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The metabolic role of LncZBTB39-1:2 in the trophoblast mobility of preeclampsia

Genes & Diseases 2018年第3期5卷 235-244页

作者： Yamin Liu Ting-Li Han Xiaofang Luo Yuxiang Bai Xuehai Chen Wei Peng Xi Xiong philip n.baker Chao Tong Hongbo Qi Canada-China-new Zealand Joint Laboratory of Maternal and Fetal Medicine Chongqing Medical UniversityChongqing400016China Department of Obstetrics and Gynaecology The First Affiliated Hospital of Chongqing Medical UniversityChina Liggins Institute The University of AucklandAucklandNew Zealand College of Medicine Biological Sciences and PsychologyUniversity of LeicesterUK

Preeclampsia is characterized by new onset of hypertension and proteinuria after 20 weeks’gestation and is a leading cause of maternal and neonatal morbidity and *** pathogenesis of preeclampsia is often associated with aberrant trophoblast function that leads to shallow placental ***,the exact underlying mechanisms remain *** LncZBTB39-1:2 expression level was investigated in 20 healthy placentae and 20 placentae with preeclampsia using qRT-PCR,and the metabolic profile of trophoblasts overexpressing LncZBTB39-1:2 in vitro was analysed using gas chromatography-mass spectrometry(GCeMS).In this study,we found that the expression of LncZBTB39-1:2 was significantly higher in preeclamptic placentae than in healthy *** metabolomics results have shown that tricarboxylic acid cycle intermediates and metabolites related to carbohydrate metabolism were decreased with the overexpression of LncZBTB39-1:2 in HTR8/SVneo *** findings were validated by detecting a lower level of intracellular ATP in HTR8/Vneo ***,the migration of HTR8/SVneo cells was compromised when cells were transfected with a plasmid encompassing LncZBTB39-1:2 *** these results,we conclude that abnormal levels of LncZBTB39-1:2 expression might lead to aberrant conditions in HTR-8/SVneo trophoblast *** conditions might be associated with dysregulated trophoblast migration and subsequent failure of uterine spiral artery remodelling,a pathogenesis recognised as a contributing factor in the aetiology of preeclampsia.

关键词： Complications GCeMS Long noncoding RnA Metabolomics Preeclampsia

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体外缺氧诱导子痫前期滋养细胞模型优化及代谢组学鉴定

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重庆医科大学学报 2017年第8期42卷 1045-1052页

作者：杨晓涛韩顶立 philip n.baker 漆洪波童超杨竹重庆医科大学附属第二医院妇产科重庆医科大学"中国-加拿大-新西兰"联合母胎医学实验室重庆400010

目的:探讨滋养细胞体外缺氧不同处理方法模拟子痫前期模型的优化研究。方法:HTR8/SVneo滋养细胞分别在1%O2(缺氧环境)和21%O2(常氧环境)培养箱中培养1 h(记为H1、n1)或2 h(记为H2、n2),缺氧1 h后复氧1 h(记为H1R1)和缺氧2 h后复氧2 h(记... 详细信息

