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Honey vesicle-like nanoparticles protect aged liver from non-alcoholic steatohepatitis

Acta Pharmaceutica Sinica B 2024年第8期14卷 3661-3679页

作者： Baolong Liu phuong linh nguyen Han Yu Xingzhi Li Huiren Wang Tram Gia Bao nguyen Prakash Kumar Sahoo Meghna Sur Jay Reddy Sarah Sillman Stephen D.Kachman Bara Altartouri Guoqing Lu Sathish Kumar Natarajan Mahesh Pattabiraman Jiujiu Yu Department of Nutrition and Health Sciences University of Nebraska-LincolnLincolnNE 68583USA Shaanxi Key Laboratory of Molecular Biology for Agriculture College of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China Department of Nutrition Case Western Reserve UniversityClevelandOH 44106USA School of Veterinary Medicine and Biomedical Sciences University of Nebraska-LincolnLincolnNE 68583USA Department of Statistics University of Nebraska-LincolnLincolnNE 68583USA Center for Biotechnology University of Nebraska-LincolnLincolnNE 68588USA Department of Biology University of Nebraska OmahaOmahaNE 68182USA Department of Chemistry University of Nebraska-KearneyKearneyNE 68849USA

Non-alcoholic steatohepatitis(NASH),an advanced form of non-alcoholic fatty liver disease(NAFLD),has emerged as the leading cause of liver failure and related ***,no medication is specifically approved to treat NAFLD or *** we report that oral administration of honey vesiclelike nanoparticles(H-VLNs)to naturally aged mice protects the liver from NASH development.H-VLNs are dominantly taken up by Kupffer cells in the liver and suppress hepatic chronic inflammation and further development of fibrosis and nodule formation in aged *** their reported antiinflammasome function,H-VLNs are found to inhibit the transcriptional activities of C-JUN and nuclear factor-kappa B(NF-κB).MicroRNAs miR5119 and miR5108 and phenolic compound luteolin in H-VLNs are identified in suppressing both the C-JUN and NF-kB ***,oral intake of H-VLNs represents a promising new user-friendly modality to prevent the development of NASH.

关键词： Honey Extracellular vesicles Exosomes Nanoparticles microRNAs Aging Inflammation Non-alcoholic steatohepatitis

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GLOBAL BOUND ON THE GRADIENT OF SOLUTIONS TO p-LAPLACE TYPE EQUATIONS WITH MIXED DATA

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Acta Mathematica Scientia 2024年第4期44卷 1394-1414页

作者： Minh-phuong TRAN The-Quang TRAN Thanh-Nhan nguyen Applied Analysis Research Group Faculty of Mathematics and StatisticsTon Duc Thang UniversityHo Chi Minh CityVietnam nguyen Huu Huan High School Thu Duc CityVietnam Group of Analysis and Applied Mathematics Department of MathematicsHo Chi Minh City University of EducationVietnam

In this paper,the study of gradient regularity for solutions of a class of elliptic problems of p-Laplace type is *** particular,we prove a global result concerning Lorentz-Morrey regularity of the non-homogeneous boundary data problem:-div((s^(2)+|▽u|^(2)p-2/2)▽u)=-div(|f|^(p-2)f)+g inΩ,u=h in■Ω,with the(sub-elliptic)degeneracy condition s∈[0,1]and with mixed data f∈L^(p)(Q;R^(n)),g∈Lp/(p-1)(Ω;R^(n))for p∈(1,n).This problem naturally arises in various applications such as dynamics of non-Newtonian fluid theory,electro-rheology,radiation of heat,plastic moulding and many *** on the idea of level-set inequality on fractional maximal distribution functions,it enables us to carry out a global regularity result of the solution via fractional maximal *** to the significance of M_(α)and its relation with Riesz potential,estimates via fractional maximal functions allow us to bound oscillations not only for solution but also its fractional derivatives of orderα.Our approach therefore has its own interest.

