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Aortic valve replacement reduces mortality in moderate aortic stenosis:a systematic review and meta-analysis

Journal of Geriatric Cardiology 2023年第1期20卷 61-67页

作者： Kyle b Franke Dimple bhatia Ross L Roberts-Thomson peter J Psaltis Adelaide Medical School The University of AdelaideAdelaideAustralia Vascular Research Centre Lifelong Health ThemeSouth Australian Health and Medical Research InstituteAdelaideAustralia Department of Cardiology Royal Adelaide HospitalAdelaideAustralia

bACKGROUND With the introduction of transcatheter aortic valve replacement and an evolving understanding of the natural progression and history of aortic stenosis,the potential for earlier intervention in appropriate patients is promising;however,the benefit of aortic valve replacement in moderate aortic stenosis remains *** Pubmed,Embase,and the Cochrane Library databases were searched up until 30th of December 2021 using keywords including moderate aortic stenosis and aortic valve *** reporting all-cause mortality and outcomes in early aortic valve replacement(AVR)compared to conservative management in patients with moderate aortic stenosis were *** ratios were generated using random-effects meta-analysis to determine effect *** 3470 publications were screened with title and abstract review,which left 169 articles for full-text *** these studies,7 met inclusion criteria and were included,totalling 4,827 *** studies treated AVR as a time-dependent co-variable in cox-regression multivariate analysis of all-cause *** with surgical or transcatheter AVR was associated with a 45% decreased risk of all-cause mortality(HR=0.55[0.42-0.68],I2=51.5%,Pblication,detection,or information biases in any of the *** In this systematic review and meta-analysis,we report a 45% reduction in all-cause mortality in patients with moderate aortic stenosis who were treated with early aortic valve replacement compared to a strategy of conservative *** control trials are awaited to determine the utility of AVR in moderate aortic stenosis.

关键词： aortic stenosis analysis

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FROM MANUFACTURING SCHEDULING TO SUPPLY CHAIN COORDINATION:THE CONTROL OF COMPLEXITY AND UNCERTAINTY

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Systems Science and Systems Engineering 2003年第3期12卷 279-297页

作者： peter b.LUH Department of Electrical & Computer Engineering University of Connecticut StorrsConnecticut06269-2157USA

With time-based competition and rapid technology advancements, effective manufacturing scheduling and supply chain coordination are critical to quickly respond to changing market conditions. These problems, however, are difficult in view of inherent complexity and various uncertainties involved. based on a series of results by the authors, decomposition and coordination by using Lagrangian relaxation is identified in this paper as an effective way to control complexity and uncertainty. A manufacturing scheduling problem is first formulated within the job shop context with uncertain order arrivals, processing times, due dates, and part priorities as a separable optimization problem. A solution methodology that combines Lagrangian relaxation, stochastic dynamic programming, and heuristics is developed. Method improvements to effectively solve large problems are also highlighted. To extend manufacturing scheduling within a factory to coordinate autonomic members across chains of suppliers, a decentralized supply chain model is established in the second half of this paper. by relaxing cross-member constraints, the model is decomposed into member-wise subproblems, and a nested optimization structure is developed based on the job shop scheduling results. Coordination is performed through the iterative updating of cross-member prices without accessing other members' private information or intruding their decision-making authorities, either with or without a coordinator. Two examples are presented to demonstrate the effectiveness of the method. Future prospects to overcome problem inseparability and improve computing efficiency are then discussed.

关键词： Manufacturing scheduling supply chain coordination complexity and uncertainty decomposition and coordination Lagrangian relaxation.

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Resistance to cis- and carboplatin initiated by epigenetic changes in ovarian cancer patients

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Cancer Drug Resistance 2019年第2期2卷 271-296页

作者： Heidi Schwarzenbach peter b.Gahan Department of Tumor biology University Medical Center Hamburg-EppendorfHamburg 20246Germany Fondazione“Enrico Puccinelli”Onlus Perugia 06126Italy

Initially,most ovarian tumors respond to the treatment with platinum components,but frequently recurrence occurs within the following two years in advanced ovarian cancer *** this regard,previous studies have shown changes in the epigenetic patterns in ovarian cancer that are linked with resistance to cis-and carboplatin ***,epigenetic changes mediated by a treatment with cis-or carboplatin could identify such patients who do or do not respond to this ***,an understanding of the impact of platinum on epigenetics in ovarian cancer is important in overcoming platinum *** this review,we delineate epigenetic abnormalities in cis-and carboplatin-resistant ovarian tumors,such as changes in DNA methylation,histone modifications and deregulation of microRNAs,and discuss the potential of epigenetic therapies in combination with platinum.

