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原发性神经炎性麻风患者随访过程中出现皮损

世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 54-54页

作者： suneetha s. sigamoni A. Kurian N. Chacko C.J.G. 牛新武 LEPRA India Blue Peter Research Center Near TEC Building Cherlapally Hyderabad 501 301 India Dr.

Background: Primary neuritic leprosy (PNL) is a rare form of leprosy where the characteristic skin lesions are absent. Investigations of apparently normal skin from the areas of sensory change have revealed microscopic evidence of nerve involvement. Clinical studies have found that a proportion of patients develop visible skin lesions during follow- up. The aim of the study was to perform a clinical and histological analysis of PNL patients who developed visible skin lesions during treatment and follow- up, to gain insight into the pathogenesis of the disease. Methods: Twenty- nine individuals in a series of 182 PNL patients developed visible skin lesions during follow- up. Analysis of the number, location, histology and time of onset of the new skin lesions in relation to the type and regularity of the treatment regimen were noted. A biopsy from the new skin lesion when available was compared with the nerve biopsy findings at the time of initial diagnosis. Results: Thirty- eight per cent of patients developed a single patch and 28% developed two patches. Over three- quarters of these were on the lower limb (47% ) or the upper limb (29% ). sixty- two per cent of patients developed the lesions within 2 years of the onset of symptoms. Patients on regular treatment developed patches earlier than those on irregular treatment or no treatment. A skin biopsy from the new patch revealed borderline tuberculoid leprosy histology in 47% of the patients. Conclusions: The findings suggest that leprosy primarily affects the nerve and that a neuritic phase precedes the development of visible cutaneous lesions.

关键词：麻风患者随访过程神经活检皮损数目组织学特征治疗规律活检标本规律治疗感觉异常治疗者

Variations in Wool Growth with Nutrient supply in Northern China

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畜牧与饲料科学 1997年第S1期22卷 104-111页

作者： D X Lu,Iner(Mongolia Academy of Animal sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)Z C Feng,(Mongolia Academy of Animal sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)H R Wang,(Mongolia Academy of Animal sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)R Z Yang,(Xinjiang Institute of Animal science.Xinjiang Academy of Animal science.Yiu Hou Road.Urumqi.Xinjiang Uygur Autonomous Region PRC)C T Ma,(Chinese Academy of Agricultural sciences.Lanzhou.Gansu.PRC)D B Purser,(CsIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)J R Lindsay(CsIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)D W peter(CsIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)

Field studies on essessment of nutritional status of the grazing sheep were carried out in each of the three major grassland regions, the eastern Inner Mongolia and beyond grassland, the Inner Mongolia - Ningxia - Gansu grassland and the Xinjiang grassland, in northern China. The results obtained showed that the wool production of fine wool sheep in these regions varied between regions and seasons, with similar seasonal patterns in all regions and that reducing the seasonal variations in nutrient supply would enhance wool production substantially. Nutritional limitations to wool growth of the grazing sheep in these regions were suggested, those were: the shortage of protein supply in winter and early spring; the poor quality of much of the pasture and the hay used as supplements, the low energy intake during winter which probably necessitated the use of body stores to maintain body temperature.

关键词： Wool Growth Nutrient supply Grazing sheep Northern China

sPIRIT 2013声明：定义临床研究方案的标准条目

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中国循证医学杂志 2013年第12期13卷 1501-1507页

作者： An-Wen Chan Jennifer M.Tetzlaff Douglas G.Altman Andreas Laupacis peter C.GΦtzsche Karmela Krleza-Jeri AsbjΦrn Hróbjartsson Howard Mann Kay Dickersin Jesse A.Berlin Caroline J.Doré Wendy R.Parulekar William s.M.summerskill Trish Groves Kenneth F.schulz Harold C.sox Frank W.Rockhold Drummond Rennie David Moher 钟丽丹郑颂华吴泰相李幼平商洪才张伯礼唐旭东吕爱平卞兆祥 sPIRIT中文工作組

临床研究方案是临床研究设计、实行、报告和评价的基础。然而，临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》（standard Protocol Items：Recommendations for Interventional Tri... 详细信息

临床研究方案是临床研究设计、实行、报告和评价的基础。然而，临床研究方案及现存的临床研究方案指引在内容和质量上差异很大。本文描述了《规范临床研究方案内容》（standard Protocol Items：Recommendations for Interventional Trials 2013 ）,简称sPIRIT2013声明，一个临床研究方案必须报告的条目指引的系统建立和范围。

关键词：临床研究条目标准

Modiﬁcation of contact lenses via metal-organic frameworks for glaucoma treatment

