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World j.urnal of Gastroenterology 2007年第26期13卷 3575-3580页

作者： Anthony j.Michaels peter V Draganov University of Florida Department of GastroenterologyHepatology and NutritionUnited States

Pain is a common symptom of pancreatic disease and is frequently difficult to manage. Pain relief provided by narcotics is often suboptimal and is associated with significant side effects. An alternative approach to pain management in pancreatic disease is the use of celiac plexus block (CPB) or neurolysis (CPN). Originally performed by anesthesiologists and radiologists via a posterior approach,recent advances in endoscopic ultrasonography (EUS) have made this technique an attractive alternative. EUS guided celiac plexus block/ neurolysis is simple to perform and avoids serious complications such as paraplegia or pneumothorax that are associated with the posterior approach. EUS guided CPN should be considered first line therapy in patients with pain due to pancreatic cancer. It provides superior pain control compared to traditional management with narcotics. A trend for improved survival in pancreatic cancer patients treated with CPN has been reported,but larger studies are needed to confirm this finding. At this time,the use of EUS guided CPB cannot be recommended as routine therapy for pain in chronic pancreatitis since only one-half of the patients experience pain reduction and the beneficial effect tends to be short lived. EUS guided CPB and CPN should be used as part of a multidisciplinary team approach for pain management.

关键词： Celiac plexus Celiac plexus neurolysis Celiacplexus block Endoscopic ultrasound Pain management

New technologies in the gastrointestinal clinic and research: Impedance and high-resolution manometry

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World j.urnal of Gastroenterology 2009年第2期15卷 131-138页

作者： j.hn E Pandolfino peter j.Kahrilas Division of Gastroenterology Department of Medicine Northwestern University Feinberg School of Medicine Suite 1400 Chicago Illinois 60611 United States

The last five years have been an exciting time in the study of esophageal motor disorders due to the recent advances in esophageal function testing. New technologies have emerged, such as intraluminal impedance, while conventional techniques, such as manometry, have enj.yed many improvements due to advances in transducer technology, computerization and graphic data presentation. While these techniques provide more detailed information regarding esophageal function, our understanding of whether they can improve our ability to diagnose and treat patients more effectively is evolving. These techniques are also excellent research tools and they have added substantially to our understanding of esophageal motor function in dysphagia. This review describes the potential benefits that these new technologies may have over conventional techniques for the evaluation of dysphagia.

关键词： Dysphagia, Multichannel intraluminal Impedance Bolus transit High-resolution manometry Esophagogastric j.nction Achalasia

Colonoscopic polypectomy and associated techniques

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World j.urnal of Gastroenterology 2010年第29期16卷 3630-3637页

作者： Christopher j.Fyock peter V Draganov Division of Gastroenterology Hepatology and NutritionUniversity of Florida

Polypectomy of colonic polyps has been shown to reduce the risk of colon cancer development and is considered a fundamental skill for all endoscopists who perform colonoscopy.A variety of polypectomy techniques and devices are available,and their use can vary greatly based on local availability and *** general,cold forceps and cold snare have been the polypectomy methods of choice for smaller polyps,and hot snare has been the method of choice for larger *** use of hot forceps has mostly fallen out of *** for difficult to remove polyps may require the use of special devices and advanced techniques and has continued to *** a result,the vast maj.rity of polyps today can be removed *** electrocautery is frequently used for polypectomy,endoscopists should be thoroughly familiar with the basic principles of electrosurgery as it pertains to *** of a polypectomy site is an important adj.nct to polypectomy and can greatly facilitate future surgery or endoscopic *** two most common post-polypectomy complications are bleeding and *** incidence can be decreased with the use of meticulous polypectomy techniques and the application of some prophylactic *** review will examine the technique of polypectomy and its complications from the perspective of the practicing gastroenterologist.

