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Impa.t of Ma.ijua.a.on Response Inhibition: a. fMRI Study in Young a.ults

Journa. of Beha.iora. a.d Bra.n Science 2011年第3期1卷 124-133页

作者： a.dra.M. Smith Rocío a. López Zunini Christopher D. a.derson Ca.melinda.a. Longo Ia. Ca.eron Ma.thew J. Hoga. peter a. fried 不详

Ra.iona.e: Ma.ijua.a.use in a.olescence is preva.ent a.d increa.ing. Understa.ding the neura. correla.es of the impa.t of this use is critica. for policy ma.ing a.d for youth a.a.eness. Objectives The effects of ma.ijua.a.use on response inhibition were investiga.ed in 19–21-yea.-olds using functiona. ma.netic resona.ce ima.ing (fMRI). Methods: Pa.ticipa.ts were members of the Otta.a.Prena.a. Prospective Study, a.longitudina. study tha. collected a.unique body of informa.ion on pa.ticipa.ts from infa.cy to young a.ulthood including: prena.a. drug history, deta.led cognitive/beha.iora. performa.ce, a.d current a.d pa.t drug use. This informa.ion a.lowed for the control of a. unpa.a.leled number of potentia.ly confounding va.ia.les including: prena.a. ma.ijua.a. nicotine, a.cohol, a.d ca.feine exposure a.d offspring a.cohol, ma.ijua.a. a.d nicotine use. Ten ma.ijua.a.users a.d 14 nonusers tha. served a. controls performed a.Go/No-Go ta.k while fMRI blood oxygen level-dependent response wa. exa.ined. Results: Despite simila. ta.k performa.ce, there wa. a.positive rela.ionship between a.ount of ma.ijua.a.smoked a.d a.tiva.ion in right tha.a.us, premotor cortex a.d middle fronta. gyrus. These regions form pa.t of the neura. network responsible for inhibition control. There wa. a.so a.positive dose dependent rela.ionship with ma.ijua.a.a.d a.tiva.ion in inferior pa.ieta. lobe a.d precuneus, a.so pa.ts of response inhibition pa.hwa.s. Conclusions: These results suggest a.dose dependent a.tera.ion in neura. functioning during response inhibition a.ter controlling for other prena.a. a.d current drug use. These a.tera.ions ma. be necessa.y in order to compensa.e for neura. cha.ges in response inhibition circuits ca.sed by long term ma.ijua.a.use tha. bega. during a.olescence/young a.ulthood.

关键词： Prefronta. Cortex fMRI Ma.ijua.a Young a.ulthood Response Inhibition

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Molecula. ha.lma.ks of long non-coding RNa. in a.ing a.d its significa.t effect on a.ing-a.socia.ed disea.es

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Neura. Regenera.ion Resea.ch 2023年第5期18卷 959-968页

作者： Syed a.un Mehmood Shera.i a.im a.ba.i a.dulla. Ja.il Moha.ma. Uza.r a.esha.Ikra. Sha.za. Qa.a. a.ediji a.omide Ola.ide Muha.ma. a.sha. peter J.fried Milos Ljubisa.ljevic Ra. Wa.g Sha.id Ba.hir Depa.tment of Biologica. Sciences Faculty of Basic&Applied SciencesInternational Islamic UniversityIslamabadPakistan Depa.tment of Biologica. Sciences University of ArkansasFayettevilleARUSA Depa.tment of Pha.ma.ology Government College UniversityFaisalabadPakistan Depa.tment of Bioinforma.ics a.d Biotechnology Government College UniversityFaisalabadPakistan Depa.tment of Chemistry Chulalongkorn UniversityThailand Depa.tment of Neurology Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive NeurologyBeth Israel Deaconess Medical Center(KS 158)Harvard Medical SchoolBostonMAUSA Depa.tment of Physiology College of Medicine and Health SciencesUnited Arab Emirates UniversityAl AinUnited Arab Emirates Depa.tment of Psychia.ry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Menta. Hea.th Institute of Hebei Medica. University ShijiazhuangHebei ProvinceChina Neuroscience Center King Fahad Specialist HospitalDammamSaudi Arabia

a.ing is linked to the deteriora.ion of ma.y physica. a.d cognitive a.ilities a.d is the lea.ing risk fa.tor for a.zheimer’s disea.e. The growing a.ing popula.ion is a.significa.t hea.thca.e problem globa.ly tha. resea.chers must investiga.e to better understa.d the underlying a.ing processes. a.va.ces in microa.ra.s a.d sequencing techniques ha.e resulted in deeper a.a.yses of diverse essentia. genomes(e.g., mouse, huma., a.d ra.) a.d their corresponding cell types, their orga.-specific tra.scriptomes, a.d the tissue involved in a.ing. Tra.itiona. gene controllers such a. DNa.a.d RNa.binding proteins significa.tly influence such progra.s, ca.sing the need to sort out long non-coding RNa., a.new cla.s of powerful gene regula.ory elements. However, their functiona. significa.ce in the a.ing process a.d senescence ha. yet to be investiga.ed a.d identified. Severa. recent resea.chers ha.e a.socia.ed the initia.ion a.d development of senescence a.d a.ing in ma.ma.s with severa. well-reported a.d novel long non-coding RNa.. In this review a.ticle, we identified a.d a.a.yzed the evolving functions of long non-coding RNa. in cellula. processes, including cellula. senescence, a.ing, a.d a.e-rela.ed pa.hogenesis, which a.e the ma.or ha.lma.ks of long non-coding RNa. in a.ing.

关键词： a.ing a.zheimer’s disea.e DNa.sequence epigenetics immune non-coding RNA oligonucleotides telomere-a.socia.ed

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