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世界电子元器件 2007年第2期 79-79页

作者： philips公司 philips公司

STB500是一个完整的、针对互联网协议机顶盒的系统解决方案，提供了所需的全部基本功能，从信号接收到AN输出和用户接口。功能强大的Nexperia媒体处理器是该解决方案的核心，可以轻松开发系统设计和软件测试。

关键词： philips 系统解 Nexperia媒体处理器 STB IP 互联网协议用户接口信号接收

数字的转换,跨越的时代——飞利浦全数字磁共振Ingenia突破性技能分析

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中国医学影像技术 2012年第12期28卷 2267-2268页

作者： philips Healthcare 飞利浦医疗保健事业部

与CT、DR等全数字影像设备不同，目前市场上的磁共振产品仍旧由线圈采集图像信号，再将模拟信号通过模拟线圈接口与同轴电缆传输到射频通道进行A—D模数转换，获取最终数字图像。

关键词：数字影像设备磁共振产品飞利浦技能模拟信号图像信号模数转换同轴电缆

Anti-aging and anti-carcinogenic effects of 1α,25-dihyroxyvitamin D_(3) on skin

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Plastic and Aesthetic Research 2022年第1期9卷 445-454页

作者： Neena philips Mikel Portillo-Esnaola philips Samuel Maria Gallego-Rentero Tom Keller JanFranco Department of Biological Sciences Fairleigh Dickinson UniversityTeaneckNJ 07601USA Department of Biology Autónoma University of Madrid(UAM)Madrid 28049Spain Instituto Ramón y Cajal de Investigación Sanitaria(IRYCIS) Madrid 28049Spain

Photoaging and carcinogenesis are facilitated by oxidative stress,inflammation,angiogenesis,and extracellular matrix(ECM)*** effects include DNA damage,membrane oxidation,lipid peroxidation,and alterations in the expression of p53 and antioxidant *** inflammatory and angiogenesis mediators include interleukin-1,tumor necrosis factor-α,interleukin-8,transforming growth factor-β,and vascular endothelial growth *** remodeling includes alterations in the expression and organization of collagen,elastin,matrix metalloproteinases,and elastase.1α,25-dihydroxy-vitamin D_(3) has antioxidant,anti-inflammatory,and ECM regulatory properties,and can counteract the processes that facilitate photoaging and *** review provides an overview of the beneficial effects of vitamin D supplementation at a molecular level,followed by a brief discussion regarding its use as a supplement.

关键词： Ultraviolet radiation superoxide dismutase p53 interleukins tumor necrosis factor-α transforming growth factor-β vascular endothelial growth factor collagen elastin matrix metalloproteinases

Identification and Analysis of Gut Microbiota and Functional Metabolism in Decompensated Cirrhosis with Infection

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Journal of Clinical and Translational Hepatology 2023年第1期11卷 15-25页

作者： Cyriac Abby philips Rizwan Ahamed Jinsha K.P.Abduljaleel Sasidharan Rajesh Philip Augustine Clinical and Translational Hepatology Monarch Liver LaboratoryThe Liver InstituteCenter of Excellence in GI SciencesRajagiri HospitalAluvaKeralaIndia Gastroenterology and Advanced GI Endoscopy Center for Excellence in Gastrointestinal SciencesRajagiri HospitalAluvaKeralaIndia Diagnostic and Interventional Gastroenterology and Hepatology Center for Excellence in Gastrointestinal SciencesRajagiri HospitalAluvaKeralaIndia

Background and Aims:Intestinal dysbiosis play a role in the adverse outcomes of sepsis and septic ***,variations in bacterial diversity and microbiota-related functional metabolic alterations within the gut microbiome in decompensated cirrhosis(DC)patients with infection remain ***:We conducted 16-srRNA sequencing on stool samples(n=51:sepsis,27/no sepsis,24)collected from consecutive DC patients upon *** diversity,significant taxa,and respective metabolic profiling were performed based on subgroup ***/Cytoscape was utilized to identify significant non-random patterns of bacterial copresence and mutual exclusion for clinical ***:Genera associated with pathogenicity in conditions of immune exhaustion(Corynebacterium,Lautropia)were predominant in patients with *** pathways associated with oxidative stress and endotoxemia[lipopolysaccharide(LPS)synthesis and sulfur relay]were significantly upregulated in *** taxa were associated with sites of infection in DC *** oxidant pathways that increase glutathione were upregulated in those without *** family of sulfur-metabolizing bacteria,exaggeration of orally predominant pathogens(Prevotella),and pathways of severe LPS-related hyperinflammatory stress were notable in those with interleukin-6 levels>1,000 pg/*** genera related to an immune deficient state was significant in DC with≥2 infection *** was associated with survival during the same ***:Specific gut microbiota and their metabolites were associated with sepsis and related events in patients with *** beneficial strains that reduce immune exhaustion and supplementation of favorable metabolites could improve therapeutics for DC and sepsis,for which larger prospective,well controlled population-based studies remain an unmet need.

