检索结果-南通市图书馆

Differential DNA methylation analysis of SUMF2,ADAMTS5,and PXDN provides novel insights into colorectal cancer prognosis prediction in Taiwan

引用

World Journal of Gastroenterology 2022年第8期28卷 825-839页

作者： Jing-Quan Su pin-Yu Lai Pei-Hsuan Hu Je-Ming Hu pi-kai chang Chao-Yang Chen Jia-Jheng Wu Yu-Jyun Lin Chien-An Sun Tsan Yang Chih-Hsiung Hsu Hua-Ching Lin Yu-Ching Chou School of Medicine National Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Division of Colorectal Surgery Department of surgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Graduate Institute of Medical Sciences National Defense Medical CenterTaipei 114TaiwanChina Department of Public Health College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Big Data Research Center College of MedicineFu-Jen Catholic UniversityNew Taipei City 242TaiwanChina Department of Health Business Administration Meiho UniversityPingtung County 912TaiwanChina Division of Colorectal Surgery Department of SurgeryCheng-Hsin General HospitalTaipei 112TaiwanChina

BACKGROUND Patients with colorectal cancer(CRC)undergo surgery,as well as perioperative chemoradiation or adjuvant chemotherapy primarily based on the tumor–node–metastasis(TNM)cancer staging ***,treatment responses and prognostic outcomes of patients within the same stage vary *** potential use of novel biomarkers can improve prognostication and shared decision making before implementation into certain *** To investigate whether SUMF2,ADAMTS5,and PXDN methylation status could be associated with CRC *** We conducted a Taiwan region cohort study involving 208 patients with CRC recruited from TriService General Hospital and applied the candidate gene approach to identify three genes involved in oncogenesis pathways.A methylation-specific polymerase chain reaction(MS-PCR)and Epi TYPER DNA methylation analysis were employed to detect methylation status and to quantify the methylation level of candidate genes in tumor tissue and adjacent normal tissue from *** evaluated SUMF2,ADAMTS5,and PXDN methylation as predictors of prognosis,including recurrence-free survival(RFS),progression-free survival(PFS),and overall survival(OS),using a Cox regression model and Kaplan–Meier *** We revealed various outcomes related to methylation and *** shorter PFS and OS were associated with the CpG_3+CpG_7 hypermethylation of SUMF2 from tumor tissue compared with CpG_3+CpG_7 hypomethylation[hazard ratio(HR)=2.24,95%confidence interval(CI)=1.03-4.85 for PFS,HR=2.56 and 95%CI=1.08-6.04 for OS].By contrast,a significantly longer RFS was associated with CpG_2 and CpG_13 hypermethylation of ADAMTS5 from normal tissue compared with CpG_2 and CpG_13 hypomethylation[HR(95%CI)=0.15(0.03-0.71)for CpG_2 and 0.20(0.04-0.97)for CpG_13].The relationship between the methylation status of PXDN and the prognosis of CRC did not reach statistical *** Our study found that CpG_3+CpG_7 hypermethylation o

关键词： DNA methylation Biomarkers Tumor tissue Adjacent normal tissue Prognosis prediction Colorectal cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

MTNR1B polymorphisms with CDKN2A and MGMT methylation status are associated with poor prognosis of colorectal cancer in Taiwan

引用

World Journal of Gastroenterology 2021年第34期27卷 5737-5752页

作者： Chia-Cheng Lee Yu-Cheng Kuo Je-Ming Hu pi-kai chang Chien-An Sun Tsan Yang Chuan-Wang Li Chao-Yang Chen Fu-Huang Lin Chih-Hsiung Hsu Yu-Ching Chou Division of Colorectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Medical Informatics Office Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Department of Public Health College of MedicineFu-Jen Catholic UniversityNew Taipei City 24205TaiwanChina Big Data Research Center College of MedicineFu-Jen Catholic UniversityNew Taipei City 24205TaiwanChina Department of Health Business Administration Meiho UniversityPingtung 91202TaiwanChina Department and Graduate Institute of Microbiology and Immunology National Defense Medical CenterTaipei 114TaiwanChina Institute of Preventive Medicine National Defense Medical CenterNew Taipei City 237TaiwanChina

