检索结果-南通市图书馆

Three-dimensional mapping and comparative analysis of the distal human corpus cavernosum and the inflatable penile prosthesis

引用

Asian Journal of Andrology 2013年第4期15卷 567-570,I0012页

作者： Tariq S Hakky Daniel Ferguson philippe e spiess Paul Bradley Tom FLue Rafael e Carrion Department of Urology University of South Florida Tampa General Circle Tampa FL 33602 USA 23D3Solutions Burnaby BCV5J 5M8 Canada and Department of Urology University of Southern California San Francisco 400 Parnassus Ave San Francisco CA 94143 USA

The intricate anatomy of the corpus cavernosum in both the flaccid and tumescent state has not been fully elucidated. We report our experience using a three-dimensional （3D） scanner to reconstruct cadaveric casts and compare them with 3D images of two prototypes of penile prosthesis. Two different models of the Titan Coloplast inflatable penile prosthesis were analyzed using a 3D scanner. The first was the standard model and the second was a newer model with a rounder silicone tip. Two cadaveric phalluses were harvested using Smooth-Cast 300Q polyurethane molding. The molds were excised and scanned along side the penile prosthesis. 3D scans were completed and analyzed using Leios Mesh software, and GOM Inspect software. The 3D scans demonstrated the mean human corporal radii 2 mm from the distal tip to be 36.51 mm （36.01-37.0 mm）, which is an obtuse angle. The standard Titan penile prosthesis spherical radius at the same level was 202.52 mm, while the new silicone tip prosthesis had a radius of 139.33 mm. 3D mapping further demonstrated the trajectory of the cavernosa appeared curvilinear and the distal ends appeared blunt. The use of cadaveric cavernosal molds in combination with the 3D scanner allowed us to accurately image the corpus cavernosum for the first time. Our findings suggest that anatomically accurate corporal tips appear to be relatively blunt and that the new Titan silicone tip penile prosthesis more closely resembles the human corporal tip.

关键词： corpus cavernosum penile prosthesis three-dimensional analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advancing the field of rare genitourinary tumors:Challenges and opportunities

引用

Asian Journal of Urology 2022年第4期9卷 347-348,F0002页

作者： philippe e.spiess Andrea Necchi Department of Genitourinary Oncology and Tumor Biology Moffitt Cancer CenterTampaUSA Vita Salute San Raffaele University and Urological Research Institute IRCCS San Raffaele Hospital and Scientific InstituteMilanItaly

Firstly,I would like to congratulate the editorial team of the Asion Journol of Urology for dedicating a speclial isue of the joumal to this important *** recent advances in our fundamental understanding of the pathop... 详细信息

关键词： urinary tumors rare

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Revisiting mechanisms of resistance to immunotherapies in metastatic clear-cell renal-cell carcinoma

引用

Cancer Drug Resistance 2023年第2期6卷 314-326页

作者： Monica Sheila Chatwal Jad Chahoud philippe e.spiess Department of Genitourinary Oncology H.Lee Moffitt Cancer Center and Research InstituteTampaFL 33612USA

Renal-cell carcinoma(RCC)remains a leading cause of cancer-related mortality *** newer therapeutic combinations of immune checkpoint inhibitors and targeted therapies have greatly improved outcomes,resistance to these therapies is becoming a challenge for long-term *** of resistance have been explored in a variety of solid tumors,including *** upon our review of the current literature on the mechanisms of resistance to immunotherapies for the management of metastatic clear-cell renal cell carcinomas(mccRCC),the ensuing conclusions have been made:The management of mccRCC has progressed substantially with the advent of checkpoint inhibitors and targeted oral therapies,alone and/or in ***,innate or developed resistance to these therapies remains an ongoing challenge,particularly to immune checkpoint inhibitors(ICIs).Several of the known mechanisms of resistance have been well defined,but recent progression in cellular therapies helps to expand the armamentarium of potential combination options that may overcome these modes of resistance and improve long-term disease control and survival for an otherwise dismal *** the ensuing review and update of the literature on the mechanisms of resistance to immunotherapies in mccRCC,we have revisited the known resistance mechanisms of immunotherapies in metastatic clear-cell RCC and explored ongoing and future strategies to overcome them.

