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World Journal of Stem Cells 2024年第2期16卷 89-101页

作者： pier Luigi Surico Anna Scarabosio Giovanni Miotti Martina Grando Carlo Salati pier cam.llo parodi Leopoldo Spadea Marco Zeppieri Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States Department of Ophthalmology Campus Bio-Medico UniversityRome 00128Italy Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy

This review comprehensively explores the versatile potential of mesenchymal stem cells(MSCs)with a specific focus on adipose-derived *** and oculoplastic surgery,encompassing diverse procedures for ocular and periocular enhancement,demands advanced solutions for tissue restoration,functional and aesthetic refinement,and *** immunomodulatory,regenerative,and healing capacities of MSCs,this review underscores the potential use of adipose-derived MSCs as a cost-effective alternative from bench to bedside,addressing common unmet needs in the field of reconstructive and regenerative surgery.

关键词： Stem cells Adipose stem cell Ocular therapy Oculoplastics Regenerative

Whole-eye transplantation: Current challenges and future perspectives

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World Journal of Transplantation 2024年第2期14卷 28-39页

作者： Anna Scarabosio pier Luigi Surico Vlad Tereshenko Rohan Bir Singh Carlo Salati Leopoldo Spadea Glenda Caputo pier cam.llo parodi Caterina Gagliano Jonathan M Winograd Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Plastic Surgery Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna"Kore"Enna 94100Italy Eye Clinic Catania University San Marco Hospital Viale Carlo Azeglio Ciampi 95121 CataniaItaly

Whole-eye transplantation emerges as a frontier in ophthalmology,promising a transformative approach to irreversible *** advancements,formidable challenges *** of donor eye viability post-enucleation necessitates meticulous surgical techniques to optimize retinal integrity and ganglion cell *** the inhibitory milieu of the central nervous system for successful optic nerve regeneration remains elusive,prompting the exploration of neurotrophic support and immunomodulatory *** tolerance,paramount for graft acceptance,confronts the distinc-tive immunogenicity of ocular tissues,driving research into targeted immunosup-pression *** and legal considerations underscore the necessity for stringent standards and ethical *** collaboration and ongoing research endeavors are imperative to navigate these ***,stem cell therapies,and precision immunomodulation represent promising avenues in this ***,the aim of this review is to critically assess the current landscape of whole-eye transplantation,elucidating the challenges and advancements while delineating future directions for research and clinical *** concerted efforts,whole-eye transplantation stands to revolu-tionize ophthalmic care,offering hope for restored vision and enhanced quality of life for those afflicted with blindness.

关键词： Eye Transplantation Optic nerve Nerve regeneration Immunological tolerance

Fat or fillers:The dilemma in eyelid surgery

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World Journal of Clinical Cases 2024年第17期12卷 2951-2965页

作者： Giovanni Miotti Luca De Marco Davide Quaglia Martina Grando Carlo Salati Leopoldo Spadea Caterina Gagliano Mutali Musa pier Luigi Surico pier cam.llo parodi Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I“Sapienza”University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna“Kore”Enna 94100Italy Eye Clinic Catania University San Marco Hospital Viale Carlo Azeglio CiampiCatania 95121Italy Department of Optometry University of BeninBenin 300283Nigeria Department of Ophthalmology Africa Eye Laser CentreKm 7Benin 300105Nigeria Schepens Eye Research Institute of Mass Eye and Ear Harvard Medical SchoolBostonMA 02114United States

The aging of the periocular region has always aroused great interest.A fresh,young,and attractive sight determined an ever-greater attention to surgical and non-surgical techniques to obtain this *** particular,the change in the concept of a young look,considered then“full”,led to the increasing use of surgical(fat grafting)or medical(hyaluronic acid)filling *** rejuvenation became increasingly popular in the field of cosmetic treatments,with a focus on achieving a youthful and refreshed *** the various techniques available,the choice between using fat grafting or fillers presented a clinical *** particular,what surgery considered of fundamental importance was a long-lasting result over *** the other hand,aesthetic medicine considered it fundamental not to have to resort to invasive *** what was the reality?Was there one path better than the other,and above all,was there a better path for patients?The minireview aims to explore the physiopathology,diagnosis,treatment options,prognosis,and future studies regarding this *** analyzed the literature produced in the last 20 years comparing the two *** literature reveals advancements in biomaterials,stem cell research and tissue engineering held promise for further enhancing the field of eyelid *** choice between fat grafting and fillers in eyelid cosmetic treatments presented a clinical *** physiopathology,accurately diagnosing eyelid aging,exploring treatment options,assessing prognosis,and conducting future studies were essential for providing optimal care to patients seeking eyelid rejuvenation.