目的:探讨滋养细胞体外缺氧不同处理方法模拟子痫前期模型的优化研究。方法:HTR8/SVneo滋养细胞分别在1%O2(缺氧环境)和21%O2(常氧环境)培养箱中培养1 h(记为H1、n1)或2 h(记为H2、n2),缺氧1 h后复氧1 h(记为H1R1)和缺氧2 h后复氧2 h(记为H2R2),H1R1后再缺氧1 h(记为H1R1H1),H2R2后再缺氧2 h(记为H2R2H2),H1R12个循环(记为H1R1H1R1)和H2R22个循环(记为H2R2H2R2),缺氧2 h后复氧6 h(记为H2R6),持续缺氧24 h,以及持续常氧4 h(记为n4)、8 h(记为n8)和24 h(记为normoxia),然后提取蛋白以Western blot检测腺苷酸活化蛋白激酶(AMP-activated protein kinase,AMPK)磷酸化水平,以验证各组处理对于诱导滋养细胞能量应激的效果;HTR8/SVneo滋养细胞在常氧或者缺氧环境培养24 h后经气相质谱技术(gas chromatography mass spectrum,GS-MS)进行细胞代谢组学分析,以验证AMPK磷酸化水平上调是否与滋养细胞代谢组变化具有一致性。结果:缺氧组AMPK的活性(1.615±0.111)明显高于常氧组(1.000±0.107)和缺氧复氧组(1.277±0.113);缺氧时显著增加的代谢物有4-甲基-2-戊酮酸(log22.597为1.377)、水合乙醛酸(log22.483为1.312)、组氨酸(log21.188为0.248)、苯丙氨酸(log21.262为0.335)、缬氨酸(log21.518为0.602)、正亮氨酸(log21.519为0.603)、乙酰丝氨酸(log21.691为0.758)、丝氨酸(log21.783为0.834)、半胱氨酸(log21.851为0.889)、蛋氨酸(log22.072为1.051)、鸟氨酸(log22.251为1.170)等;而棕榈反油酸(log20.127为-2.983)、11,14,17-廿碳三烯酸(log20.334为-1.583)、二十四单烯酸(log20.600为-0.738)、共轭亚油酸(log20.680为-0.557)、顺式十八碳烯酸(log20.711为-0.492)、9-十七碳烯酸(log20.782为-0.355)、二十二碳六烯酸(log20.829为-0.271)、二十碳五烯酸(log20.841为-0.250)、芥酸(log20.844为-0.244)、二十二碳五烯酸(log20.898为-0.156)、柠檬酸(log20.279为-1.842)、苹果酸(log20.208为-2.264)、琥珀酸(log20.254为-1.980)、顺乌头酸(log20.260为-1.946)、β-柠檬酸-左旋谷氨酸(log20.093为-3.430)、β-丙氨酸(log20.139为-2.851)、胱硫醚(log20.267为-1.904)、顺式-4-羟脯氨酸(log20.500为-1.000)等在缺氧时显著降低。代谢途径结果分析显示缺氧时滋养细胞中核苷酸代谢[log2(1.811、1.149)分别为0.857、0.201]、能量代谢[log2(1.510、1.173、1.149)分别为0.595、0.230、0.201]、维生素代谢[log2(1.045、1.052、1.125)分别为0.064、0.073、0.170]、氨基酸代谢[log2(1.245、1.020、1.027、1.123、1.127、1.076)分别为0.316、0.028、0.039、0.167、0.173、0.106]、信号转导(log21.046为0.065)、蛋白翻译(log21.026为0.037)等途径被激活,而碳水化合物[log2(0.857、0.857、0.799)分别为-0.222、-0.222、-0.323]、脂肪酸[log2(0.944、0.912、0.826)分别为-0.083、-0.133、-0.276]、内分泌代谢[log2(0.885、0.799、0.799)分别为-0.176、-0.323、-0.323]和其他第二代谢物生物合成[log2(0.947、0.871、0.743)分别为-0.079、-0.199、-0.428]等代谢途径显著受到抑制。结论:单纯缺氧模型更适合用于子痫前期病理生理机制的体外研究。

关键词：子痫前期 HTR8/SVneo滋养细胞缺氧腺苷酸活化蛋白激酶气相质谱技术

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妊娠糖尿病抑制胎盘AKT-mTOR及SIRT1信号通路

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重庆医科大学学报 2017年第8期42卷 1023-1028页

作者：张莉余昕烊徐萍 philip n.baker 漆洪波童超张华重庆医科大学附属第一医院产科重庆医科大学"中国-加拿大-新西兰"联合母胎医学实验室重庆400016 莱切斯特大学医学院

目的:探讨AKT-mTOR信号通路与SIRT1在妊娠期糖尿病(gestational diabetes mellitus,GDM)编程胎儿生长发育中的作用。方法:收集重庆医科大学附属第一医院2014年12月至2015年6月分娩的15例GDM和15例正常产妇的胎盘组织,应用Western blot... 详细信息