关键词： Colonic polyp Polypectomy Colonoscopy Polypectomy technique Complications

The new COVID-19 poor and the neglected tropical diseases resurgence

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Infectious Diseases of Poverty 2021年第1期10卷 1-3页

作者： peter j.Hotez Alan Fenwick David Molyneux Department of Pediatrics Texas Children's Hospital CenterforVaccine DevelopmentNational School of Tropical MedicineBaylor College of MedicineHoustonTXUSA Department of Molecular Virology and Microbiology Texas Children's Hospital Center for Vaccine DevelopmentNational School of Tropical MedicineBaylor College of MedicineHoustonTXUSA Hagler Institute for Advaneed Study at Texas A&M University College StationTXUSA Department of Biology Baylor UniversityWacoTXUSA j.mes A Baker III Institute of Public Policy Rice UniversityHoustonTXUSA Scowcroft Institute of International Affairs Bush School of Government and Public ServiceTexas A&M UniversityCollege StationTXUSA School of Public Health Faculty of MedicineImperial College Lon don LondonUK. Centre for Neglected Tropical Diseases Liverpool School ofTropical MedicineLiverpoolUK.

More than 100 million people are facing a return to extreme poverty because of coronavirus disease 2019(COVID-19),while new estimates suggest that three nations—India,Nigeria,and the Democratic Republic of the Congo-may suffer the greatest economic *** findings will have profound consequences in terms of our ability to control or eliminate the most widely prevalent neglected tropical diseases.

关键词： neglected tropical consequences

Protective and Regenerative Efficacy of a Plant Oil-Based Day and Night Cream: Investigated by a Novel Approach to Reveal the Impact of Blue Light Irradiation on Epidermal Barrier Integrity and Lipid Matrix

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j.urnal of Cosmetics, Dermatological Sciences and Applications 2024年第3期14卷 227-241页

作者： Dorothee Dähnhardt Stephan Dähnhardt-Pfeiffer Isabel Simon Dana Ditgen Inge Holland Dörte Segger peter Staib Microscopy Services Dhnhardt GmbH Flintbek Germany Research & Development and Regulatory Affairs Kneipp GmbH Wuerzburg Germany SGS INSTITUT FRESENIUS GmbH Hamburg Germany

In recent years, the harmful effects of blue light (400 - 500 nm) as a component of visible light (400 - 700 nm) have increasingly gained attention of science, industry, and consumers. To date, only a few in vivo test methods for measuring the effects of blue light on the skin have been described. A direct measurement method that can detect the immediate effects of blue light on the epidermal permeability barrier (EPB) is still lacking. In this study, we present a new methodological approach that can be used to investigate both the protective and regenerative effects of cosmetic products on the EPB after blue light irradiation. In a study with 14 female volunteers, it was investigated whether the regular application of an O/W emulsion (day cream) can strengthen and protect the epidermal barrier against damaging blue light radiation of 60 j.cm2 (protective study design) and also whether a disruption of the epidermal barrier caused by blue light radiation is restored faster and better by the regular application of another O/W emulsion (night cream) than in product-untreated skin (regenerative study design). The two O/W emulsions are different in plant oil, active ingredient composition and texture. The seven-day treatment with the day cream initially led to a significant increase in the normalized lipid lamellae length in the intercellular space, whereas the irradiation with blue light after 24 hours led to a significant decrease in the lipid lamellae length in the untreated test area, but not in the area previously treated with the product. Regarding the regenerative study design, a two-day treatment with the night cream was able to restore a blue-light-induced decrease in lipid lamellae length in the intercellular space. In summary, with the study designs presented here, the protective and regenerative effect of two cosmetic products could be demonstrated for the first time on the integrity of the EPB after blue light irradiation and the data showed that the Lipbarv

关键词： Skin Care Blue Light Irradiation Skin Barrier Intercellular Lipid Lamellae Electron Microscopy

Contact Dermatitis 4th ed. 2006

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Those amazing dinoflagellate chromosomes

2006年

作者： peter j. Frosch Torkil Menne j.an-Pierre Lepoittevin

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Cell Research 2003年第4期13卷 215-217页

作者： peter j.RIZZO Department of Biology Texas A & M University College Station TX 77843 USA