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Aggregate 2024年第5期5卷 358-370页

作者： Alexey V.Yaremenko Roman O.Melikov Nadezhda A.Pechnikova Iaroslav B.Belyaev Alina Ringaci Tamara V.Yaremenko Aziz B.Mirkasymov Alexandr A.Tamgin Vladislav I.Rodionov sofya M.Dolotova Grigory A.Plisko Evgeny D.semivelichenko Anna s.Rogova Albert R.Muslimov Arina s.Ivkina Dmitry Yu.Ivkin Valery P.Erichev sergey M.Deyev sergey E.Avetisov Yongjiang Li Hai-Jun Liu Ivan V.Zelepukin Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMassachusettsUSA Aristotle University of Thessaloniki ThessalonikiGreece shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of sciences MoscowRussia Moscow Center for Advanced studies MoscowRussia Faculty of Biology Saint Petersburg State UniversitySaint PetersburgRussia saint petersburg Pasteur Institute Saint PetersburgRussia Department of Chemistry Boston UniversityBostonMassachusettsUSA sechenov University MoscowRussia saint petersburg state Chemical and Pharmaceutical University Saint PetersburgRussia peter the Great st.petersburg Polytechnic University Saint PetersburgRussia sirius University of science and Technology SiriusRussia RM Gorbacheva Research Institute Pavlov UniversitySaint PetersburgRussia Research Institute of Eye Diseases MoscowRussia Department of Medicinal Chemistry Uppsala UniversityUppsalaSweden

The prevention of blindness from glaucoma requires multiple treatments to lower intraocular ***,human contact lenses are modiﬁed with highly porous metal-organic frameworks with sustained release of brimonidine for prolonged glaucoma *** metal-organic frameworks were screened for their attachment to lenses,loading with brimonidine,and drug-release ***-mized therapeutic ocular lenses conjugated with MIL-101(Cr)frameworks maintain optical transparency and *** of lenses with MIL-101(Cr)nanoparticles reduced brimonidine washout with tears and ensured a gradual and localized release of the drug into the eyeball through the *** hybrid lenses provided a 4.5-fold better decrease in eye pressure,compared by area under the curve(AUC)value to a commercially available brimonidine tartrate *** lenses did not induce any notable eye irritation or corneal damage in *** newly devel-oped hybrid lenses are expected to provide a robust platform for the therapy and prevention of various ocular diseases.

关键词： brimonidine contact lenses drug delivery glaucoma intraocular pressure metal-organic frameworks nanoparticles

新研究确定了与肝病和脂肪代谢有关的肝细胞突变

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中西医结合肝病杂志 2021年第11期31卷 1011-1011页

作者： stanley W. K. Ng Foad J. Rouhani simon F. Brunner Natalia Brzozowska Federico Abascal Luiza Moore Lia Chappell Daniel Leongamornlert Aleksandra Ivovic Philip Robinson Timothy Butler Mathijs A. sanders Nicholas Williams Tim H. H. Coorens Jon Teague Keiran Raine Adam P. Butler Yvette Hooks Beverley Wilson Natalie Birtchnell Michael R. stratton Iñigo Martincorena Raheleh Rahbari peter J. Campbell Foad J. Rouhani & Huw Naylor sarah J. Aitken & Matthew Hoare sarah J. Aitken & susan E. Davies sarah J. Aitken Ming Yang Efterpi Nikitopoulou Christian Frezza Matthew Hoare Cancer Genome Project Wellcome Sanger Institute Hinxton UK Department of Hematology Erasmus University Medical Center Rotterdam The Netherlands stem Cell Institute University of Cambridge Cambridge UK Department of surgery Addenbrooke’s Hospital Cambridge UK CRUK Cambridge Institute Cambridge UK Department of Pathology Addenbrooke’s Hospital Cambridge UK MRC Toxicology Unit University of Cambridge Cambridge UK MRC Cancer Unit University of Cambridge Cambridge UK Department of Medicine University of Cambridge Addenbrooke’s Hospital Cambridge UK

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NEAT1、FOXO1和GP... 详细信息

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NEAT1、FOXO1和GPAM 五个基因在肝病患者的肝细胞中发生了突变,过程如图a所示。而其中的FOXO1、CIDEB、GPAM三个基因是对肝细胞如何代谢脂肪和对胰岛素作出反应有直接影响的基因。

关键词： FOXO1 肝病患者细胞突变肝细胞脂肪代谢胰岛素 GPA 剑桥大学

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运动表现分析：过去、现在与未来

Notes,outline and divergence times of Basidiomycota

体育 2023年第7期

作者：易清黎涌明张铭鑫崔一雄刘天彪张绍良龚炳南黄展煜周长敬 Miguel style='hight:20px width:20px ' src='https://***/jpg/G8/2023/G8AH706.jpg' />ngel Gómez Ruano Daniel Memmert peter O'Donoghue 刘鸿优

