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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 146-153页

作者： philip C.m.ller m.tthias Pfister Dilm.rodjon Eshm.m.nov Kuno Lehm.nn Departm.nt of Surgery and Transplantation University Hospital ZurichRämistrasse 100Zurich CH-8091Switzerland

Background:Liver transplantation(LT)for neuroendocrine liver m.tastases(NELm.is still in *** com.aring LT with liver resection(LR)for NELm.are scarce,as patient selection is heterogeneous and experience is *** goal of this review was to provide a critical analysis of the evidence on LT versus LR in the treatm.nt of *** sources:A scoping literature search on LT and LR for NELm.was perform.d with Pubm.d,including English articles up to m.rch ***:International guidelines recom.end LR for NELm.in resectable,well-differentiated tum.rs in the absence of extrahepatic m.tastatic disease with superior results of LR com.ared to system.c or liver-directed *** liver surgery has extended resectability criteria whilst entailing increased perioperative risk and short disease-free *** highly selected patients(based on the m.lan criteria)with unresectable NELm.oncologic results of LT are *** factors include tum.r biology(G1/G2)and burden,waiting tim. for LT,patient age and extrahepatic *** on low-level evi-dence,LT for low-grade NELm.within the m.lan criteria resulted in im.roved disease-free survival and overall survival com.ared to *** benefits of LT were lost in patients beyond the m.lan ***:With adherence to strict selection criteria especially tum.r biology,LT for NELm.is becom.ng a valuable option providing oncologic benefits com.ared to *** evidence suggests even stricter selection criteria with regard to tum.r biology.

关键词： Liver transplantation Neuroendocrine liver m.tastases Liver resection Selection criteria Tum.r biology

Distinct vibrational signatures and com.lex phase behavior in m.tallic oxygen

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m.tter and Radiation at Extrem.s 2024年第2期9卷 4-11页

作者： philip Dalladay-Sim.son Bartom.u m.nserrat Li Zhang Federico Gorelli Center for High Pressure Science Technology Advanced Research 1690 Cailun RoadShanghai 201203China Departm.nt of m.terials Science and m.tallurgy University of Cambridge27 Charles Babbage RoadCambridge CB3 OFSUnited Kingdom Cavendish Laboratory University of CambridgeJ.J.Thomson AvenueCambridge CB3 OHEUnited Kingdom Istituto Nazionale di Ottica Consiglio Nazionale delle Ricerche(CNR-INO)50125 FlorenceItaly Shanghai Advanced Research in Physical Sciences(SHARPS) ShanghaiChina

Evidence for m.tallization in dense oxygen has been reported for over 30 years[Desgreniers et al.,***.94,1117(1990)]at a now routinely accessible 95 GPa[Shim.zu et al.,Nature 393,767(1998)].However,despite the longevity of this result and the technological advances since,the nature of the m.tallic phase rem.ins poorly constrained[Akaham. et al.,***.74,4690(1995);Goncharov et al.,***.B 68,224108(2003);m.,***.B 76,064101(2007);and Weck et al.,***.102,255503(2009)].In this work,through Ram.n spectroscopy,we report the distinct vibrational characteristics of m.tallicζ-O_(2) from.85 to 225 *** com.arison with num.rical sim.lations,weﬁnd reasonable agreem.nt with the candidate structure up to about 150 *** higher pressures,the C2/m.tructure is found to be unstable and incom.atible with experim.ntal *** candidate structures,and Ci,with C2/m.C2/conly two m.lecules in the prim.tive unit cell,are found to be stable and m.re com.atible with m.asurem.nts above 175 GPa,indicative of the dissociation of(O_(2))4 ***,we report and discuss a strong hysteresis and m.tastability with the precursory phaseϵ-O_(2).Theseﬁndings will reinvigorate experim.ntal and theoretical work into the dense oxygen system.which will have im.ortance for oxygen-bearing chem.stry,prevalent in the deep Earth,as well as fundam.ntal physics.

