Macro-or microencapsulation of pig islets to cure type 1 diabetes

作     者：Denis Dufrane Pierre Gianello 

作者机构：Department of Health SciencesInstitute for Experimental and ClinicalExperimental Surgery and TransplantationCatholic University of LouvainB-1200 BrusselsBelgium 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第47期

页      面：6885-6893页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by European Grant Titled Xenome UE LSHBCT-2006-037377 

主　　题：Cell transplantation Diabetes mellitus type 1 Islets of Langerhans Porcine Xenografts 

摘      要：Although allogeneic islet transplantation can successfully cure type 1 diabetes,it has limited *** example,organs are in short supply;several human pancreas donors are often needed to treat one diabetic recipient;the intrahepatic site may not be the most appropriate site for islet implantation;and immunosuppressive regimens,which are associated with side effects,are often required to prolong survival of the islet *** alternative source of insulinproducing cells would therefore be of major *** represent a possible alternative source of beta *** of pig islets may appear difficult because of the immunologic species barrier,but pig islets have been shown to function in primates for at least 6 mo with clinically incompatible ***,a bioartificial pancreas made of encapsulated pig islets may resolve issues associated with islet *** several groups have shown that encapsulated pig islets are functional in small-animal models,less is known about the use of bioartificial pancreases in large-animal *** this review,we summarize current knowledge of encapsulated pig islets,to determine obstacles to implantation in humans and possible solutions to overcome these obstacles.