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Science China(Technological Sciences) 2024年第4期67卷 1124-1132页

作者： XIAO Lu GUO XiaoXiang SUN YuTong WANG Gang LONG WeiMin LIAW peter k. REN JingLi School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190China Institute of Materials Shanghai UniversityShanghai 200444China Sk. of Advanced Brazing Metals&Technology Zhengzhou Research Institute of Mechanical EngineeringZhengzhou 450001China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA

This study investigated the atomic-scale deformation mechanism of multiphase CoCrFeNi high-entropy alloys(HEAs)at liquid helium,liquid nitrogen,and room temperatures.A million-atom multiphase HEA was prepared using molecular dynamics simulation involving melt and quench *** HEA exhibited high-density dislocations and some twins,consistent with experimental *** analysis revealed an inconsistent evolution of the microstructure under tensile *** particular,the elastic and initial plastic stages exhibited an increase in the disordered structure at the expense of the face-centered cubic and hexagonal close-pack.d structures,followed by a subsequent transformation involving multiple structural ***,through sparse identification,a model depicting microstructural evolution during tension was extracted for the CoCrFeNi HEA at three typical temperatures and three tensile *** model highlighted the importance of the body-centered cubic structure in the evolutionary process.

关键词： high-entropy alloy data-driven method microstructure evolution multiphase structure molecular dynamics simulation

Multiple sclerosis drug repurposing for neuroregeneration

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Neural Regeneration Research 2024年第3期19卷 507-508页

作者： peter Göttle Michael Dietrich Patrick.k.ry Department of Neurology Medical FacultyHeinrich-Heine UniversityDüsseldorfGermany

Multiple sclerosis(MS)is an autoimmune disorder of the central nervous system(CNS)and is primarily characterized by immune cell infiltration leading to relapses followed by remission phases and a disease course turning progressive over time with neurodegenerative processes tak.ng over(Amin and Hersh,2023).Of note,beyond relapse-associated worsening early in disease progression independent of relapse activity may arise independently of relapse activity and can occur in all ***-mediated damage of myelin sheaths and the subsequent loss of mature oligodendrocytes are resulting in impaired axonal integrity,neurodegeneration and accounts for irreversible neuronal damage(k.hlmann et al.,2023).The current landscape of available disease-modifying therapies comprises mainly immunomodulatory drugs that effectively diminish relapses and slow down progression at the onset form of the disease,namely relapsing MS(RMS).In this regard,a number of drugs have been approved as disease-modifying therapies for MS by US Food and Drug Administration and European Medicines Agencies(Box 1).

关键词： drugs impaired irreversible

Chemical short-range-order induced multiscale strengthening in refractory medium entropy alloys

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Acta Mechanica Sinica 2024年第6期40卷 41-49页

作者： Weizheng Lu Yang Chen Jia Li peter k.Liaw Qihong Fang State k.y Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha410082China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN37996USA

High/medium entropy alloys(H/MEAs)are generally possible to exhibit chemical short-range order(SRO).However,the complex role of SRO on mechanical properties from nano-scale to meso-scale is still challenging so ***,we study the strengthening mechanism and deformation behavior in a model body-centered-cubic HfNbTa MEA by using atomic-scale molecular dynamics,micro-scale dislocation dynamics,and meso-scale crystal plasticity finite *** SRO inhibits dislocation nucleation at the atomic scale,improving the flow *** SRO-induced ultrastrong local stress fluctuation greatly improves the micro-scale dislocation-based strength by the significant dislocation forest ***,the Ta-rich locally ordered structure leads to an obvious heterogeneous strain and stress partitioning,which forms a strong strain gradient in the adjacent grain interiors and contributes to the strong back.stress-induced strain hardening.