关键词： gradient estimates p-Laplace quasilinear elliptic equation fractional maximal operators Lorentz-Morrey spaces

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Advancing Wound Filling Extraction on 3D Faces:An Auto-Segmentation and Wound Face Regeneration Approach

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 2197-2214页

作者： Duong Q.nguyen Thinh D.Le phuong D.nguyen Nga T.K.Le H.nguyen-Xuan Department of Mathematics and Statistics Quy Nhon UniversityQuy Nhon City55100Viet Nam Applied Research Institute for Science and Technology Quy Nhon UniversityQuy Nhon City55100Viet Nam CIRTECH Institute HUTECH UniversityHo Chi Minh City72308Viet Nam

Facial wound segmentation plays a crucial role in preoperative planning and optimizing patient outcomes in various medical *** this paper,we propose an efficient approach for automating 3D facial wound segmentation using a two-stream graph convolutional *** method leverages the Cir3D-FaIR dataset and addresses the challenge of data imbalance through extensive experimentation with different loss *** achieve accurate segmentation,we conducted thorough experiments and selected a high-performing model from the *** selectedmodel demonstrates exceptional segmentation performance for complex 3D facial ***,based on the segmentation model,we propose an improved approach for extracting 3D facial wound fillers and compare it to the results of the previous *** method achieved a remarkable accuracy of 0.9999993% on the test suite,surpassing the performance of the previous *** this result,we use 3D printing technology to illustrate the shape of the wound *** outcomes of this study have significant implications for physicians involved in preoperative planning and intervention *** automating facial wound segmentation and improving the accuracy ofwound-filling extraction,our approach can assist in carefully assessing and optimizing interventions,leading to enhanced patient ***,it contributes to advancing facial reconstruction techniques by utilizing machine learning and 3D bioprinting for printing skin tissue *** source code is available at https://***/SIMOGroup/WoundFilling3D.

关键词： 3D printing technology face reconstruction 3D segmentation 3D printed model

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Prevalence and risk factors associated with long COVID symptoms in children and adolescents in a southern province of Vietnam

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Asian Pacific Journal of Tropical Medicine 2024年第3期17卷 119-128,I0001,I0002页

作者： Huynh Ngoc linh nguyen The Tan Le Thi Minh Thu nguyen Tu Loan nguyen Thi To Uyen Le Thanh Thao Trang Truong Thanh Nam Doan Hoang Phu Faculty of Medicine Ca Mau Medical CollegeCa Mau 98000Vietnam Ca Mau Obstetrics and Pediatrics Hospital Ca Mau 98000Vietnam Faculty of Basic Science and Public Health Dong Thap Medical CollegeDong Thap 81000Vietnam Graduate University of Sciences and Technology Vietnam Academy of Science and TechnologyHa Noi 10000Vietnam Community Public Health Research Program School of Public HealthWalailak UniversityNakhon Si Thammarat 80160Thailand Faculty Public Health Can Tho University of Medicine and PharmacyCan Tho City 94000Vietnam Doctoral Program in Health Sciences College of Graduate StudiesWalailak UniversityNakhon Si Thammarat 80160Thailand

Objective:To investigate the prevalence and risk factors associated with long COVID symptoms among children and adolescents who have recovered from ***:This study applied a cross-sectional approach within community settings in a southern province of Vietnam.A structured questionnaire featuring socio-demographic information and common long COVID symptoms was *** correlation coefficients assessed associations among pairs of long COVID ***,multivariable logistic regression models were performed to investigate the risk factors of long COVID in recovered COVID-19 children and ***:Among 422 participants,39.3%reported long COVID symptoms,with a prevalence of 45.2%(SD=0.5)in children and 22.2%(SD=0.4)in *** symptoms reported were cough 34.6%(SD=0.5),fatigue 20.6%(SD=0.4),shortness of breath 10.9%(SD=0.3),and lack of appetite 6.6%(SD=0.3).Concerning risk factors of long COVID,a higher risk was observed among demographic groups,including girls(OR 1.25,95%CI 1.15-1.37;P<0.001,reference:boys),children compared to adolescents(OR 1.24,95%CI 1.12-1.37;P<0.001),overweight individuals(OR 1.14,95%CI 1.02-1.27;P=0.018,reference:healthy weight),and participants without any COVID-19 vaccination(OR 1.36,95%CI 1.20-1.54;P<0.001),or have received only one single dose(OR 1.35,95%CI 1.10-1.64;P=0.004)compared to those who have received two ***,patients with a COVID-19 treatment duration exceeding two weeks also had a higher risk of long COVID(OR 1.32,95%CI 1.09-1.60;P=0.003)than those who recovered less than seven ***:The insights from this study provide crucial guidance for predicting the factors associated with the occurrence of long COVID in pediatric patients,contributing to strategic interventions aimed at mitigating the long COVID risks among children and adolescents in Vietnam.

