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Emodin alleviates cardiac fibrosis by suppressing activation of cardiac fibroblasts via upregulating metastasis associated protein 3

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Acta Pharmaceutica Sinica B 2019年第4期9卷 724-733页

作者： Dan Xiao Yue Zhang Rui Wang Yujie Fu Tong Zhou Hongtao Diao Zhixia Wang Yuan Lin Zhange Li Lin Wen Xujuan Kang philipp kopylov Dmitri Shchekochikhin Yong Zhang Baofeng Yang Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)Harbin Medical UniversityHarbin 150081China Department of Pharmacy The First Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of Preventive and Emergency Cardiology Sechenov First Moscow State Medical UniversityMoscow 119991Russian Federation Institute of Metabolic Disease Heilongjiang Academy of Medical ScienceHarbin 150086China Department of Pharmacology and Therapeutics Melbourne School of Biomedical SciencesFaculty of MedicineDentistry and Health SciencesThe University of MelbourneMelbourne 3010Australia

Excess activation of cardiac fibroblasts inevitably induces cardiac fibrosis. Emodin has been used as a natural medicine against several chronic diseases. The objective of this study is to determine the effects of emodin on cardiac fibrosis and the underlying molecular mechanisms. Intragastric administration of emodin markedly decreased left ventricular wall thickness in a mouse model of pathological cardiac hypertrophy with excess fibrosis induced by transaortic constriction(TAC) and suppressed activation of cardiac fibroblasts induced by angiotensin II(AngII). Emodin upregulated expression of metastasis associated protein 3(MTA3) and restored the MTA3 expression in the setting of cardiac fibrosis. Moreover, overexpression of MTA3 promoted cardiac fibrosis;in contrast, silence of MTA3 abrogated the inhibitory effect of emodin on fibroblast activation. Our findings unraveled the potential of emodin to alleviate cardiac fibrosis via upregulating MTA3 and highlight the regulatory role of MTA3 in the development of cardiac fibrosis.

关键词： Emodin Cardiac fibrosis MTA3 Angiotensin Ⅱ Cardiac fibroblast Mouse

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Pharmacodynamics of frigid zone plant Taxus cuspidata *** *** skin melanin deposition,oxidation,inflammation and allergy

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Frigid Zone Medicine 2023年第1期3卷 42-52页

作者： Yang Shi Ling Liu Heyang Sun Chen Chen Jing Feng Yongchao Chen Yuan Lin philipp kopylov Qi Wang Yong Zhang Department of Pharmacology(the State-Province Key Laboratories of Biomedicine Pharmaceutics of China Key Laboratory of Cardiovascular ResearchMinistry of Education)College of PharmacyHarbin Medical UniversityHarbin 150081China Department of Medicinal chemistry and natural medicinal chemistry College of PharmacyHarbin Medical UniversityHarbin 150081China Research Unit of Noninfectious Chronic Diseases in Frigid Zone Chinese Academy of Medical Sciences2019RU070Harbin 150081China Institute of Metabolic Disease Heilongjiang Academy of Medical ScienceHarbin 150086China Department of Preventive and Emergency Cardiology Sechenov First Moscow State Medical UniversityMoscow 119991Russia

Background:Taxus cuspidata *** *** a precious species of frigid zone plant belonging to the Taxaceae family,which possesses anticancer,anti-inflammatory,hypoglycemic,and antibacterial pharmacological *** taxane extracted from Taxus chinensis has been reported to elicit antioxidant activities,whether Taxus cuspidata *** *** skin-protective actions against injuries remained *** study aims to explore the pharmacological effects of three Taxus extracts on skin melanin deposition,oxidation,inflammation,and allergy so as to provide new ideas for the prevention and treatment of various diseases related to skin ***:Skin melanin deposition was evaluated by measuring melanin content in the skin of guinea pigs by alkali lysis *** capacity was evaluated by measuring superoxide dismutase(SOD)concentration and glutathione(GSH)content in skin tissue homogenates of Kunming mice by SOD assay kit and micro reduced GSH assay *** quantitative real-time polymerase chain reaction(qRT-PCR)and western blotting were used to examine the levels of both SOD and recombinant glutathione peroxidase 4(GPX4).Skin inflammation was evaluated by xylene-induced ear swelling test and egg-white-induced paw swelling test in *** a mouse model of skin allergy induced by 4-aminopyridine(4-AP),allergy was determined by licking body counts and histamine concentrations in tissue homogenates using enzyme-linked immunosorbent assay(ELISA)*** proinflammatory factors tumor necrosis factor(TNF)-αand interleukin(IL)-1βwere measured by *** and eosin(HE)staining was conducted to assess the degree of skin ***:All three Taxus extracts including Taxus chinensis essential oil,Taxus chinensis extract and Taxus chinensis extract compound reduced the melanin deposits in the back skin relative to the non-treated control animals,of which Taxus chinensis essential oil produced the greatest *** contrast,the three Taxus extracts elev

关键词： Taxus cuspidata S.et Z. skin melanin deposition oxidation inflammation allergy

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