检索结果-南通市图书馆

Macro-or microencapsulation of pig islets to cure type 1 diabetes

World Journal of Gastroenterology 2012年第47期18卷 6885-6893页

作者： Denis Dufrane pierre gianello Department of Health Sciences Institute for Experimental and ClinicalExperimental Surgery and TransplantationCatholic University of LouvainB-1200 BrusselsBelgium

Although allogeneic islet transplantation can successfully cure type 1 diabetes,it has limited *** example,organs are in short supply;several human pancreas donors are often needed to treat one diabetic recipient;the intrahepatic site may not be the most appropriate site for islet implantation;and immunosuppressive regimens,which are associated with side effects,are often required to prolong survival of the islet *** alternative source of insulinproducing cells would therefore be of major *** represent a possible alternative source of beta *** of pig islets may appear difficult because of the immunologic species barrier,but pig islets have been shown to function in primates for at least 6 mo with clinically incompatible ***,a bioartificial pancreas made of encapsulated pig islets may resolve issues associated with islet *** several groups have shown that encapsulated pig islets are functional in small-animal models,less is known about the use of bioartificial pancreases in large-animal *** this review,we summarize current knowledge of encapsulated pig islets,to determine obstacles to implantation in humans and possible solutions to overcome these obstacles.

关键词： Cell transplantation Diabetes mellitus type 1 Islets of Langerhans Porcine Xenografts

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Adult-to-adult living-donor liver transplantation: The experience of the Université catholique de Louvain

引用

Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 132-142页

作者： Samuele Iesari Milton Eduardo Inostroza Nú?ez Juan Manuel Rico Juri Olga Ciccarelli Eliano Bonaccorsi-Riani Laurent Coubeau pierre-Fran?ois Laterre pierre Goffette Chantal De Reyck Beno?t Lengelé pierre gianello Jan Lerut Starzl Abdominal Transplant Unit Cliniques Universitaires Saint-Luc Institut de Recherche Expérimentale et Clinique Université catholique de Louvain Department of Biotechnological and Applied Clinical Sciences University of L’Aquila Hepatobiliopancreatic Unit Las Higueras Hospital Cirugía de Trasplantes Centro Médico Imbanaco Department of Intensive Care Cliniques Universitaires Saint-Luc Université catholique de Louvain Department of Radiology Cliniques Universitaires Saint-Luc Université catholique de Louvain Department of Plastic and Reconstructive Surgery Cliniques Universitaires Saint-Luc Université catholique de Louvain P?le de Chirurgie Expérimentale et Transplantation Institut de Recherche Expérimentale et Clinique Université catholique de Louvain

Background: Liver transplantation is the treatment for end-stage liver diseases and well-selected malignancies. The allograft shortage may be alleviated with living donation. The initial UCLouvain experience of adult living-donor liver transplantation(LDLT) is presented. Methods: A retrospective analysis of 64 adult-to-adult LDLTs performed at our institution between 1998 and 2016 was conducted. The median age of 29(45.3%) females and 35(54.7%) males was 50.2 years(interquartile range, IQR 32.9–57.5). Twenty-two(34.4%) recipients had no portal hypertension. Three(4.7%) patients had a benign and 33(51.6%) a malignant tumor [19(29.7%) hepatocellular cancer, 11(17.2%) secondary cancer and one(1.6%) each hemangioendothelioma, hepatoblastoma and embryonal liver sarcoma]. Median donor and recipient follow-ups were 93 months(IQR 41–159) and 39 months(22–91), respectively. Results: Right and left hemi-livers were implanted in 39(60.9%) and 25(39.1%) cases, respectively. Median weights of right-and left-liver were 810 g(IQR 730–940) and 454 g(IQR 394–534), respectively. Graft-to-recipient weight ratios(GRWRs) were 1.17%(right, IQR 0.98%-1.4%) and 0.77%(left, 0.59%-0.95%). One-and five-year patient survivals were 85% and 71%(right) vs. 84% and 58%(left), respectively. Oneand five-year graft survivals were 74% and 61%(right) vs. 76% and 53%(left), respectively. The patient and graft survival of right and left grafts and of very small( < 0.6%), small(0.6%–0.79%) and large( ≥0.8%) GRWR were similar. Survival of very small grafts was 86% and 86% at 3-and 12-month. No donor died while five(7.8%) developed a Clavien–Dindo complication IIIa, IIIb or IV. Recipient morbidity consisted mainly of biliary and vascular complications; three(4.7%) recipients developed a small-for-size syndrome according to the Kyushu criteria. Conclusions: Adult-to-adult LDLT is a demanding procedure that widens therapeutic possibilities of many hepatobiliary diseases. The donor procedure can be done safely

关键词： Liver transplantation Living-donor Hepatocellular cancer Secondary liver tumor Small-for-size syndrome Small-for-size graft

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：