关键词： Long COVID Prevalence Risk factors Children Adolescent Vietnam

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Influence of different land-use types on selected soil properties related to soil fertility in A Luoi District,Thua Thien Hue,Vietnam

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Soil Ecology Letters 2024年第1期6卷 131-140页

作者： Khoa Phuc nguyen Tan Trong Tran Huy Dinh Le phuong Thuy nguyen Hien Thao Thi Pham Dien Thanh nguyen Ngu Huu nguyen University of Agriculture and Forestry Hue UniversityHue CityThua Thien Hue 52000Vietnam School of Biotechnology Tan Tao UniversityTan Duc ECityDuc HoaLong An850000Vietnam

Land use type affects the physicochemical properties of *** value of OM and TN is high in acacia *** acidity of soil is considered a serious constraint for *** cash crops are acacia,cassava,banana,rice and *** fertility is affected by land-use types and land management,which exacerbates soil erosion and various other forms of soil degradation in the mountainous regions of *** study was conducted in A Luoi District,Thua Thien Hue,Vietnam to identify the effects of land-use types on specific soil physicochemical characteristics related to soil *** physicochemical properties,such as organic matter(OM),total nitrogen(TN),total phosphorous(TP),and K+were significantly affected by land-use *** results showed that the soils were sandy in rice but clay loam for acacia and *** mean bulk density value of acacia soil was significantly greater than that of other *** were higher in the acacia soils than those in the rice,maize,and banana *** OM content was significantly higher in the acacia,cassava,and banana soils than those in the rice and maize *** mean of exchangeable K+in the rice soil was higher compared to those in other soils and was affected by land-use *** high exchangeable acidity content in the soils was probably due to intensive ***,both land use type and management did not affect the CEC ***,the inappropriate land use caused the disturbance of soil physicochemical properties,indicating that the conditions of rice and maize soils are becoming worse than acacia ***,lowering the intensity of cultivation,adopting incorporated soil fertility management,and applying organic fertilizer should preserve the existing conditions and enhance soil properties.

关键词： Land-use types soil characteristics soil frility suitable crop Vietnam

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Comparative Chemical Research in Essential Oils from Six Apiaceae Species Growing in the Northern Region of Vietnam

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Phyton-International Journal of Experimental Botany 2024年第7期93卷 1677-1687页

作者： nguyen Quang Hung nguyen Thanh Tung nguyen phuong Hanh Chu Thi Thu Ha nguyen Thi Nhung nguyen Thai An Vu Xuan Giang Luong Van Hao Oleh Koshovyi Ain Raal Institute of Ecology and Biological Resources Vietnam Academy of Science and Technology(VAST)Cau GiayHa Noi100000Viet Nam Graduate University of Science and Technology Vietnam Academy of Science and Technology(VAST)Cau GiayHa Noi100000Viet Nam Department of Pharmacognosy Faculty of Pharmacognosy and Traditional MedicineHanoi University of PharmacyHoan KiemHa Noi100000Viet Nam Sa Pa Research Center of Medicinal Materials National Institute of Medicinal MaterialsDien Bien PhuSa PaLao Cai330000Viet Nam Institute of Pharmacy Faculty of MedicineUniversity of TartuTartu50411Estonia