目的:探讨AKT-mTOR信号通路与SIRT1在妊娠期糖尿病(gestational diabetes mellitus,GDM)编程胎儿生长发育中的作用。方法:收集重庆医科大学附属第一医院2014年12月至2015年6月分娩的15例GDM和15例正常产妇的胎盘组织,应用Western blot检测胎盘中AKT-mTOR磷酸化水平与SIRT1的表达水平。以人绒毛外滋养细胞(HTR8/SVneo)体外培养,分为空白对照组、渗透对照组和高糖组。各组处理后使用Western blot检测AKT-mTOR总蛋白和磷酸化水平,以及SIRT1的表达水平,应用流式细胞术(flow cytometry)检测各组的凋亡率。db/+杂合雌鼠妊娠至18.5 d处死后,取其胎盘组织,对其进行基因型鉴定后,选取野生型子代胎盘为GDM组,C57雌鼠胎盘组织为正常对照组,每组各6只。然后应用Western blot检测胎盘组织中AKT-mTOR信号通路。结果:AKT及其下游mTOR磷酸化水平在GDM胎盘中的表达明显低于正常胎盘(0.347±0.031 vs.1.000±0.175,P=0.004;0.465±0.045 vs.1.000±0.098,P=0.000)。同样,GDM组的SIRT1的表达水平也明显低于正常组(0.682±0.055 vs.1.000±0.127,P=0.044);在细胞模型中,经高糖处理后,AKT-mTOR磷酸化水平明显降低(0.512±0.056 vs.1.103±0.111,P=0.023;0.262±0.091 vs.1.153±0.057,P=0.001),而SIRT1的表达同样明显降低(0.472±0.034 vs.1.013±0.098,P=0.040)。高糖组的细胞凋亡率明显升高(14.550±1.624 vs.9.547±0.685,P=0.032)。在动物模型中,GDM组的AKT-mTOR磷酸化水平明显降低(0.527±0.080 vs 1.000±0.055,P=0.003;0.418±0.059 vs.1.000±0.084,P=0.001)。结论:宫内高血糖环境可能通过抑制胎盘AKT-mTOR信号通路,从而编程子代的发育轨迹。

关键词：妊娠期糖尿病胎盘 AKT mTOR SIRT1

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慢性砷暴露对小鼠脑和血清代谢组学的影响

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南方医科大学学报 2016年第9期36卷 1192-1197页

作者：代华夏茵茵 Ting-Li Han philip n.baker 唐旭张瑞源杜航蔡同建程淑群重庆医科大学公共卫生与管理学院医学与社会发展研究中心健康领域社会风险预测治理协同创新中心重庆400016 奥克兰大学里金斯研究所新西兰奥克兰重庆市职业病防治院理化检验科重庆400060 第三军医大学军事预防医学院流行病学教研室重庆400038

目的观察慢性砷暴露对小鼠皮层及血清代谢组学的影响,探讨其神经毒性机制。方法将12只C57BL/6J三周龄雄鼠,按体质量随机分为2组,暴露组饮用含50 mg/L亚砷酸钠水12周,对照组饮用蒸馏水。暴露结束后,采用氢化物发生一原子荧光光谱法测定... 详细信息

目的观察慢性砷暴露对小鼠皮层及血清代谢组学的影响,探讨其神经毒性机制。方法将12只C57BL/6J三周龄雄鼠,按体质量随机分为2组,暴露组饮用含50 mg/L亚砷酸钠水12周,对照组饮用蒸馏水。暴露结束后,采用氢化物发生一原子荧光光谱法测定脑砷含量;气相色谱/质谱联用法(GC/MS)对砷暴露组和对照组小鼠皮层和血清进行代谢组学研究,运用主成分分析法(PCA)分析比较两组代谢产物的差异,两样本t检验筛选两组间差异性代谢产物,利用代谢途径在线分析工具查找其影响的相关代谢途径。结果砷暴露组脑砷含量高于对照组,差异具有统计学意义(P<0.05);砷暴露组大脑皮层中苯丙氨酸、酪氨酸、组氨酸、赖氨酸和柠檬酸含量升高,血清中丝氨酸、甘氨酸、脯氨酸、天门冬氨酸及谷氨酸含量升高,而α-酮戊二酸含量下降。PCA分析显示暴露组与对照组小鼠皮层和血清代谢特征存在差异,差异具有统计学意义(P<0.05)。结论慢性砷暴露可通过干扰皮层和血清氨基酸类代谢和三羧酸循环,导致神经递质合成障碍以及干扰能量代谢而影响中枢神经系统功能。

