Resistance to cis- and carboplatin initiated by epigenetic changes in ovarian cancer patients
作者机构：Department of Tumor BiologyUniversity Medical Center Hamburg-EppendorfHamburg 20246Germany Fondazione“Enrico Puccinelli”OnlusPerugia 06126Italy
出 版 物：《Cancer Drug Resistance》 (癌症耐药（英文）)
年 卷 期：2019年第2卷第2期
页 面：271-296页
学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Ovarian cancer carboplatin cisplatin resistance DNA methylation histone modifications microRNAs
摘 要：Initially,most ovarian tumors respond to the treatment with platinum components,but frequently recurrence occurs within the following two years in advanced ovarian cancer *** this regard,previous studies have shown changes in the epigenetic patterns in ovarian cancer that are linked with resistance to cis-and carboplatin ***,epigenetic changes mediated by a treatment with cis-or carboplatin could identify such patients who do or do not respond to this ***,an understanding of the impact of platinum on epigenetics in ovarian cancer is important in overcoming platinum *** this review,we delineate epigenetic abnormalities in cis-and carboplatin-resistant ovarian tumors,such as changes in DNA methylation,histone modifications and deregulation of microRNAs,and discuss the potential of epigenetic therapies in combination with platinum.
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