Our study aimed to compare the essential oil(EO)concentration and composition of several Apiaceae species growing in the Northern region of *** yields of EOs from materials ranged from 0.03%(root EO of Angelica acutiloba and aerial parts EO of Heracleum bivittatum)-0.27%(leaf EO of Xyloselinum vietnamense).Gas chromatography-mass spectrometry(GC-MS)allowed the identiﬁcation of 74 components in the EOs of six Apiaceae species,making up 94.4%–100.0%of the *** EO from Angelica acutiloba,(Z)-ligustilide accounted for an extremely large proportion(94.9%).EO of Angelica pubescens was dominated by six character-istic components includingα-pinene(21.5%),β-phellandrene(18.1%),p-cymene(12.2%),3-methylnonane(8.7%),o-cymene(8.1%),and D-sylvestrene(6.2%).The EO from Cryptotaenia japonica was characterized by high amounts ofα-selinene(48.7%),β-selinene(23.7%),and trans-β-farnesene(5.4%).The EOs from leaves and stems of Xyloselinum vietnamense were characterized by high concentrations of sabinene(69.8%and 33.8%),4-terpineol(8.7%and 7.4%)andβ-pinene(4.0%and 6.5%)while EOs from aerial parts and root of Xylo-selinum leonidii comprise four characteristic monoterpenes includingα-pinene(28.2%and 52.8%),β-pinene(7.9%and 10.3%),β-phellandrene(7.6%and 15.3%),and sabinene(3.0%and 4.1%).Additionally,cryptone is also one of the major components in the EO of Xyloselinum leonidii(13.2%in the aerial parts oil and 2.8%in the root oil).In the EOs isolated from the aerial parts and root of Heracleum bivittatum,α-pinene(22.5%and 70.2%)andβ-pinene(43.2%and 20.0%)were the predominant *** appeared in the EO from aerial parts of Heracleum bivittatum with a relatively high concentration(13.5%)while bornyl acetate(5.1%)was also one of the main components in the EO from its aerial parts but was not detected in other Apiaceae species in the present *** databases help identify and control the quality of plant material studied from the family Apiaceae growing in Vietnam.

关键词： Apiaceae essential oil terpenoids gaschromatography-mass spectrometry

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Dry eye rate and its relationship with disease stage in patients with primary hypertension:a cross-sectional study in Vietnam

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 653-658页

作者： Tran Tat Thang Pham Hong phuong nguyen Sa Huynh nguyen Trung Kien nguyenDuy Toan nguyen Thi Thu Ha Le Ha Khoa nguyen Huu Dung Thai Doan Thang Le Viet Thang Nghe An Eye Hospital Nghe An 43000Vietnam Nghe An Friendship General Hospital Nghe An 43000Vietnam Military Hospital 103 Ha Noi 100000Vietnam Vietnam Military Medical University Ha Noi 100000Vietnam Hanoi Medical University Ha Noi 100000Vietnam Bạch Mai Hospital Ha Noi 100000Vietnam TTH Vinh General Hospital Nghe An 100000Vietnam

AIM:To determine the dry eye(DE)rate and its relationship with disease stage in patients with primary ***:A cross-sectional study included 432 patients with primary hypertension(with an equal number of patients in each group:144 in stage Ⅰ,Ⅱ,and Ⅲ hypertension)and 144 healthy subjects as a control *** Ocular Surface Disease Index(OSDI)and Schirmer Ⅰ test without anesthetics were conducted on all 576 *** with OSDI scores<13 and Schirmer Ⅰ values equal to or under 10 mm were diagnosed with ***:The ratio of DE in hypertension patients was higher than in the control group(41.7%versus 18.8%;P<0.001).The proportion of patients with DE increased gradually according to the hypertension stage:27.1% in stage Ⅰ,40.3% in stage Ⅱ,and 57.6% in stage Ⅲ,P<***,duration of hypertension,plasma urea,creatinine,and high-sensitivity C-reactive protein(CRP-hs)levels in hypertension patients with DE were higher than those without DE,P<*** age,a long duration of hypertension,diabetes mellitus,elevated plasma creatinine,and CRP-hs levels were independent factors associated with DE in primary hypertension patients,P<***:DE is a common disorder associated with advanced age,a long duration of hypertension,diabetes mellitus,elevated plasma CRP-hs,and creatinine levels in patients with primary hypertension.

关键词： primary hypertension dry eye stage of hypertension plasma creatinine

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Shilian Dashan With the Propagation of the Caodong Sect in Cochinchina in the Seventeenth Century

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Philosophy Study 2024年第4期14卷 194-203页

作者： Ngoc phuong nguyen Guangxi University for Nationalities NanningChina

The prosperous development of the“Maritime Silk Road”in the 17th century not only brought convenience in sea transportation and promoted trade between countries,but also acted as a bridge connecting *** bridge has the function of cultural exchange between peoples,especially in introducing and promoting China’s cultural and ideological quintessence with neighboring *** this period,Linji and Caodong sects of Chinese Zen Buddhism were spread directly into Cochinchina of Dai Viet through Chinese senior monks who followed merchant ships to this *** them was the Most Venarable Shilian Dashan,a senior monk at Changshou Temple,Guangzhou,who accepted Lord nguyen Phuc Chu’s invitation to teach the Soto Dharma in Cochinchina for nearly two years(1695-1696).Based on the study of relevant historical documents and autobiographical works on this trip byMost ***,the article presents his biography and ***,this article analyzes the method of spreading Dharma,Chan ideology,as well as the significance of his Dharma propagation activities for Buddhism in Cochinchina at that time.