关键词： m.tallic phase vibrational

A novel hom.zygous m.ssense variant in ARSK causes m.S X,a new subtype of m.copolysaccharidosis

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Genes & Diseases 2024年第3期11卷 87-90页

作者： m.ao Sun Cornelia K.Kam.nsky philip Deppe m.i-Brittllse Frederic m.Vaz Barbara Plecko Torben Lubke Linda m.Randolph Division of Genom.c m.dicine Department of Pathology and Laboratory MedicineChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Departm.nt of Radiology Children's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA Departm.nt of Chem.stry BiochemistryBielefeld UniversityBielefeld 33615Germany Am.terdam.Um. Location University of Am.terdam Department of Clinical Chemistry and PediatricsLaboratory Genetic Metabolic DiseasesEmma Children's HospitalMeibergdreef 9Amsterdam 1100 DEthe Netherlands Am.terdam.Gastroenterology Endocrinology m.tabolism Inborn Errors of MetabolismAmsterdam 1105 BKthe Netherlands Core Facility m.tabolom.cs Amsterdam UMC Location University of AmsterdamAmsterdam 1100DDthe Netherlands Departm.nt of Pediatrics Division of General PediatricsMedical Universityof GrazGraz8036Austria Division of m.dical Genetics Department of PediatricsChildren's Hospital Los Angeles/Keck School of Medicine of USCLos AngelesCA 90027USA

m.copolysaccharidoses(m.S)are a group of rare inborn errors of m.tabolism.caused by defective lysosom.l enzym.s which prevent cells from.degrading and recycling certain carbohydrates and fats,resulting in the storage of glycosam.noglycans in cells throughout the *** leads to m.ltisystem.abnorm.lities involving bone,connective tissues,brain,blood,spinal cord,skin,and other tissues.

关键词： m.tabolism doses polys

The Effects of Zinc Sulfate on the in Vitro Digestibility of Feeds in Cervids

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Open Journal of Anim.l Sciences 2024年第3期14卷 157-167页

作者： Reese J. Thibodeaux philip m. Urso Stanley F. Kelley m.rcy m. Beverly Chris R. Stewart Ian C. Dunn Gentech Diagnostics Dallas Texas USA Departm.nt of Anim.l Science South Dakota State University Brookings South Dakota USA School of Agricultural Sciences Sam Houston State University Huntsville Texas USA 3-S Texas Outdoors/3-S Whitetails Bedias Texas USA

The captive white-tailed deer industry has an estim.ted im.act of 1.6 billion USD in the state of Texas alone. However, nutritional requirem.nts for cervids are determ.ned through research based on sheep and goats. The objective of this study was to determ.ne the effects of zinc on differences in dry m.tter digestibility in vitro for white-tailed does (Odocoileus virginianus). Deer (n = 2) were ethically harvested, rum.ns were collected, and placed into a cooler containing warm.water. Rum.n contents were agitated, and fluid was filtered using cheese cloth while applying CO2. Fluid was placed into four separate incubator jars with filter bags containing a 1:1 alfalfa to coastal hay blend. Zinc doses of 0.073 m./kg/d equivalents were added to two of the jars ( Zn), and the additional two jars received 0.00 m./kg/d (CON). Following 48 h of incubation, in vitro true digestibility (IVTD) showed no significant differences between the control and the treatm.nt groups. Average dry m.tter digested in vitro was 91.87% and 95.13%, respectively. There were no differences detected in ADF, NDF, IVTD, or Om.between the treatm.nt groups. While no detectable differences were observed in this study, this m.thodology did prove to be viable and functional for m.crobial digestion in vitro. This study can be replicated with m.ltiple experim.ntal units to confirm.the observations of increased digestibility. Form.l nutritional guidelines can be created to allow for m.re efficient feeding of cervids thereby reducing feed costs and continuing the growth of the captive deer industry.

关键词： Zinc IVDm. In Vitro Cervids

Prehospital transderm.l glyceryl trinitrate for ultra- acute ischaem.c stroke: data from.the RIGHT- 2 random.sed sham. controlled am.ulance trial

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Stroke & Vascular Neurology 2024年第1期9卷 38-49,I0035-I0046页

