Identifying more reliable parameters for the detection of change during the follow-up of mild to moderate keratoconus patients

作     者：Ivo Guber Colm McAlinden François Majo Ciara Bergin 

作者机构：Department of OphthalmologyUniversity of GenevaGenevaSwitzerland Department of OphthalmologyGlangwili HospitalHywel Dda University Health BoardCarmarthenUK School of Ophthalmology and OptometryWenzhou Medical UniversityWenzhouZhejiangChina Jules-Gonin Eye HospitalUniversity of LausanneFondation Asile des AveuglesLausanneSwitzerland 

出 版 物：《Eye and Vision》 (眼视光学杂志（英文）)

年 卷 期：2017年第4卷第1期

页      面：143-149页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Pentacam Keratoconus Progression Repeatability Precision Corneal crosslinking 

摘      要：Background:Reaching a consensus on which parameters are most reliable at detecting progressive keratoconus patients with serial topography imaging is not *** aim of the study was to isolate the parameters best positioned to detect keratoconus progression using the Pentacam HR^(®)measures based on the respective limits of repeatability and range of ***:Using the Pentacam HR^(®),a tolerance index was calculated on anterior segment parameters in healthy and keratoconic *** tolerance index provides a scale from least to most affected parameters in terms of measurement noise relative to that observed in healthy ***,based on the“number of incrementsfrom no disease to advanced disease,a relative utility(RU)score was also *** values close to 1 indicate parameters best positioned to detect a change in keratoconic ***:The tolerance index values indicated that 36%of ocular parameters for keratoconic eyes had repeatability limits which were wider than normative limits(worse),but 28%of the ocular parameters were narrower than normative limits(better).Considering only those parameters with a RU greater than 0.95,a small number of parameters were within this range,such as corneal curvature and asphericity ***:This study demonstrates that measurement error in keratoconic eyes is significantly greater than healthy *** implemented here provide guidance on the levels of expected precision in keratoconic eyes relative to healthy eyes to aid clinicians in distinguishing real change from *** maximal keratometry(Kmax),central corneal thickness(CCT)and thinnest corneal thickness(TCT)were highlighted as problematic indices for the follow-up of keratoconus in terms of repeatability.