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The influence of non-bound amino acid inclusions and starch-protein digestive dynamics on growth performance of broiler chickens offered wheat-based diets with two crude protein concentrations

2001年

作者： peter n. Stearns

来源：畅想之星图书光盘版（南... 评论

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Animal nutrition 2023年第4期15卷 399-408页

作者： Shemil P.Macelline Michael T.Kidd peter V.Chrystal Mehdi Toghyani peter H.Selle Sonia Y.Liu Poultry Research Foundation The University of SydneyCamden NSW 2570Australia School of Life and Environmental Sciences Faculty of ScienceThe University of SydneySydney NSW 2006Australia Center of Excellence for Poultry Science University of ArkansasFayettevilleAR 72701USA Complete Feed Solutions Howick2145New Zealand Sydney School of Veterinary Science The University of SydneySydney NSW 2006Australia

The primary objective of this study was to investigate the influence of high and low inclusions of nonbound amino acid(nBAA)in standard and reduced-crude protein(CP),wheat-based diets on growth performance in broiler *** treatments were formulated to either 210 or 180 g/kg ***210 g/kg CP diets contained either 12.1 or 21.1 g/kg nBAA and 180 g/kg CP diets contained either 44.0 or55.5 g/kg *** formulations also generated different dietary starch:protein ratios which impacted on starch-protein digestive *** of the four dietary treatments were offered to 7 replicates of15 birds housed in floor pens from 14 to 35 days post-hatch or a total of 420 male Ross 308 *** performance,relative abdominal fat-pad weights,breast muscle and leg shank yields were *** starch and protein(n)digestibility coefficients,disappearance rates and starch:protein disappearance rate ratios were *** ileal digestibility coefficients and disappearance rates of 16 amino acids were determined at 35 days post-hatch and free concentrations of 20 amino acids in systemic plasma were determined at 34 days *** transition from 210 to 180 g/kg CP diets depressed weight gain by 11.3%(1742 versus 1964 g/bird)and FCR by 10.4%(1.606 versus 1.455),although both parameters were subject to treatment *** treatment interaction(PnBAA inclusions significantly improved FCR by 4.17%(1.424 versus1.486)in birds offered 210 g/kg CP diets,but significantly depressed FCR by 3.36%(1.632 versus 1.579)in180 g/kg CP diets.A quadratic relationship(r=0.860;Pn dietary nBAA inclusions and FCR was detected,which indicated that when nBAA inclusions exceed 18.5 g/kg efficiency of feed conversion ***,a multiple linear regression(r=0.913;PnBAA inclusions and analysed dietary starch:protein ratios were significantly(P<0.001)related to ***

关键词： Amino acid Broiler non-bound amino acid Reduced-crude protein

The organization and function of the Golgi apparatus in dendrite development and neurological disorders

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Genes & Diseases 2023年第6期10卷 2425-2442页

作者： Meilan Chen Lu Xu Yi Wu peter Soba Chun Hu Key Laboratory of Brain Cognition and Education SciencesMinistry of Education Institute for BrainScience and RehabilitationSouth China Normal UniversityGuangzhouGuangdong 510631China Department of Ophthalmology Guangdong Second Provincial General HospitalGuangzhouGuangdong 510320China LIMES Institute Department of Molecular Brain Physiology and BehaviorUniversity of BonnBonn 53115Germany Institute of Physiology and Pathophysiology Friedrich-Alexander-Universität Erlangen-NürnbergErlangen 91054Germany

Dendrites are specialized neuronal compartments that sense, integrate and transfer information in the neural network. Their development is tightly controlled and abnormal dendrite morphogenesis is strongly linked to neurological disorders. While dendritic morphology ranges from relatively simple to extremely complex for a specified neuron, either requires a functional secretory pathway to continually replenish proteins and lipids to meet dendritic growth demands. The Golgi apparatus occupies the center of the secretory pathway and is regulating posttranslational modifications, sorting, transport, and signal transduction, as well as acting as a non-centrosomal microtubule organization center. The neuronal Golgi apparatus shares common features with Golgi in other eukaryotic cell types but also forms distinct structures known as Golgi outposts that specifically localize in dendrites. However, the organization and function of Golgi in dendrite development and its impact on neurological disorders is just emerging and so far lacks a systematic summary. We describe the organization of the Golgi apparatus in neurons, review the current understanding of Golgi function in dendritic morphogenesis, and discuss the current challenges and future directions.

关键词： Dendrite Golgi Golgi outposts Microtubule neurodevelopmental disorders Secretory pathway

Diagnosis in bile acid-CoA:Amino acid n-acyltransferase deficiency

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World Journal of Gastroenterology 2012年第25期18卷 3322-3326页

作者： nedim Hadzi Laura n Bull peter T Clayton AS Knisely Paediatric Liver Service and Institute of Liver Studies King's College HospitalLondon SE5 9RSUnited Kingdom Liver Center Laboratory University of California San FranciscoSan FranciscoCA 94110United States Biochemistry Research Group Clinical and Molecular Genetics UnitUniversity College London Institute of Child HealthLondon WC1 N1EHUnited Kingdom Institute of Liver Studies King's College HospitalLondon SE5 9RSUnited Kingdom

Cholate-CoA ligase(CCL) and bile acid-CoA:amino acid n-acyltransferase(BAAT) sequentially mediate bile-acid *** can cause intrahepatic *** has required gene *** assessed potential clinical utility of immunostaining of liver for CCL and *** commercially available antibodies against BAAT and CCL,we immunostained liver from an infant with jaundice,deficiency of amidated bile acids,and transcription-terminating mutation in *** was normally *** expression was not *** may facilitate diagnosis in bileacid amidation defects.

关键词：酰基转移酶胆汁酸辅酶A 氨基酸诊断缺乏症免疫组化染色 CCL

Optical properties of excitons in strained Ga_x In_1-x As/GaAs quantum dot: effect of geometrical confinement on exciton g-factor

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Chinese Optics Letters 2013年第8期11卷 80-86页

作者： n. R. Senthil Kumar A. John peter Chang Woo Lee Department of Physics RVS School of Engineering College Department of Physics Govt.Arts College Department of Chemical Engineering and Green Energy Center College of EngineeringKyung Hee University

Taking into account anisotropy, nonparabolicity of the conduction band, and geometrical confinement, we discuss the heavy-hole excitonic states in a strained GaxIn1-xAs/GaAs quantum dot for various Ga alloy contents. The strained quantum dot is considered as a spherical InAs dot surrounded by a GaAs barrier material. The dependence of the effective excitonic g-factor as a function of dot radius and Ga ion content is numerically measured. Interband optical energy with and without the parabolic effect is computed using structural confinement. The interband matrix element for different Ga concentrations is also calculated. The oscillator strength of interband transitions on the dot radius is studied at different Ga concentrations in the GaxIn1-xAs/GaAs quantum dot. Heavy-hole excitonic absorption spectra are recorded for various Ga alloy contents in the GaxIn1-xAs/GaAs quantum dot. Results show that oscillator strength diminishes when dot size decreases because of the dominance of the quantum size effect. Furthermore, exchange enhancement and exchange sDlitting increase as exciton confinement inereases.

关键词： GaAs effect of geometrical confinement on exciton g-factor Optical properties of excitons in strained Gax In1-x As/GaAs quantum dot

Contemporary outcomes of patients undergoing robotic-assisted radical cystectomy:A comparative analysis between intracorporeal ileal conduit and neobladder urinary diversions

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Asian Journal of Urology 2023年第4期10卷 446-452页

作者： Jordan M.Rich Shivaram Cumarasamy Daniel Ranti Etienne Lavallee Kyrollis Attalla John P.Sfakianos nikhil Waingankar peter n.Wiklund Reza Mehrazin Department of Urology Icahn School of Medicine at Mount SinaiNew YorkNYUSA Department of Urology Karolinska University HospitalSolnaSweden

Objective We aimed to compare perioperative and oncologic outcomes for patients undergoing robotic-assisted radical cystectomy(RARC)with intracorporeal ileal conduit(IC)and neobladder(nB)urinary *** Patients undergoing RARC with intracorporeal urinary diversion between January 2017 and January 2022 at the Icahn School of Medicine at Mount Sinai,new York,nY,USA were *** demographics,clinical characteristics,perioperative,and oncologic outcomes were *** was estimated with Kaplan-Meier *** Of 261 patients(206[78.9%]male),190(72.8%)received IC while 71(27.2%)received nB *** age was greater in the IC group(71[interquartile range,IQR 65-78]years vs.64[IQR 59-67]years,pnd BMI was 26.6(IQR 23.2-30.4)kg/m^(2).IC group was more likely to have prior abdominal or pelvic radiation(15.8%vs.2.8%,p=0.014).American Association of Anesthesiologists scores were comparable between *** IC group had a higher proportion of patients with pathological tumor stage 2(pT2)tumors(34[17.9%]vs.10[14.1%],p=0.008)and pathological node stages pn2-n3(28[14.7%]vs.3[4.2%],pn operative time(272[IQR 246-306]min vs.341[IQR 303-378]min,pnd estimated blood loss(250[150-500]mL vs.325[200-575]mL,p=0.002).Thirty-and 90-day complication rates were 44.4%and 50.2%,respectively,and comparable between ***-Dindo grades 3-5 complications occurred in 27(10.3%)and 34(13.0%)patients within 30 and 90 days,respectively,with comparable rates between *** follow-up was 324(IQR 167-552)days,and comparable between ***-Meier estimate for overall survival at 24 months was 89%for the IC cohort and 93%for the nB cohort(hazard ratio 1.23,95%confidence interval 1.05-2.42,p=0.02).Kaplan-Meier estimate for recurrence-free survival at 24 months was 74%for IC and 87%for nB(hazard ratio 1.81,95%confidence interval 0.82-4.04,p=0.10).Conclusion Patients undergoing intracorporeal IC urinary

关键词： Robotic Radical cystectomy Intracorporeal Ileal conduit neobladder Urinary diversion Oncologic outcome

Peri-Gondwanan terranes in the Romanian Carpathians:A review of their spatial distribution,origin,provenance,and evolution

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Geoscience Frontiers 2014年第3期5卷 395-411页

作者： Ioan Balintoni Constantin Balica Mihai n.Ducea Horst-peter Hann Department of Geology Babes-Bolyai University400084 Cluj-NapocaRomania Department of Geosciences The University of Arizona1040 E.4th StreetTucsonAZ 85721USA Faculty of Geology and Geophysics Bucharest UniversityStr.N.Balcescu Nr 1BucurestiRomania Institut fr Geowissenschaften Universitt Tbingen72076 TbingenGermany

The basement of the Romanian Carpathians is made of neoproterozoic to early Paleozoic peri- Gondwanan terranes variably involved in the Variscan orogeny, similarly to other basement terrains of Europe. They were hardly dismembered during the Alpine orogeny and traditionally have their own names in the three Carpathian areas. The Danubian domain of the South Carpathians comprises the Dragsan and Lainici-Paiius peri-Amazonian terranes. The Dragsan terrane originated within the ocean surrounding Rodinia and docked with Rodinia at -800 Ma. It does not contain Cadomian magmatism and consequently it is classified as an Avalonian extra-Cadomian terrane, The Lainici-Pfiius terrane is a Ganderian fragment strongly modified by Cadomian subduction-related magmatism, It is attached to the Moesia platform. The TisoviD terrane is an ophiolite that marks the boundary between Drfagsan and Lainici-Paius terranes. The other basement terranes of the Romanian Carpathians originated close to the Ordovician north- African orogen, as a result of the eastern Rheic Ocean opening and closure. Except for the Sebes-Lotru terrane that includes a lower metamorphic unit of Cadomian age, all the other terranes （Bretila, Tulghes, negrisoara and Rebra in the East Carpathians, Somes, Biharia and Baia de Aries in the Apuseni mountains, Fagaras, Leaota, Carat and Pades in the South Carpathians） represent late Cambrian-Ordovician rock assemblages. Their provenance, is probably within paleo-nortbeast Africa, close to the Arabian-nubian shield. The late Cambrian-Ordovician terranes are defined here as Carpathian-type terranes. According to their lithostratigraphy and origin, some are of continental margin magmatic arc setting, whereas others formed in rift and back-arc environment and closed to passive continental margin settings. In a paleo- geographic reconstruction, the continental margin magmatic arc terranes were first that drifted out, followed by the passive continental margin terranes with the b

关键词： Romanian Carpathians pre-Alpine terranes U-Pb Geochronology Avalonian-type and Carpathian-type terranes Tornquist Rheic and Paleotethyan sutures Ordovician north-African orogen

Phylogenetic Relationships of 3/3 and 2/2 Hemoglobins in Archaeplastida Genomes to Bacterial and Other Eukaryote Hemoglobins

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Molecular Plant 2011年第1期4卷 42-58页

作者： Serge n. Vinogradov Ivan Fernandez David Hoogewijs Rail Arredondo-peter Department of Biochemistry and Molecular Biology Wayne State University School of Medicine Detroit MI 48201 USA Laboratorio de Biofisica y Biologia Molecular Facultad de Ciencias Universidad Autonoma del Estado de Morelos 62210 Cuernavaca Morelos Mexico Institute of Physiology and Zurich Center for Integrative Human Physiology (ZIHP) University of Zurich Zurich Switzerland