关键词：代谢组学砷暴露神经毒性主成分分析法

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苯并[a]芘暴露大鼠的皮层代谢组学研究

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南方医科大学学报 2018年第2期38卷 162-167页

作者：王晶李春林白璐璐唐强虎张瑞源 Ting-Li Han 郭玉明 philip n.baker 夏茵茵涂白杰重庆医科大学公共卫生与管理学院//医学与社会发展研究中心//健康领域社会风险预测治理协同创新中心重庆400016 奥克兰大学里金斯研究所昆士兰大学人口健康学院流行病学和生物统计学系莱斯特大学医学院生物科学与心理学院

目的基于气相色谱/质谱联用技术(GC/MS)的代谢组学方法,分析苯并[a]芘(B[a]P)暴露后大鼠皮层内源性小分子代谢物的变化,研究其神经毒性机制。方法将五日龄SD大鼠随机分为对照组和B[a]P暴露组(2 mg/kg),连续灌胃染毒7周以构建B[a]P暴露... 详细信息

目的基于气相色谱/质谱联用技术(GC/MS)的代谢组学方法,分析苯并[a]芘(B[a]P)暴露后大鼠皮层内源性小分子代谢物的变化,研究其神经毒性机制。方法将五日龄SD大鼠随机分为对照组和B[a]P暴露组(2 mg/kg),连续灌胃染毒7周以构建B[a]P暴露模型。染毒结束后,Morris水迷宫(MWM)测定大鼠的空间学习能力;电镜观察皮层神经元超微结构;GC/MS检测皮层代谢谱,结合偏最小二乘法判别分析(PLS-DA)和两独立样本t检验分析筛选两组间的差异代谢物,Cytoscape软件分析与差异代谢物相关的代谢通路。结果与对照组相比,B[a]P暴露大鼠出现较长的逃避潜伏期(P1,P<0.05),分析差异代谢物得到9条与B[a]P神经毒性机制相关的通路,这些通路涉及氨基酸代谢、三羧酸循环以及维生素B3(烟酸和烟酰胺)代谢。结论 B[a]P可干扰机体的正常代谢,其神经毒性机制可能与氨基酸类代谢紊乱、三羧酸循环紊乱以及维生素代谢紊乱等有关。

关键词： B[a]P 皮层代谢组学神经毒性

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High-repetition-rate source of nanosecond duration kA-current pulses driven by relativistic laser pulses

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High Power Laser Science and Engineering 2024年第3期12卷 106-115页

作者： Michael Ehret Jakub Cikhardt philip Wykeham Bradford Iuliana-Mariana Vladisavlevici Tomas Burian Diego de Luis Jose Luis Henares Rubén Hernández Martín Jon Imanol Apiñaniz Roberto Lera JoséAntonio Pérez-Hernández João Jorge Santos Giancarlo Gatti Centro de Láseres Pulsados(CLPU) VillamayorSpain Czech Technical University in Prague Faculty of Electrical EngineeringPragueCzech Republic Univ.Bordeaux-CnRS-CEA Centre Lasers Intenses et Applications(CELIA)UMR 5107TalenceFrance Department of Radiation and Chemical Physics FZU-Institute of Physics of the Czech Academy of SciencesPragueCzech Republic

We report the first high-repetition-rate generation and simultaneous characterization of nanosecond-scale return currents of kA-magnitude issued by the polarization of a target irradiated with a PW-class high-repetition-rate titanium:sapphire laser system at relativistic *** present experimental results obtained with the VEGA-3 laser at intensities from5×10^(18)to 1.3×10^(20)W cm^(-2).A non-invasive inductive return-current monitor is adopted to measure the derivative of return currents of the order of kA ns-1and analysis methodology is developed to derive return *** compare the current for copper,aluminium and Kapton targets at different laser *** data show the stable production of current peaks and clear prospects for the tailoring of the pulse shape,which is promising for future applications in highenergy-density science,for example,electromagnetic interference stress tests,high-voltage pulse response measurements and charged particle beam *** compare the target discharge of the order of hundreds of nC with theoretical predictions and a good agreement is found.