关键词： Stem cells Adipose stem cell Ocular therapy Oculoplastics Regenerative

Fat management in upper blepharoplasty:Addition or subtraction blepharoplasties,how and when

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World Journal of Clinical Cases 2024年第16期12卷 2796-2802页

作者： Giovanni Miotti Jacopo Di Filippo Martina Grando Carlo Salati pier cam.llo parodi Leopoldo Spadea Caterina Gagliano Mutali Musa Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Internal Medicine Azienda Sanitaria Friuli OccidentaleSan Vito al Tagliamento 33078Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Department of Medicine and Surgery University of Enna"Kore"Enna 94100Italy Eye Clinic Catania University San Marco HospitalCatania 95121Italy Department of Optometry University of BeninBenin 3000283Nigeria Department of Ophthalmology Centre for Sight AfricaNkporOnitsha 434112Niger

BACKGROUND As one of the most common aesthetic surgical procedures carried out today,blepharoplasty should be in the repertoire of every plastic *** term blepharoplasty encompasses a wide range of techniques and options that must be tailored to the specific defect and patient one has to treat.A sound knowledge of the upper and lower eyelids’anatomy is essential for proper surgical *** have shifted towards more conservative methods(especially of the fat compartment)and sometimes in combination with augmentation techniques,helping to reach a rejuvenated *** To present an overview of the surgical techniques considered for upper lid blepharoplasty and fat pad management,in addition to information on how a surgeon may approach the best treatment for his patient based on current publications in *** We searched the literature published between 2013,to 2023 using Medline and Reference Citation *** database was searched using the keywords“upper blepharoplasty”AND“fat”.Papers without full text/abstracts and reviews were *** search strategy followed the *** American Society of Plastic Surgeons guidelines for Therapeutic Studies checklist was used to assess all *** authors individually reviewed each article and rated them for importance and relevance to the topic.A consensus was sought and the most relevant *** After the application of the selection criteria used in our review,13 publications were found to address upper lid blepharoplasty *** of these studies were reviews and three were retrospective *** publications were comparative studies and a further two were clinical *** The tendency of modern surgery is to be conservative,by removing adipose tissue only if strictly necessary and restoring the volume of the upper eyelid in a concept of beauty that espouses a"full"*** is no gold standard technique to achieve younger and enhanced eyelids

关键词： Blepharoplasty Fat pads Eye lid surgery Cosmetic aesthetic surgery Rejuvenation Plastic surgery

Stem cell therapy in ocular pathologies in the past 20 years

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World Journal of Stem Cells 2021年第5期13卷 366-385页

作者： Giovanni Miotti pier cam.llo parodi Marco Zeppieri Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

Stem cell therapies are successfully used in various fields of *** new approach of research is also expanding in *** investments,resources and important clinical trials have been performed in stem cell research and in potential *** recent years,great strides have been made in genetic research,which permitted and enhanced the differentiation of stem ***,the possibility of exploiting stem cells from other districts(such as adipose,dental pulp,bone marrow stem cells,etc.)for the treatment of ophthalmic diseases,renders this topic ***,great strides have been made in biomedical engineering,which have proposed new materials and threedimensional structures useful for cell therapy of the *** encouraging results obtained on clinical trials conducted on animals have given a significant boost in the creation of study protocols also in *** are limited to date,but clinical trials continue to *** attention is centered on the literature reported over the past 20 years,considering animal(the most represented in literature)and human clinical trials,which are *** aim of our review is to present a brief overview of the main types of treatments based on stem cells in the field of ophthalmic pathologies.

