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国际医学放射学杂志 2024年第3期 371-371页

作者： j.S.Yi H.j.Ki Y.S.jeon j.j.park T.j.Lee j.T.Kwak 黄世豪

摘要目的旨在评估侧支图预测急性前循环缺血性脑卒中后病变进展和缺血半暗带的能力。方法从前瞻性收集的数据库中选定数据进行回顾性分析。基于扩散加权成像

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Why do‘OFF’periods still occur during continuous drug delivery in parkinson’s disease?

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Translational Neurodegeneration 2022年第1期11卷 280-293页

作者： Silvia Rota Daniele Urso Daniel j.van Wamelen Valentina Leta Iro Boura Per Odin Alberto j.Espay peter jenner K.Ray Chaudhuri Department of Basic and Clinical Neurosciences Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonLondonUK parkinson’s Foundation Centre of Excellence King’s College HospitalLondonUK Department of Neuroimaging Institute of PsychiatryPsychology and NeuroscienceKing’s College LondonLondonUK Centre for Neurodegenerative Diseases and the Aging Brain Department of Clinical Research in NeurologyUniversity of Bari‘Aldo Moro“Pia Fondazione Cardinale G.Panico”73039 TricaseItaly Donders Institute for Brain Cognition and BehaviourDepartment of NeurologyRadboud University Medical CentreNijmegenThe Netherlands School of Medicine University of CreteCreteGreece Department of Neurology University Hospital of HeraklionCreteGreece Division of Neurology Department of Clinical Sciences LundLund UniversityLundSweden University of Cincinnati Gardner Neuroscience Institute Gardner Family Center for Parkinson’s Disease and Movement DisordersDepartment of NeurologyUniversity of CincinnatiCincinnatiOHUSA Institute of Pharmaceutical Sciences Faculty of Life Science and MedicineKing’s College LondonLondonUK.

Continuous drug delivery(CDD)is used in moderately advanced and late-stage parkinson’s disease(PD)to control motor and non-motor fluctuations(‘OFF’periods).Transdermal rotigotine is indicated for early fluctuations,while subcutaneous apomorphine infusion and levodopa-carbidopa intestinal gel are utilised in advanced *** three strategies are considered examples of continuous dopaminergic stimulation achieved through CDD.A central premise of the CDD is to achieve stable control of the parkinsonian motor and non-motor states and avoid emergence of‘OFF’***,data suggest that despite their efficacy in reducing the number and duration of‘OFF’periods,these strategies still do not prevent‘OFF’periods in the middle to late stages of PD,thus contradicting the widely held concepts of continuous drug delivery and continuous dopaminergic *** these emergent‘OFF’periods still occur is *** this review,we analyse the potential reasons for their *** contribution of drug-and device-related involvement,and the problems related to site-specific drug delivery are *** propose that changes in dopaminergic and non-dopaminergic mechanisms in the basal ganglia might render these persistent‘OFF’periods unresponsive to dopaminergic therapy delivered via CDD.

关键词： ‘OFF’periods Continuous drug delivery Continuous dopaminergic stimulation Rotigotine patch Subcutaneous apomorphine infusion Levodopa-carbidopa intestinal gel

Global Reference Grids for Big Earth Data

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Big Earth Data 2022年第3期6卷 251-255页

作者： Robert G.Gibb Matthew B.j.Purss Zoheir Sabeur peter Strobl Tengteng Qu Manaaki Whenua–Landcare Research Palmerston NorthNew Zealand Pangaea Innovations Pty.Ltd CanberraAustralia Department of Computing and Informatics Talbot CampusUniversity of BournemouthBournemouthUK European Commission Joint Research Centre(JRC)IspraItaly College of Engineering Peking UniversityBeijingChina

The emerging field of Discrete Global Grid Systems(DGGS)provides a way to organise,store and analyse spatio-temporal data at multiple resolutions and scales(from near global scales down to microns).DGGS partition the entire planet into a discrete hierarchy of global tessellations of progressively finer resolution zones(or cells).Data integration,decomposition and aggregation are optimised by assigning a unique spatio-temporal identifier to each *** identifiers are encodings of both the zone’s location and its *** a result,complex multi-dimensional,multi-resolution spatio-temporal operations are simplified into sets of 1D array and filter operations.

