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Biobanking efforts and new advances in male Fertility preservation for rare and endangered species

Asian Journal of Andrology 2015年第4期17卷 640-645页

作者： pierre Comizzoli Smithsonian Conservation Biology Institute National Zoological Park Veterinary Hospital PO Box 37012 Washington DC 20013 USA.

Understanding and sustaining biodiversity is a multi-disciplinary science that benefits highly from the creation of organized and accessible collections of biomaterials （Genome Resource Banks）. Large cryo-collections are invaluable tools for understanding, cataloging, and protecting the genetic diversity of the world＇s unique animals and plants. Specifically, the systematic collection and preservation of semen from rare species has been developed significantly in recent decades with some biobanks now being actively used for endangered species management and propagation （including the introduction of species such as the black-footed ferret and the giant panda）. Innovations emerging from the growing field of male fertility preservation for humans, livestock species, and laboratory animals are also becoming relevant to the protection and the propagation of valuable domestic and wild species. These new approaches extend beyond the ＂classical＂ methods associated with sperm freezing to include testicular tissue preservation combined with xenografting or in vitro culture, all of which have potential for rescuing vast amounts of unused germplasm. There also are other options under development that are predicted to have a high impact within the next decade （stem cell technologies, bio-stabilization of sperm cells at ambient temperatures, and the use of genomics tools）. However, biobanking efforts and new fertility preservation strategies have to expand the way beyond mammalian species, which will offer knowledge and tools to better manage species that serve as valuable biomedical models or require assistance to reverse endangerment.

关键词： conservation cryobiology endangered species male fertility spermatozoa

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Upward surface movement above deep coal mines after closure and flooding of underground workings

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International Journal of Mining Science and Technology 2018年第1期28卷 53-59页

作者： André Vervoort pierre-Yves Declercq Department of Civil Engineering KU Leuven Geological Survey of Belgium Royal Belgian Institute of Natural Sciences

After the mass closures of entire coal mine districts in Europe at the end of the last century, a new phenomenon of surface movement was observed—an upward *** most surface movement(i.e., subsidence) occurs in the months and years after mining by the longwall method, surface movement still occurs many decades after mining is *** the closure and flooding of underground excavations and surrounding rock, this movement was *** paper focuses on quantifying the upward movement in two neighboring coal mines(Winterslag and Zwartberg, Belgium).The study is based on data from a remote sensing technique: interferometry with synthetic aperture radar(INSAR).The results of the study show that the rate of upward movement in the decade after closure is about 10 mm/year on *** upward movements are not linked directly to the past exploitation directly underneath a *** amounts of subsidence at specific locations are linked mainly to their positions relative to an inverse trough shape situated over the entire mined-out areas and their immediate *** features, such as geological faults, can have a secondary effect on the local variation of the *** processes of subsidence and uplift are based on completely different *** is initiated by a caving process, while the process of uplift is clearly linked to flooding.

关键词： Coal mining Surface movement Subsidence Uplift Radar-interferometry

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Surface movement above old coal longwalls after mine closure

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International Journal of Mining Science and Technology 2017年第3期27卷 481-490页

作者： André Vervoort pierre-Yves Declercq Department of Civil Engineering KU Leuven Leuven 3001 Belgium Geological Survey of Belgium Royal Belgian Institute of Natural Sciences Brussels 1000 Belgium

Although most subsidence occurs in the months and years after mining by the longwall method, surface movement is still occurring many decades after the mining. The aim of the study is to quantify the long term behavior. Satellite data(radar-interferometry) were analyzed to study an area of about 2 km^2 during the 18 years following the closure of the underground infrastructure and the flooding of the underground workings and rock mass. It was observed that, on average, a residual downward movement took place till 7–12 years after the closure, followed by a clear uplift. However, the first signs of an uplift occurred in certain sub-areas 3–4 years after the closure. Zones within the area studied were identified with either larger or smaller movements. However, the spatial variation of the surface subsidence or uplift could not be directly explained by the characteristics of mining.

