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Pediatric Investigation 2021年第2期5卷 136-139页

作者： Heidi C smith-Vaughan Allen C Cheng sepehr N.Tabrizi Danielle F Wurzel Jemima Beissbarth Amanda J Leach peter s morris Michael J Binks Paul J Torzillo Anne B Chang Robyn L Marsh Menzies school of Health Research Charles Darwin UniversityDarwinAustralia school of Medicine Griffith UniversityGold CoastAustralia Monash University MelbourneAustralia Murdoch Children's Research Institute The Royal Children’s HospitalMelbourneAustralia Department of Obstetrics and Gynaecology University of MelbourneParkvilleVictoriaAustralia Royal Darwin Hospital DarwinAustralia Royal Prince Alfred Hospital SydneyAustralia Dept of Respiratory and sleep Medicine I Queensland Children’s HospitalBrisbaneAustralia

Maternal urogenital human papillomavirus(HPV)infection may place neonates at risk of HPV acquisition and subsequently lower respiratory infections as HPV can influence development of *** respiratory HPV prevalence is not known in remote-dwelling Aboriginal infants,who are at high risk of respiratory infection and where the population prevalence of urogenital HPV in women is *** data are necessary to inform HPV vaccination regimens.A retrospective analysis using PCR specific for HPV was performed on 64 stored nasopharyngeal swabs from remote-dwelling Aboriginal infantss of age,with and without hospitalised *** DNA was not detected in any *** the negative result,we cannot exclude a role for HPV in respiratory infections affecting infants in this population;however,our data do not support HPV as an important contributor to acute respiratory infection in remote-dwelling Aboriginal children.

关键词： Human papillomavirus Nasopharyngeal swabs Infants

Can non-typeable Haemophilus influenzae carriage surveillance data infer antimicrobial resistance associated with otitis media?

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Pediatric Investigation 2023年第1期7卷 13-22页

作者： sophia Bowman-Derrick Tegan M.Harris Jemima Beissbarth Mariana Kleinecke Katrina Lawrence Teresa M.Wozniak Amy Bleakley Angela Rumaseb Michael J.Binks Robyn L.Marsh peter s.morris Amanda J.Leach Heidi smith-Vaughan Menzies school of Health Research Charles Darwin UniversityDarwinAustralia Australian e-Health Research Centre CsIRO BrisbaneAustralia Royal Darwin Hospital DarwinAustralia

Importance:In remote communities of the Northern Territory,Australia,children experience high rates of otitis media(OM),commonly caused by non-typeable Haemophilus influenzae(NTHi).Few data exist on antibiotic susceptibility of NTHi from ***:To determine whether population-level nasopharyngeal NTHi antibiotic susceptibility data could inform antibiotic treatment for ***:NTHi isolates(n=92)collected from ear discharge between 2003 and 2013 were selected to time-and age-match NTHi isolates from the nasopharyngeal carriage(n=95).Antimicrobial susceptibility were *** trees and a genome-wide association study(GWAs)were performed to determine the similarity of nasopharyngeal and ear isolates at a population ***:Among 174 NTHi isolates available for antimicrobial susceptibility testing,10.3%(18/174)were resistant to ampicillin and 9.2%(16/174)were resistant to *** numbers of isolates(≤3)were resistant to tetracycline,chloramphenicol,or amoxicillin-clavulanic *** was no statistical difference in the proportion of ampicillin-resistant(P=0.11)or trimethoprim-sulfamethoxazole-resistant isolates(P=0.70)between ear discharge and nasopharynx-derived NTHi *** multi-drug resistant NTHi isolates were *** trees showed no clustering of 187 Haemophilus influenzae isolates based on anatomical niche(nasopharynx or ear discharge),and no genetic variations that distinguished NTHi derived from ear discharge and nasopharyngeal carriage were evident in the ***:In this population-level study,nasopharyngeal and ear discharge isolates did not represent distinct microbial *** results support tracking of population-level nasopharyngeal NTHi antibiotic resistance patterns to inform clinical management of OM in this population.

