Two-Year Heart Failure Study with Allogeneic Myoblast Transplantation

作     者：Wenbin Li Keqiang Wang Qizhong Shi Ping Lu B. S. Dawei Chen Baoquan Zhang Hengtian Qi Fei Wang Hongzhe Fan Hao Guo Liping Lu Feng Lu Jie Liu Yangyang Li Yingjie Yang Danlin M. Law Peter K. Law Wenbin Li;Keqiang Wang;Qizhong Shi;Ping Lu;B. S. Dawei Chen;Baoquan Zhang;Hengtian Qi;Fei Wang;Hongzhe Fan;Hao Guo;Liping Lu;Feng Lu;Jie Liu;Yangyang Li;Yingjie Yang;Danlin M. Law;Peter K. Law

作者机构：Cardiac Surgery Center Beijing Institute of Heart Lung and Blood Vessel Disease Beijing Anzhen Hospital Capital Medical Univer-sity Beijing China Department of Cardiothoracic Surgery Third Hospital Affiliated to Xinxiang Medical University Xinxiang China Cell Therapy Institute Wuhan China 

出 版 物：《Open Journal of Regenerative Medicine》 (再生医学期刊（英文）)

年 卷 期：2021年第10卷第1期

页      面：1-18页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Heart Failure Allogeneic Myoblast Transplantation 

摘      要：Objectives: Allogeneic myoblast transplantation (AMT), cyclosporine immunosuppression and coronary artery bypass grafting (CABG) were used to treat end-stage heart failure (HF) subjects without hope of obtaining a heart transplant. Background: Severe myocardial infarction conveys serious complications such as ventricular aneurysm, wall thinning and rupture with fatal consequences. Methods: After meeting Inclusion/Exclusion criteria and signing Patient Informed Consents, 10 HF subjects having mean thinnest wall thickness of 2.21 ± 0.55 mm and ventricular aneurysms were admitted under intensive care. Each subject took daily cyclosporine for three weeks. On the third day of cyclosporine administration, approximately 1 billion myoblasts were implanted through 20 injections into the infarcted myocardium following CABG. Results: Safety No subject suffered death, viral infection, malignant arrhythmia, reduction in cardiac output, immune rejection, or aneurysm growth. No significant difference was found before versus after treatment in the mean levels of blood routine, liver and kidney enzymes, electrolytes and fibrinogen. Efficacy Emission computed tomography (ECT) and magnetic resonance (MR) demonstrated significant increases in viability and perfusion. Mean left ventricular ejection fraction (LVEF) significantly increased (P Conclusions: For the first time, AMT in adjunct use with CABG and cyclosporine demonstrated that cell survived and engrafted in patients with ischemic cardiomyopathy;in this small study the cell transplant was safe. The improvement in heart function and quality of lif