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Pancreatic panniculitis and elevated serum lipase in metastasized acinar cell carcinoma of the pancreas: A case report and review of literature

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World Journal of Clinical Cases 2020年第21期8卷 5304-5312页

作者： Rainer Christoph miksch Tobias S Schiergens maximilian Weniger matthias Ilmer philipp m kazmierczak markus O Guba martin K Angele Jens Werner Jan G D'Haese Department of General Visceraland Transplantation SurgeryLudwig-Maximilians-University MunichMunich 81377BavariaGermany Department of General Visceral Transplantat Vasc&Thorac Surg Campus GrosshadernUniversity of MunichMunich 81377Germany Department of General Ludwig Maximilians-University(LMU)Munich 81377Germany Department of Radiology Ludwig-Maximilians-University MunichMunich 81377Germany Department of Surgery University of MunichKlinikum GrosshadernMunich University HospitalMunich 81377Germany Department of General University of MunichKlinikum GrosshadernHospital of the University of MunichMunich 81377Germany Department of General Klinikum Univ MunchenKlin Allgemeine Viszeral Transplantat Gefass&ThStandort GrosshadernLudwig-Maximilians-University(LMU)Munich 81377Germany

BACKGROUND Pancreatic panniculitis is an extremely rare condition associated with different underlying pancreatic disorders and characterized by subcutaneous fat necrosis induced by elevated serum lipase *** lesions usually affect the lower extremities and may precede abdominal symptoms of pancreatic *** cell carcinoma(ACC)of the pancreas is a rare pancreatic neoplasm,accounting for only 1%-2%of pancreatic tumors in *** present the case of a 72-year-old man with ACC of the pancreatic head and synchronous liver *** the primary tumor and liver metastases were *** lipase was elevated before surgery and decreased to normal *** serum lipase levels at follow-up led to the diagnosis of hepatic *** disease progression was then accompanied by pancreatic panniculitis,with subcutaneous fat necrosis and acute *** the best of our knowledge,only 4 cases have been reported in the literature and each showed a similar association of serum lipase levels with pancreatic panniculitis and progression of *** Clinical symptoms and progression of ACC may correlate with serum lipase levels,suggesting potential usefulness as a follow-up biomarker.

关键词： Pancreatic panniculitis Lipase Acinar cell carcinoma Pancreatic cancer Case report

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Thermocatalytic Oxidation of Chloro-Derivatives of Propane Occurring in Industrial Wastes

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Pedosphere 2002年第4期12卷 349-352页

作者： Z.GORZKA m.kazmierczak T.PARYJCZAK A.ZARCZYNSKI Institute of General and Ecological Chemistry Technical University of Lodz 90-924 Lodz ul. Zwirki 36 波兰 Institute of General and Ecological Chemistry Technical University of Lodz 90-924 Lodz ul. Zwirki 36

The process of treatment and utilization of organic chlorinecompounds: 1,2-dichloropropane and propylene chlorohydrin, wereinvestigated with application of contact catalysts to obtain thelowest possible temperature of the process by selection of propercatalysts and determination of optimum reaction *** were carried out with application of oxide, copper-zinc(TmC-2, TCm 3/1) and platinum (PA-2) Catalysts. Results ofinvestigations proved the possibility of total oxidation ofabove-mentioned compounds And components of industrial wastewater inthe temperature range form 350 to 450 deg. C.

关键词： chloro-organic substances 1,2-dichloropropane propylene chorohydrin thermocatalytic treatment

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Dupilumab-associated ulcerative keratitis

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International Journal of Ophthalmology(English edition) 2022年第6期15卷 1020-1022页

作者： matthew m Wilson philipp K Roberts mark Daniell Corneal Service Royal Victorian Eye and Ear HospitalEast MelbourneVictoria 3002Australia medical University of Vienna Vienna 1090Austria Department of Surgery(Ophthalmology) University of MelbourneParkvilleVIC 3013Australia Surgical Research Unit Centre for Eye Research Australia(CERA)University of MelbourneMelbourneVIC 3013Australia

Dear Editor,We present a case of a healthy 32-year-old man who developed bilateral corneal ulceration 3 wk after commencing dupilumab for atopic dermatitis. Dupilumab is a recently introduced systemic monoclonal antibody used in the treatment of moderate-to-severe atopic dermatitis, showing efficacy in clinical trials;. Several publications have reported ocular surface complications associated with dupilumab.

关键词： dermatitis clinical keratitis

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Characterization and mode of action analysis of black soldier fly(Hermetia illucens)larva-derived hemocytes

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Insect Science 2022年第4期29卷 1071-1095页

作者： Yvette m.von Bredow Ariane müller philipp F.Popp Denis Iliasov Christoph-Rüdiger von Bredow Justus-Liebig-Universität Gießen Institut für Allgemeine Zoologie und EntwicklungsbiologieZelluläre Erkennungs-und AbwehrprozesseGießenGermany Technische Universität Dresden Fakultät BiologieInstitut für ZoologieDresdenGermany Technische Universität Dresden Fakultät BiologieInstitut für MikrobiologieDresdenGermany Present address:philipp F.Popp Institute for Biology-Bacterial PhysiologyHumboldt-Universität zu BerlinBerlinGermany

With the growing importance of the black soldier fly(Hermetia illucens)for both sustainable food production and waste management as well as for science,a great demand of understanding its immune system ***,we present the first description of the circulating larval hemocytes with special emphasis on uptake of microorganisms and distinguishing hemocyte *** histological,zymographic,and cytometric methods and with a set of hemocyte binding lectins and antibodies,the hemocytes of *** are identified as plasmatocytes,crystal cells,and putative *** hemocyte counts(THC)are determined,and methods for THC determination are *** 1100 hemocytes per microliter hemolymph are present in naive animals,while hemocyte density decreases dramatically shortly after wounding,indicating a role of hemocytes in response to wounding(and immune response in general).The determination of the relative abundance of each hemocyte type(differential hemocyte count,DHC)revealed that plasmatocytes are highly abundant,whereas prohemocytes and crystal cells make up only a small percentage of the circulating *** are not only the most abundant but also the professional phagocytes in *** rapidly engulf and take up bacteria both in vivo and in vitro,indicating a very potent cellular defense against invading *** bioparticles such as yeasts are also removed from circulation by phagocytosis,but slower than *** is the first analysis of the potent cellular immune response in the black soldier fly,and a first toolbox that helps to identify hemocyte(types)is presented.

关键词： black soldier fly(Hermetia ilucens) cellular immunity crystal cell hemocyte types immunity of economically imporant insects microbe phagoeytosis plasmatocyte

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How competitive is the‘pioneer-climax’tree species Nothofagus alpina in pristine temperate forests of Chile?

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Journal of Plant Ecology 2019年第1期12卷 144-156页

作者： Rebekka Bögelein Cecilia APérez philipp Schäferand Frank m.Thomas Faculty of Regional and Environmental Sciences GeobotanyUniversity of TrierBehringstraße 2154296 TrierGermany Present address:Thünen-Institut Institut für WaldökosystemeAlfred-Möller-Straße 116225 EberswaldeGermany Departamento de Ecología de Ecosistemas Instituto de Ecología y Biodiversidad(IEB)Alameda 340SantiagoChile

Aims Nothofagus species are constitutive elements of the temperate forests along the Southern Andes *** deciduous Nothofagus alpina is a fast-growing,but long-lived opportunistic pioneer spe-cies(‘pioneer-climax species’)and co-occurs with the evergreen *** tested whether *** is competitively superior to *** in mature stands and whether intra-specific competition in *** is stronger than inter-specific competition with *** In a pristine old-growth forest in South-Central Chile,we compared the growth of *** trees in pure stands and in mixture with *** to the growth of *** and calculated compe-tition *** related growth variables to climate data and weather *** Findings In ***,juvenile basal area increment was signifi-cantly higher in pure than in mixed *** to our hypothesis,*** exhibited larger radial stem increments than *** in the most recent 40 *** the most recent two decades,this was caused by high growth rates of large *** *** both Nothofagus species,stem growth was negatively related to temperature,but *** responded more sensitively to weather conditions than *** ***,stem increment was negatively related to the intensity of competition,but the size of the competition effects on this species was similar in pure and mixed ***,compared to ***,the‘pioneer-climax species’concept is even more appropriate for *** with its relatively high growth rates even in the early stages of its life.

关键词： competition index dendroecology growth-competition relationship pointer year productivity tree-ring analysis

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Diarrhea after bariatric procedures:Diagnosis and therapy

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World Journal of Gastroenterology 2017年第26期23卷 4689-4700页

作者： Yves m Borbély Alice Osterwalder Dino Kroll philipp C Nett Roman A Inglin Clinic for Visceral Surgery and medicine InselspitalBern University HospitalUniversity of Bern