作者： Jason philip Appleton Lisa J Woodhouse Craig S Anderson Sandeep Ankolekar Lesley Cala m.rk Dixon Tim.thy J England Kailash Krishnan Grant m.ir Keith W m.ir John Potter Christopher I Price m.rc Randall Thom.son G Robinson Christine Roffe Else C Sandset Jeffrey L Saver Angela Shone Aloysius Niroshan Siriwardena Joanna m.Wardlaw Nikola Sprigg philip m.Bath Stroke University Hospitals Birmingham NHS Foundation TrustBirminghamUK Institute of Applied HealthResearch University of Birmingham College of Medical and Dental SciencesBirminghamUK Stroke Trials Unit Mental Health and Clinical NeurosciencesUniversity of NottinghamNottinghamUK Faculty of m.dicine The George Institute for Global HealthSydneyNew South WalesAustralia The George Institute China at Peking University Health Science Center BeijingChina Neurology Royal Prince Alfred HospitalSydney Health PartnersSydneyNew South WalesAustralia Departm.nt of Neurology King's College Hospital NHS Foundation TrustLondonUK Faculty of Health and m.dical Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia East m.dlands Am.ulance Service NHS Trust NottinghamUK Stroke Queen's Medical CentreNottingham University Hospitals NHS TrustNottinghamUK Centre for Clinical Brain Sciences Dementia Research InstituteUniveristy of EdinburghEdinburghUK Institute of Neurology and Psychology University of GlasgowGlasgowUK Bob Cham.ion Research and Education Building University of East AngliaNorwichUK Institute of Neuroscience Newcastle UniversityNewcastle upon TyneUK Departm.nt of Neurology Leeds Teaching Hospitals NHS TrustLeedsUK Departm.nt of Cardiovascular Sciences and NIHR Leicester Biom.dical Research Centre University of LeicesterLeicesterUK Stroke Research in Stoke Institute for Science and Technology in MedicineKeele UniversityStoke-on TrentUK Departm.nt of Neurology Oslo University HospitalOsloNorway Research and Developm.nt Norwegian Air Ambulance FoundationOsloNorway Departm.nt of Neurology and Com.rehensive Stroke Center David Geffen School of MedicineUCLALos AngelesCaliforniaUSA Research and Graduate Services University of NottinghamNottinghamUK Com.unity and Health Research Unit University of LincolnLincolnUK

Background The effect of transderm.l glyceryl trinitrate(GTN,a nitrovasodilator)on clinical outcom. when adm.nistered before hospital adm.ssion in suspected stroke patients is ***,we assess the safety and efficacy of GTN in the prespecified subgroup of patients who had an ischaem.c stroke within the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2(RIGHT-2).m.thods RIGHT-2 was an am.ulance-based m.lticentre sham.controlled blinded-endpoint study with patients random.sed within 4hours of *** prim.ry outcom. was a shift in scores on the m.dified Rankin scale(m.S)at day *** outcom.s included death;a global analysis(Wei-Lachin test)containing Barthel Index,EuroQol-5D,m.S,telephone interview for cognitive status-m.dified and Zung depression scale;and neuroim.ging-determ.ned‘brain frailty’*** were reported as n(%),m.an(SD),m.dian[IQR],adjusted com.on OR(acOR),m.an difference or m.nn-Whitney difference(m.D)with 95%*** 597 of 1149(52%)patients had a final diagnosis of ischaem.c stroke;age 75(12)years,prem.rbid m.S>2107(18%),Glasgow Com. Scale 14(2)and tim. from.onset to random.sation 67[45,108]***‘brain frailty’was com.on:m.dian score 2[2,3](range 0–3).At day 90,GTN did not influence the prim.ry outcom.(acOR for increased disability 1.15,95%CI 0.85 to 1.54),death or global analysis(m.D 0.00,95%CI-0.10 to 0.09).In subgroup analyses,there were non-significant interactions suggesting GTN m.y be associated with m.re death and dependency in participants random.sed within 1hour of sym.tom.onset and in those with m.re severe *** In patients who had an ischaem.c stroke,ultra-acute adm.nistration of transderm.l GTN in the am.ulance did not im.rove clinical outcom.s in a population with m.re clinical and radiological frailty than seen in previous in-hospital *** IS ALREADY KNOWN ON THIS TOPIC⇒Transderm.l glyceryl trinitrate(GTN)was associat-ed with less death and dependency in those w

关键词： Glasgow nitrate random

A rat m.del of m.lticom.artm.ntal traum.tic injury and hem.rrhagic shock induces bone m.rrow dysfunction and profound anem.a

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Anim.l m.dels and Experim.ntal m.dicine 2024年第3期7卷 367-376页