BACKGROUND Identifying novel colorectal cancer(CRC)prognostic biomarkers is crucial to helping clinicians make appropriate therapy *** plays a major role in managing the circadian rhythm and exerts oncostatic effects on different kinds of *** To explore the relationship between MTNR1B single-nucleotide polymorphism(SNPs)combined with gene hypermethylation and CRC *** A total of 94 CRC tumour tissues were *** for the four MTNR1B SNPs(rs1387153,rs2166706,rs10830963,and rs1447352)was performed using multiplex polymerase chain *** relationships between the MTNR1B SNPs and CRC 5-year overall survival(OS)was assessed by calculating hazard ratios with 95%*** All SNPs(rs1387153,rs2166706,rs10830963,and rs1447352)were correlated with decreased 5-year *** stratified analysis,rs1387153,rs10830963,and rs1447352 risk genotype combined with CDKN2A and MGMT methylation status were associated with 5-year OS.A strong cumulative effect of the four polymorphisms on CRC prognosis was *** haplotypes of MTNR1B SNPs were also associated with the 5-year ***1B SNPs combined with CDKN2A and MGMT gene methylation status could be used to predict shorter CRC *** The novel genetic biomarkers combined with epigenetic biomarkers may be predictive tool for CRC prognosis and thus could be used to individualise treatment for patients with CRC.

关键词： Colorectal cancer Melatonin Hypermethylation Polymorphism Prognosis Biomarker

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Efficient and simple synthesis of B_(2)O_(3)-Al_(2)O_(3)nanocomposites assisted by deep eutectic solvent for production of 5-hydroxymethylfurfural from glucose

引用

Nano Research 2025年第1期18卷 236-248页

作者： Yuchen Wang kai Rong Shanlei chang Youxing Fang Shaojun Dong State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China College of Chemistry Jilin UniversityChangchun 130012China

The catalytic conversion of glucose to high valueadded platform chemical 5-hydroxymethylfurfural(HMF)is a promising biorefinery process,and alumina-boria catalysts are considered to be green and mild solid acid catalysts for this catalytic ***,compared to the common synthesis methods with complicated steps,we reported a simple and efficient strategy to prepare B_(2)O_(3)-Al_(2)O_(3)nanocomposites by calcining cost-effective glucose-urea deep eutectic solvent(DES)solution containing the *** prepared B_(2)O_(3)-Al_(2)O_(3)nanocomposites exhibited an open three-dimensional skeleton and two-dimensional porous lamellar substructure,endowing them with a high specific surface area(228.27 m2/g).The introduction of boron changed the ratios of different aluminum species(AlⅣ,AlⅤ,and AlⅥ)and borate species(BO3 and BO4),thus further affecting the acidity and the types of acid sites of the *** prepared B_(2)O_(3)-Al_(2)O_(3)bifunctional acid catalysts possessing abundant Lewis acid sites and adjustable Brønsted acid sites showed complete glucose conversion and 55.38%of HMF yield under the optimum *** study proposed a concise method to synthesize alumina-boria solid acid catalysts assisted by glucose-urea *** hope to extend the application and prospect of this efficient and simple synthesis strategy.

关键词： 5-hydroxymethylfurfural(HMF) deep eutectic solvent glucose alumina-boria acid catalyst

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

LEGENDRE TRANSFORM-DUAL SOLUTION FOR INVESTMENT AND CONSUMPTION PROBLEM UNDER THE VASICEK MODEL

引用

Journal of Systems Science & Complexity 2014年第5期27卷 911-927页

作者： chang Hao chang kai Department of Mathematics Tianjin Polytechnic University School of Management Tianjin University School of Finance Zhejiang University of Finance & Economics

This paper studies an investment and consumption problem with stochastic interest rate,where interest rate is governed by the Vasicek *** financial market is composed of one riskfree asset and one risky asset,in which stock price dynamics is assumed to be generally correlated with interest rate *** aim is to maximize expected utility of consumption and terminal wealth in the finite *** transform is used to deal with this investment and consumption problem and the explicit solutions of the optimal investment and consumption strategies with power and logarithm preference are ***,the authors add a numerical example to analyze the effect of market parameters on the optimal investment and consumption strategy and provide some economic implications.