关键词： High/medium entropy alloys Multiscale strengthening Chemical short-range order

Net effect of air pollution controls on health risk.in the Beijing-Tianjin-Hebei region during the 2022 winter Olympics and Paralympics

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Journal of Environmental Sciences 2024年第1期135卷 560-569页

作者： Changqing Lin peter k.k.Louie Alexis k.H.Lau Jimmy C.H.Fung Zibing Yuan Minghui Tao Xuguo Zhang Md.Shak.aoat Hossain Chengcai Li Xiang Qian Lao Division of Environment and Sustainability The Hong Kong University of Science and TechnologyHong KongChina Environmental Protection Department Hong Kong Government SARHong KongChina Department of Civil and Environmental Engineering The Hong Kong University of Science and TechnologyHong KongChina Guangdong-Hongk.ng-Macao Joint Laboratory of Collaborative Innovation for Environmental Quality The Hong Kong University of Science and TechnologyHong KongChina Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina School of Environment and Energy South China University of TechnologyGuangzhou 510006China Hubei k.y Laboratory of Critical Zone Evolution School of Geography and Information EngineeringChina University of GeosciencesWuhan 430074China Department of Public Health and Informatics Jahangirnagar UniversityDhaka 1342Bangladesh Department of Atmospheric and Oceanic Sciences School of PhysicsPeking UniversityBeijing 100871China Jock.y Club School of Public Health and Primary Care The Chinese University of Hong KongHong KongChina

Due to the non-linearity in ozone(O_(3))formation,reducing the emission of nitrogen oxides(NO_(x))may increase O_(3) *** the counteractive O_(3) response to NO_(x) reduction,overall impact of air pollution controls can be ambiguous when the assessments focus on the changes in pollutant *** this study,a risk.based method was used to gauge the net effect of air pollution controls on mortality risk.in the Beijing–Tianjin–Hebei(BTH)region during the 2022 Winter Olympics and Paralympics(WOP).This mega-event presents a unique opportunity to investigate the efficacy of deep cuts in pollutant *** show that O_(3) concentrations greatly increased as nitrogen dioxide(NO_(2))concentrations decreased in the *** to the active photochemical formations,O_(3) became the dominant pollutant that affected human health during the *** the substantial O_(3) increases,the health benefits of NO_(2) reductions overwhelmed the adverse health effects of O_(3) increases in most regions of the BTH(at 81 out of 112 stations).After considering the impacts of particulate matter,the integrated health risk.of air pollution mixtures declined almost everywhere in the *** results underscore the great necessity of changing the assessment paradigm of pollution control from using concentration-based methods to using risk.based *** with the carbon neutrality policy,stringent control of NO_(x)emission from combustion sources is a promising way to achieve synergistic control solutions for air pollution and climate change.

关键词： Ozone Nitrogen dioxide Health risk Carbon neutrality Mega-events

Thin-Shell Wormholes Admitting Conformal Motions in Spacetimes of Embedding Class One

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International Journal of Astronomy and Astrophysics 2024年第3期14卷 162-171页

作者： peter k. F. k.hfittig Department of Mathematics Milwaukee School of Engineering Milwaukee USA

This paper discusses the feasibility of thin-shell wormholes in spacetimes of embedding class one admitting a one-parameter group of conformal motions. It is shown that the surface energy density σis positive, while the surface pressure is negative, resulting in , thereby signaling a violation of the null energy condition, a necessary condition for holding a wormhole open. For a Morris-Thorne wormhole, matter that violates the null energy condition is referred to as “exotic”. For the thin-shell wormholes in this paper, however, the violation has a physical explanation since it is a direct consequence of the embedding theory in conjunction with the assumption of conformal symmetry. These properties avoid the need to hypothesize the existence of the highly problematical exotic matter.

关键词： Thin-Shell Wormholes Conformal Symmetry Embedding Class One Exotic Matter

Macroscopic Traversable Wormholes: Minimum Requirements

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International Journal of Astronomy and Astrophysics 2024年第3期14卷 230-243页

作者： peter k. F. k.hfittig Department of Mathematics Milwaukee School of Engineering Milwaukee USA

While wormholes are just as good a prediction of Einstein’s theory as black.holes, they are subject to severe restrictions from quantum field theory. To allow for the possibility of interstellar travel, a macroscopic wormhole would need to maintain sufficiently low radial tidal forces. It is proposed in this paper that the assumption of zero tidal forces, i.e., the limiting case, is sufficient for overcoming the restrictions from quantum field theory. The feasibility of this approach is subsequently discussed by 1) introducing the additional conditions needed to ensure that the radial tidal forces can indeed be sufficiently low and 2) by viewing traversable wormholes as emergent phenomena, thereby increasing the lik.lihood of their existence.