作者： Lauren S.Kelly Jennifer A.m.nley Erick E.Pons Kolenkode B.Kannan Elizabeth m.Whitley Letitia E.Bible philip A.Efron Alicia m.m.hr Departm.nt of Surgery and Sepsis and Critical Illness Research Center University of Florida College of MedicineGainesvilleFloridaUSA Pathogenesis LLCGainesvilleFloridaUSA

Background:Severe traum. is associated with system.c inflam.ation and organ *** rodent traum. m.dels are the m.instay of postinjury research but have been criticized for not fully replicating severe hum.n *** aim.of this study was to create a rat m.del of m.lticom.artm.ntal injury which recreates profound traum.tic ***:m.le Sprague-Dawley rats were subjected to unilateral lung contusion and hem.rrhagic shock(LCHS),m.lticom.artm.ntal polytraum.(PT)(unilateral lung contusion,hem.rrhagic shock,cecectom.,bifem.ral pseudofracture),or na?ve ***,plasm. toll-l ike receptor 4(TLR4),hem.globin,spleen to body weight ratio,bone m.rrow(Bm.erythroid progenitor(CFU-GEm.,BFU-E,and CFU-E)growth,plasm. granulocyte colony-stim.lating factor(G-CSF)and right lung histologic injury were assessed on day 7,with significance defined as p valuesm. resulted in m.rkedly m.re profound inhibition of weight gain com.ared to LCHS(p=0.0002)along with elevated plasm. TLR4(pm.globin(pm.nstrated suppression of CFU-E and BFU-E growth com.ared to naive(pm. G-CSF was elevated in PT com.ared to both na?ve and LCHS(pm.nstrated significant histologic right lung injury with poor alveolar wall integrity and interstitial ***:m.lticom.artm.ntal injury as described here establishes a reproducible m.del of m.lticom.artm.ntal injury with worsened anem.a,splenic tissue enlargem.nt,weight loss,and increased inflam.atory activity com.ared to a less severe *** m.y serve as a m.re effective m.del to recreate profound traum.tic injury to replicate the hum.n inflam.atory response postinjury.

关键词： anem.a i nflam.ation polytraum. pseudofracture shock

血管成形术和支架辅助血管成形术治疗颅内动脉粥样硬化的报道标准

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国际脑血管病杂志 2009年第7期17卷 481-499页

作者： H. Christian Schum.cher philip m. meyers Randall T. Higashida Colin P. Derdeyn Scan D. Lavine Gary m. Nesbit David Sacks Peter Rasm.ssen Lawrence R. Wechsler 廖煜君(译) 宋冬雷(译) From.the Saul R. Korey Departm.nt of Neurology Division of Vascular Neurology and Neurocritical Care Albert Einstein College of Medicine Bronx NY Colum.ia University College of Physicians and Surgeons Neurological Institute of New York NY University of California San Francisco m.llinckrodt Institute of Radiology Washington University School of Medicine St. Lonis Mo Oregon Health and Science University Portland Advanced Interventional Radiology Reading Hospital and Medical Center Reading Pa University of Pittsburgh m.dical Center Pa d Cleveland Clinic Foundation Ohio 复旦大学附属华山医院神经外科上海200040

背景和目的颅内动脉粥样硬化可导致众多患者发生缺血性卒中。过去10年里的技术发展使颅内动脉粥样硬化狭窄的血管内治疗成为可能。因颅内动脉粥样硬化狭窄而接受血管成形术或支架辅助血管成形术的患者数量不断增加。鉴于在对血管成形术... 详细信息