关键词： Haemophilus influenzae Otitis media Antimicrobial resistance

Testosterone and cardiovascular disease in men

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Asian Journal of Andrology 2012年第3期14卷 428-435,I0007页

作者： Paul D morris Kevin s Channer sheffield Teaching Hospital NHs Trust Sheffield S10 2JF UK

Despite regional variations in the prevalence of coronary artery disease （CAD）, men are consistently more at risk of developing and dying from CAD than women, and the gender-specific effects of sex hormones are implicated in this inequality. This ＇Perspectives＇ article reviews the current evidence regarding the cardiovascular effects of testosterone in men including an examination of the age-related decline in testosterone, the relationship between testosterone levels and coronary disease, coronary risk factors and mortality. We also review the vaso-active effects of testosterone, and discuss how these have been used in men with heart failure and angina. We discuss the ＇cause＇ versus ＇effect＇ controversy, regarding low testosterone levels in men with coronary heart disease, as well as concerns over the use of testosterone replacement therapy in middle aged and elderly men. The article concludes with a discussion regarding the future direction for work in this interesting area, including the relative merits of screening for, and treating hypogonadism with testosterone replacement therapy in men with heart disease.

关键词： atherosclerosis chronic heart failure ischaemic heart disease replacement therapy testosterone

Neutropenia in colorectal cancer treated with oxaliplatin-based hyperthermic intraperitoneal chemotherapy: An observational cohort study

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World Journal of Gastrointestinal Oncology 2020年第5期12卷 549-558页

作者： peter H Cashin Lana Ghanipour Malin Enblad David L morris Department of surgical sciences Section of SurgeryUppsala UniversityAkademiska SjukhusetUppsala 75185Sweden Department of surgery University of New South WalesSydney 2217New South WalesAustralia

BACKGROUND The implications of neutropenia after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy(HIPEC)treatment have never been *** To evaluate the occurrence of neutropenia and its effect on the risk of increased Clavien-Dindo morbidity as well as its effect on overall or disease-free *** All patients with colorectal peritoneal metastases(1996-2015)completing cytoreductive surgery and oxaliplatin-based HIPEC treatment from a biinstitutional database(Uppsala and sydney)were included in the ***-Dindo grade 3-4 morbidity differences between the neutropenia group vs nonneutropenia group were calculated and Kaplan-Meier curves with log rank test were *** and multivariable Cox regression models for diseasefree survival were *** Two hundred and forty-six patients were identified–32 postoperative any-grade neutropenia patients and 214 non-neutropenia *** neutropenia group had more combination oxaliplatin+irinotecan treatment than the nonneutropenia group(66%vs 13%,P=0.0001).The neutropenia group was not associated with increased Clavien-Dindo grade 3-4 *** overall survival was 53 mo vs 37 mo for the neutropenia and non-neutropenia group,P=*** disease-free survival was 16 mo vs 11 mo,respectively,P=*** was an independent prognostic factor for disease-free survival with hazard ratio:0.58,95%confidence interval:0.36-0.95,P=*** 13%of patients developed neutropenia which was not associated with increased Clavien-Dindo grade 3-4 *** was an independent positive prognostic factor for disease-free survival and was associated with more intense HIPEC *** is in direct contrast to the current paradigm of decreasing the treatment intensity.

关键词： Colorectal cancer Peritoneal metastases Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Oxaliplatin Neutropenia

Links between global CO_2 variability and climate anomalies of biomes

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science China Earth sciences 2008年第5期51卷 740-747页

作者： peter s. BAKWIN school of Earth and Environmental sciences Queens College City University of New York New York 11367 USA

The global rate of fossil fuel combustion continues to rise, but the amount of CO2 accumulating in the atmosphere has not increased accordingly. The causes for this discrepancy are widely debated. Par- ticularly, the location and drivers for the interannual variability of atmospheric CO2 are highly uncertain. Here we examine links between global atmospheric CO2 growth rate (CGR) and the climate anomalies of biomes based on (1986―1995) global climate data of ten years and accompanying satellite data sets. Our results show that four biomes, the tropical rainforest, tropical savanna, C4 grassland and boreal forest, and their responses to climate anomalies, are the major climate-sensitive CO2 sinks/sources that control the CGR. The nature and magnitude by which these biomes respond to climate anomalies are generally not the same. However, one common influence did emerge from our analysis; the ex- tremely high CGR observed for the one extreme El Nio year was caused by the response of the tropical biomes (rainforest, savanna and C4 grassland) to temperature.