关键词： Coal mining Surface movement Subsidence Uplift Radar-interferometry

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Research on fabrication and properties of nanoporous GaN epilayers

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Rare Metals 2006年第Z2期25卷 5-10页

作者： NOUET Gérard RUTERANA pierre Laboratoire Structures des Interfaces et Fonctionnalité des Couches Minces UMR CNRS 6176 ENSICAEN6 Boulevard du Maréchal Juin 14050 Caen Cedex France

Gallium nitride (GaN) epilayers with nanopore arrays were fabricated by inductive coupled plasma (ICP) etching using anodic aluminum oxide (AAO) as mask. Nanoporous AAO templates were formed by anodizing the Al films deposited on GaN epilayers. The diameter of the perforations in the AAO masks could be easily controlled by tuning the technique parameters of AAO fabrication process. Cl2/Ar and Cl2/He were employed as etching gas. Scanning electron microscopy (SEM) analysis shows that vertical nanoporous arrays with uniform distribution can directly be transferred from AAO masks to GaN films in some proper conditions. Photoluminescence (PL) spectra, X-ray diffraction (XRD) and Raman spectroscopy were applied to assess properties of the nanoporous GaN films with different average pore diameters and interpore distances.

关键词： nanoporous GaN ICP etching

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Foreword to the special section on synchronous programming

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Frontiers of Computer Science 2013年第5期7卷 595-597页

作者： Jean-pierre TALPIN INRIA Rennes-Bretagne-Atlantique Rennes 35042 France

1 Introduction Embedded systems are ubiquitous. In applications ranging from avionics, automotive, and industrial process control all the way to the handheld personal digital assistants （PDAs）, cell phones, and bio-...

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Monoaminergic and catecholaminergic activation of the central pattern generator for locomotion following spinal cord injury Innovative therapeutic approaches

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Neural Regeneration Research 2009年第10期4卷 796-800页

作者： pierre A.Guertin Neuroscience Unit Laval University Medical Center(CHUL-CHUQ) Faculty of Medicine Department of Anatomy and PhysiologyLaval University

The development of secondary health complications following spinal cord injury has been increasingly recognized by healthcare professionals as a major concern. These problems most specifically affect complete or near-complete spinal cord injury patients （e.g., those with minimal mobility）, who are not typically rehabilitated with treadmill training approaches, because motor control and leg movements are largely impaired. However, recent pharmaceutical advances in central pattern generator activation may provide new therapeutic hopes for these spinal cord injury patients. This article provides a comprehensive overview, for the non-specialist, of the most recent advances in this field.

关键词： central pattern generator locomotion spinal cord injury mice

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A Hybrid Methodology for Short Term Temperature Forecasting

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International Journal of Intelligence Science 2020年第3期10卷 65-81页

作者： Wissam Abdallah Nassib Abdallah Jean-Marie marion Mohamad Oueidat pierre Chauvet Angevin Research Laboratory in Systems Engineering University of Angers Angers France Computer Science and Systems Laboratory Polytech Marseille Aix Marseille University Aix-en-Provence France Angevin Research Laboratory in Systems Engineering Université Catholique de l’Ouest Angers France Department of Industrial Engineering and Maintenance Faculty of Technology Lebanese University Beirut Lebanon Angevin Research Laboratory in Systems Engineering Université Catholique de l’Ouest Angers France

Developing a reliable weather forecasting model is a complicated task, as it requires heavy IT resources as well as heavy investments beyond the financial capabilities of most countries. In Lebanon, the prediction model used by the civil aviation weather service at Rafic Hariri International Airport in Beirut (BRHIA) is the ARPEGE model, (0.5) developed by the weather service in France. Unfortunately, forecasts provided by ARPEGE have been erroneous and biased by several factors such as the chaotic character of the physical modeling equations of some atmospheric phenomena (advection, convection, etc.) and the nature of the Lebanese topography. In this paper, we proposed the time series method ARIMA (Auto Regressive Integrated Moving Average) to forecast the minimum daily temperature and compared its result with ARPEGE. As a result, ARIMA method shows better mean accuracy (91%) over the numerical model ARPEGE (68%), for the prediction of five days in January 2017. Moreover, back to five months ago, in order to validate the accuracy of the proposed model, a simulation has been applied on the first five days of August 2016. Results have shown that the time series ARIMA method has offered better mean accuracy (98%) over the numerical model ARPEGE (89%) for the prediction of five days of August 2016. This paper discusses a multiprocessing approach applied to ARIMA in order to enhance the efficiency of ARIMA in terms of complexity and resources.