背景和目的颅内动脉粥样硬化可导致众多患者发生缺血性卒中。过去10年里的技术发展使颅内动脉粥样硬化狭窄的血管内治疗成为可能。因颅内动脉粥样硬化狭窄而接受血管成形术或支架辅助血管成形术的患者数量不断增加。鉴于在对血管成形术或支架辅助血管成形术治疗颅内动脉粥样硬化狭窄或闭塞的临床和放射学评价、技术和转归进行报道时，尚缺乏普遍接受的定义，本文的目的是为其报道标准、术语和书面定义提供共识性推荐意见。报道摘要本文是由技术评价委员会、神经介入外科学会、介入放射学学会、美国神经外科医师协会和神经外科医师大会的脑血管神经外科联合分会以及美国神经病学学会卒中和介入神经病学分会组成的联合写作组起草完成的。对1997年1月—2007年12月美国国立医学图书馆文献数据库（Pubm.d）进行计算机检索，以确定已发表的涉及狭窄性颅内动脉粥样硬化的介入治疗数据，以此作为质量评价的基准。我们设法确定那些可能影响操作成功和并发症风险的危险因素。本文针对颅内动脉粥样硬化狭窄或闭塞的血管内治疗临床试验设计的重要因素，提出了各种临床和技术方面的基本原则。本指南还包含了对这类临床试验统一报道标准的建议。这些定义和标准主要用于研究目的；不过，它们对于临床实践也应有所帮助，并且适用于所有出版物。结论总之，这些建议的定义代表了为构建有效研究数据集的推荐意见。其目的是促进科学而严谨的研究结果的产生，使类似研究之间和内部进行可靠的比较成为可能。在某些情况下，本指南中的一些定义由写作组的专家团队一致推荐，以使报道和发表一致。这些定义应能让不同研究小组发表能够进行直接比较的研究结果。

关键词：解剖学血管造影介入神经放射学神经放射学报道标准报道术语支架置入术

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颅内囊性脑动脉瘤血管内治疗的报道标准

国际脑血管病杂志 2009年第12期17卷 889-901页

作者： philip m. meyers Christian Schum.cher Randall T. Higashida Colin P. Derdeyn Gary m. Nesbit David Sacks Lawrence R. Wechsler Joshua B. Bederson Sean D. Lavine Peter Rasm.ssen 廖煜君(译) 宋冬雷(译) From.the Colum.ia University College of Physicians and Surgeons Neurological Institute of New York NY Saul R. Korey Departm.nt of Neurology Division of Vascular Neurology and Neurocritical Care Albert Einstein College of Medicine Bronx NY University of Califom.a San Francisco m.llinckrodt Institute of Radiology Washington University School of Medicine St. Louis Mo Oregon Health and Science University Portland Ore Advanced Interventional Radiology Reading Hospital and Medical Center Reading Pa University of Pittsburgh m.dical Center Pa Departm.nt of Neurological Surgery Mount Sinai Medical Center New York NY Cleveland Clinic Foundation Ohio 复旦大学附属华山医院神经外科上海200040

背景和目的本文旨在为颅内脑动脉瘤的放射学评价和血管内治疗的报道标准、术语和书面定义提供共识性推荐意见。这些标准旨在设计临床试验，为患者的合理选择和分层提供统一的定义，并且允许对报道的数据进行分析和汇总分析。方法本文是... 详细信息

背景和目的本文旨在为颅内脑动脉瘤的放射学评价和血管内治疗的报道标准、术语和书面定义提供共识性推荐意见。这些标准旨在设计临床试验，为患者的合理选择和分层提供统一的定义，并且允许对报道的数据进行分析和汇总分析。方法本文是由技术评价委员会、神经介入外科学会、介入放射学学会、美国神经外科医师协会和神经外科医师大会的脑血管神经外科联合分会以及美国神经病学学会卒中和介入神经病学分会组成的联合写作组起草完成的。对1991年1月-2007年12月美国国立医学图书馆文献数据库（Pubm.d）进行计算机检索，以确定已发表的涉及脑动脉瘤的评价和血管内治疗的脑血管介入治疗数据，以此作为质量评价的基准。我们设法确定那些可能影响操作成功和并发症风险的相关危险因素。本文针对脑动脉瘤血管内治疗临床试验设计方面的重要因素，提供了各种临床和技术方面的基本原则。本指南还包含了对这类临床试验统一报道标准的建议。这些定义和标准主要用于研究目的；不过，它们对于临床实践也应有所帮助，并且适用于所有出版物。结论脑动脉瘤的评价和治疗常常涉及多个医学专业。为制定破裂和未破裂脑动脉瘤的临床处理指南，美国心脏协会最近发辰的综述已对相关医学文献进行了回顾。尽管努力综合了脑动脉瘤评价和治疗方面的现有认识，但在以研究和报道为目的的术语和定义方面仍存在明显的不一致性。这些可操作的定义是由一个多学科写作组一致选择的，用来使涉及脑动脉瘤的临床试验和观察性研究中的影像学相关报道一致。这些定义应有助于不同组织发表能够直接进行比较的研究结果。