关键词： Ovarian cancer carboplatin cisplatin resistance DNA methylation histone modifications microRNAs

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Predictive value of exosomes and their cargo in drug response/resistance of breast cancer patients

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Cancer Drug Resistance 2020年第1期3卷 63-82页

作者： Heidi Schwarzenbach peter b.Gahan Department of Tumor biology University Medical Center Hamburg-EppendorfHamburg 20246Germany Fondazione“Enrico Puccinelli”Onlus Perugia 06123Italy

Exosomes are small extracellular vesicles engaged in intercellular communication in both healthy and tumor *** released by the primary tumor,they transfer their cargo including nucleic acids,proteins,and lipids to target cells,thus modulating the character and fate of the recipient *** propagating their oncogenic content,exosomes are able to promote tumor progression,angiogenesis,metastases,and drug *** functions as delivery vehicles of biological material make exosomes promising biomarkers for the early prediction of disease progression and drug resistance in breast cancer,as well as for therapeutic targeting of molecules to treat this deadly *** the present review,we accentuate the relevance of exosomes as vehicles of prognostic and predictive markers and target molecules,and describe their potential therapeutic applications as drug cargo *** made an extensive literature research to clarify the association of their cargo,including exosomal DNA and RNA molecules,with the propagation of drug resistance.

关键词： breast cancer exosomes exosomal DNA mRNA non-coding RNAs microRNAs lncRNAs

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Circulating non-coding RNAs in recurrent and metastatic ovarian cancer

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Cancer Drug Resistance 2019年第3期2卷 399-418页

作者： Heidi Schwarzenbach peter b.Gahan Department of Tumor biology University Medical Center Hamburg-EppendorfHamburg 20246Germany Fondazione“Enrico Puccinelli”Onlus Perugia 06123Italy

Ovarian cancer has a poor outcome because it is usually detected at advanced tumor stages,and the majority of the patients develop disease relapse as a result of chemotherapy *** most lethal gynecological malignancy metastasizes within the peritoneal fluid or ascites to pelvic and distal *** ovarian cancer progression and metastasis,small non-coding RNAs(ncRNAs),including long noncoding RNAs and microRNAs have been recognized as important *** dysregulation modulates gene expression and cellular signal pathways and can be detected in liquid *** this review,we provide an overview on circulating plasma and serum ncRNAs participating in tumor cell migration and invasion,and contributing to recurrence and metastasis of ovarian *** will also discuss the development of potential,novel therapies using ncRNAs as target molecules or tumor markers for ovarian cancer.

关键词： Ovarian cancer recurrence metastasis epithelial-mesemchmal transition non-coding RNAs chemotherapy tumor markers

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Genetic outcomes from the translocations of the critically endangered woylie

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Current Zoology 2013年第3期59卷 294-310页

作者： Carlo PACIONI Adrian F. WAYNE peter b. S. SPENCER School of Veterinary and Life Sciences Murdoch University Murdoch 6150 Western Australia Department of Environment and Conservation Science Division Manjimup 6258 Western Australia

Translocations are an important conservation strategy for many species. However simply observing demographic growth of a translocated population is not sufficient to infer species recovery. Adequate genetic representation of the source population（s） and their long-term viability should also be considered. The woylie bettongia penicillata ogilbyi has been subject to more formal translocations for conservation than any other marsupial that, up until recently, has resulted in one of the most suc- cessful species recoveries in Australia. We used mitochondrial and nuclear DNA markers to assess the genetic outcomes of trans- located woylie populations. These populations have lost genetic variability, differentiated fxom their source population and the supplementation program on two island populations appears to have failed. We discuss the conservation implications that our re- suits have for managing threatened species, outline some general recommendations for the management of present and future translocations and discuss the appropriate sampling design for the establishment of new populations or captive breeding programs that may mitigate the genetic ＇erosion＇ seen in our study species. This research provides some practical outcomes and a pragmatic understanding of translocation biology. The findings are directly applicable to other translocation programs .

关键词： bettongia penicillata Macropod translocation Supplementation Microsatellites mtDNA

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biomaterials for stem cell engineering and biomanufacturing

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bioactive Materials 2019年第1期4卷 366-379页

作者： Yibo Xu Chuanxin Chen peter b.Hellwarth Xiaoping bao Davidson School of Chemical Engineering Purdue UniversityWest LafayetteWest LafayetteIN47907USA

Recent years have witnessed the expansion of tissue failures and *** uprising of regenerative medicine converges the sight onto stem cell-biomaterial based *** engineering and regenerative medicine proposes the strategy of constructing spatially,mechanically,chemically and biologically designed biomaterials for stem cells to grow and ***,this paper summarized the basic properties of embryonic stem cells(ESCs),induced pluripotent stem cells(iPSCs)and adult stem *** properties of frequently used biomaterials were also described in terms of natural and synthetic ***,the combination of stem cells and biomaterials for tissue repair applications was reviewed in terms of nervous,cardiovascular,pancreatic,hematopoietic and musculoskeletal ***,stem-cell-related biomanufacturing was envisioned and the novel biofabrication technologies were discussed,enlightening a promising route for the future advancement of large-scale stem cell-biomaterial based therapeutic manufacturing.