关键词： current pulses electromagnetic pulse application high-power laser relativistic laser plasma

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A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

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Bio-Design and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos P.J.Dijkstra C.Mota J.Bauer H.Ferreira Rui L.Reis n.neves S.Camarero-Espinosa M.B.baker L.Moroni Department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

Melt extrusion-based additive manufacturing(ME-AM)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of AM scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(PCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight PCL75k at different *** porous three-dimensional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight PCL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent model compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(BMP-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hMSCs)was *** two weeks of culturing in a basic medium,cells expressed higher levels of BMP receptor II(BMPRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for ME-AM community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density Click chemistry Human

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Loss to Specialized Cardiology Follow-Up in Adults Living with Congenital Heart Disease

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Congenital Heart Disease 2024年第1期19卷 49-63页

作者： Cheryl Dickson Danielle Osborn David baker Judith Fethney David S.Celermajer Rachael Cordina Department of Cardiology Royal Prince Alfred HospitalSydneyAustralia Department of Cardiothoracic Surgery Westmead HospitalSydneyAustralia Susan Wakil School of nursing and Midwifery The University of SydneySydneyAustralia Sydney Medical School The University of SydneySydneyAustralia

Background:Much has been written about the loss to follow-up in the transition between pediatric and adult Congenital Heart Disease(CHD)care *** less is understood about the loss to follow-up(LTF)after a successful *** is critical too,as patients lost to specialised care are more likely to experience mor-bidity and premature ***:To understand the prevalence and reasons for loss to follow-up(LTF)at a large Australian Adult Congenital Heart Disease(ACHD)***:Patients with moderate or highly complex CHD and gaps in care of>3 years(deﬁned as LTF)were identiﬁed from a comprehensive ACHD *** telephone interviews examined current care and barriers to clinic ***:Overall,407(22%)of ACHD patients(n=1842)were *** mean age at LTF was 31(SD 11.5)years and 54%were male;311(76%)were *** to adults seen regularly,lost patients were younger,with a greater socio-economic disadvantage,and had less complex CHD(pnterviewed 59 patients(14%).The top 3 responses for care absences were“feeling well”(61%),losing track of time(36%),and not needing fol-low-up care(25%).Conclusions:A large proportion of the ACHD population becomes lost to specialised cardiac care,even after a successful *** Australian study reports younger age,moderate complexity defects,and socio-economic disadvantage as predictive of loss to *** study highlights the need for novel approaches to patient-centered service delivery even beyond the age of transition and resources to maintain patient engagement within the ACHD service.

关键词： Loss to follow-up follow-up adult congenital heart disease lapse in care gaps in care care gaps care continuity ACHD predictors

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The association of diet quality and physical activity with cardiovascular disease and mortality in 85,545 older Australians:A longitudinal study

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Journal of Sport and Health Science 2024年第6期13卷 841-850页

作者： Ding Ding Joe Van Buskirk Stephanie Partridge philip Clare Edward Giovannucci Adrian Bauman nicole Freene Robyn Gallagher Binh nguyen Sydney School of Public Health Faculty of Medicine and Healththe University of SydneyCamperdownNSW 2006Australia Charles Perkins Centre the University of SydneyCamperdownNSW 2006Australia Sydney Local Health District CamperdownNSW 2050Australia School of Health Sciences Faculty of Medicine and Healththe University of SydneyCamperdownNSW 2006Australia national Drug and Alcohol Research Centre UNSW SydneySydneyNSW 2052Australia Departments of nutrition and Epidemiology Harvard T.H.Chan School of Public HealthBostonMA 02115USA Faculty of Health University of CanberraCanberraACT 2617Australia Susan Wakil School of nursing and Midwifery the University of SydneyCamperdownNSW 2050Australia