关键词： Time Series Analysis ARIMA Auto Regressive Integrated Moving Average Weather Forecasting Model Multiprocessing

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Active Matter, Microreversibility, and Thermodynamics

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Research 2020年第1期2020卷 1921-1940页

作者： pierre Gaspard Raymond Kapral Center for Nonlinear Phenomena and Complex Systems UniversitéLibre de Bruxelles(U.L.B.)Code Postal 231Campus PlaineB-1050 BrusselsBelgium Chemical Physics Theory Group Department of ChemistryUniversity of TorontoTorontoOntarioCanada M5S 3H6

Active matter,comprising many active agents interacting and moving in fluids or more complex environments,is a commonly occurring state of matter in biological and physical *** its very nature,active matter systems exist in nonequilibrium *** this paper,the active agents are small Janus colloidal particles that use chemical energy provided by chemical reactions occurring on their surfaces for propulsion through a diffusiophoretic *** a result of interactions among these colloids,either directly or through fluid velocity and concentration fields,they may act collectively to form structures such as dynamic clusters.A general nonequilibrium thermodynamics framework for the description of such systems is presented that accounts for both self-diffusiophoresis and diffusiophoresis due to external concentration gradients,and is consistent with *** predicts the existence of a reciprocal effect of diffusiophoresis back onto the reaction rate for the entire collection of colloids in the system,as well as the existence of a clustering instability that leads to nonequilibrium inhomogeneous system states.

关键词： mechanism nonequilibrium system

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Macro-or microencapsulation of pig islets to cure type 1 diabetes

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World Journal of Gastroenterology 2012年第47期18卷 6885-6893页

作者： Denis Dufrane pierre Gianello Department of Health Sciences Institute for Experimental and ClinicalExperimental Surgery and TransplantationCatholic University of LouvainB-1200 BrusselsBelgium

Although allogeneic islet transplantation can successfully cure type 1 diabetes,it has limited *** example,organs are in short supply;several human pancreas donors are often needed to treat one diabetic recipient;the intrahepatic site may not be the most appropriate site for islet implantation;and immunosuppressive regimens,which are associated with side effects,are often required to prolong survival of the islet *** alternative source of insulinproducing cells would therefore be of major *** represent a possible alternative source of beta *** of pig islets may appear difficult because of the immunologic species barrier,but pig islets have been shown to function in primates for at least 6 mo with clinically incompatible ***,a bioartificial pancreas made of encapsulated pig islets may resolve issues associated with islet *** several groups have shown that encapsulated pig islets are functional in small-animal models,less is known about the use of bioartificial pancreases in large-animal *** this review,we summarize current knowledge of encapsulated pig islets,to determine obstacles to implantation in humans and possible solutions to overcome these obstacles.

关键词： Cell transplantation Diabetes mellitus type 1 Islets of Langerhans Porcine Xenografts

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Reactivation of latent tuberculosis with TNF inhibitors: critical role of the beta 2 chain of the IL-12 receptor

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Cellular & Molecular Immunology 2021年第7期18卷 1644-1651页

作者： Marie Robert pierre Miossec Department of Clinical Immunology and Rheumatology and immunogenomics and inflammation research unitUniversity of LyonHôpital Edouard HerriotLyonFrance

Tumor necrosis factor(TNF)inhibitors have improved a lot the treatment of numerous diseases,with the well-known example of rheumatoid arthritis(RA).In the early 2000s,postmarketing data quickly revealed an alarming number of severe tuberculosis(TB)under such *** findings were consistent with previous results in mice where TNF is essential for lymph node formation and granuloma *** effects of TNF inhibition on RA synovium structure are very similar to those on granuloma,with changes in cellular interactions,cytokine,and chemokine *** addition to the role of TNF in granuloma,the interleukin(IL)-12/interferon(IFN)-γpathway is required for an efficient host defense against *** and secondary immunodeficiencies affecting this pathway lead to severe bacillus Calmette-Guérin(BCG)reaction or full *** chronic inflammation as in RA induces a systemic Th1 defect that predisposes to TB through specific downregulation of the IL-12Rß2 *** TNF inhibitors are initiated,this transiently increases this risk of TB,through effects on cellular interactions in a latent TB *** a later stage,when a better control disease activity is obtained,the risk of TB is reduced but not *** the clear benefit from TNF inhibition,latent TB infection screening at baseline is essential for an optimal safety.

关键词： tuberculosis TNF inhibition rheumatoid arthritis cytokines

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