对运动表现分析的发展历程、现状、未来进行研究发现，运动表现分析起源于标记分析，历经一个多世纪的实践与研究完成了由方法向方法论的转型，进入21世纪后逐渐发展成为运动科学(sports science)的一个新兴分支学科。在运动表现分析实... 详细信息

对运动表现分析的发展历程、现状、未来进行研究发现，运动表现分析起源于标记分析，历经一个多世纪的实践与研究完成了由方法向方法论的转型，进入21世纪后逐渐发展成为运动科学(sports science)的一个新兴分支学科。在运动表现分析实践中采用定性、定量以及两者相结合的方法对“人的运动”进行直接描述和分析，分析手段主要包括标记分析和移动分析，通常需要从方法和学科2个层面来理解其定义。技术和战术表现评估、信效度分析、负荷监控以及学科交叉研究是近年来运动表现分析领域的研究热点。运动表现分析相关专业的设立以及运动表现分析师这一新职业的出现有力地推动了运动训练的科学化。当前，运动表现分析的理论基础、技术手段、人才培养和学科影响力等方面还面临挑战，未来其理论体系将趋向完善，向分析智能化、服务对象大众化和人才培养专业化等方向发展。

关键词：运动表现分析运动表现分析师运动科学标记分析移动分析 performance analysis performance analyst sports science notational analysis motion analysis

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Fungal Diversity 2019年第6期99卷 105-367页

作者： Mao-Qiang He Rui-Lin Zhao Kevin D.Hyde Dominik Begerow Martin Kemler Andrey Yurkov Eric H.C.McKenzie Olivier Raspe Makoto Kakishima santiago sanchez-Ramırez Else C.Vellinga Roy Halling Viktor Papp Ivan V.Zmitrovich Bart Buyck Damien Ertz Nalin N.Wijayawardene Bao-Kai Cui Nathan schoutteten Xin-Zhan Liu Tai-Hui Li Yi-Jian Yao Xin-Yu Zhu An-Qi Liu Guo-Jie Li Ming-Zhe Zhang Zhi-Lin Ling Bin Cao Vladimir Antonin Teun Boekhout Bianca Denise Barbosa da silva Eske De Crop Cony Decock Balint Dima Arun Kumar Dutta Jack W.Fell Jozsef Geml Masoomeh Ghobad-Nejhad Admir J.Giachini Tatiana B.Gibertoni sergio P.Gorjon Danny Haelewaters shuang-Hui He Brendan P.Hodkinson Egon Horak Tamotsu Hoshino Alfredo Justo Young Woon Lim Nelson Menolli Jr Armin Mesic Jean-Marc Moncalvo Gregory M.Mueller La szlo G.Nagy RHenrik Nilsson Machiel Noordeloos Jorinde Nuytinck Takamichi Orihara Cheewangkoon Ratchadawan Mario Rajchenberg Alexandre G.s.silva-Filho Marcelo Aloisio sulzbacher Zdenko Tkalcec Ricardo Valenzuela Annemieke Verbeken Alfredo Vizzini Felipe Wartchow Tie-Zheng Wei Michael WeiB Chang-Lin Zhao Paul M.Kirk state Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101People’s Republic of China Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand College of Life sciences University of Chinese Academy of SciencesHuairou DistrictBeijing 100408People’s Republic of China Ruhr-Universitat Bochum AG GeobotanikND03UniversitatsstraBe 15044801 BochumGermany Leibniz Institute DsMZ-German Collection of Microorganisms and Cell Cultures InhoffenstraBe 7B38124 BrunswickGermany Manaaki Whenua-Landcare Research Private Bag 92170AucklandNew Zealand Research Department Meise Botanic GardenNieuwelaan 381860 MeiseBelgium service General de l'Enseignement superieur et de la Recherche scientifique Federation Wallonie-BruxellesLavallee 11080 BrusselsBelgium University of Tsukuba TsukubaIbaraki 305-8572Japan Department of Ecology and Evolutionary Biology University of Toronto25 Willcocks St.TorontoON M5S 3B2Canada Berkeley USA Institute of systematic Botany The New York Botanical GardenBronxNY 10458-5126USA Department of Botany Szent Istvan University1518 BudapestHungary Komarov Botanical Institute Russian Academy of SciencesProfessor Popov st.2Saint PetersburgRussia 197376 Institut pour systematique Ecologie Biodiversite(IsYEB UMR 7205) Sorbonne universiteMuseum National d’Histoire Naturelle CP 39CNRSDepartement Origines et Evolution12 Rue Buffon75005 ParisFrance Institute of Microbiology Beijing Forestry UniversityBeijing 100083People’s Republic of China Department of Biology Research Group MycologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium state Key Laboratory of Applied Microbiology southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Institute of MicrobiologyGuangzhou 510070People’s Republic of China Department of Botany Moravian Mu

