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Does knowledge of physical activity recommendations increase physical activity among Chinese college students？ Empirical investigations based on the transtheoretical model

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journal of Sport and Health Science 2018年第1期7卷 77-82页

作者： Kahar Abula peter Gropel Kai Chen jürgen Beckmann Technical University of Munich Munchen 80992 Germany South West jiao Tong University Chengdu 611756 China

Background: Based on the transtheoretical model, the current study investigated whether awareness of physical activity(PA) recommendations had an impact on the stages of PA behavior change and levels of PA among Chinese college ***: In Study 1, with a cross-sectional study design, 9826 students were recruited, and their knowledge of international PA recommendations,PA stage distribution, and self-reported PA level were surveyed. Pearson's χ2 test was used to test whether those participants who were aware and not aware of PA guidelines were equally distributed across the stages of PA behavior, and independent t test was conducted to test the group difference in the actual levels of PA. In Study 2, 279 students who were not aware of the PA recommendations were randomly allocated to either an intervention group or a control group, and only those in the intervention group were presented with international PA guidelines. In both groups,students' PA stages and PA level were examined before the test and then 4 months post-test. Mc Nemar's test for correlated proportions and repeated-measures analysis of variance were conducted to examine the changes in PA stage membership and PA level after the ***: Study 1 results revealed that only 4.4% of the surveyed students had correct knowledge of PA recommendations. Those who were aware of the recommendations were in later stages of PA behavior(χ~2(4) = 167.19, p < 0.001). They were also significantly more physically active than those who were not aware of the recommendations(t(443.71) = 9.00, p < 0.001, Cohen's d = 0.53). Study 2 results demonstrated that the intervention group participants who were at the precontemplation and contemplation stages at the pre-test each progressed further in the PA stages in the post-test(χ~2(1) = 112.06, p < 0.001; χ~2(1) = 118.76, p = 0.03, respectively), although no significant change in PA level was observed(t(139) < 1, p = 0.89).Conclusion: The results showed that

关键词： Behavior change Physical activity level Physical activity recommendations Public health policy Stages of change Transtheoretical model

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Another look at social innovation:From community-For community

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International journal of Innovation Studies 2022年第2期6卷 92-101页

作者： Lisa j.Daniel peter jenner School of Business and Creative Industries University of the Sunshine CoastFraser CoastQueensland4655Australia

Social innovation(SI)continues to raise interest among scholars and policymakers,as a potential panacea for social disenfranchisement and civic *** is troubling is diverse perspectives of SI abound,creating inconsistencies in methodological approaches which confound theory *** paper clarifies that discussion by considering the locus of initiation and locus of benefit as informing characteristics that differentiate grounded social innovation from other types of well-recognized socially beneficent *** notion of‘from community e for community’is presented to aid understanding of the unique nature of authentically grounded social *** paper is significant as it presents a practical approach to help researchers and practitioners consider where opportunities for targeted policy support,institutional involvement,and agency action can aid community development and wellbeing.

关键词： Social innovation Community markets Social change Community development

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Neurological consequences of systemic inflammation in the premature neonate

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Neural Regeneration Research 2017年第6期12卷 890-896页

作者： Aparna Patra Hong Huang john A.Bauer peter j.Giannone OMNI Academic Service Line and Division of Neonatology Department of Pediatrics Kentucky Children's Hospital College of MedicineUniversity of Kentucky

Despite substantial progress in neonatal care over the past two decades leading to improved survival of extremely premature infants, extreme prematurity continues to be associated with long term neurodevelopmental impairments. Cerebral white matter injury is the predominant form of insult in preterm brain leading to adverse neurological consequences. Such brain injury pattern and unfavorable neurologic sequelae is commonly encountered in premature infants exposed to systemic inflammatory states such as clinical or culture proven sepsis with or without evidence of meningitis, prolonged mechanical ventilation, bronchopulmonary dysplasia, necrotizing enterocolitis and chorioamnionitis. Underlying mechanisms may include cytokine mediated processes without direct entry of pathogens into the brain, developmental differences in immune response and complex neurovascular barrier system that play a critical role in regulating the cerebral response to various systemic inflammatory insults in premature infants. Understanding of these pathologic mechanisms and clinical correlates of such injury based on serum biomarkers or brain imaging findings on magnetic resonance imaging will pave way for future research and translational therapeutic opportunities for the developing brain.