关键词： Stem cells Multipotent mesenchymal cells Adipose stem cells Novel therapies Eye pathology Cornea Cell therapies New materials

Modern blepharoplasty:From bench to bedside

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World Journal of Clinical Cases 2023年第8期11卷 1719-1729页

作者： Giovanni Miotti Marco Zeppieri Giacomo Pederzani Carlo Salati pier cam.llo parodi Department of Medical Surgical and Health SciencesPlastic and Reconstructive Surgery UnitUniversity of TriesteTrieste 34123Italy Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

The demand for procedures aiming to rejuvenate the upper third part of the face and the periocular region has increased in the past several *** is one of the most frequently performed procedures worldwide to *** is currently the first choice in order to achieve permanent and effective results;however,it is burdened by potential surgical complications feared by *** is an increasing trend in individuals to request less invasive,non-surgical,effective,and safe procedures for eyelid *** aim of this minireview is to present a brief overview of non-surgical blepharoplasty techniques that have been reported in the literature in the past 10 *** modern techniques that provide a rejuvenation of the entire area have been *** less invasive methods have been proposed in the current literature and in modern-day routine clinical *** fillers are a commonly chosen option for providing enhanced aesthetic results,especially considering that volume loss can be one of the main underlying causes of facial and periorbital *** acid use may be considered when the problem is represented by periorbital excess fat *** simultaneous excess and loss of elasticity of the skin can be assessed with techniques such as lasers and plasma ***,techniques such as platelet-rich plasma injections and the insertion of twisted polydioxanone threads are emerging as viable methods to rejuvenate the periorbital region.

关键词： Non-surgical blepharoplasty Laser treatment Dermatochalasis Aesthetic Non-invasive procedures Hyaluronic acid Plasma exeresis Eyelids

How and when of eyelid reconstruction using autologous transplantation

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World Journal of Transplantation 2022年第7期12卷 175-183页

作者： Giovanni Miotti Marco Zeppieri Agostino Rodda Carlo Salati pier cam.llo parodi Department of Plastic Surgery University Hospital of UdineUdine 33100Italy Department of Medical Surgical and Health SciencesPlastic and Reconstructive Surgery UnitUniversity of TriesteTrieste 34123Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy

Reconstructive surgery of the eyelid after tumor excision,trauma or other causes can be challenging,especially due to the complexities of the anatomic structures and to the necessity of both functional and aesthetic successful *** aim of this minireview was to investigate the use of tissue transplantation in eyelid *** procedures are various,based on the use of both flaps,pedicled or free,and grafts,in order to guarantee adequate tissue reconstruction and blood supply,which are necessary for correct *** techniques normally include the use of local tissues,combining non-vascularized grafts with a vascularized flap for the two lamellae repair,to attempt a reconstruction similar to the original *** defects are too wide,vast,deep,and complex or when no adjacent healthy tissues are available,distant area tissues need to be recruited as free flaps or grafts and paired with mucosal layer *** regards to the anterior lamella,full thickness skin grafts are commonly *** regards to the reconstruction of posterior lamella,there are different graft options,which include conjunctival or tarsoconjunctival,mucosal or palatal or cartilaginous grafts usually combined with local *** flap transplantation,normally reserved for rare select cases,include the use of the radial forearm and anterolateral flaps combined with mucosal grafts,which are surgical options currently reported in the literature.

关键词： Eyelid reconstruction Graft transplantation Flap transplantation Eyelid lamella grafts Cartilage grafts Dermis grafts Mucosa grafts

Allogeneic epidermal substitutes in the treatment of chronic diabetic leg and foot ulcers

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Plastic and Aesthetic Research 2014年第1期1卷 75-81页

作者： Andrea Marchesi Marco Brioschi pier cam.llo parodi Matteo Marchesi Roberto Brambilla Luca Vaienti Department of Plastic and Reconstructive Surgery IRCCS San Donato PolyclinicUniversity of Milan20097 MilanItaly Department of Plastic and Reconstructive Surgery University of Udine33100 UdineItaly Department of Biomedical Science for Health Section of Legal and Insurance MedicineUniversity of Milan20133 MilanItaly Wound Care Unit Zucchi Clinical Institutes20052 MonzaItaly.

Aim:Diabetic foot ulcers are the most common cause of nontraumatic lower extremity amputations in the industrialized ***-engineering products offer a lower extremity salvage strategy when healing does not proceed according to the standard of *** allogeneic sheets are available for the management of diabetic leg and foot ***:The endpoints of this case series study regard preliminary outcomes of the application of allogeneic keratinocytes composed of benzyl ester of hyaluronic acid to 16 diabetic foot and leg ulcers in 11 patients with type 2 diabetes ***:Between 21 and 70 days after cellular therapy,6 out of 16 lesions were completely healed,reducing the wound dimension by 70%and improving the wound bed score by 52%.Conclusion:The clinical results of the new allogeneic sheets indicate that allogeneic keratinocytes may represent an effective and safe therapy for diabetic foot and leg ulcers in the multidisciplinary approach to this diabetes-related complication.