关键词： biomes carbon cycle climate anomaly NDVI El Nio

Localized CO_2 laser bonding process for MEMs packaging

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中国有色金属学会会刊：英文版 2006年第B2期16卷 577-581页

作者： sUN Li A. P. MALsHE s. CUNNINGHAM A. morris Department of Mechanical Engineering University of Arkansas Fayetteville AR 72701 USA wispry Inc. Irvine CA 92618 USA wispry Inc. Cary NC 27513 USA

The packaging poses a critical challenge for commercialization of MEMs products. Major problems with the packaging process include degraded reliability caused by the excess stress due to thermal mismatch and altered performance of the MEMs device after packaging caused by thermal exposure. The localized laser bonding technique for ceramic MEMs packaging to address above-mentioned challenges was investigated. A continuous wave CO2 laser was used to locally heat sealing material for ceramic MEMs package lid to substrate bonding. To determine the laser power density and scanning speed, finite element analysis thermal models were constructed to simulate the localized laser bonding process. Further, the effect of external pressure at sealing ring on the bonding formation was studied. Pull testing results show that the scanning speed and external pressure have significant influence on the pull strength at the bonding interface. Cross-sectional microscopy of the bonding interface indicates that the packages bonded with relatively low scanning speed and external pressure conditions have higher bonding quality. This research demonstrates the potential of localized laser bonding process for ceramic MEMs packaging.

关键词：微电子机械系统 MEMs 封装局部激光焊接过程有限元分析

Reply to Letter by Dr. Christoph Kupferschmid： Commentary on ＂Countries with high circumcision prevalence have lower prostate cancer mortality＂

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Asian Journal of Andrology 2016年第6期18卷 950-951页

作者： Mitchell s Wachtel shengping Yang Brian J morris Texas Tech University Health sciences Center Lubbock Texas USA school of Medical sciences University of Sydney Sydney New South Wales Australia

Dear Editor, We thank Dr. Kupferschmid for his interest in our study, which examined male circumcision （MC） and prostate cancer mortality〉2 Considerable strong evidence has been accumulated since 1951.3 Most of his references4-10 do not address MC and the risk of death from prostate cancer. That is a different question than MC and the risk of developing prostate cancer, which none of his references validly assess. One reference addressed bacterial colonization,6 not prostate cancer. Another7 concerned sexually transmitted infections and prostate cancer.

关键词： @@

Numerical study on the Influence Mechanism of Inlet Distortion on the stall Margin in a Transonic Axial Rotor

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Journal of Thermal science 2012年第3期21卷 209-214页

作者： scott C.morris Hessert Laboratory Department of Mechanical and Aerospace EngineeringUniversity of Notre Dame

A numerical study is conducted to investigate the influence of inlet flow condition on tip leakage flow (TLF) and stall margin in a transonic axial rotor.A commercial software package FLUENT,is used in the *** rotor investigated in this paper is ND_TAC rotor,which is the rotor of one-stage transonic compressor in the University of Notre *** varied inlet flow conditions are *** inlet boundary condition with hub distortion provides higher axial velocity for the incoming flow near tip region than that for the clean inflow,while the incoming main flow possesses lower axial velocity near the tip region at tip distortion inlet boundary *** the total pressure ratio curves for the three inlet flow conditions,it is found that the hub dis-torted inlet boundary condition improves the stall margin,while the tip distorted inlet boundary condition dete-riorates compressor *** axial location of interface between tip leakage flow (TLF) and incoming main flow (MF) in the tip gap and the axial momentum ratio of TLF to MF are further *** is demonstrated that the axial momentum balance is the mechanism for interface *** hub distorted inflow could de-crease the axial momentum ratio,suppress the movement of the interface between TLF and MF towards blade leading edge plane and thus enhance compressor stability.

