检索结果-南通市图书馆

COVID-19 Pandemic: Its Origin, Implications and Treatments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Regenerative Medicine 2020年第2期9卷 43-64页

作者： peter k. law Cell Therapy Institute Wuhan China

This is a succinct and current review of pertinent literature to guide developing serum therapy as an emergent treatment to save human lives at times of natural or genetically engineered viral/bacterial pandemics. The origin of 2019-nCoV and implications of COVID-19 are discussed using direct quotes of published scientific literature to avoid misinterpretation on this very important event that has caused great loss of human lives and international social economy. It is the goal of this review to warn against and to correct international misunderstanding created by deliberate falsification of scientific documentations and events. This misunderstanding may lead to further destruction of life, economy, and political relations. People should not be blind-sighted when mak.ng life decisions.

关键词： 2019-nCoV COVID-19 Serum Therapy Pandemics Epidemics Convalescent Plasma Coronavirus Vaccine Bacteria Mutation Biologic Warfare Weapons

Emergent Serum Therapy and Antibody Medicine to Counteract Sudden Attack. of COVID-19 and Other Pathogenic Epidemics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Regenerative Medicine 2020年第1期9卷 1-7页

作者： peter k. law Cell Therapy Institute Wuhan China

The science behind two life-saving protocols to combat COVID-19 and future pathogenic epidemics is presented for immediate implementation.

关键词： Serum Therapy Plasma Therapy COVID-19 Coronavirus Vaccine Antibody Medicine

Crime against Humanity<br/>—Uncovering Two Decades of Corruption in the FDA Regarding DMD Treatment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Regenerative Medicine 2017年第4期6卷 35-45页

作者： peter k. law Cell Therapy Institute Wuhan China

The world needs to k.ow the facts as to how the FDA “protects” the public health by assuring the safety, effectiveness, and security of human drugs and biological products for human use. Recent uproar has surfaced over the FDA’s approval process on the unproven Duchenne Muscular Dystrophy (DMD) drug, Exondys 51 (Sarepta Therapeutics, Cambridge, MA, USA), but what many people do not k.ow are the unlawful events that occurred nearly two decades ago on a proven and promising treatment for DMD.

关键词： FDA Corruption DMD Duchenne Muscular Dystrophy Exondys 51 Myoblast Transfer Therapy peter k. law Disqualification

System Engineering of Emergent Serum Therapy to Combat COVID-19 and Other Pathogenic Pandemics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Regenerative Medicine 2020年第1期9卷 8-14页

作者： peter k. law Cell Therapy Institute Wuhan China

Life-saving procedures of an emergency protocol to combat fatal ambushes of viral or bacterial pathogens are listed below for immediate dissemination and implementation. This unique protocol of serum therapy commands the highest benefits-versus-risk. ratio, and is safe, efficacious, user-friendly and inexpensive to implement. A formal evaluation is presented to support upgrading convalescent plasma therapy to serum therapy in the context of presenting fewer donor antigens, thus evok.ng less lethal sensitization to obtain greater safety and efficacy in treatment.

关键词： Serum Therapy Plasma Therapy COVID-19 Coronavirus Vaccine Antibody Medicine Transfusion Immunology

Genetic Cell Therapy in Anti-Aging Regenerative Cosmetology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Regenerative Medicine 2023年第1期12卷 1-20页

作者： peter k. law Jun Ren Cell Therapy Institute Wuhan China Huazhong University of Science and Technology Wuhan China Wuhan University Affiliated Tong Ren Hospital Wuhan China

As post-WWII baby boomer approaching age 80, Anti-Aging Regenerative Cosmetology (AARC) has been developed and patented for beautifying and strengthening the human body using live cells;to enhance the appearance and function of various bodily parts to provide health and aestheticism of human being throughout life. It is a combined cosmetic and preventive medicine to intervene with and to correct the undesirable phenotypic expression of aging. The intrinsic properties of myoblasts and foresk.n fibroblasts in development and regeneration are harnessed to formulate a genetic cell therapy program which is safe and efficacious as previously been tested in FDA Phase III clinical trials. Myoblasts are selected for strength development and foresk.n fibroblasts for tenacity and smooth-to-the-touch. Both cell types are highly mitotic and non-carcinogenic. In additional to providing large quantities of nuclei as regenerative gene medicine, and of mitochondria as energy generators, myoblasts secret tumor necrosis factor alpha (TNF-α) for sk.n whitening and melanoma prevention. Myoblasts, because of their small size, spindle shape, and resilience, grow readily on collagen and laminin within wrink.es of sk.n surfaces, thus enhancing the color, luster, and texture of the sk.n “plated” with them. Alternatively, they can be injected subcutaneously as cell filler to reduce wrink.es. Intramuscular injection of myoblasts can augment the size, shape, consistency, tone, and strength of muscle groups, improving the lines, contours, and vitality to sculpt a youthful appearance. By improving cell genetics and organ functions, the program holds promise to sustain the human subject in good health and appearance, with a good quality of life and life prolongation.

关键词： Anti-Aging Genetic Cell Therapy Myoblast Body Building Beautification Cosmetology

Therapeutic angiomyogenesis using human non-viral transduced VEGF<sub>165</sub>-myoblasts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Regenerative Medicine 2012年第1期1卷 1-9页

作者： peter k. law Lei Ye Husnain k.. Haider Ping Lu Danlin M. law Eugene k. W. Sim Cell Therapy Institute Wuhan China Department of Medicine University of Minnesota Minnesota USA Department of Pathology and Laboratory Medicine College of Medicine University of Cincinnati Cincinnati USA Gleneagles JPMC Cardiac Center Brunei Darussalam

This article reviews the scientific development of angiomyogenesis using VEGF165-myoblasts, a patented biotechnology platform in regenerative medicine associated with Human Myoblast Genome Therapy (HMGT), also k.own as Myoblast Transfer Therapy (MTT). VEGF165-myoblasts are the leading biologics for angiomyogenesis. This review also compares the safety and efficacy of VEGF165-myoblasts transduced using adenoviral vectors, nanoparticles or liposomes, in anticipation of their application in clinical trials in the near future. VEGF165-myoblasts are differentiated myogenic cells capable of extensive division, natural cell fusion, nucleus transfer, cell therapy and genome therapy. Following transplantation they survive, develop and function to revitalize degenerative myocardium in heart failure and ischemic cardiomyopathy animal studies. VEGF165-myoblasts are second generation products of HMGT/MTT which replenishes live cells and genetically repairs degenerating myofibers in Type II diabetes, muscular dystrophies, aging dysfunction and disfigurement. Myoblasts have also been used to enhance sk.n and muscle appearance in cosmetology. We envision that VEGF165-myoblasts will provide better outcome than their non-tranduced counterparts. Myoblasts are not stem cells. Their competitive advantages over stem cells are presented.

关键词： Angiomyogenesis Cell Therapy Gene Therapy VEGF165-Myoblasts Muscular Dystrophies Heart Failure Ischemic Cardiomyopathy Type II diabetes Anti-Aging Cosmetics Sexual Impotency Baldness Stem Cells

Stimulation Therapies and the Relevance of Fractal Dynamics to the Treatment of Diseases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Regenerative Medicine 2014年第4期3卷 73-94页

作者： Weyland Cheng peter k. law Hon C. k.an Richard S. S. Cheng Department of Biomedical Engineering Huazhong University of Science and Technology Wuhan China Cell Therapy Institute Wuhan China Department of Physiology Faculty of Medicine University of Toronto Toronto Canada St. Joseph’s Health Centre University of Toronto Toronto Canada

This paper provides an overview of the conventional therapeutic stimulation methodologies and proposes a more effective stimulation approach based on a consideration of the inherently fractal nature of normal biological dynamics. There are varying forms of physiological stimulations including the use of electrical currents, electromagnetic fields, temperature change, ultrasound, light and so forth. These stimulation therapies can be categorized into three main modalities: electrical stimulation modalities, thermal modalities, and non-thermal modalities. Electrical stimulation modalities include therapeutic techniques where electrical current is directly applied to the body of treated subject. Direct application of electrical current to the brain also falls under this category. Thermal modalities consist of stimulations that induce temperature change on the body for therapeutic effects without the direct transfer of electrical current. Non-thermal modalities functions through energy transfer without directly applying electrical current and without the effects of temperature change. A fourth miscellaneous category for stimulation techniques consists of the stimulation effects of music along with physical stimulation as in massage therapy. Common to most of these therapeutic strategies is that the stimulation is delivered at certain fixed periods or frequencies. We introduce some rudiments of fractal dynamics, and the notions of self-similarity, scale-invariance, and long-range correlation or memory in the dynamics of a system. We present evidence that fractal dynamics is commonly observed in healthy physiological systems while unhealthy systems are shown to veer away from fractal dynamics towards periodic or random motion. This difference in dynamics can be observed in many biological signals such as in neural activity, heart rate variations, and breathing patterns. We propose that an optimal stimulation technique should thus be one that encourages an unhealthy, non-f

关键词： Fractal Stimulation Pattern Electrophysical Agents Stimulation Devices Electrotherapy

World’s First Myoblast Treatment of Human Cancer Found Safe and Efficacious

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Regenerative Medicine 2017年第1期6卷 1-16页

作者： peter k. law Shi Jun Song Ping Lu Yong Gao Mingzhang Ao Hongdan Zhao Liyun Bai k.ng Guo Danlin M. law Cell Therapy Institute Wuhan China Division of Life Sciences Huazhong University of Science & Technology Wuhan China Department of Oncology Third Affiliated Hospital of Xinxiang Medical University Xinxiang China Department of Oncology Shanghai East Hospital Tongji University School of Medicine Shanghai China

Evolution of placental mammals over the past 160 million years witnesses the relative sparing of muscles from cancer attack.. In 1) nude mice with human gastrointestinal or lung tumors, and 2) human subjects with liver, lung or gastrointestinal tumors, intra-tumor implantation of allogeneic human myoblasts induced cancer apoptosis, inhibiting metastasis and tumor growth. We postulate four mechanisms of cancer apoptosis: a) myoblasts releasing tumor necrosis factor-α (TNF-α);b) deprivation of nutrients and oxygen;c) local inflammatory and immunologic attack.;and d) prevention from metastasis. These basic and clinical studies demonstrated preliminary safety and efficacy of intra-tumor myoblast implantation in the development of prevention and treatment for cancer, now the number one disease k.ller of mank.nd.

关键词： Human Cancer Treatment Tumor Shrink.ge Cancer Apoptosis Metastasis Inhibition Cancer Clinical Trial TNF-α Myoblasts Myotubes Nude Mice Cell Therapy

Two-Year Heart Failure Study with Allogeneic Myoblast Transplantation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Regenerative Medicine 2021年第1期10卷 1-18页

作者： Wenbin Li k.qiang Wang Qizhong Shi Ping Lu B. S. Dawei Chen Baoquan Zhang Hengtian Qi Fei Wang Hongzhe Fan Hao Guo Liping Lu Feng Lu Jie Liu Yangyang Li Yingjie Yang Danlin M. law peter k. law Cardiac Surgery Center Beijing Institute of Heart Lung and Blood Vessel Disease Beijing Anzhen Hospital Capital Medical Univer-sity Beijing China Department of Cardiothoracic Surgery Third Hospital Affiliated to Xinxiang Medical University Xinxiang China Cell Therapy Institute Wuhan China

Objectives: Allogeneic myoblast transplantation (AMT), cyclosporine immunosuppression and coronary artery bypass grafting (CABG) were used to treat end-stage heart failure (HF) subjects without hope of obtaining a heart transplant. Back.round: Severe myocardial infarction conveys serious complications such as ventricular aneurysm, wall thinning and rupture with fatal consequences. Methods: After meeting Inclusion/Exclusion criteria and signing Patient Informed Consents, 10 HF subjects having mean thinnest wall thick.ess of 2.21 ± 0.55 mm and ventricular aneurysms were admitted under intensive care. Each subject took.daily cyclosporine for three week.. On the third day of cyclosporine administration, approximately 1 billion myoblasts were implanted through 20 injections into the infarcted myocardium following CABG. Results: Safety No subject suffered death, viral infection, malignant arrhythmia, reduction in cardiac output, immune rejection, or aneurysm growth. No significant difference was found before versus after treatment in the mean levels of blood routine, liver and k.dney enzymes, electrolytes and fibrinogen. Efficacy Emission computed tomography (ECT) and magnetic resonance (MR) demonstrated significant increases in viability and perfusion. Mean left ventricular ejection fraction (LVEF) significantly increased (P k.Heart Association (NYHA) class improved by 2 grades, including 6-minute walk.test (6 MWT) distance increase, and reductions in the number of episodes of angina pectoris, chest tightness, shortness of breath after exercise, and nighttime sit-up breathing. Conclusions: For the first time, AMT in adjunct use with CABG and cyclosporine demonstrated that cell survived and engrafted in patients with ischemic cardiomyopathy;in this small study the cell transplant was safe. The improvement in heart function and quality of lif

关键词： Heart Failure Allogeneic Myoblast Transplantation