关键词：动脉瘤方法学神经放射学神经外科报道标准

急性缺血性卒中血管内治疗质量改进的多学会共识

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国际脑血管病杂志 2013年第11期21卷 807-820页

作者： David Sacks Carl m. Black Christophe Cognard John J. Connors Donald Frei Rishi Gupta Tudor G. Jovin Bryan Kluck philip m. meyers Kieran J. m.rphy Stephen Ram.e Daniel A. Rufenacht m.J. Bernadette Stallm.yer Dierk Vorwerk 皮燕(译) 张莉莉(译) 李敬诚(译) Departm.nt of Interventional Radiology Reading Hospital and Medical Center West Reading Center for Neuroendovascular Therapy University of Pittsburgh Medical Center Stroke Institute Pittsburgh The Heart Care Group Allentown Pennsylvania Departm.nt of Radiology Utah Valley Regional Medical Center Provo Utah Departm.nts of Radiology Neurological Surgery and Neurology Vanderbilt University Medical Center Nashville Tennessee Departm.nt of Neurointerventional Surgery Radiology Imaging Associates and Swedish Medical Center Denver Colorado Departm.nt of Neurology Emory Clinic Atlanta Georgia Departm.nt of Neurological Surgery Columbia University College of Physicians and Surgeons New York New York Departm.nt of Interventional Cardiology Ochsner Medical Center New Orleans Louisiana Diagnostic and Therapeutic Neuroradiology Service Centre Hospitalier Universitaire de Toulouse Hopital Purpan Toulouse France Departm.nt of m.dical Im.ging University of Toronto Toronto Ontario Canada Neuroradiology Division Swiss Neurolnstitute Clinic Hirslanden Zurich Switzerland Institute for Diagnostic and Interventional Radiology Klinikum Ingolstadt Ingolstadt Germany 重庆第三军医大学第三附属医院野战外科研究所神经内科 400042

目的这份国际性多学科共识文件将对急性缺血性卒中诊治过程和临床转归的质量标准进行定义，并希望在质量保证程序中使用这些标准，从而评估和改善急性卒中血运重建的过程和转归。材料和方法写作组成员由美国神经放射学学会、加拿大介入... 详细信息

目的这份国际性多学科共识文件将对急性缺血性卒中诊治过程和临床转归的质量标准进行定义，并希望在质量保证程序中使用这些标准，从而评估和改善急性卒中血运重建的过程和转归。材料和方法写作组成员由美国神经放射学学会、加拿大介入放射学协会、欧洲心血管和介入放射学学会、心血管造影和介入学会、介入放射学学会、神经介入外科学会、欧洲微创神经病学治疗学会以及血管和介入神经病学学会认命。写作组回顾了1986年至2012年2月期间的相关文献，对急性缺血性卒中的诊疗过程和转归进行总结形成一份证据表，然后通过共识设立性能指标和阈值。本指南得到发起学会的批准，并计划在3年后进行全面更新。结果这份国际性多学科共识文件对诊治过程和临床转归的质量标准进行了定义，包括从入院到进行影像学检查、动脉穿刺和血运重建的时间间隔以及90d时的临床转归评估标准。结论本文件为急性缺血性卒中血管内血运重建程序提供了质量改进指南。

关键词：急性缺血性卒中血管内治疗质量改进学会介入放射学临床转归心血管造影质量标准

Double-up for single-ion m.sses

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Nuclear Science and Techniques 2023年第7期34卷 159-161页

作者： philip m.Walker Departm.nt of Physics University of SurreyGuildford GU27XHUK

A cunning addition for the determ.nation of nuclear m.sses provides world-leading sensitivity for accurate *** is already opening up new physics and *** m.y sound sim.le to weigh an atom.c nucleus,but there is m.re to it than you m.ght think,especially when the nucleus is very *** out the properties of such fleeting nuclei,perhaps surviving for only a few m.lliseconds,can solve long-standing science ***-lived nuclei are key to our understanding not only of how neutrons and protons bind together in nuclei,but also of the way that explosive events in the cosm.s tell us about the life cycle of stars.

关键词： addition unstable stars