关键词： Allogeneic keratinocytes diabetic ulcer epidermal substitutes hyaluronic acid

Surgical pitfalls with custom-made porous hydroxyapatite cranial implants

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Plastic and Aesthetic Research 2015年第1期2卷 7-11页

作者： Bruno Zanotti Angela Verlicchi Roberto Stefini Attilio Carlo Salgarelli Nicola Zingaretti pier cam.llo parodi Casadei Matteo Massimo Robiony Department of Neurosurgery University Hospital S.Maria della Misericordia33100 UdineItaly Neurology Unit Free University of Neuroscience“Anemos”42124 Reggio EmiliaItaly Department of Neuroscience Neurosurgery UnitUniversity of Brescia25123 BresciaItaly Department of Head and Neck Surgery Unit of Maxillofacial SurgeryModena and Reggio Emilia University41124 ModenaItaly Department of Plastic and Reconstructive Surgery University Hospital S.Maria della Misericordia33100 UdineItaly Department of Maxillo-Facial Surgery University Hospital S.Maria della Misericordia33100 UdineItaly

Aim:Cranioplasty implants are used primarily in cases of surgical cranial decompression following pathological elevations of intracranial *** bone substitutes include porous hydroxyapatite(HA)and *** material is used,however,prosthetic cranial implants are susceptible to intra-and postsurgical complications and even *** aim of this study was to investigate such occurrences in HA cranioplasty implants,seeking not only to determine the likely causes(whether correlated or not with the device itself)but also,where possible,to suggest ***:We analyzed information regarding failures or complications reported in postmarketing surveillance and clinical studies of patients treated worldwide with custom-made HA cranial implants(Custom Bone Service Fin-Ceramica Faenza,Italy)in the period ***:The two most common complications were implant fractures(84 cases,2.9%of the total fitted)and infections(51 cases,1.77%).Conclusion:Although cranioplasties are superficial and not difficult types of surgery,and use of custom-made implants are often considered the“easy”option from a surgical perspective,these procedures are nonetheless plagued by potential *** performed well they yield more than satisfactory results from the points of view of both the patient and surgeon,but lack of appropriate care can open the door to numerous potential sources of failure,which can compromise-even irreparably-the ability to heal.

关键词： Cranial cranioplasty custom-made hydroxyapatite implants

A study of correlation between prosthetic breast reconstruction, antibiotic prophylaxis and surgical wound drains

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整形与美容研究：英文版 2017年第2期4卷 24-31页

作者： EmanueIe Rampino Cordaro NicoIa Zerbinati AIice Garzitto Daria AImesberger MicheIa Francescon RaffaeIe Rauso Mario Cherubino pier camiIIo parodi Department of Plastic Reconstructive Surgery University of Udine33100UdineItaly Department of Surgical and Morphological Sciences University of Insubria21100VareseItaly Department of Dentistry University of Foggia71121FoggiaItaly Department of Biotechnology and Science of Life University of Insubria21100VareseItaly

Aim:The primary aim of this investigation into the correlation between prosthetic breast reconstruction,antibiotic prophylaxis and surgical drains was to determine whether the short-term prophylaxis recommended in the current guidelines is in fact able to sterilize the peri-prosthetic pocket in patients undergoing prosthetic breast reconstruction via tissue expansion,permanent implant placement,or Becker implants,as well as augmentation to correct ***:A total of 96 women who had undergone prosthetic breast reconstruction surgery were *** were recruited from the Plastic Surgery Clinic,Gemona,and the Surgery Clinic,Udine,both affiliated with the Udine'Santa Maria della Misericordia'University Hospital between May 2013 and May *** patients were administered the recommended short-term antibiotic prophylaxis,i.e.2 g cephazolin(plus 1 g eventually given after 3.5 h of surgery)30 min before *** pertaining to each patient were kept in a specific study ***:Samples of peri-prosthetic drainage fluid were taken from 92.5%of the recipients of breast reconstruction/implant *** 2.3%of the samples analyzed were found to be positive for microbial ***:The results of this preliminary study are encouraging,demonstrating that the guidelines regarding short-term antibiotic prophylaxis are indeed effective.

关键词： Breast implant antibiotic prophylaxis drains infections breast reconstruction