关键词： premature consequences inflammation prematurity extremely translational dysplasia sepsis necrotizing neurological

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Fungal-contaminated grass and well water and sporadic amyotrophic lateral sclerosis

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Neural Regeneration Research 2019年第9期14卷 1490-1493页

作者： peter William French Russell Ian Ludowyke Gilles j.Guillemin School of Medicine University of New South WalesSydneyNSWAustralia Willoughby SydneyNSWAustralia Neuroinflammation Group Department of Biological SciencesFaculty of Medicine and Health SciencesMacquarie UniversitySydneyNSWAustralia

Fungi are important infectious disease-causing agents,but are often overlooked as environmental factors in *** review several lines of evidence that point to a potential fungal origin of sporadic amyotrophic lateral sclerosis(ALS),the most common form of motor neurone *** 90%cases of ALS are sporadic,and the aetiology of sporadic ALS is still *** have previously postulated that grass or soil-associated fungal infections may be a leading cause of sporadic *** we extend this proposal to water-associated fungi.A wide variety of fungi have been reported in drinking water including Acremonium,Alternaria,Aspergillus,Cladosporium,Fusarium,Penicillium and *** of these are known to produce neurotoxic *** this,drinking water is not routinely monitored for fungal *** contamination could explain the close correlation between distribution of well water and cases of sporadic ALS in the United *** propose several mechanisms by which an opportunistic fungal infection from environmental exposure(to water,soil or plants)can lead to long term neuronal degradation resulting in the hallmarks of *** confirmed,the association between fungal infection and sporadic ALS could lead to novel treatment strategies for this progressive and fatal disease.

关键词： amyotrophic lateral sclerosis fungi motor neurone disease mycotoxins neurotoxins ALS well water sporadic ALS

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Novel oncogenes and tumor suppressor genes in hepatocellular carcinoma

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Liver Research 2021年第4期5卷 195-203页

作者： Fang Wang peter Breslin S j Wei Qiu Department of Surgery and Cancer Biology Loyola University Chicago Stritch School of MedicineMaywoodILUSA Department of Molecular/Cellular Physiology Cancer BiologyCardinal Bernardin Cancer CenterLoyola University Medical Centerand BiologyLoyola University ChicagoChicagoILUSA

Hepatocellular carcinoma(HCC)is a very deadly *** initiation and progression involve multiple genetic events,including the activation of proto-oncogenes and disruption of the function of specific tumor suppressor *** of oncogenes stimulates cell growth and survival,while loss-of-function mutations of tumor suppressor genes result in unrestrained cell *** this review,we summarize the new findings that identified novel proto-oncogenes and tumor suppressors in HCC over the past five *** findings may inspire the development of novel therapeutic strategies to improve the outcome of HCC patients.

关键词： Hepatocellular carcinoma(HCC) Oncogene Tumor suppressor Activation Loss-of-function

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Endoscopic Management of Pediatric Cholesteatoma

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journal of Otology 2020年第1期15卷 17-26页

作者： peter j.Ryan Nirmal P.Patel Department of Otolaryngology and Head and Neck Surgery Royal North Shore HospitalSt LeonardsNSWAustralia Kolling Deafness Research Centre Macquarie University and University of SydneyNSWAustralia

Pediatric cholesteatoma occurs in one of two forms:congenital cholesteatoma,developing from embryonic epidermal cell rests or acquired cholesteatoma,associated with a focal defect in the tympanic *** disease has been traditionally managed with the operating microscope,often requiring mastoidectomy for adequate visualization of and access to the middle ear and mastoid ***,advances in endoscopic equipment have enabled otologists to manage most cases of pediatric cholesteatoma via a minimally-invasive,transcanal endoscopic *** review discusses the current literature relating to the etiopathogenesis,assessment and endoscopic management of pediatric *** outcomes of endoscopic treatment,emerging trends and technologies are also reviewed.

关键词： Cholesteatoma Pediatric Endoscopic Minimally-invasive Middle ear Mastoid

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Aortic valve replacement reduces mortality in moderate aortic stenosis:a systematic review and meta-analysis

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journal of Geriatric Cardiology 2023年第1期20卷 61-67页

作者： Kyle B Franke Dimple Bhatia Ross L Roberts-Thomson peter j Psaltis Adelaide Medical School The University of AdelaideAdelaideAustralia Vascular Research Centre Lifelong Health ThemeSouth Australian Health and Medical Research InstituteAdelaideAustralia Department of Cardiology Royal Adelaide HospitalAdelaideAustralia

BACKGROUND With the introduction of transcatheter aortic valve replacement and an evolving understanding of the natural progression and history of aortic stenosis,the potential for earlier intervention in appropriate patients is promising;however,the benefit of aortic valve replacement in moderate aortic stenosis remains *** Pubmed,Embase,and the Cochrane Library databases were searched up until 30th of December 2021 using keywords including moderate aortic stenosis and aortic valve *** reporting all-cause mortality and outcomes in early aortic valve replacement(AVR)compared to conservative management in patients with moderate aortic stenosis were *** ratios were generated using random-effects meta-analysis to determine effect *** 3470 publications were screened with title and abstract review,which left 169 articles for full-text *** these studies,7 met inclusion criteria and were included,totalling 4,827 *** studies treated AVR as a time-dependent co-variable in cox-regression multivariate analysis of all-cause *** with surgical or transcatheter AVR was associated with a 45% decreased risk of all-cause mortality(HR=0.55[0.42-0.68],I2=51.5%,P<0.001).All studies were representative of the overall cohort with appropriate sample sizes,with no evidence of publication,detection,or information biases in any of the *** In this systematic review and meta-analysis,we report a 45% reduction in all-cause mortality in patients with moderate aortic stenosis who were treated with early aortic valve replacement compared to a strategy of conservative *** control trials are awaited to determine the utility of AVR in moderate aortic stenosis.