Land plants and algae form a supergroup, the Archaeplastida, believed to be monophyletic. We report the results of an analysis of the phylogeny of putative globins in the currently available genomes to bacterial and other eu- karyote hemoglobins （Hbs）. Archaeplastida genomes have 3/3 and 2/2 Hbs, with the land plant genomes having group 2 2/ 2 Hbs, except for the unexpected occurrence of two group 1 2/2 Hbs in Ricinus communis. Bayesian analysis shows that plant 3/3 Hbs are related to vertebrate neuroglobins and bacterial flavohemoglobins （FHbs）. We sought to define the bacterial groups, whose ancestors shared the precursors of Archaeplastida Hbs, via Bayesian and neighbor-joining anal- yses based on COBALTalignment of representative sets of bacterial 3/3 FHb-like globins and group I and 2 2/2 Hbs with the corresponding Archaeplastida Hbs. The results suggest that the Archaeplastida 3/3 and group 1 2/2 Hbs could have orig- inated from the horizontal gene transfers （HGTs） that accompanied the two generally accepted endosymbioses of a pro- teobacterium and a cyanobacterium with a eukaryote ancestor. In contrast, the origin of the group 2 212 Hbs unexpectedly appears to involve HGT from a bacterium ancestral to Chloroflexi, Deinococcales, Bacilli, and Actinomycetes. Furthermore, although intron positions and phases are mostly conserved among the land plant 3/3 and 2/2 globin genes, introns are absent in the algal 3/3 genes and intron positions and phases are highly variable in their 2/2 genes. Thus, introns are irrelevant to globin evolution in Archaeplastida.

关键词： Algae Archaeplastida evolution hemoglobin land plants truncated Hbs

High Responsivity and Ultra-Low Detection Limits in nonlinear a-Si:H p-i-n Photodiodes Enabled by Photogating

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Photonic Sensors 2023年第4期13卷 27-38页

作者： Andreas BABLICH Maurice MÜLLER Rainer BORnEMAnn Andreas nACHTIGAL peter HARInG BOLÍVAR Institute of Graphene-Based nanotechnology University of SiegenHölderlinstr.357076 SiegenGermany Institute of High Frequency and Quantum Electronics University of SiegenHölderlinstr.357076 SiegenGermany

Photodetectors operating at the wavelength in the visible spectrum are key components in high-performance optoelectronic *** this work,massive nonlinearities in amorphous silicon p-i-n photodiodes enabled by the photogating are presented,resulting in responsivities up to 744 mA/W at blue *** detectors exhibit significant responsivity gains at optical modulation frequencies exceeding MHz and a more than 60-fold enhanced spectral response compared to the non-gated *** detection limits down to 10.4 nW/mm^(2) and mean signal-to-noise ratio enhancements of 8.5dB are demonstrated by illuminating the sensor with an additional 6.6μW/mm^(2) red ***-optical simulations verify photocarrier modulation due to defect-induced field screening to be the origin of such high responsivity *** experimental results validate the theory and enable the development of commercially viable and complementary metal oxide semiconductor(CMOS)compatible high responsivity photodetectors operating in the visible range for low-light level imaging and detection.

关键词： Photogating amorphous silicon a-Si:H nonlinearity photodetector responsivity gain

Update of endoscopy in liver disease:More than just treating varices

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World Journal of Gastroenterology 2012年第5期18卷 401-411页

作者： Christoforos Krystallis Gail S Masterton peter C Hayes John n Plevris Centre for Liver and Digestive Disorders The Royal InfirmaryUniversity of EdinburghEdinburgh EH16 4SAUnited Kingdom

The management of complications in liver disease is often complex and *** has undergone a period of rapid expansion with numerous novel and specialized endoscopic modalities that are of increasing value in the investigation and management of the patient with liver *** this review,relevant literature search and expert opinions have been used to provide a brief overview and update of the current endoscopic management of patients with liver disease and portal *** main areas covered are safety of endoscopy in patients with liver disease,the use of standard endoscopy for the treatment of varices and the role of new endoscopic modalities such as endoscopic ultrasound,esophageal capsule,argon plasma coagulation,spyglass and endomicroscopy in the investigation and treatment of liver-related gastrointestinal and biliary *** is clear that the role of the endoscopy in liver disease is well beyond that of just treating *** the technology in endoscopy expands,so does the role of the endoscopist in liver disease.

关键词：静脉曲张内镜治疗肝病肝脏疾病文献检索使用标准挑战性