关键词： Stem cells biomaterial Regenerative medicine biofabrication biomanufacturing

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Cellular senescence:from anti-cancer weapon to anti-aging target

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Science China(Life Sciences) 2020年第3期63卷 332-342页

作者： Lifeng Yuan peter bAlexander Xiao-Fan Wang Program in Cellular and Molecular Medicine Boston Children’s HospitalBostonMA 02115USA Department of Genetics Harvard Medical SchoolBostonMA 02115USA Duke University Medical Center DurhamNC 27710USA

Cellular senescence(CS)is a state of stable cell cycle arrest characterized by the production and secretion of inflammatory *** studies described oncogene-induced senescence(OIS)as a barrier to tumorigenesis,such that the therapeutic induction of CS might represent a rational anti-cancer ***,the validity of this approach has been borne out by the development and approval of the cyclin-dependent kinase(CDK)inhibitor palbociclib for the treatment of breast *** from tumors,senescent cells have also been shown to accumulate during natural mammalian aging,where they produce detrimental effects on the physiology of surrounding ***,pharmacological senescent cell depletion has been proposed as an approach to delay age-related functional decline;this has been formally demonstrated in animal *** this review article,we describe the current mechanistic understanding of cellular senescence at the molecular level and how it informs the development of new therapeutic strategies to combat cancer and aging.

关键词： cellular senescence cancer healthy aging pro-senescence cancer therapy senolytic therapies

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Application of Generalized Standard Addition Method and Ultraviolet Spectroscopy to Quantify Electrolytic Depolymerization of Lignin

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Journal of Analysis and Testing 2020年第1期4卷 35-44页

作者： Zewei Chen Mahtab NaderiNasrabadi John A.Staser peter b.Harrington Department of Chemistry and biochemistry Clippinger LaboratoriesOhio UniversityAthensOH 45701USA Department of Chemical and biomolecular Engineering Center for Electrochemical Engineering ResearchOhio UniversityAthensOH 45701USA

Industrial lignin waste is an important byproduct of bio-refineries and the paper *** of industrial lignin could generate useful aromatic *** group has focused on electrolytic decomposition of biorefinery *** quantify electrolytic decomposition of the lignin in a highly caustic solution,ultraviolet(UV)spectroscopy provides a useful *** conversion of the neat lignin to the oxidized products achieved by the electrolytic reactor may be measured by quantifying the amount of unreacted neat lignin that remains in the *** the properties of electrolytic decomposition products are largely unknown,a useful approach to quantify decomposition of the neat lignin is to use a multivariate calibration method referred to as the generalized standard addition method(GSAM).In this approach,the electrolytic decomposition products represent a background interference and the neat lignin that remains can be *** approach allows the conversion of the neat lignin to be calculated in a solution that is a complex mixture.

关键词： GSAM Lignin depolymerization Electrolytic reactor UV spectroscopy best linear unbiased estimator(bLUE)

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Spectral Representation of Proton NMR Spectroscopy for the Pattern Recognition of Complex Materials

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Journal of Analysis and Testing 2017年第2期1卷 1-11页

作者： peter de b.Harrington Xinyi Wang Clippinger Laboratories Department of Chemistry and BiochemistryCenter for Intelligent Chemical InstrumentationOhio UniversityAthensOH 45701-2979USA

Proton nuclear magnetic resonance(NMR)spectroscopy provides a powerful tool for chemical profiling,also known as spectral fingerprinting,because of its inherent *** is now increasing in use for authentication of complex ***,the absorbance spectrum is used that is obtained as the phase-corrected real component of the Fourier transform(FT)of the free induction decay(FID).However,the practice discards half the information that is available in the dispersion spectrum obtained as the imaginary component from the *** qualitative analysis or quantitative analysis of small sets of absorbance peaks,the symmetric and sharp peaks of the real spectra work ***,for pattern recognition of entire spectra,trading peak resolution for peak reproducibility is *** absolute value of the complex spectrum gives the length or magnitude of magnetization vector in the complex plane;therefore,the magnitude relates directly to the signal(i.e.,induced magnetization).The magnitude spectrum is obtained as the absolute value from the real and imaginary spectral components after the FT of the *** breaking with tradition and using the magnitude spectrum the reproducibility of the spectra and consequent recognition rates can be *** study used a 500-MHz 1H NMR instrument to obtain spectra from 4 diverse datasets;12 tea extracts,8 liquor samples,9 hops extracts,and 25 Cannabis *** classifiers were statistically evaluated using 100 bootstrapped Latin *** classifiers were a fuzzy rule-building expert system(FuRES)tree,support vector machine trees(SVMTreeG and SVMTreeH),a regularized linear discriminant analysis(LDA),super partial least squares discriminant analysis(sPLS-DA),and a one against all support vector machine(SVM).All classifiers gave better or equivalent results for the magnitude spectral representation than for the real spectra,except for one case of the 24 *** addition,the enhanced reproducibilit

关键词： Cannabis Tea Hops Liquor HumulusNMR fingerprinting Magnitude spectrum Absolute value spectrum Pattern recognition Classification

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