The Basidiomycota constitutes a major phylum of the kingdom Fungi and is second in species numbers to the *** present work provides an overview of all validly published,currently used basidiomycete genera to date in a single *** outline of all genera of Basidiomycota is provided,which includes 1928 currently used genera names,with 1263 synonyms,which are distributed in 241 families,68 orders,18 classes and four *** provide brief notes for each accepted genus including information on classification,number of accepted species,type species,life mode,habitat,distribution,and sequence ***,three phylogenetic analyses with combined LsU,ssU,5.8s,rpb1,rpb2,and ef1 datasets for the subphyla Agaricomycotina,Pucciniomycotina and Ustilaginomycotina are conducted,*** time estimates are provided to the family level with 632 species from 62 orders,168 families and 605 *** study indicates that the divergence times of the subphyla in Basidiomycota are 406-430 Mya,classes are 211-383 Mya,and orders are 99-323 Mya,which are largely consistent with previous *** this study,all phylogenetically supported families were dated,with the families of Agaricomycotina diverging from 27-178 Mya,Pucciniomycotina from 85-222 Mya,and Ustilaginomycotina from 79-177 *** times as additional criterion in ranking provide additional evidence to resolve taxonomic problems in the Basidiomycota taxonomic system,and also provide a better understanding of their phylogeny and evolution.

关键词： Classification Molecular clock Fungi systematics Taxonomy

悉尼宣言——从基本原则视角重新审视法庭科学的本质

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证据科学 2023年第4期31卷 498-512页

作者：克劳德·鲁丽贝卡·布赫弗兰克·克里斯皮诺彼得·德·福雷斯特克里斯·伦纳尔皮埃尔·玛格特米歇尔·米兰达纳娅姆·尼克达恩利奥利维尔·里博阿拉斯泰尔·罗斯希拉·威利斯何晓丹(译) 张保生(校) 澳大利亚悉尼科技大学法庭科学中心国际法庭科学协会芬兰国家调查局法庭科学实验室加拿大魁北克大学化学、生物化学和物理系犯罪调查实验室美国纽约市立大学约翰·杰伊刑事司法学院澳大利亚西悉尼大学理学院瑞士洛桑大学刑事科学学院美国纽约州立大学法明代尔州立学院英国邓迪大学利弗休姆法医学研究中心澳大利亚维多利亚法医学院中国政法大学司法文明协同创新中心中国政法大学司法鉴定科学研究院中国政法大学证据科学研究院/证据科学教育部重点实验室

与其他更成熟的学科不同,人们对法庭科学的本质尚缺乏共识和广泛认可,其目的和基本原则仍然缺失,甚至被歪曲。虽然许多法庭科学先辈都认识到这一点,并将其视为学科发展之关键所在,但这种基础研究却长期受到忽视。《悉尼宣言》试图超越... 详细信息

与其他更成熟的学科不同,人们对法庭科学的本质尚缺乏共识和广泛认可,其目的和基本原则仍然缺失,甚至被歪曲。虽然许多法庭科学先辈都认识到这一点,并将其视为学科发展之关键所在,但这种基础研究却长期受到忽视。《悉尼宣言》试图超越组织、技术和规程的视角,通过研究其基础理论,重新审视法庭科学的本质。它的内容包括法庭科学的定义和七项基本原则,强调了现场痕迹在案件调查中的关键作用。《悉尼宣言》还讨论了法庭科学家工作的关键特征,包括案情、时间不对称性、一系列不确定性、广泛的科学知识、伦理、批判性思维和逻辑推理等。《悉尼宣言》认为这些原则应成为法庭科学执业的基础,并指导其教育和研究方向。最终,这些原则将使法庭科学在整体上更加相关、有效和可靠。

关键词：痕迹原则符号线索案情时间不对称性不确定性伦理批判性思维逻辑推理

CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay shou-shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov serge Bondarenko stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen shanhong Chen shanzhen Chen shao-Long Chen shaomin Chen shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De sio Elisa Del Core shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central south University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu Kaitengsifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRs/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-synchrotron DEsY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential super Proton Proton Collider(sPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(sR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the sR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise