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MicroRNA-184 negatively regulates corneal epithelial wound healing via targeting CDC25A,CARM1,and LAsP1

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Eye and Vision 2020年第2期7卷 336-346页

作者： Qiongjie Cao Weiwei Xu Weiwei Chen Dewei Peng Qi Liu Jing Dong peter s.reinach Dongsheng Yan school of Ophthalmology and Optometry Eye HospitalWenzhou Medical University270 Xueyuan RoadWenzhou 325027ZhejiangChina state Key Laboratory of Ophthalmology Optometry and Visual ScienceWenzhouZhejiangChina

Background:MicroRNAs(miRNAs)play critical roles in corneal development and functional *** previous study identified miR-184 as one of the most highly expressed miRNAs in the corneal *** though its expression level plummeted dramatically during corneal epithelial wound healing(CEWH),its precise role in mediating corneal epithelial renewal was *** present study aimed to reveal the function and mechanism of miR-184 in regulating ***:Quantitative RT-PCR analysis characterized the miR-184 expression pattern during CEWH in *** miR-184 injection determined its effect on this process in *** evaluated the effects of miR-184 and its target genes on the proliferation,cell cycle,and migration of human corneal epithelial cells(HCECs)using MTs,flow cytometry,and wound-healing assay,*** analysis,in conjunction with gene microarray analysis and cell-based luciferase assays,pinpointed gene targets of miR-184 contributing to ***:MiR-184 underwent marked downregulation during mouse *** miR-184 overexpression delayed this process in ***,miR-184 transfection into HCECs significantly inhibited cell proliferation,cell cycle progression,and cell ***-184 directly targeted CDC25A,CARM1,and LAsP1,and downregulated their expression in ***1 downregulation inhibited both HCEC proliferation and migration,whereas a decrease in LAsP1 gene expression only inhibited ***:Our results demonstrate that miR-184 inhibits corneal epithelial cell proliferation and migration via targeting CDC25A,CARM1,and LAsP1,suggesting it acts as a negative modulator during ***,identifying strategies to suppress miR-184 expression levels has the potential to promote CEWH.

关键词： miR-184 Corneal epithelial wound healing Proliferation Migration CDC25A CARM1 LAsP1

Choroidal blood perfusion as a potential“rapid predictive index”for myopia development and progression

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Eye and Vision 2021年第3期8卷 1-5页

作者： Xiangtian Zhou Cong Ye Xiaoyan Wang Weihe Zhou peter reinach Jia Qu Eye Hospital and school of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhouZhejiangChina National Clinical Research Center for Ocular Diseases WenzhouZhejiangChina state Key Laboratory of Optometry Ophthalmology and Vision ScienceWenzhouZhejiangChina Research Unit of Myopia Basic Research and Clinical Prevention and Control Chinese Academy of Medical Sciences(2019RU025)WenzhouZhejiangChina

Myopia is the leading cause of visual impairment *** lack of a“rapid predictive index”for myopia development and progression hinders the clinic management and prevention of *** article reviews the studies describing changes that occur in the choroid during myopia development and proposes that it is possible to detect myopia development at an earlier stage than is currently possible in a clinical setting using choroidal blood perfusion as a“rapid predictive index”of myopia.

关键词： Myopia Choroidal thickness Choroidal blood perfusion Rapid predictive index

Links between global CO_2 variability and climate anomalies of biomes

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science China Earth sciences 2008年第5期51卷 740-747页

作者： peter s. BAKWIN school of Earth and Environmental sciences Queens College City University of New York New York 11367 USA

The global rate of fossil fuel combustion continues to rise, but the amount of CO2 accumulating in the atmosphere has not increased accordingly. The causes for this discrepancy are widely debated. Par- ticularly, the location and drivers for the interannual variability of atmospheric CO2 are highly uncertain. Here we examine links between global atmospheric CO2 growth rate (CGR) and the climate anomalies of biomes based on (1986―1995) global climate data of ten years and accompanying satellite data sets. Our results show that four biomes, the tropical rainforest, tropical savanna, C4 grassland and boreal forest, and their responses to climate anomalies, are the major climate-sensitive CO2 sinks/sources that control the CGR. The nature and magnitude by which these biomes respond to climate anomalies are generally not the same. However, one common influence did emerge from our analysis; the ex- tremely high CGR observed for the one extreme El Nio year was caused by the response of the tropical biomes (rainforest, savanna and C4 grassland) to temperature.

关键词： biomes carbon cycle climate anomaly NDVI El Nio

Effect of Osmotic stress in Early stages of Ontogenesis on Root Respiration, Growth, sugar Content,and Cell Injury in Maize seedlings Differing in Drought sensitivity

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Journal of Integrative Plant Biology 2006年第7期48卷 814-822页

作者： Lukás, Kolarovic Miroslava Luxová peter Valentovic Institute of Botany Slovak Academy of Sciences Dubravská cesta 14 Bratislava 84523 Slovakia

Cultivars of maize （Zea mays L.） with different sensitivity to drought were exposed to 0.3 mol/L sorbitol （-1.4 MPa water potential） for 24 h. Exposure to water deficiency significantly reduced the growth of both shoots （coleoptile and hypocotyl） and roots. shoot growth was inhibited more than the growth of roots. Osmotic stress enhanced accumulation of soluble sugars. Electrolyte leakage, a cell injury index, was slightly increased after 0.3 mol/L sorbitoh Respiration was measured in the presence and absence of 2,6-dlchloro-phenol indophenoh 2,6-Dichloro-phenol indophenol did not influence respiration rates, because statistically equal results were observed under both conditions. Total respiration （VT） decreased after osmoticum treatment. There were no significant differences in the VT among the cultlvars analysed. The decrease In VT was caused by a decline In the activities and capacities of both cytochrome （Vcyt, Vcyt） and alternative pathway （Valt, Valt） of respiration. A high residual respiration （Vres） was observed, up to 27% of total uninhibited respiration. The result of uncoupler use clearly indicated that coupling was maintained after 24 h of osmotic stress. The recovery of the respiration rate was comparable with that of non-stressed control rates. According to these observations, no possible mltochondrial damage is expected. Water deficiency did not induce a stimulation of the alternative oxidase, so we assume that the stimulation of the alternative pathway is not related to drought stress resistance; rather, the function of the alternative pathway is to balance carbon metabolism and electron transport in a response to a changing environment.

关键词： alternative oxidase (AOX) alternative respiration 2,6-dichloro-phenol indophenol (DCPIP) maize osmotic stress sugars uncoupler.

Abstracts from the 15th International Myopia Conference

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Eye and Vision 2016年第1期3卷 211-221页

作者： Alexandra Benavente-Perez Ann Nour Tobin Ansel Kathleen Abarr Luying Yan Keisha Roden David Troilo Chanyi Lu Miaozhen Pan Min Zheng Jia Qu Xiangtian Zhou Christine F. Wildsoet Fan Lu Jie Chen Jinhua Bao Liang Hu Qinmei Wang Zibing Jin Frances Rucker stephanie Britton stephan Hanowsky Molly spatcher Hui-Ying Kuo Ching-Hsiu Ke I-Hsin Kuo Chien-Chun Peng Han-Yin sun Ian G. Morgan Jeremy A. Guggenheim Rupal L. shah Cathy Williams Jinglei Yang peter s. reinach sen Zhang Wenfeng sun Bo Liu Fen Li Xiaoqing Li Aihua Zhao Tianlu Chen Wei Jia Jun Jiang Haoran Wu Kazuo Tsubota Hiroko Ozawa Hidemasa Torii shigemasa Takamizawa Toshihide Kurihara Kazuno Negishi Klaus Graef Daniel Rathbun Frank schaeffel Ladan Ghodsi William K. stell Machelle T. Pardue Ranjay Chakraborty Han na Park Curran s. sidhu P. Michael Iuvone Michael J Collins Nethrajeith srinvasalu sally A. McFadden Paul N. Baird Pablo Artal Pauline Cho sW Cheung Pei-Chang Wu Quan V. Hoang Duk C. Lee Erica G. Landis Michael A. Bergen Curran sidhu samer Hattar Richard A. stone Ravi Metlapally Ruiqin Li Qinglin Xu Hong Zhong Chenglin Pan Weizhong Lan Xiaoning Li Ling Chen Zhikuan Yang scott A. Read seang-Mei saw shi-Jun Weng Xiao-Hua Wu Kang-Wei Qian Yun-Yun Li Guo-Zhong Xu Furong Huang Xiong-Li Yang Yong-Mei Zhong Earl L smith, III Baskar Arumugam Li-Fang Hung Lisa A. Ostrin Klaus Trier Monica Jong Brien A. Holden Thomas Chuen Lam samantha shan Bing Zuo Dennis Yan-yin Tse Jingfang Bian King-Kit Li Quan Liu Chi-ho To Timothy J. Gawne John T. siegwart, Jr. Alexander H. Ward Thomas T. Norton Yan Zhang Yue Liu Carol Ho Eileen Phan Abraham Hang Emily Eng Christine Wildsoet Department of Biological sciences SUNY College of Optometry New York NY 10036 USA school of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China Center for Eye Disease & Development School of Optometry & Vision Science Program University of California Berkeley Berkeley CA 94720-2020 USA Wenzhou Medical University Wenzhou Zhejiang 325027 China Biomedical science and Disease New England College of Optom Boston MA USA school of Optometry Chung Shan Medical University Taichung City 402 Taiwan Institute of Medicine Chung Shan Medical University Taichung City 402 Taiwan Division of Biochemistry and Molecular Biology Research School of Biology Australian National University Canberra Australia state Key Laboratory of Ophthalmology and Division of Preventive Ophthalmology Zhongshan Ophthalmic Center Sun Yat-Sen University Guangzhou China school of Optometry & Vision sciences Cardiff University Cardiff UK school of social and Community Medicine University of Bristol Bristol UK school of and Eye Hospital Wenzhou Medical University Wenzhou Zhejiang 325027 China state Key Laboratory Cultivation Base and Key Laboratory of Vision science Ministry of Health and Zhejiang Provincial Key Laboratory of Ophthalmology and Optometry Wenzhou Zhejiang 325027 People’s Republic of China shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Shanghai 200233 China Eye Hospital of Wenzhou Medical University Wenzhou Zhejiang 325027 China Department of Ophthalmology Keio University School of Medicine Shinjuku-ku Tokyo 160-8582 Japan General Medicine Ichikawa Medical Center Urayasu City Chiba 279-0001 Japan Ophthalmic Research Institute University of Tuebingen 72076 Tuebingen Germany Bernstein Center for Computational Neuroscience Tuebingen 72076 Tuebingen Germany Werner Reichardt Centre for Integrative Neuroscience Otfried-Mueller-Straße 25 Tueb

To assess the peripheral refractive changes that occur when eye growth decelerates in *** We measured peripheral refraction and on-axis vitreous chamber depth on a total of 53 marmosets;36 treated monocularly for 12 weeks 9 hrs/day(26 with-5 D contact lenses,10 with+5 D)and 17 untreated *** the 26 marmosets treated with-5 D,10 wore contact lenses 9 hrs/day without interruptions and were mea-sured at the end of 10 weeks of treatment(T10)and after 4 weeks of recovery(R14).Eight had both contact lenses removed for 30 mins twice/day(mid-morning and mid-afternoon)during the first four weeks of treatment(early interruption group)and eight had the lenses removed during the second four weeks of treatment(late interruption group).The two interruption groups were measured after 4,8 and 12 weeks of treatment only(T4,T8,T12).

关键词： removed treatment untreated

Projection on segre varieties and determination of holomorphic mappings between real submanifolds Dedicated to Professor sheng GONG on the occasion of his 75th birthday

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science China Mathematics 2006年第11期49卷 1611-1624页

作者： BAOUENDI M s EBENFELT peter ROTHsCHILD Linda P Department of Mathematics University of California at san Diego La JollaCA 92093-0112USA

It is shown that a germ of a holomorphic mapping sending a real-analytic generic submanifold of finite type into another is determined by its projection on the segre variety of the target manifold. A necessary and sufficient condition is given for a germ of a mapping into the segre variety of the target manifold to be the projection of a holomorphic mapping sending the source manifold into the target. An application to the biholomorphic equivalence problem is also given.

关键词： segre variety, generic submanifold, segre mappings, finite type, biholomorphic equivalence.

Cancer vaccines:shared tumor antigens return to the spotlight

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signal Transduction and Targeted Therapy 2020年第1期5卷 324-325页

作者： Lijin Li s.peter Goedegebuure William Gillanders Department of surgery Washington University School of MedicineSt LouisMOUSA The Alvin J.siteman Cancer Center at Barnes-Jewish Hospital and Washington University school of Medicine St LouisMOUSA

sahin et *** reported interim data from a phase 1 clinical trial(NCT02410733)treating melanoma patients with a RNAlipoplex vaccine(RNA-LPX),targeting melanoma TAA.1 The trial is a multicenter,non-randomized,open-label,dose-escalation trial designed to evaluate the safety and tolerability of BNT111 targeting four melanoma TAA(NY-EsO-1,MAGE-A3,tyrosinase,and TPTE).secondary endpoints include vaccine-induced immune responses and clinical response of patients with measurable disease.

关键词： vaccine melanoma clinical

Absolute characterization of high numerical aperture microscope objectives utilizing a dipole scatterer

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Light(science & Applications) 2021年第12期10卷 2342-2348页

作者： Jörg s.Eismann Martin Neugebauer Klaus Mantel peter Banzer Institute of Physics University of GrazNAWI GrazUniversitätsplatz 58010 GrazAustria Max Planck Institute for the science of Light Staudtstr.291058 ErlangenGermany Institute of Optics Information and PhotonicsUniversity Erlangen-NurembergStaudtstr.7/B291058 ErlangenGermany

Measuring the aberrations of optical systems is an essential step in the fabrication of high precision optical *** a characterization is usually based on comparing the device under investigation with a calibrated reference ***,when working at the cutting-edge of technology,it is increasingly difficult to provide an even better or well-known reference *** this manuscript we present a method for the characterization of high numerical aperture microscope objectives,functioning without the need of calibrated reference *** technique constitutes a nanoparticle,acting as a dipole-like scatterer,that is placed in the focal volume of the microscope *** light that is scattered by the particle can be measured individually and serves as the reference wave in our *** the well-characterized scattered light as nearly perfect reference wave is the main idea behind this manuscript.

关键词： characterization scatter scattered

An empirical movement model for sixgill sharks in Puget sound： Combining observed and unobserved behavior

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Current Zoology 2012年第1期58卷 103-115页

作者： Levin, Phillip s. Horne, peter Andrews, Kelly s. Williams, Greg Northwest Fisheries science Center 2725 Montlake Blvd E Seattle WA 98112 USA

Understanding the movement of animals is fundamental to population and community ecology. Historically, it has been difficult to quantify movement patterns of most fishes, but technological advances in acoustic telemetry have increased our abilities to monitor their movement. In this study, we combined small-scale active acoustic tracking with large-scale passive acoustic monitoring to develop an empirical movement model for sixgill sharks in Puget sound, WA, UsA. We began by testing whether a correlated random walk model described the daily movement of sixgills; however, the model failed to capture home-ranging behavior. We added this behavior and used the resultant model （a biased random walk model） to determine whether daily movement patterns are able to explain large-scale seasonal movement. The daily model did not explain the larger-scale pat- terns of movement observed in the passive monitoring data. In order to create the large-scale patterns, sixgills must have per- formed behaviors （large, fast directed movements） that were unobserved during small-scale active tracking. In addition, seasonal shifts in location were not captured by the dally model. We added these ＇unobserved＇ behaviors to the model and were able to capture large-scale seasonal movement of sixgill sharks over 150 days. The development of empirical models of movement al- lows researchers to develop hypotheses and test mechanisms responsible for a species movement behavior and spatial distribution. This knowledge will increase our ability to successfully manage species of concern [Current Zoology 58 （1）： 103-115, 2012].

关键词： Hexanchus griseus Movement Correlated random walk Biased random walk Displacement Movement model