关键词： operations simplified partition

Synchronization criteria for coupled Hopfield neural networks with time-varying delays

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Chinese Physics B 2011年第11期20卷 140-150页

作者： M.j.park O.M.Kwon ju H.park S.M.Lee E.j.Cha School of Electrical Engineering Chungbuk National University Department of Electrical Engineering Yeungnam University School of Electronic Engineering Daegu University Department of Biomedical Engineering School of MedicineChungbuk National University

This paper proposes new delay-dependent synchronization criteria for coupled Hopfield neural networks with time-varying delays. By construction of a suitable Lyapunov Krasovskii＇s functional and use of Finsler＇s lemma, novel synchronization criteria for the networks are established in terms of linear matrix inequalities （LMIs） which can be easily solved by various effective optimization algorithms. Two numerical examples are given to illustrate the effectiveness of the proposed methods.

关键词： Hopfield neural networks coupling delay synchronization Lyapunov method

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风能及其利用

风能及其利用

Designing an evidence-based free-flap pathway in head and neck reconstruction

1984年

作者：（美）派克（j.park）孙云龙译

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World journal of Otorhinolaryngology-Head and Neck Surgery 2022年第2期8卷 126-132页

作者： Michelle Mark Michael Eggerstedt Matthew j.Urban Samer Al-Khudari Ryan Smith peter Revenaugh Department of Otorhinolaryngology-Head and Neck Surgery Section of Facial Plastic and Reconstructive SurgeryRush University Medical CenterChicagoIllinoisUSA

Background:The use of autologous free-tissue transfer is an increasingly utilized tool in the ladder of reconstructive options to preserve and restore function in patients with head and neck *** article focuses on the evidence surrounding perioperative care that optimizes surgical outcomes and describes one tertiary center's approach to standardized free-flap *** Sources:This article examines English literature from PubMed and offers expert opinion on perioperative free-flap care for head and neck ***:Free-flap reconstruction for head and neck cancer is a process that,while individualized for each patient,is best supported by a comprehensive and standardized care *** optimization begins in the preoperative phase and a thoughtful approach to intraprofessional communication and evidence-based practice is rewarded with improved outcomes.

关键词： facial plastics and reconstruction free-flap tissue transfer head and neck oncology

Leader-following consensus criteria for multi-agent systems with time-varying delays and switching interconnection topologies

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Chinese Physics B 2012年第11期21卷 144-153页

We consider multi-agent systems with time-varying delays and switching interconnection topologies. By con- structing a suitable Lyapunov-Krasovskii functional and using the reciprocally convex approach, new delay-dependent consensus criteria for the systems are established in terms of linear matrix inequalities （LMIs）, which can be easily solved by using various effective optimization algorithms. Two numerical examples are given to illustrate the effectiveness of the proposed methods.

关键词： consensus multi-agent systems time delay Lyapunov method

Whatever happened to China’s neglected tropical diseases?

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Infectious Diseases of Poverty 2019年第5期8卷 1-3页

作者： peter j.Hotez Texas Children's Hospital Center for Vaccine Development Departments of Pediatrics and Molecular Virology&MicrobiologyNational School of Tropical MedicineBaylor College of MedicineHoustonTXUSA Hagler Institute for Advanced Studies at Texas A&M University College StationTXUSA Department of Biology Baylor UniversityWacoTXUSA james A Baker III Institute of Public Policy Rice UniversityHoustonTXUSA Scowcroft Institute of International Affairs Texas A&M UniversityCollege StationTXUSA

Before the founding of the People's Republic of China 70 years ago,both extreme poverty and parasitic infections and other neglected tropical diseases were highly *** to social development,particularly economic reforms since the 1980s,poverty has since been dramatically reduced,and China became increasingly urbanized and *** parallel,China's economic transformation translated into similar and remarkable reductions in neglected tropical *** and colleagues report in their review published in Infectious Diseases of Poverty,the elimination or near elimination as a public health problem of lymphatic filariasis,trachoma,soil-transmitted helminth infections,schistosomiasis and other neglected tropical *** note,neglected tropical disease control and poverty reduction each appear to reinforce the ***'s formula for success in parasitic and neglected tropical disease control might translate to other parts of the world,such as in sub-Saharan Africa through China's new Belt and Road Initiative.

