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Let-7 in endometrial exosome/microvesicles induces a pluripotent paused state in mice

Let-7 in endometrial exosome/microvesicles induces a pluripo...

中国生理学会生殖科学专业委员会—中国动物学会生殖生物学分会第二次联合学术年会暨“生殖科学专业委员会第二次学术交流会”和“生殖生物学分会第十六次学术年会”

作者： Weimin Liu Ziru Niu Ranran Chen Ronald TK Pang philip C.N.chiu William S.B.Yeung ShenZhen institute University of HongKong Department of OG University of HongKong

Embryo dormancy(embryo diapause) is a reproductive strategy used by approximately 100 different mammals to avoid the risk of exposing their offsprings to unfavourable environmental conditions by delaying embryo *** molecular mechanism of embryonic diapause is not yet *** hypothesize that endometrial exosome/microvesicles(EV) regulates embryo *** detected miRNA profiles in EV between dormant and activated uterine fluid and found that the members of let-7 family were highly expressed in dormant uterine fluid ***,embryos have ability to take up endometrial exosomes/*** examine the roles of let-7 in embryo dormancy,we eletroporated let-7 a into embryos and found that embryos electroporated with let-7 can be alive even after the culture for up to Day 13.18.8%of embryos from let-7 g transgenic mice developed to term after culture for 6 days(ie Day 10).Microarray analysis showed that 47%gene expression were similar between let-7-treated and P4-induced dormant embryos compared to D4 or E2-activated embryos and most of genes were related to cell cycle and *** results showed that let-7 has an important role in the process of embryo dormancy in *** level of let-7 was elevated in Iin28 transgenic embryos which were transferred into wild-type delayed implantation model for 3 *** result suggests that the increased levels of let-7 in dormant embryo were mainly derived from outside *** exosomes/microvesicle of highly expressed let-7 prolonged the survival time of embryos in *** conclusion,our results demonstrated that let-7 of endometrial exosomes/microvesicles regulated embryo dormancy in mice.

关键词： exosome/microvesicle embryo diapause let-7

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A Potential Anti-metastatic Chinese Herb Andrographis paniculata—Its In Vitro Activities in Esophageal Cancer Cells and Endothelial Cells

A Potential Anti-metastatic Chinese Herb Andrographis panicu...

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第十四届全国中药和天然药物学术研讨会

作者： Grace Gar-Lee Yue Julia Kin-Ming Lee Kar-Man Chan Kwok-Pui Fung philip Wai-Yan chiu Clara Bik-San Lau The Chinese University of Hong Kong

＜正＞Esophageal cancer is associated with high postoperative recurrence and systemic *** adjuvant chemotherapy and concurrent radiation have shown favourable efficacies,searching for alternative treatments for metast...

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Randomised controlled trial comparing modified Sano's and narrow band imaging international colorectal endoscopic classifications for colorectal lesions

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World Journal of Gastrointestinal Endoscopy 2018年第9期10卷 210-218页

作者： Leonardo Zorrón Cheng Tao Pu Kuan Loong Cheong Doreen Siew Ching Koay Sze Pheh Yeap Amanda Ovenden Mahima Raju Andrew Ruszkiewicz philip W chiu James Y Lau Rajvinder Singh Department of Gastroenterology Lyell McEwin Hospital Medical School University of Adelaide Department of Pathology Lyell McEwin Hospital Department of Surgery the Chinese University of Hong Kong

AIM To assess the utility of modified Sano′s(MS) vs thenarrow band imaging international colorectal endoscopic(NICE) classification in differentiating colorectal *** Patients undergoing colonoscopy between 2013 and 2015 were enrolled in this *** on the MS or the NICE classifications,patients were randomised for real-time endoscopic *** was followed by biopsies,endoscopic or surgical *** endoscopic diagnosis was then compared to the final(blinded) *** primary endpoint was the sensitivity(Sn),specificity(Sp),positive predictive value(PPV) and negative predictive value(NPV) of differentiating neoplastic and non-neoplastic polyps(MSⅡ/Ⅱo/Ⅲa/Ⅲb vs I or NICE 1 vs 2/3).The secondary endpoints were "endoscopic resectability"(MSⅡ/Ⅱo/Ⅲa vs Ⅰ/Ⅲb or NICE 2 vs 1/3),NPV for diminutive distal adenomas and prediction of post-polypectomy surveillance *** A total of 348 patients were *** Sn,Sp,PPV and NPV in differentiating neoplastic polyps from non-neoplastic polyps were,98.9%,85.7%,98.2% and 90.9% for MS;and 99.1%,57.7%,95.4% and 88.2% for NICE,*** area under the receiver operating characteristic curve(AUC) for MS was 0.92(95%CI:0.86-0.98);and AUC for NICE was 0.78(95%CI:0.69,0.88).The Sn,Sp,PPV and NPV in predicting "endoscopic resectability" were 98.9%,86.1%,97.8% and 92.5% for MS;and 98.6%,66.7%,94.7% and 88.9% for NICE,*** AUC for MS was 0.92(95%CI:0.87-0.98);and the AUC for NICE was 0.83(95%CI:0.75-0.90).The AUC values were statistically different for both comparisons(P = 0.0165 and P = 0.0420,respectively).The accuracy for diagnosis of sessile serrated adenoma/polyp(SSA/P) with high confidence utilizing MS classification was 93.2%.The differentiation of SSA/P from other lesions achieved Sp,Sn,PPV and NPV of 87.2%,91.5%,89.6% and 98.6%,*** NPV for predicting adenomas in diminutive rectosigmoid polyps(n = 150) was 96.6% and 95% with MS and NICE ***

关键词： Colorectal polyps Colorectal adenomas Colorectal neoplasm Colorectal lesions Randomised controlled trial Colonoscopy Magnifying colonoscopy Endoscopic imaging

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内镜检查：早期喉部和下咽部癌的NBI，AFI，和SMR诊断技术

内镜检查：早期喉部和下咽部癌的NBI，AFI，和SMR诊断技术

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中华医学会第十次全国耳鼻咽喉-头颈外科学术会议

作者： Hing-sang Chan philip W.Y.chiu Alexander Vlantis Raymond K.Y.Tsang C Andrew van Hasselt Siu-Kwan Ng Michael C.F.Tong Department of Otorhinolaryngology Head and Neck Surgerythe Chinese University of Hong Kong Department of Surgery The Chinese University of Hong KongHong Kong SAR

前言大部分头颈部鳞状上皮细胞癌(HNSCc)表现为处于进展期，大范围的手术切除会造成严重的功能障碍和美容上的畸形，总存活数常让人失望。除了局部病变，同期或不同期SCC(短程化疗，小细胞癌)的发生对病死率产生显著影响。

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美国全髋置换关节负重面应用的流行情况调研

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中华骨科杂志 2010年第3期30卷 I0012-I0017页

作者： Kevin J. Bozic, MD MBA Steven Kurtz, PhD Edmund Lau, MS Kevin Ong, PhD Vanessa chiu, MPH Thomas P. Vail, MD Harry E. Rubash, MD Danie J. Berry, MD 田丰德(译) 赵德伟(译) Investigation performed at the Department of Orthopaedic Surgery and philip R. Lee Institute for Health Policy Studies University of California San Francisco San Francisco California and Exponent Inc. Philadelphia Pennsylcanina 大连大学附属中山医院 116001

背景：硬性对硬性材料的负重面有提高全髋关节置换假体植入物生存的潜力。然而，对于使用这些先进技术的特定适应证仍然存在争议。本研究的日的是从患者、医院、地域和支付人特点几方面对美国全髋关节置换中负重面应用情况进行流行病学... 详细信息

背景：硬性对硬性材料的负重面有提高全髋关节置换假体植入物生存的潜力。然而，对于使用这些先进技术的特定适应证仍然存在争议。本研究的日的是从患者、医院、地域和支付人特点几方面对美国全髋关节置换中负重面应用情况进行流行病学研究。方法：应用全国住院病例数据库资料，对从2005年10月1日至2006年12月31日，在美国进行的112095例初次全髋关节置换病例的负重面类型及其人口统计学特征进行分析。病例按照年龄、性别、普查区域、付款人类别和医院的类型进行分组，计算每种类型髋关节负重面在各组中的使用率。

关键词：关节负重流行情况应用全髋置换美国全髋关节置换病例数据库调研

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介绍杀虫剂进入昆虫体内的途径、转移机制及作用方式的新理论

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华南农业大学学报 1986年第3期 5-15页

作者：赵善欢陈文奎华南农业大学昆虫毒理研究室华南农业大学昆虫毒理研究室

本文着重介绍了英国昆虫毒理学家philip Gerolt近年来所提出的有关杀虫剂毒理学方面的一些新理论、新观点。Gerolt一反传统的经典理论,认为:①大多数杀虫剂主要是通过气管系统这一途径进入昆虫体内;②杀虫剂在虫体内的转移过程中,血淋... 详细信息

本文着重介绍了英国昆虫毒理学家philip Gerolt近年来所提出的有关杀虫剂毒理学方面的一些新理论、新观点。Gerolt一反传统的经典理论,认为:①大多数杀虫剂主要是通过气管系统这一途径进入昆虫体内;②杀虫剂在虫体内的转移过程中,血淋巴是次要的,而主要是通过昆虫表皮的侧向扩散和在真皮细胞与内表皮之间的主动运输,再经由气管系统而到达作用靶子;③昆虫中毒死亡是由于杀虫剂影响了昆虫表皮内的水分平衡,使机体受到“原发性损伤”,同时,到达靶子的杀虫剂可使中枢神经系统脱水并引起组织变性所造成的。Gerolt的这些新理论和新观点是很值得我们重视并加以研究讨论的。

关键词：昆虫体作用方式昆虫毒理学气管系统灭多虫原发性损伤侧向扩散中枢神经系统血淋巴中毒死亡

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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