关键词： Inlet distortion tip leakage flow stall margin axial momentum balance

7．0T功能MR波谱动态定量检测视觉皮层代谢物对视觉刺激的反应

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中华放射学杂志 2012年第10期46卷 875-880页

作者：林艳 morris peter 吴仁华汕头大学医学院第二附属医院医学影像科 515041 英国诺丁汉大学sir peter Mansfield磁共振中心

目的采用超高场强（7．0T）功能MR波谱（fMRs），动态定量检测人脑枕叶视觉皮层代谢物对视觉刺激的反应，探讨人脑在功能活动状态下的能量代谢和神经递质传递的活动情况。方法9名健康志愿者参与本次试验。采用人体7．0TMR扫描仪及16通... 详细信息

目的采用超高场强（7．0T）功能MR波谱（fMRs），动态定量检测人脑枕叶视觉皮层代谢物对视觉刺激的反应，探讨人脑在功能活动状态下的能量代谢和神经递质传递的活动情况。方法9名健康志愿者参与本次试验。采用人体7．0TMR扫描仪及16通道敏感相位编码技术（sENsE）头线圈。首先进行fMRI检查，明确视觉皮层的最大激活区。然后进行。H-MRs检查，ROI为2cm×2cm×2cm，定位于视觉皮层最大激活层面。采用短TE激励回波采集模式（sTEAM）序列采集波谱数据，^1H-MRs扫描过程中同时给予受试者与fMRI检查相同的视觉刺激。运用线性拟合模型（LCModel）以水为内标准，分别测定各代谢物在静息期和刺激期的绝对浓度。采用配对设计数据的Wilcoxon符号秩和检验比较各代谢物浓度在刺激前后差异是否有统计学意义。结果视觉刺激状态下，天冬氨酸、谷氨酰胺及甘氨酸的浓度分别为（3．20±0．28）、（2．07±0．10）和（1．65±0．11）μmol／g，较静息期[分别为（3．52±0．28）、（2．25±0．10）和（1．85±0．11）μmol／g]降低，差异有统计学意义（Z值分别为-2．073、-2．073、-2．429，P值均〈0．05）。谷氨酸、谷胱甘肽及乳酸的浓度分别为（11．50±0．11）、（2．45±0．10）和（0．89±0．05）μmol／g，较静息期[分别为（11．28±0．11）、（2．28±0．10）和（0．79±0．05）μmol／g]升高，差异有统计学意义（Z值分别为2．521、2．310、2．016，P值均〈0．05）。葡萄糖浓度[（1．54±0．23）μmol／g]在刺激状态下有降低趋势，但与静息期[（1．78±0．28）μmol／g]比较差异无统计学意义（Z=-1．897，P〉0．05）。结论7．0TfMRs结合LCModel可以定量检测人脑视觉皮层多种代谢物对视觉刺激的反应变化。视觉刺激状态下，激活区乳酸、葡萄糖和天冬氨酸的变化提示脑能量代谢水平的升高；谷氨酸升高伴随谷氨酰胺下降可能提示兴奋性神经递质传递活动的改变；谷胱甘肽升高则提示脑激活状态下抗氧自由基活动增强。

关键词：磁共振波谱学视觉能量代谢

Fabrication of sub-20 nm Mos_(2) horizontal nanowire on silicon substrates by inclusion of precursors into polystyrene-bpolyethylene oxide nanopatterns: Detailed structural investigation

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Nano Research 2024年第3期17卷 2145-2153页

作者： Tandra Ghoshal Michael A.morris school of Chemistry AMBER and CRANNTrinity College DublinDublinIrelandD02 AK60

Herein,we demonstrate the fabrication of sub-20 nm Mos_(2) horizontal nanowire arrays on silicon substrates using a self-assembled block copolymer assisted in situ inclusion *** separated long-range ordered polystyrene-b-polyethylene oxide(Ps-b-PEO)block copolymer(BCP)line-space nanopatterns were achieved through thermo-solvent *** patterns produced had long-range order and domain sizes>1μ*** BCP structures were lightly etched and modified by anhydrous ethanol to facilitate insertion of molybdenum precursor within the film maintaining the parent BCP *** ordered molybdenum oxide nanowire arrays were then fabricated by ultraviolet(UV)/ozone treatment at room *** oxides were converted to sulphides by thermal evaporation at different temperatures in Ar/H_(2) environment.X-ray photoelectron spectroscopy revealed the composition and phases of the molybdenum oxide and sulphide *** mapping was performed to investigate the interfaces between the oxide and sulphide nanowires with the substrate *** formation and stability of the sulphide nanowires were studied at different *** photoluminescence and Raman properties were studied at different formation temperatures to investigate defects and estimate the number of layers.

关键词： Mos_(2) block copolymer nanowires inclusion X-ray photoelectron spectroscopy(XPs) mapping photoluminescence