关键词： Shilian Dashan Buddhism in Cochinchina Caodong Chan

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Oxygen functionalization-assisted anionic exchange toward unique construction of flower-like transition metal chalcogenide embedded carbon fabric for ultra-long life flexible energy storage and conversion

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Carbon Energy 2024年第1期6卷 72-93页

作者： Roshan M.Bhattarai Kisan Chhetri Nghia Le Debendra Acharya Shirjana Saud Mai Cao Hoang phuong Lan nguyen Sang Jae Kim Young Sun Mok Department of Chemical Engineering Jeju National UniversityJejuRepublic of Korea Department of Nano Convergence Engineering Jeonbuk National UniversityJeonjuRepublic of Korea Regional Leading Research Center(RLRC)for Nanocarbon-based Energy Materials and Application Technology Jeonbuk National UniversityJeonjuRepublic of Korea Department of Chemistry Mississippi State UniversityStarkvilleMississippiUSA Nanomaterials and System Laboratory Department of Mechatronics EngineeringJeju National UniversityJejuRepublic of Korea

The metal-organic framework(MOF)derived Ni–Co–C–N composite alloys(NiCCZ)were“embedded”inside the carbon cloth(CC)strands as opposed to the popular idea of growing them upward to realize ultrastable energy storage and conversion *** NiCCZ was then oxygen functionalized,facilitating the next step of stoichiometric sulfur anion diffusion during hydrothermal sulfurization,generating a flower-like metal hydroxysulfide structure(NiCCZOS)with strong partial implantation inside *** obtained NiCCZOS shows an excellent capacity when tested as a supercapacitor electrode in a three-electrode ***,when paired with the biomass-derived nitrogen-rich activated carbon,the asymmetric supercapacitor device shows almost 100%capacity retention even after 45,000 charge–discharge cycles with remarkable energy density(59.4 Wh kg^(-1)/263.8μWh cm^(–2))owing to a uniquely designed ***,the same electrode performed as an excellent bifunctional water-splitting electrocatalyst with an overpotential of 271 mV for oxygen evolution reaction(OER)and 168.4 mV for hydrogen evolution reaction(HER)at 10 mA cm−2 current density along with 30 h of unhinged chronopotentiometric stability performance for both HER and ***,a unique metal chalcogenide composite electrode/substrate configuration has been proposed as a highly stable electrode material for flexible energy storage and conversion applications.

关键词： carbon cloth energy conversion energy storage flexible metal embedding ultra-stable

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Clinical Case Report of Acute Heart Injury and Acute Rhabdomyolysis Due to Cyanide Poisoning

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Open Journal of Emergency Medicine 2024年第2期12卷 29-32页

作者： nguyen Dang Duc nguyen phuong Sinh Lam nguyen Hong Anh Poison Control Center of Bach Mai Hospital Hanoi Vietnam Thai nguyen Medicine and Pharmacy University Thai Nguyen Vietnam

Cyanide poisoning is one of the most dangerous poisonings, and it can be absorbed into the body through the mouth, inhalation and through the skin. A 32-year-old female patient was admitted to our poison control center because of high fever, severe vomiting, and seizures. Physical examination found that the patient was drowsy, had a high fever of 40 degrees Celsius, pulse of 140 beats/minute, and increased tendon and bone reflexes. Exploiting the patient’s information, it was discovered that the patient bought Cyanide to drink with the intention of committing suicide. The patient was quickly treated with gastric lavage and activated charcoal. Echocardiography recorded EF: 35%, reduced movement of the entire myocardium. CK blood test: 4562 U/L. The patient’s condition rapidly deteriorated and the patient was made ECMO, IHD and CVVHDF. After 3 days of treatment, the patient’s condition did not improve, so the family asked for the patient to go home. This article aims to describe the rapidly progressing and severe damage to the heart and muscles of patients with cyanide poisoning.

关键词： Cyanide Poisoning Acute Heart Injury Acute Rhabdomyolysis

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