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Effects of albendazole,artesunate,praziquantel and miltefosine,on Opisthorchis viverrini cercariae and mature metacercariae

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Asian Pacific Journal of Tropical Medicine 2017年第2期10卷 120-126页

作者： phornphitcha pechdee Monticha Chaiyasaeng Chanisala Sereewong Jukkrid Chaiyos Apiporn Suwannatrai Sutee Wongmaneeprateep Smarn Tesana Food-Borne Parasite Research Group Department of ParasitologyFaculty of MedicineKhon Kaen University Department of Fisheries Faculty of AgricultureKhon Kaen University

Objective:To explore larvicidal effects of anthelmintic drugs on Opisthorchis viverrini(***) for alternative approach to interrupting its cycle for developing a field-based control ***:The larvicidal activities of albendazole(A1),artesunate(Ar),praziquantel(Pzq) and miltefosine(Mf) on *** cercariae and mature metacercariae were *** concentrations(LC_(50) and LC_(95)) of these drugs were *** metacercariae previously exposed to various concentrations of the drugs were administered to *** were harvested 30 d post infection and worm recovery rates ***,Ar,Pzq and Mf produced morphological degeneration and induced shedding tails of cercariae after 24 h ***:The LC_(50) and LC_(95) of Al,Ar,Pzq and Mf on cercariae were 0.720 and 1.139,0.350 and 0.861,0.017 and 0.693,and 0.530 and 1.134 ppm,***_(50) and LC_(95) of Ar on mature metacercariae were 303.643 and 446.237 ppm and of Mf were 289.711 and 631.781 ppm,respectively but no lethal effect in Pzq-and Al-treated groups(up to 1 ppt).No worms were found in hamsters administered Pzq-treated *** adult worms from Al-treated metacercariae were significantly bigger in size compared to the control group(P<0.05).Fecundity and body width were greater in adults from Mf-treated metacercariae compared to the control group(P<0.05).Conclusions:The larvicidal effects of these drugs were high efficacy to *** cercariae but lesser efficacy to *** should be further studied with the eventual aim of developing a field-based control program.

关键词： Albendazole Artesunate Praziquantel Miltefosine Opisthorchis viverrini Cercariae

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