Dinoflagellates are a very large and diverse group of eukaryotic algae that play a maj.r role in aquatic food webs of both fresh water and marine habitats. Moreover, the toxic members of this group pose a health threat in the form of red tides. Finally, dinoflagellates are of great evolutionary importance, because of their taxonomic position, and their unusual chromosome structure and composition. While the cytoplasm of dinoflagellates is typically eukaryotic, the nucleus is unique when compared to the nucleus of other eukaryotes. More specifically, while the chromosomes of all other eukaryotes contain histones, dinoflagellate chromosomes lack histones completely. There are no known exceptions to this observation: all dinoflagellates lack histones, and all other eukaryotes contain histones. Nevertheless, dinoflagellates remain a relatively unstudied group of eukaryotes.

关键词： dinofiagellates chromosomes histones histone-like proteins.

Participation of CD45,NKR-P1A and ANK61 antigen in rat hepatic NK cell(pit cell)-mediated target cell cytotoxicity

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World j.urnal of Gastroenterology 2000年第4期6卷 546-552页

作者： David Vermiilen Bülent Ahishali Vasilis Triantis Karin Vanderkerken peter j. K.Kuppen Eddie Wisse Laboratory for Cell Biology and Histology. Department of Hematology and immunology Free University of Brussels(VUB)Brussels-JetteBelgium K Vanderkerken is a postdoctoral researcher of the Fund for Scientific Research Flanders. Department of Surgery and Pathology Leiden University Medical CenterLeidenThe Netherlands

AIM Several triggering receptors have beendescribed to be involved in natural killer（NK）cell-mediated target *** these studies,NKcells derived from blood or spleen were *** are liver-specific NK cells that possess ahigher level of natural cytotoxicity and a differentmorphology when compared to blood NK *** aim of this study was to characterize the roleof the NK-triggering molecules NKR-P1A,ANK61antigen,and CD45 in pit cell-mediated killing oftarget *** 51Cr-release and DNA fragmentationwere used to quantify target cell lysis andapoptosis,*** Flow cytometric analysis showed thatpit cells expressed CD45,NKR-P1A,and *** of pit cells with monoclonalantibody（mAb）to CD45（ANK74）not onlyinhibited CC531s or YAC-1 target lysis but alsoapoptosis induced by pit *** mAbs to NKR-P1A（3.2.3）and ANK61 antigen（ANK61）had no effect on pit cell-mediated CC531s or YAC-1 targetcytolysis or apoptosis,while they did increase theFcγ receptor positive（FcγR+）P815 cytolysis *** enhanced cytotoxicity could beinhibited by 3,4-dichloroisocoumarin,an inhibitorof *** These results indicate that CD45participates in pit cell-mediated CC531s and YAC-1target cytolysis and ***-P1A andANK61 antigen on pit cells function as activationstructures against FcγR+ P815 cells,which wasmediated by the perforin/granzyme pathway.

关键词： hepatic NK cells pit cells cytolysis apoptosis perforin/granzyme pathway

Fundamentals of business statistics 4

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On the Applications of the Linear Recurrence Relationships to Pseudoprimes

2006年

作者： Dennis j. Sweeney Thomas A. williams David R. Anderson

本书将统计学的概念与方法应用于商务领域, 旨在为解决商务活动中的各种问题提供有力的工具。

ISBN: (数字)7302140839

ISBN: (纸本)7302140839

本书将统计学的概念与方法应用于商务领域, 旨在为解决商务活动中的各种问题提供有力的工具。

关键词： Commercial statistics.

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j.urnal of Mathematical Research with Applications 2019年第6期39卷 563-574页

作者： Tianxiao HE peter j.-S.SHIUE Department of Mathematics Illinois Wesleyan University Department of Mathematical Sciences University of Nevada Las Vegas

We present here some results on the applications of linear recursive sequences of order 2 to the Fermat pseudoprimes, Fibonacci pseudoprimes, and Dickson pseudoprimes.

关键词： Girard-Waring identities Recursive sequences Fermat’s pseudoprimes Fibonacci numbers Lucas numbers Fibonacci pseudoprimes Dickson numbers Dickson pseudoprimes