关键词： Metastatic clear-cell renal-cell carcinoma immune therapy checkpoint inhibitor resistance chimeric antigen receptor T-cell therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Augmented reality assisted surgery： a urologic training tool

引用

Asian Journal of Andrology 2016年第5期18卷 732-734页

作者： Ryan M Dickey Neel Srikishen Larry I Lipshultz philippe e spiess Rafael e Carrion Tariq S Hakky Scott Department of Urology Baylor College of Medicine Houston 77030 USA University of South Florida Department of Urology Tampa 33606 USA.

Augmented reality is widely used in aeronautics and is a developing concept within surgery. In this pilot study, we developed an application for use on Google Glass optical head-mounted display to train urology residents in how to place an inflatable penile prosthesis. We use the phrase Augmented Reality Assisted Surgery to describe this novel application of augmented reality in the setting of surgery. The application demonstrates the steps of the surgical procedure of inflatable penile prosthesis placement. It also contains software that allows for detection of interest points using a camera feed from the optical head-mounted display to enable faculty to interact with residents during placement of the penile prosthesis. Urology trainees and faculty who volunteered to take part in the study were given time to experience the technology in the operative or perioperative setting and asked to complete a feedback survey. From 30 total participants using a lO-point scale, educational usefulness was rated 8.6, ease of navigation was rated 7.6, likelihood to use was rated 7.4, and distraction in operating room was rated 4.9. When stratified between trainees and faculty, trainees found the technology more educationally useful, and less distracting. Overall, 81% of the participants want this technology in their residency program, and 93% see this technology in the operating room in the future. Further development of this technology is warranted before full release, and further studies are necessary to better characterize the effectiveness of Augmented Reality Assisted Surgery in urologic surgical training.

关键词： andrology augmented reality assisted surgery Google glass inflatable penile prosthesis optical head mounted display surgical education

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Updates in the use of radiotherapy in the management of primary and locally-advanced penile cancer

引用

Asian Journal of Urology 2022年第4期9卷 389-406页

作者： Akshar Patel Arash O.Naghavi Peter A.Johnstone philippe e.spiess G.Daniel Grass University of South Florida Morsani College of Medicine TampaFLUSA Department of Radiation Oncology H.Lee Moffitt Cancer Center and Research InstituteTampaFLUSA Department of Genitourinary Oncology H.Lee Moffitt Cancer Center and Research InstituteTampaFLUSA

Objective:Penile cancer is a rare malignancy in most developed countries,but may represent a significant oncologic challenge in certain African,Asian,and South American *** treatment approaches have been described in penile cancer,including *** review aimed to provide a synopsis of radiotherapy use in penile cancer management and the associated *** addition,we aimed to discuss palliative radiation for metastases to the penis and provide a brief overview of how tumor biology may assist with treatment ***:Peer-reviewed manuscripts related to the treatment of penile cancer with radio-therapy were evaluated by a PubMed search(1960-2021)in order to assess its role in the definitive and adjuvant *** manuscripts were also evaluated for descriptions of radiation-related ***:Though surgical resection of the primary is an excellent option for tumor control,select patients may be treated with organ-sparing radiotherapy by either external beam radiation or *** from randomized controlled trials comparing radiotherapy and surgery are lacking,and thus management is frequently determined by institutional practice patterns and available ***,this lack of clinical trial data leads to divergence in opinion regarding lymph node *** is further complicated in that many cited studies evaluating lymph node radiotherapy used non-modern radiotherapy delivery *** toxicity from either surgery or radiotherapy remains a challenging problem and further risk assessment is needed to guide intensification with multi-modal *** differences in tumor biology,based on human papillomavirus infection,may help aid future prognostic and predictive models in patient risk stratification or treatment ***:Penile cancer is a rare disease with limited clinical trial data driving the majority of treatment *** a result,the goal of management

关键词： Brachytherapy Chemoradiation Radiation Radiotherapy Penile cancer Squamous cell carcinoma of the penis Penile-sparing Penile metastase Human papillomavirus

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genitourinary melanoma:An overview for the clinician

引用

Asian Journal of Urology 2022年第4期9卷 407-422页

作者： Danielle K.DePalo Kelly M.elleson Michael J.Carr philippe e.spiess Jonathan S.Zager Department of Cutaneous Oncology Moffitt Cancer CenterTampaFLUSA Department of Surgery University of LouisvilleLouisvilleKYUSA Department of Genitourinary Oncology Moffitt Cancer CenterTampaFLUSA