关键词： Morris-Thorne Wormholes Traversability Minimum Requirements Stability Compatibility with Quantum Field Theory

Full-spectrum Bi@SrTiO_(3) for bi-directional promotion effects on photocatalytic redox reaction:Insight into intermediates and mechanism

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Journal of Rare Earths 2024年第5期42卷 917-929,I0004页

作者： Bin Liu Nanhao Zhou Jun Liu Xinglei Wang peter k.J.Robertson Xiaoyuan Chen Chao Chen Jianmin Luo Chuanyi Wang School of Chemistry and Civil Engineering Shaoguan UniversityShaoguan512005China Chengdu Customs Technology Center Chengdu610041China k.y Laboratory of Pollutant Chemistry and Environmental Treatment College of Chemistry and Environmental ScienceYili Normal UniversityYining835000China School of Chemistry and Chemical Engineering Queen's University BelfastStranmillis RoadBelfastBT95AGUnited Kingdom Guangzhou Institute of Industrial Intelligence(GIII) Guangzhou511400China

The development of full-spectrum photocatalysts active in the near-infrared(NIR)region has gained increasing attention for deleterious pollutant *** integration of plasmonic metals with semico nductors is an effective way to widen the light re sponse range of photocatalysts due to the strong light absorption and fast plasmonic energy transfer of the localized surface plasmon resonance(LSPR).In this work.the full-spectrum responsive Bi@SrTiO_(3) was prepared via facile solvothermal chemical *** optimal Bi@SrTiO_(3) achieves exceptional photocatalytic Cr(VI)reduction efficiency and tetracycline degradation,realizing bi-directional promotion effects on redox *** to density functional theory(DFT)simulations,the extraordinary photocatalytic performance is attributed to the tunable builtin electric field(IEF)of the Ohmic *** favorable adaptability in real water and high stability of BSTO-25 were proved by experime ntal *** the po ssible photocatalytic mechanism was proposed based on theoretical calculation and experimental ***,the non-toxicity of the BSTO-25 was evaluated by *** cultivation,which further proves the feasibility of treating wastewater with *** work.provides a new perspective on constructing full-spectrum-driven photocatalysts for applications dealing with environmental remediation.

关键词： Full-spectrum photocatalysts Localized surface plasmon resonance Ohmic contact Cr(Ⅵ)reduction Antibiotic degradation Rare earths

Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

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Journal of Molecular Cell Biology 2024年第1期16卷 54-65页

作者： peter Zorn Jaime Calvo Sánchez Tala Alak.ras Barbara Schreier Michael Gek.e Stefan Hüttelmaier Marcel k.hn Junior Group‘Non-coding RNAs and RBPs in Human Diseases’ Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany Julius Bernstein Institute of Physiology Medical FacultyUniversity of Halle–Wittenberg06112 Halle(Saale)Germany Institute of Molecular Medicine Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany

Alternative splicing is one of the major cellular processes that determine the tissue-specific expression of protein ***,it remains challenging to identify physiologically relevant and tissue-selective proteins that are generated by alternative ***,we investigated the target spectrum of the splicing factor Rbfox1 in the cardiac muscle context in more *** using a combination of in silico target prediction and in-cell validation,we identified several focal adhesion proteins as alternative splicing targets of *** focused on the alternative splicing patterns of vinculin(metavinculin isoform)and paxillin(extended paxillin isoform)and identified both as potential Rbfox1 *** analyses suggested that both isoforms are promoted by Rbfox1 due to binding in the *** adhesions play an important role in the cardiac muscle context,since they mainly influence cell shape,cytosk.letal organization,and cell–matrix *** data confirmed that depletion of Rbfox1 changed cardiomyoblast morphology,cytosk.letal organization,and multinuclearity after differentiation,which might be due to changes in alternative splicing of focal adhesion ***,our results indicate that Rbfox1 promotes alternative splicing of focal adhesion genes in cardiac muscle cells,which might contribute to heart disease progression,where downregulation of Rbfox1 is frequently observed.