Diarrhea after bariatric procedures, mainly those with malabsorptive elements including Roux-Y Gastric Bypass and Biliopancreatic Diversion, is common and an essential determinant of quality of life and microand macronutrient deficiencies. Bariatric surgery is the only sustainably successful method to address morbid obesity and its comorbidities, particularly gaining more and more importance in the specific treatment of diabetic patients. Approximately half a million procedures are annually performed around the world, with numbers expected to rise drastically in the near future. A multitude of factors exert their influence on bowel habits; preoperative comorbidities and procedure-related aspects are intertwined with postoperative nutritional habits. Diagnosis may be challenging owing to the characteristics of postbariatric surgery anatomy with hindered accessibility of excluded segments of the small bowel and restriction at the gastric level. Conventional testing measures, if available, generally yield low accuracy and are usually not validated in this specific population. Limited trials of empiric treatment are a practical alternative and oftentimes an indispensable part of the diagnostic process. This review provides an overview of causes for chronic post-bariatric surgery diarrhea and details the particularities of its diagnosis and treatment in this specific patient population. Topics of current interest such as the impact of gut microbiota and the influence of bile acids on morbid obesity and especially their role in diarrhea are highlighted in order to provide a better understanding of the specific problems and chances of future treatment in post-bariatric surgery patients.

关键词： Bariatric surgery Diarrhea malnutrition malabsorption Steatorrhea Dumping syndrome Bile acids and salts Gut microbiota Blind loop syndrome

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Influence of structural depth of laser-patterned steel surfaces on the solid lubricity of carbon nanoparticle coatings

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Friction 2023年第7期11卷 1276-1291页

作者： Timothy mACLUCAS Lukas DAUT philipp GRÜTZmACHER maria Agustina GUITAR Volker PRESSER Carsten GACHOT Sebastian SUAREZ Frank mÜCKLICH Chair of Functional materials Saarland UniversitySaarbrücken 66123Germany Institute for Engineering Design and Product Development TU WienWien 1060Austria INm–Leibniz Institute for New materials Saarbrücken 66123Germany Department of materials Science&Engineering Saarland UniversitySaarbrücken 66123Germany Saarene-Saarland Center for Energy materials and Sustainability Saarbrücken 66123Germany

Carbon nanoparticle coatings on laser-patterned stainless-steel surfaces present a solid lubrication system where the pattern's recessions act as lubricant-retaining *** study investigates the influence of the structural depth of line patterns coated with multi-walled carbon nanotubes(CNTs)and carbon onions(COs)on their respective potential to reduce friction and *** laser interference patterning(DLIP)with a pulse duration of 12 ps is used to create line patterns with three different structural depths at a periodicity of 3.5μm on AISI 304 steel ***,electrophoretic deposition(EPD)is applied to form homogeneous carbon nanoparticle coatings on the patterned *** ball-on-disc experiments are conducted on the as-described surfaces with an alumina counter body at a load of 100 *** results show that the shallower the coated structure,the lower its coefficient of friction(COF),regardless of the particle ***,with a minimum of just below 0.20,CNTs reach lower COF values than COs over most of the testing *** resulting wear tracks are characterized by scanning electron microscopy,transmission electron microscopy,and energy-dispersive X-ray *** friction testing,the CNTs remain in contact,and the immediate proximity,whereas the CO coating is largely *** of structural depth,no oxidation occurs on CNT-coated surfaces,whereas minor oxidation is detected on CO-coated wear tracks.

关键词： solid lubricant coatings carbon nanotubes carbon onions direct laser interference patterning(DLIP)surface structuring electrophoretic deposition(EPD)

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Viscoelasticity and shear resistance at the aggregate scale of structured and organic carbon-free Chernozems

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Pedosphere 2023年第5期33卷 754-764页

作者： Christoph HAAS Rainer HORN philipp SAGGAU Rainer DUTTmANN Institute for Plant Nutrition and Soil Science University of KielKiel 24118Germany Department of Geography Division of Landscape Ecology and Geoinformation SciencesUniversity of KielKiel 24118Germany

Soil rheology characterises the flow behaviour of soils at the particle-particle to aggregate *** sweep tests(ASTs)are often the method of choice for parameterizing soil flow properties,such as the shear strain values at the end of the linear viscoelastic range(i.e.,the deformation is mainly elastic)and at the yield point(i.e.,elastic equals plastic deformation).Samples from seven soil profiles and five soil depths of Chernozems,collected in the maidanetske study area,close to Uman City of Ukraine,were analysed to evaluate the effect of soil organic carbon(SOC)on the parameters related to soil microstructural stability derived from *** organic carbon was removed with H_(2)O_(2)to determine the soil texture-dependent values of soil rheological properties,which were compared to the values determined for samples with intact water-stable *** shear resistance-related parameters increased for aggregated soil samples compared to SOC-free soil samples,indicating an increase in soil stability due to *** contrast,the values of the overall viscoelasticity and the shear strain were reduced for aggregated soil samples,indicating decreased soil *** functions were applied to predict the shear strain-dependent loss and storage moduli and shear stress values as a function of SOC *** particles(630–2000μm)and volumetric water content improved the *** conclude that increased SOC content,through the gluing and cementing effects of SOC and altered aggregate shapes compared to SOC-free soil materials,contributes to higher microstructural ***,the increased water content in the SOC-containing soil samples reversed soil strengthening *** was due to the fact that a more rapid increase in positive water pressure under shear stress weakened the samples and the spherical aggregates began to rotate more easily,thus loosing energy,when compared to platy particles of the SOC-free soil materials.