关键词： Dynamic programming investment and consumption Legendre transform the closedform solution the Vasicek model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

引用

Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning chang Liu Yu-Chi Liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Matched glass-to-Kovar seals in N_2 and Ar atmospheres

引用

International Journal of Minerals,Metallurgy and Materials 2013年第9期20卷 874-882页

作者： Cheng-hsien Kuo pi-ying Cheng chang-pin Chou Department of Mechanical Engineering Chiao Tung University

The oxidation of Kovar alloy was investigated, the wetting and spreading behavior of hard and soft glasses on Kovar alloy were studed by using the sessile drop method, and the quality and the seal strength of glass-Kovar seals were tested. The experimental results indicated that the preoxidation of Kovar alloy for approximately 10 min at 700℃ in air resulted in excellent adherence in glass-Kovar seals. The wetting and spreading behavior of glass on preoxidized Kovar alloy were superior to that on nonoxidized Kovar alloy. The wetting ability of ASF110 glass, at 950℃ and 980℃ in Ar and N2 atmospheres, was significantly superior to that of ASF200R and ASF700 glasses. The seal quality of the glass-preoxidized Kovar seal was superior to that of the glass-nonoxidized Kovar seal. The shear strength of the ASFll0 glass-preoxidized Kovar seal, which was prepared at 980℃ for 20 min in an Ar atmosphere, was approximately 3.9 MPa.

关键词： Kovar alloy glass sealing argon nitrogen oxidation wetting

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sea surface temperature evolution in the Yellow Sea Warm Current pathway and its teleconnection with high and low latitude forcing during the mid-late Holocene

引用

Journal of Oceanology and Limnology 2022年第1期40卷 93-109页

作者： Zhong pi Fengming chang Tiegang LI Yikun CUI Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of SciencesQingdao 266071China Key Laboratory of Marine Sedimentology and Environmental Geology First Institute of OceanographyMinistry of Natural Resources(MNR)Qingdao 266061China Laboratory for Marine Geology and Environment Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China School of Geography and Ocean Science Collaborative Innovation Center of South China Sea StudiesNanjing UniversityNanjing 210023China

Sea surface temperature(SST)in the Yellow Sea Warm Current(YSWC)pathway is sensitive to the East Asian Winter Monsoon(EAWM)and ***,the role of the YSWC in the evolution of regional SST remains ***,we present new U 37 k′based SST and grain size sequences spanning the last 6092 years in the sediment core Z1,which was retrieved from the central Yellow Sea muddy ***,U 37 k′-SST gradually increased since 6.1 ka BP,with a series of centennial-scale fl *** variation was mainly caused by EAWM when YSWC was weak between 6.1 and~3.9 ka BP,as shown by the end-member content of grain ***,after YSWC was fully developed,i.e.,since~3.9 ka BP,it exerted critical eff ects on SST evolution in its *** 1010-and 538-year cycles of the SST sequence indicated a basic control of solar activity on the oceanic conditions in the Yellow *** is suggested that the variation of total solar irradiance was amplifi ed by thermohaline circulation and then transmitted to the Yellow Sea through the ***,the tropical Pacifi c signal of El Niño was transmitted to the YSWC through the Kuroshio *** dual properties of warm water transported by YSWC to compensate the EAWM and driving by Kuroshio Current closely linked the variation of SST in the YSWC pathway to the Northern Hemisphere high latitude climate and the tropical Pacifi *** fi ndings highlight the signifi cance of YSWC on regional SST evolution and its teleconnection to high and low latitude forcing,which grains a better understanding of the long-term evolution of SST in the middle latitude Yellow Sea.