Genitourinary (GU) melanoma is a rare presentation of melanoma accounting for approximately 0.5% of all *** melanomas include primary melanomas of the vulva,vagina,uterine cervix,ovary,penis,scrotum,urethra,bladder,ureter,and *** melanomas are often diagnosed in advanced stages and stigma is thought to contribute to delays in *** the likely diagnosing provider,it is imperative that dermatologists,urologists,and gynecologists are aware of these uncommon sites of *** there have been major advances in the treatment of melanomas as a whole in the last 10 years,their applications to GU melanomas have often been *** melanomas have not been included in many of the major phase II clinical trials which brought contemporary advanced treatments to market and the prognoses for GU melanomas remain *** to the rarity of GU melanomas,much of the literature provides gener alized recommendations across multiple different organs affected by GU melanomas or omits certain topics,making it difficult to appreciate the funda-mentals of the individual *** review aimed to provide background information on the pathogenesis and epidemiology of the different sites of GU melanomas and categorize data specific to the presentation,staging,treatment,and prognosis of each type of GU melanoma to guide the *** was also meant to encourage a multidisciplinary approach to the management of these patients as it spans the expertise of surgical oncologists,medical oncologists,radiation oncologist,dermatologists,urologists,and gynecologists.

关键词： Genitalia Female Male Melanoma Rare diseases Staging Treatment Urinary tract

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genitourinary manifestations of Lynch syndrome in the urological practice

引用

Asian Journal of Urology 2022年第4期9卷 443-450页

作者： Chiara Lonati Claudio Simeone Nazareno Suardi philippe espiess Andrea Necchi Marco Moschini Urology Unit ASST Spedali Civili di BresciaDepartment of Medical and Surgical SpecialtiesRadiological Science and Public HealthUniversity of BresciaBresciaItaly Department of Urology Luzerner KantonsspitalLucerneSwitzerland Department of Genitourinary Oncology H.Lee Moffitt Cancer Center and Research InstituteTamplaFLUSA University Vita-Salute San Raffaele MilanItaly Department of Medical Oncology IRCCS San Raffaele Hospital and Scientific InstituteMilanItaly Division of experimental Oncology/Unit of Urology Urological Research InstituteIRCCS Ospedale San RaffaeleMilanItaly

Objective:Lynch syndrome(LS)is an autosomal dominant hereditary disorder resulting from germline mutation in at least one of the four mismatch repair genes or in ePCAM *** a clinical perspective,LS patients exhibit an increased predisposition to multiple primary malignancies and early age of onset compared to general *** aimed to provide a comprehensive overview of all the genitourinary manifestations of LS,focusing on incidence,diagnosis,clinical features,therapeutic strategies,and screening ***:Previous literature was assessed through Medline,Scopus,and Google Scholar data-bases.A narrative review of the most relevant articles from January 1996 to June 2021 on urological manifestations of LS was ***:In the LS tumor spectrum,upper tract urothelial carcinoma(UTUC)represents the third most frequent malignancy,and the first most common cancer in the urological field,with an approximately 14-fold increased risk of developing UTUC compared to general *** diagnosis among patients experiencing UTUC as first malignancy is a step-by-step process,including(i)clinical criteria,(ii)molecular testing,and(iii)genetic testing to confirm the hereditary *** current european Association of Urology(eAU)guidelines recommend to perform molecular testing among UTUC patients under 65 years old,or UTUC patients with personal history of LS-related tumor,or UTUC patients with one first-degree relative under the age of 50 years with LS-related tumor,or UTUC patients with two first-degree relatives with LS-related tumor regardless of age of *** diagnosed LS patients should be referred to a multidisci-plinary management,including gastroenterologists and ***,considering the increased risk of metachronous recurrence,treatments other than radical nephroureterectomy may be a valuable therapeutic *** urological malignancies other than UTUC should be included in the LS tumor spectrum is still cont

关键词： Hereditary disease Hereditary nonpolyposis colorectal cancer Lynch syndrome Mismatch repair Upper tract urothelial carcinoma

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of modelled-and remote sensing-derived daily snow line altitudes at Ulugh Muztagh,northern Tibetan Plateau