Background:A quality diet and an active lifestyle are both important cornerstones of cardiovascular disease(CVD)***,despite their interlinked effects on metabolic health,the 2 behaviors are rarely considered jointly,particularly within the context of CVD *** examined the independent,interactive,and joint associations of diet and physical activity with CVD hospitalization,CVD mortality,and all-cause ***:CVD-free Australian participants aged 4574 years(n=85,545)reported physical activity,diet,sociodemographic,and lifestyle characteristics at baseline(20062009)and follow-up(20122015),and data were linked to hospitalization and death registries(03/31/2019 for CVD hospitalization and all-cause mortality and 12/08/2017 for CVD mortality).Diet quality was categorized as low,medium,and high based on meeting dietary *** activity was operationalized as(a)total moderate-to-vigorous physical activity(MVPA)as per guidelines,and(b)the composition of MVPA as the ratio of vigorous-intensity physical activity(VPA)to total *** used a left-truncated cause-specific Cox proportional hazards model using time-varying ***:During a median of 10.7 years of follow-up,6576 participants were admitted to the hospital for CVD and 6581 died from all causes(876 from CVD during 9.3 years).A high-quality diet was associated with a 17%lower risk of all-cause mortality than a low-quality diet,and the highest MVPA category(compared with the lowest)was associated with a 44%and 48%lower risk of CVD and all-cause mortality,*** interactions between diet and physical activity were *** all outcomes,the lowest risk combinations involved a high-quality diet and the highest MVPA *** for total MVPA,some VPA was associated with further risk reduction of CVD hospitalization and all-cause ***:For CVD prevention and longevity,one should adhere to both a healthy d

关键词： Diet Physical activity Cardiovascular disease Mortality Cohort studies

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Enhanced wear resistance,antibacterial performance,and biocompatibility using nanotubes containing nano-Ag and bioceramics in vitro

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Bio-Design and Manufacturing 2024年第5期7卷 670-686页

作者： Qingge Wang Jia Liu Hong Wu Jingbo Liu Yaojia Ren Luxin Liang Xinxin Yan Ian.baker Shifeng Liu V.V.Uglov Chengliang Yang Liqiang Wang State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Affiliated Hospital of Youjiang Medical University for nationalities Guangxi Key Laboratory for Preclinical and Translational Research on Bone and Joint Degenerative DiseasesGuangxi Zhuang Autonomous Region Engineering Research Center for Biomaterials in Bone and Joint Degenerative DiseasesGuangxi Key Laboratory for Biomedical Material ResearchBaise 533000China Department of Orthopedics The Second Xiangya HospitalCentral South UniversityChangsha 410011China Department of Orthopedics Renmin HospitalWuhan UniversityWuhan 430060China Thayer School of Engineering Dartmouth CollegeHanoverNH 03755-8000USA School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Belarusian State University 220030 MinskBelarus State Key Laboratory of Metal Matrix Composites School of Material Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

A good Ti-based joint implant should prevent stress shielding and achieve good bioactivity and anti-infection *** meet these requirements,the low-elastic-modulus alloy—Ti–35nb–2Ta–3Zr—was used as the substrate,and functional coatings that contained bioceramics and Ag ions were prepared for coating on TiO_(2)nanotubes(diameter:(80±20)nm and(150±40)nm)using anodization,deposition,and spin-coating *** effects of the bioceramics(nano-β-tricalcium phosphate,microhydroxyapatite(micro-HA),and meso-CaSiO_(3))and Ag nanoparticles(size:(50±20)nm)on the antibacterial activity and the tribocorrosion,corrosion,and early in vitro osteogenic behaviors of the nanotubes were *** tribocorrosion and corrosion results showed that the wear rate and corrosive rate were highly dependent on the features of the nanotube ***-HA showed great wear resistance with a wear rate of(1.26±0.06)×10^(−3)mm^(3)/(n·m)due to adhesive and ***-CaSiO_(3)showed enhanced cell adhesion,proliferation,and alkaline phosphatase *** coatings that contained nano-Ag exhibited good antibacterial activity with an antibacterial rate of≥89.5%against Escherichia *** findings indicate that hybrid coatings may have the potential to accelerate osteogenesis.

关键词： βTi alloy Surface modification Wear resistance Corrosion resistance Osteogenic behavior Antibacterial activity

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