关键词： Control Elimination Neglected tropical diseases Parasitic infections People's Republic of China Poverty reduction

Individual effect of Y and Nd on the microstructure formation of Mg-Y-Nd alloys processed by severe plastic deformation and their effect on the subsequent mechanical and corrosion properties

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journal of Magnesium and Alloys 2023年第2期11卷 509-521页

作者： Maria Zemkova peter Minarik jan Dittrich jan Bohlen Robert Kral Charles University Department of Physics of MaterialsKe Karlovu 512116PragueCzechia University of Zilina Research CentreUniverzitna8215/1Zilina01026Slovakia Institute of Material and Process Design Helmholtz-Zentrum Hereon21502GeesthachtGermany

This work investigated the effect of sole yttrium and neodymium alloying on the microstructure formation during severe plastic deformation by equal channel angular pressing(ECAP) and an impact on the mechanical strength and corrosion resistance of binary Mg-3Y and Mg-3Nd *** results are compared with a ternary Mg-4Y-3Nd alloy,which represents a simplified version of the commercially successful WE43 *** extensive study comprises a thorough microstructural analysis performed by scanning and transmission electron microscopy,including electron backscatter diffraction and texture analysis performed by X-ray *** is shown that the presence of Nd primarily caused precipitation during the processing of the Mg-3Nd alloy,while Y remained dissolved in the magnesium matrix in the Mg-3Y *** difference resulted in a significantly smaller average grain size in the Mg-3Y alloy(~0.77 nm) than in the Mg-3Nd alloy(~1.3 μm) after the final step of the processing and formation of a slightly different ***,the composition and the processing affected the mechanical and corrosion properties of the investigated materials,measured by compression deformation tests,microhardness measurement,and electrochemical impedance *** study shows that the ECAP-processed W3 sample exhibits a surprisingly good combination of ultrafine-grain structure,weak crystallographic texture,high strength,and high corrosion resistance compared with the other investigated *** attributes make this material very interesting for utilisation in the industry and/or medicine.

关键词： Magnesium Rare earth elements Microstructure Texture Mechanical strength Corrosion

Liquid-liquid extraction and separation of total rare earth(RE) metals from polymetallic manganese nodule leaching solution

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journal of Rare Earths 2015年第2期33卷 207-213页

作者： P.K.Parhi K.H.park C.W.Nam j.T.park Mineral Resources Research Division Korea Institute of Geoscience & Mineral Resources (KIGAM)Daejeon 305-350 Republic of Korea School of Applied Science and Center of Industrial Technology KIIT UniversityBhubaneswar 751024 Odisha India

The study on the solvent extraction for quantitative and selective separation of total rare earth metals from the polymetallic nodule leach liquor was investigated. The typical leach liquor bearing 0. 094 g/L total rare earth, 0. 23 g/L Mn, 0.697 g/L Cu, 0.2 g/L Fe, 0.01 g/L Co and 0.735 g/L Ni was subjected to the removal iron content by precipitation method using Ca（OH）2 at pH 3.95, prior to solvent extraction of rare earth metals. Three different organo-phosphoric acid reagents（D2EHPA, PC88 A, Cyanex 272） were used to ascertain their performances and selectivity towards the loading of rare earth metals in presence of other base metals. Based on the results of eq. pH effect, the performances of above three extractants followed the order as： D2EHPA〉PC88A〉Cyanex 272. To ensure the absence of extraction of base metals（Cu, Co, Ni）, the eq. pH of the solution was optimized at the level of 2.21, though higher rare earth metal extraction efficiency was observed at higher eq. pH with either of the extractants. The complete process flow diagram for substantial recovery of total rare earth was developed using D2 EHPA. Extraction isotherm plot was constructed at A：O=12：1, 3-stages and pHe=2.21, using 0.8 mol/L D2 EHPA and the predicted condition of this study was further confirmed by 6-Cycles Counter Current Simulation（CCS） study. The stripping of total rare earth from loaded organic phase（LO） was conducted using HCl solution. Mc-Cabe Thiele diagram study carried out at A：O=1：5 using 4 mol/L HCl showed that three theoretical stages were needed for quantitative stripping of total rare earth. The subsequent stripped solution resulted thus led to contain total rare earth of 5.6 g/L indicating a very high enrichment of total metals by solvent extraction（SX） process.

关键词： total rare earth (RE) metals SX D2EHPA HCl deep sea nodule