关键词： Microbiome Portal hypertension Sepsis Acute-on-chronic liver failure Multidrug resistance

Clinical outcomes and gut microbiota analysis of severe alcohol-associated hepatitis patients undergoing healthy donor fecal transplant or pentoxifylline therapy:single-center experience from Kerala

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Gastroenterology Report 2022年第1期10卷 566-574页

作者： Cyriac Abby philips Rizwan Ahamed Sasidharan Rajesh Shobhit Singh Ajit Tharakan Jinsha K.Abduljaleel Philip Augustine Clinical and Translational Hepatology The Liver InstituteCenter of Excellence in GI SciencesRajagiri HospitalChunangamvelyAluvaErnakulamKeralaIndia Monarch Liver Laboratory The Liver InstituteCenter of Excellence in GI SciencesRajagiri HospitalChunangamvelyAluvaErnakulamKeralaIndia Department of Gastroenterology and Advanced GI Endoscopy Center of Excellence in GI SciencesRajagiri HospitalChunangamvelyAluvaErnakulamKeralaIndia Diagnostic and Interventional Radiology Center of Excellence in GI SciencesRajagiri HospitalChunangamvelyAluvaErnakulamKeralaIndia

Background Severe alcohol-associated hepatitis(SAH)patients with infections have a high short-term mortality *** microbiota dysbiosis plays an important role in the pathogenesis of *** studies have demonstrated long-term benefits with healthy donor fecal microbiota transplantation(FMT).Data on FMT compared with pentoxifylline for SAH and relevant gut microbial changes are lacking in *** From January 2019 to February 2021,retrospective analysis of a single hospital’s records revealed 47 SAH patients undergoing FMT(100mL/day via nasoduodenal tube for 7days)and 25matched patients receiving pentoxifylline(400mg/8 h for 28days).The primary end point was a 6-month survival *** end points included incidence of ascites,hepatic encephalopathy,infections,acute kidney injury,and gutmicrobiota changes between post-therapy *** discovery and network analysis were also performed to identify significant taxa of gutmicrobiota in post-treatment groups in retrospectively stored stool *** All were *** 6-month survival rate was higher in the patients undergoing FMT than in patients receiving pentoxifylline(83.0%vs 56.0%,P=0.012).At the end of 6-month follow-up,the incidences of clinically significant ascites(56.0%vs 25.5%,P=0.011),hepatic encephalopathy(40.0%vs 10.6%,P=0.003),and critical infections(52.0%vs 14.9%,P<0.001)in patients administered pentoxifylline were significantly higher than those in patients treated with *** 3 months,biomarker analysis revealed a significant abundance of Bifidobacterium and Eggerthella in the FMT group and the pentoxifylline group,*** 6 months,Bifidobacterium in the FMT group and pathogenic Aerococcaceae in the pentoxifylline group were *** analysis showed beneficial taxa(Bifidobacterium)as a central influencer in those undergoing FMT at 6 *** Healthy donor FMT improved survival rate and reduced liver-related complications compared with pe

关键词： fecal microbiota stool transplant alcoholic hepatitis liver transplant dysbiosis

Still'dwelling in the possibility'-critical update on stem cell therapy for acute on chronic liver failure

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World Journal of Stem Cells 2020年第10期12卷 1124-1132页

作者： Cyriac Abby philips Philip Augustine The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682025KeralaIndia Department of Gastroenterology and Advanced GI Endoscopy Cochin Gastroenterology GroupErnakulam Medical CenterKochi 682025KeralaIndia

Stem cells therapy could improve survival in patients with liver *** on stem cell therapy and related growth factors in decompensated cirrhosis has been on the forefront but has shown heterogenous *** high-quality studies have shown a lack of efficacy and *** with acute-on-chronic liver failure(ACLF)are a unique group with high mortality in the short-term associated with rapid onset extrahepatic organ *** these patients,there is an urgent need to identify treatments that can improve liver cell function and mass,prevent sepsis/organ failure,ameliorate systemic inflammation,and increase transplant-free *** cells are a novel treatment in ACLF but with unclear efficacy and *** this narrative review,we discuss the basics of liver regeneration in patients with ACLF and update current clinical status of stem cell use in patients with ACLF for improving our understanding of future directions.