引用

Journal of Mountain Science 2016年第4期13卷 593-613页

作者： Marinka spiess eva HUINTJeS Christoph SCHNeIDeR Department of Geography RWTH Aachen UniversityWiillnerstr.5b52066 AachenGermany Humbold University Berlin Unter den Linden 610099 BerlinGermany

The ice cap Ulugh Muztagh in the central Kunlun Shan at the northern fringe of the Tibetan Plateau is a very isolated region with arid cold conditions. No observational, meteorological or glaciological ground truth data is available. Using the Moderate-resolution Imaging Spectroradiometer(MODIS) Level 1 radiance Swath Data(MOD02QKM) with a spatial resolution of 250 m, transient snow lines during the months of July to September in 2001 to 2014 are derived. Results are used to calibrate the physical based Coupled Snowpack and Ice surface energy and Mass balance model(COSIMA). The model runs on a representative detail region of Ulugh Muztagh(UM) on a digital elevation model with the same spatial resolution as the MODIS bands. In the absence of field observations, the model is driven solely by dynamically downscaled global analysis data from the High Asia Refined analysis(HAR). We compare remote sensing derived and modelled mean regional transient snow line altitudes in the course of consecutive summer seasons in 2008 to 2010. The resulting snow line altitude(SLA) and annual equilibrium line altitude(eLA) proxy of both methods coincide very well in their interannual variability in accordance with interannual variability of climatic conditions. Since SLAs of both methods do notconsistently agree on a daily basis a usage of remote sensing derived SLAs for model calibration in the absence of field observation data is only limitedly feasible for daily analysis. eLA approximation using the highest SLA at the end of ablation period may not be applied to UM because the negative winter mass balance(MB) is not reflected in the summer SLA. The study reveals moderate negative MB for UM throughout the modelling period. The mean regional MB of UM accounts for-523±410 mm w.e. a-1 in the modelling period. Hence UM seems not to belong to the area of the ‘Karakorum anomaly' comprising a region of positive mass balances in recent years which has its centre presumably in the Western Kunlu

关键词： Ulugh Muztagh Imaging spectroradiometer MODIS COSIMA energy balance Snow line Tibetan Plateau Kunlun Shan

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adding memory to pressure-sensitive phosphors

引用

Light(Science & Applications) 2019年第1期8卷 1-10页

作者： Robin R.Petit Simon e.Michels Ang Feng philippe F.Smet LumiLab Department of Solid State SciencesGhent UniversityKrijgslaan 281-S19000 GentBelgium

Mechanoluminescence(ML)is the phenomenon describing the emission of light during mechanical action on a solid,leading to applications such as pressure sensing,damage detection and visualization of stress *** most cases,this mechanical action releases energy that was previously stored in the crystal lattice of the phosphor by means of trapped charge carriers.A drawback is the need to record the ML emission during a pressure *** this work,we provide a method for adding a memory function to these pressure-sensitive phosphors,allowing an optical readout of the location and intensity of a pressure event in excess of 72 h after the *** is achieved in the BaSi_(2)O_(2)N_(2):eu^(2+) phosphor,where a broad trap depth distribution essential for the process is *** merging optically stimulated luminescence(OSL),thermoluminescence(TL)and ML measurements,the influence of light,heat and pressure on the trap depth distribution is carefully *** analysis demonstrates that mechanical action can not only lead to direct light emission but also to a reshuffling of trap *** memory effect not only is expected to lead to new pressure sensing applications but also offers an approach to study charge carrier transitions in energy storage phosphors.

关键词： luminescence occupation adding

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

提高农产品的利用减少粮食供应不足——食品科学与技术在应对全球粮食供应不足中的适度贡献

引用

中国食品学报 2009年第6期9卷 1-9页

作者： Walter e.L. spiess 德国卡尔斯鲁厄工业大学德国卡尔斯鲁厄76131

世界约六分之一的人口遭受严重的饥饿和营养不良的危害。遭受饥饿的热点地区并非均匀地分布在全球各地，其中非洲最严重!但在东南亚、中美洲、南美洲甚至在诸如欧洲和美国的许多地区也同样有人遭受饥饿。

关键词：粮食供应科学与技术农产品食品营养不良饥饿非均匀东南亚

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：