关键词： Yellow Sea Warm Current U 37 k′-SST East Asian Winter Monsoon Kuroshio Current high and low latitude forcing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Topological insulating phase in commonly used semiconductors

引用

National Science Review 2014年第1期1卷 34-35页

作者： kai chang SKLSM Institute of Semiconductors Chinese Academy of Sciences

Interface polarization between commonly used semiconductors provides a possible method to drive commonly used semiconductors into their topological insulating *** insulators(TIs)have attracted interest over recent years,with properties such as an insulating bulk region,robust metallic edges or surface modes and topological *** have potential applications ranging from spintronic devices to quantum computation[1–8].Despite recent progress,

关键词： Ga As Topological insulating phase in commonly used semiconductors

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Reverse Engineering of Machine-tool Settings with Modified Roll for Spiral Bevel pinions

引用

Chinese Journal of Mechanical Engineering 2013年第3期26卷 573-584页

作者： LIU Guanglei chang kai LIU Zeliang School of Mechatronics Northwestern Polytechnical University

Although a great deal of research has been dedicated to the synthesis of spiral bevel gears, little related to reverse engineering can be found. An approach is proposed to reverse the machine-tool settings of the pinion of a spiral bevel gear drive on the basis of the blank and tooth surface data obtained by a coordinate measuring machine(CMM). Real tooth contact analysis(RTCA) is performed to preliminary ascertain the contact pattern, the motion curve, as well as the position of the mean contact point. And then the tangent to the contact path and the motion curve are interpolated in the sense of the least square method to extract the initial values of the bias angle and the higher order coefficients(HOC) in modified roll motion. A trial tooth surface is generated by machine-tool settings derived from the local synthesis relating to the initial meshing performances and modified roll motion. An optimization objective is formed which equals the tooth surface deviation between the real tooth surface and the trial tooth surface. The design variables are the parameters describing the meshing performances at the mean contact point in addition to the HOC. When the objective is optimized within an arbitrarily given convergence tolerance, the machine-tool settings together with the HOC are obtained. The proposed approach is verified by a spiral bevel pinion used in the accessory gear box of an aviation engine. The trial tooth surfaces approach to the real tooth surface on the whole in the example. The results show that the convergent tooth surface deviation for the concave side on the average is less than 0.5 μm, and is less than 1.3 μm for the convex side. The biggest tooth surface deviation is 6.7 μm which is located at the corner of the grid on the convex side. Those nodes with relative bigger tooth surface deviations are all located at the boundary of the grid. An approach is proposed to figure out the machine-tool settings of a spiral bevel pinion by way of reverse engi

关键词： spiral bevel gears pinion manufacture parameters modified roll real tooth contact analysis reverse engineering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spin-orbit interaction induced Casimir-Lifshitz torque between two-dimensional electron gases

引用

Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 134-142页

作者： Jia-Nan Rong Liang Chen kai chang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China School of Mathematics and Physics North China Electric Power UniversityBeijing 102206China School of Physics Zhejiang UniversityHangzhou 310027China College of Materials Science and Opto-electronic Technology University of Chinese Academy of SciencesBeijing 100049China

We investigate theoretically the Casimir interaction between two parallel two-dimensional electron gases(2DEGs)with Rashba and Dresselhaus spin-orbit interactions(SOIs),based on the quantum field *** derive an analytical expression for the polarization tensor and obtain the solution to the motion equation of the electromagnetic(EM)*** calculate the CasimirLifshitz torque(CLT)between two parallel 2DEGs with Rashba and Dresselhaus SOIs,which can be tuned by changing the relative strength between two *** anisotropic Casimir energy between 2DEGs caused by the interplay between the SOIs of 2DEGs offers a new origin of CLT and a new type of optoelectronic device.

关键词： Casimir torque two-dimensional electron gas spin-orbit interaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：