关键词： Portal hypertension Regenerative therapy Mesenchymal stem cells Liver failure Sepsis

Healthy Donor Fecal Microbiota Transplantation for Recurrent Bacterial Cholangitis in Primary Sclerosing Cholangitis-A Single Case Report

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Journal of Clinical and Translational Hepatology 2018年第4期6卷 438-441页

作者： Cyriac Abby philips Philip Augustine Nikhil Phadke The Liver Unit Cochin Gastroenterology GroupP.A.A.Ernakulam Medical CentreNational Highway Bypass(NH-66)PalarivattomKochiKeralaIndia Gastroenterology Cochin Gastroenterology GroupP.A.A.Ernakulam Medical CentreNational Highway Bypass(NH-66)PalarivattomKochiKeralaIndia Molecular Cellular and Developmental BiologyGenepath DxPhadke HospitalShivajinagarPuneMaharashtraIndia

Recurrent acute bacterial cholangitis is a unique indication for liver transplantation in primary sclerosing *** present the first report on utility of healthy donor fecal transplantation for management of recurrent acute bacterial cholangitis in a primary sclerosing cholangitis *** demonstrate the striking liver biochemistry,bile acid and bacterial community changes following intestinal microbiota transplantation associated with amelioration of recurrent cholangitis.

关键词： FMT Sclerosing cholangitis Stool transplant Gut microbiome Microbiota

Detection of leaf structures in close-range hyperspectral images using morphological fusion

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Geo-Spatial Information Science 2017年第4期20卷 325-332页

作者： Gladys Villegas Wenzhi Liao Ronald Criollo Wilfried philips Daniel Ochoa Department of Telecommunications and Information Processing Ghent University-imec Ghent Belgium Facultad de Ingeniería en Eléctrica y Computación ESPOL Polytechnic University Escuela Superior Politécnica del Litoral Guayaquil Ecuador

Close-range hyperspectral images are a promising source of information in plant biology,in particular,for in vivo study of physiological *** this study,we investigate how data fusion can improve the detection of leaf elements by combining pixel reflectance and morphological *** detection of image regions associated to the leaf structures is the first step toward quantitative analysis on the physical effects that genetic manipulation,disease infections,and environmental conditions have in *** tested our fusion approach on Musa acuminata (banana) leaf images and compared its discriminant capability to similar techniques used in remote *** results demonstrate the efficiency of our fusion approach,with significant improvements over some conventional methods.

关键词： Hyperspectral fusion morphology plant biology

Complementary and Alternative Medicine-related Drug-induced Liver Injury in Asia

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Journal of Clinical and Translational Hepatology 2019年第3期7卷 263-274页

作者： Cyriac Abby philips Philip Augustine Sasidharan Rajesh Praveen Kumar Y Deepak Madhu The Liver Unit and Monarch Liver Lab Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Gastroenterology Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Interventional Radiology Cochin Gastroenterology GroupErnakulam Medical CentreKochiKeralaIndia Gastroenterology Government Medical CollegeThrissurKeralaIndia Gastroenterology Aster MIMSCalicutKeralaIndia

The use of complementary and alternative medicines(CAMs)for treatment of acute and chronic diseases is on the rise world over,especially in Asian countries,and mostly in China and ***-induced liver injury(DILI)due to CAM is increasingly reported in the literature from multiple centers all around the world and with large-number patient series published from the West,mostly based on nation-wide DILI networks and multicenter *** DILI networks are lacking among major Asian countries with high incidence of CAM *** medical societies dealing with drug toxicity,CAM practice and hepatobiliary disease have adopted an integrated approach to establishing identification,diagnosis and treatment of CAM-related DILI,representing a systematic approach that could be iterated by other countries for improving patient *** this exhaustive review,we provide published data on CAM-related DILI in Asia,with detail on incidences along with analysis of patient population and their clinical *** and clear discussion on commonly implicated CAM agents in major Asian countries and associated chemical and toxicology analyses as well as descriptions of liver biopsy findings are discussed with future directions.

关键词： CAM Herbals Ayurveda Chinese DILI Hepatitis Cirrhosis ACLF Liver biopsy

微辐射CT成像平台——星光iDose^4及其临床应用

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中国医学影像技术 2013年第12期29卷 2057-2058页

作者： philips Healthcare 飞利浦医疗保健事业部

CT的临床应用愈来愈广泛，成为医源性辐射剂量的主要来源。为控制和降低CT检查的辐射剂量，业已对CT的硬件和软件进行了诸多改进，如降低管电流、增加螺距、降低管电压等。但是．这些方法均是通过改进X线采集环节来降低辐射剂量。其成... 详细信息

CT的临床应用愈来愈广泛，成为医源性辐射剂量的主要来源。为控制和降低CT检查的辐射剂量，业已对CT的硬件和软件进行了诸多改进，如降低管电流、增加螺距、降低管电压等。但是．这些方法均是通过改进X线采集环节来降低辐射剂量。其成效有限，且已渐入瓶颈。

关键词：辐射剂量 CT成像临床应用 CT检查医源性管电流管电压