion from the left-handed *** observed that the non-linearity of Navier-Stokes has the structure of a crossproduct and its weak(distributional)form is a determinant that involves the vorticity,the velocity and a test function,we revisit the conservation of energy and the balance of helicity in a geometrical *** show that in the case of a finite-time blow-up,both spin-definite components of the flow will explode simultaneously and with equal rates,*** in 3D are the result of a conflict of spin,which is impossible in the poorer geometry of 2D *** investigate the role of the local and non-local determinants ∫_(0)^(T) ∫_(R^(3))det(curlu,u,(-△)^(θ)u) and their spin-definite counterparts,which drive the enstrophy and,more generally,are responsible for the regularity of the flow and the emergence of singularities or *** such,they are at the core of turbulence phenomena.

关键词： Navier-Stokes vorticity hydrodynamic spin critical determinants turbulence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A mediation system for continuous spatial queries on a unified schema using Apache Spark

引用

Big Earth Data 2024年第1期8卷 115-141页

作者： Thi Thu Trang Ngo françois Pinet David Sarramia Myoung-Ah Kang UniversitéClermont Auvergne ISIMAAubièreFrance UniversitéClermont Auvergne INRAEUR TSCFClermont-FerrandFrance UniversitéClermont Auvergne CNRS/IN2P3LPCClermont-FerrandFrance

Recent advances in big and streaming data systems have enabled real-time analysis of data generated by Internet of Things(IoT)systems and sensors in various *** this context,many applications require integrating data from several heterogeneous sources,either stream or static *** such as Apache Spark are able to integrate and process large datasets from different ***,these frameworks are hard to use when the data sources are heterogeneous and *** address this issue,we propose a system based on mediation techniques for integrating stream and static data *** integration process of our system consists of three main steps:configuration,query expression and query *** the configuration step,an administrator designs a mediated schema and defines mapping between the mediated schema and local data *** the query expression step,users express queries using customized SQL grammar on the mediated ***,our system rewrites the query into an optimized Spark application and submits the application to a Spark *** results are continuously returned to *** experiments show that our optimizations can improve query execution time by up to one order of magnitude,making complex streaming and spatial data analysis more accessible.

关键词： Streaming data streaming data integration mediator geospatial data continuous queries

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Immune precision medicine for cancer:a novel insight based on the efficiency of immune effector cells

引用

Cancer Communications 2019年第1期39卷 318-333页

作者： Jean-françois Rossi Patrice Céballos Zhao-Yang Lu Institut Sainte Catherine 84918 AvignonFrance UniversitéMontpellier 1 UFR Médecine34396 MontpellierFrance Département d’Hématologie CHU de Montpellier34295 MontpellierFrance Unitéde Thérapie Cellulaire CHU Saint-Eloi34295 MontpellierFrance

Cancer cell growth is associated with immune surveillance ***,restoring the desired immune response against cancer cells remains a major therapeutic *** to the recent advances in biological knowledge,efficient therapeutic tools have been developed to support the best bio-clinical approaches for immune precision *** of the most important successes in immune therapy is represented by the applicational use of monoclonal antibodies,particularly the use of rituximab for B-cell lymphoproliferative *** recently,other monoclonal antibodies have been developed,to inhibit immune checkpoints within the tumor microenvironment that limit immune suppression,or to enhance some immune functions with immune adjuvants through different targets such as Toll-receptor *** aim is to inhibit cancer proliferation by the diminishing/elimination of cancer residual cells and clinically improving the response duration with no or few adverse *** effect is supported by enhancing the number,functions,and activity of the immune effector cells,including the natural killer(NK)lymphocytes,NKT-lymphocytes,γδT-lymphocytes,cytotoxic T-lymphocytes,directly or indirectly through vaccines particularly with neoantigens,and by lowering the functions of the immune suppressive *** these new therapeutics and their personalized usage,new considerations have to be taken into account,such as epigenetic regulation particularly from microbiota,evaluation of transversal functions,particularly cellular metabolism,and consideration to the clinical consequences at the body *** aim of this review is to discuss some practical aspects of immune therapy,giving to clinicians the concept of immune effector cells balancing between control and *** precision medicine is a combination of modern biological knowledge and clinical therapeutic decisions in a global vision of the patient.

关键词： Precision therapy Immunotherapy NK lymphocytes T-lymphocytes Dendritic cells Vaccination Cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：