关键词： aortic stenosis analysis

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Early Warning Smartphone Diagnostics for Water Security and Analysis Using Real-Time pH Mapping

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Photonic Sensors 2015年第4期5卷 289-297页

作者： Md. Arafat HOSSAIN john CANNING Sandra AST peter j. RUTLEDGE Abbas jAMALIPOUR interdisciplinary Photonics Laboratories (iPL) School of Chemistry The University of Sydney NSW 2006 Australia School of Chemistry The University of Sydney NSW 2006 Australia Wireless Networking Group (WING) School of Electrical and Information Engineering The University of Sydney NSW2006 Australia

Early detection of environmental disruption, unintentional or otherwise, is increasingly desired to ensure hazard minimization in many settings. Here, using a field-portable, smartphone fluorimeter to assess water quality based on the pH response of a designer probe, a map of pH of public tap water sites has been obtained. A custom designed Android application digitally processed and mapped the results utilizing the global positioning system （GPS） service of the smartphone. The map generated indicates no disruption in pH for all sites measured, and all the data are assessed to fall inside the upper limit of local government regulations, consistent with authority reported measurements. This implementation demonstrates a new security concept： network environmental forensics utilizing the potential of novel smartgrid analysis with wireless sensors for the detection of potential disruption to water quality at any point in the city. This concept is applicable across all smartgrid strategies within the next generation of the Internet of Things and can be extended on national and global scales to address a range of target analytes, both chemical and biological.

关键词： Lab-in-a-phone Intemet of Things optical sensing and sensor smartphone sensor photonic sensor fluorescence water security

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Hepatocellular transport proteins and their role in liver disease

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World journal of Gastroenterology 2001年第2期7卷 157-169页

作者： Carmen Stanca Diana jung peter j.Meier Gerd A.Kullak-Ublick Division of Gastroenterology and Hepatology and Division of Clinical Pharmacology and Toxicology Department of Internal MedicineUniversity HospitalCH-8091 Zurich/Switzerland

MOLECULAR PHYSIOLLGY OF HEPATOCELLULAR TRANSPORT PROTEINS Basolaferal transport systems Na+-dependent bile salt uptake Uptake of bile salts into the liver was first isolated perfused rat liver[1],isolated hepatocyte... 详细信息

关键词： ATP-Binding Cassette Transporters Animals Carrier Proteins Hepatocytes Humans Liver Liver Diseases Organic Anion Transporters Organic Cation Transport Proteins Research Support, Non-U.S. Gov't

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Burn Injuries in Elderly—A Retrospective Analysis of a Ten Year Period

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Modern Plastic Surgery 2012年第2期2卷 13-19页

作者： Frank Siemers Eirini Liodaki Karl L. Mauss Felix H. stang Tobias von Wild peter Mailaender Plastic Surgery University Clinic Schleswig-Holstein Lubeck Germany

Objective: Geriatric patients represent a separate group in the treatment of burn injury regarding pathogenesis, pathophysiology and therapeutic procedure. Methods: From 2000 to 2010 on our burn unit 53 patients aged over 60 years were treated. The mean age of the 27 women and 26 men was 76 years (60 - 102 years), with an average of 33.2% of total burn surface area. 25 patients (47.2%) had severe inhalation injury, 77.4% of the patients suffered full thickness burn injuries. Mean ABSI Score was 12. Relevant additional diseases were coronary heart disease, heart insufficiency, hypertension, COPD, adiposity and chronic alcoholism. Results: 22 patients were treated by early operative intervention (day 0 - 4), 13 of these patients survived further process. In 17 cases first operative procedure could take place only at a later date, 14 patients deceased before operation. 26 patients developed pneumonia. The total morbidity amounted to 26 of 53 patients (49%). A total of 19 injured with a burn index over 80 survived. 9 of them had an index of more than 100. Usual indices as the “Zellweger Index” and the ABSI-Score are not adequate to determine the prognosis of thermal injuries in the elderly. Conclusion: The treatment of elderly with burn trauma is affected by many factors. Compared to younger patients the increased incidence of an inhalation injury is decisive for the prognosis of older patients. The frequency of pre-existing diseases is clearly largely than with younger burn injured patients. These prognostically relevant parameters were not sufficiently considered by established score systems.

关键词： Burn Injury Intensive Care Elderly

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