关键词： Rbfox1 alternative splicing focal adhesion cardiac muscle cells

Vine pruning waste-based activated carbon for cerium and lanthanum adsorption from water and real leachate

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Journal of Rare Earths 2024年第10期42卷 1960-1968页

作者： Raphael Forgearini Pinheiro Alejandro Grimm k.tia da Boit Martinello Mohammad Rizwan k.an Naushad Ahmad Luis Felipe Oliveira Silva Irineu Antônio Schadach De Brum Guilherme Luiz Dotto Glaydson simões dos Reis Research Group on Adsorptive and Catalytic Process Engineering(ENGEPAC) Federal University of Santa MariaAv.Roraima1000-797105900Santa MariaRSBrazi Department of Forest Biomaterials and Technology Biomass Technology CentreSwedish University of Agricultural SciencesUmed SE-90183Sweden Universidad De La Costa Calle 58#55-66080002BarranquillaAtlanticoColombia Department of Chemistry College of ScienceKing Saud UniversityRiyadh11451Kingdom of Saudi Arabia Institute of Chemistry Federal University of Rio Grande do Sul90040-060Porto AlegreBrazil

In this study,vine pruning wastes(VPW)were used as raw material to develop an alternative activated carbon(VPW-AC)for adsorbing and concentrating rare earth elements cerium(Ce(Ⅲ))and lanthanum(La(Ⅲ))from synthetic and real leachate *** Ce and La adsorption studies evaluated the effects of VPW-AC dosage,pH,contact time,rare earth initial concentration,and *** VPW-AC adsorbent was subjected to many physicochemical characterization methods to correlate and understand its adsorptive *** characterization data indicate a carbonaceous adsorbent with a specific surface area of 467 m^(2)/*** potential indicates a material with a negatively charged surface at a pH higher than 3.1,which is extremely beneficial to cations *** both rare earths elements(REEs),the adsorption capacity increases with the increase of the pH,reaching its maximum at pH *** k.netic data are well fitted by Avrami-fractional o rder,while the Liu model agreeably fits equilibrium *** maximum adsorption capacities for Ce(Ⅲ)and La(Ⅲ)are 48.45 and 53.65 mg/g at 298 k.*** thermodynamic studies suggest that the adsorption process is favorable,spontaneous,and exothermic for both *** filling,surface complexation,and ion exchange are the dominant ***,the VPW-AC was subjected to the recovery of REEs from real phosphogypsum leachate,and it is proved that it can be successfully used to recover REEs in a real process.

关键词： Vine pruning wastes Sustainable carbon adsorbent Rare earth elements Phosphogypsum leachate Ion-exchange mechanism

Relationship between the unique microstructures and behaviors of high-entropy alloys

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1350-1363页

作者： Yaqi Wu peter k.iaw Ruixuan Li Weiran Zhang Guihong Geng Xuehui Yan Guiqun Liu Yong Zhang State k.y Laboratory for Advanced Metals and Materials University of Science and Technology BeijingBeijing 100083China Department of Materials Science and Engineering The University of TennesseeKnoxvilleTN 37996USA Xi’an Rare Metal Materials Institute Co.Ltd. Xi’an 710016China School of Materials Science and Engineering North Minzu UniversityYinchuan 750030China GRIMAT Engineering Institute Co. Ltd.Beijing 101407China

High-entropy alloys(HEAs),which were introduced as a pioneering concept in 2004,have captured the k.en interest of nu-merous ***,in this context,can be perceived as representing disorder and *** contrast,elemental composi-tions within alloy systems occupy specific structural sites in space,a concept referred to as *** accordance with Shannon entropy,structure is analogous to ***,the arrangement of atoms within a material,termed its structure,plays a pivotal role in dictating its *** addition to expanding the array of options for alloy composites,HEAs afford ample opportunities for diverse structural *** profound influence of distinct structural features on the exceptional behaviors of alloys is underscored by numer-ous *** features include remark.bly high fracture strength with excellent ductility,antiballistic capability,exceptional radi-ation resistance,and corrosion *** this paper,we delve into various unique material structures and properties while elucidating the intricate relationship between structure and performance.

关键词： high-entropy alloys unique microstructure special properties alloy design