关键词： aggregation rheology shear strain shear stress soil organic carbon depletion soil stability

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Diagnostic imaging advances in murine models of colitis

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World Journal of Gastroenterology 2016年第3期22卷 996-1007页

作者： markus Brückner philipp Lenz marcus m mücke Faekah Gohar Peter Willeke Dirk Domagk Dominik Bettenworth Department of medicine B University Hospital of MünsterAlbert-Schweitzer-Campus 1D-48149 MünsterGermany Department of Paediatric Rheumatology and Immunology University Hospital of MünsterAlbert-Schweitzer-Campus 1D-48149 MünsterGermany Department of medicine D University Hospital of MünsterAlbert-Schweitzer-Campus 1D-48149 MünsterGermany Department of medicine I Josephs-Hospital WarendorfAcademic Teaching HospitalUniversity of MünsterAm Krankenhaus 2D-48231 WarendorfGermany

Inflammatory bowel diseases(IBD) such as Crohn's disease and ulcerative colitis are chronic-remittent inflammatory disorders of the gastrointestinal tract still evoking challenging clinical diagnostic and therapeutic situations. murine models of experimental colitis are a vital component of research into human IBD concerning questions of its complex pathogenesis or the evaluation of potential new drugs. To monitor the course of colitis, to the present day, classical parameters like histological tissue alterations or analysis of mucosal cytokine/chemokine expression often require euthanasia of animals. Recent advances mean revolutionary noninvasive imaging techniques for in vivo murine colitis diagnostics are increasingly available. These novel and emerging imaging techniques not only allow direct visualization of intestinal inflammation, but also enable molecular imaging and targeting of specific alterations of the inflamed murine mucosa. For the first time, in vivo imaging techniques allow for longitudinal examinations and evaluation of intra-individual therapeutic response. This review discusses the latest developments in the different fields of ultrasound, molecularly targeted contrast agent ultrasound, fluorescence endoscopy, confocal laser endomicroscopy as well as tomographic imaging with magnetic resonance imaging, computed tomography and fluorescence-mediated tomography,discussing their individual limitations and potential future diagnostic applications in the management of human patients with IBD.

关键词： confocal laser endomicroscopy contrastenhanced ultrasound Dextran Sodium Sulphate colitis experimental colitis fluorescence imaging endoscopy Imaging Inflammatory bowel disease Tomography

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Direct laser interference patterning of nonvolatile magnetic nanostructures in Fe60Al40 alloy via disorder‐induced ferromagnetism

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Opto-Electronic Advances 2020年第1期3卷 1-7页

作者： philipp Graus Thomas Bmöller Paul Leiderer Johannes Boneberg Nikolay I.Polushkin Department of Physics University of Konstanz78457 KonstanzGermany Institute for Physics of microstructures of RAS 603950 GSP-105 Nizhny NovgorodRussian

Current magnetic memories are based on writing and reading out the domains with opposite orientation of the magnetization ***,information can be encoded in regions with a different value of the saturation *** latter approach can be realized in principle with chemical order-disorder transitions in intermetallic ***,we study such transformations in a thin-film(35 nm)Fe60Al40 alloy and demonstrate the formation of periodic magnetic nanostructures(PmNS)on its surface by direct laser interference patterning(DLIP).These PmNS are nonvolatile and detectable by magnetic force microscopy(mFm)at room temperature after DLIP with a single nanosecond *** provide different arguments that the PmNS we observe originate from increasing magnetization in maxima of the interference pattern because of chemical disordering in the atomic lattice of the alloy at temperatures T higher than the critical temperature Tc for the order(B2)-disorder(A2)***,our simulations of the temporal evolution of a partially ordered state at T>Tc reveal that the disordering rate is significant even below the melting ***,we find that the PmNS are erasable with standard thermal annealing at T

关键词： thin films laser patterning magnetic dots magnetic memory

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