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MicroRNA-184 negatively regulates corneal epithelial wound healing via targeting CDC25A,CARM1,and LAsP1

Eye and Vision 2020年第2期7卷 336-346页

作者： Qiongjie Cao Weiwei Xu Weiwei Chen Dewei Peng Qi Liu Jing Dong peter s.reinach Dongsheng Yan school of Ophthalmology and Optometry Eye HospitalWenzhou Medical University270 Xueyuan RoadWenzhou 325027ZhejiangChina state Key Laboratory of Ophthalmology Optometry and Visual ScienceWenzhouZhejiangChina

Background:MicroRNAs(miRNAs)play critical roles in corneal development and functional *** previous study identified miR-184 as one of the most highly expressed miRNAs in the corneal *** though its expression level plummeted dramatically during corneal epithelial wound healing(CEWH),its precise role in mediating corneal epithelial renewal was *** present study aimed to reveal the function and mechanism of miR-184 in regulating ***:Quantitative RT-PCR analysis characterized the miR-184 expression pattern during CEWH in *** miR-184 injection determined its effect on this process in *** evaluated the effects of miR-184 and its target genes on the proliferation,cell cycle,and migration of human corneal epithelial cells(HCECs)using MTs,flow cytometry,and wound-healing assay,*** analysis,in conjunction with gene microarray analysis and cell-based luciferase assays,pinpointed gene targets of miR-184 contributing to ***:MiR-184 underwent marked downregulation during mouse *** miR-184 overexpression delayed this process in ***,miR-184 transfection into HCECs significantly inhibited cell proliferation,cell cycle progression,and cell ***-184 directly targeted CDC25A,CARM1,and LAsP1,and downregulated their expression in ***1 downregulation inhibited both HCEC proliferation and migration,whereas a decrease in LAsP1 gene expression only inhibited ***:Our results demonstrate that miR-184 inhibits corneal epithelial cell proliferation and migration via targeting CDC25A,CARM1,and LAsP1,suggesting it acts as a negative modulator during ***,identifying strategies to suppress miR-184 expression levels has the potential to promote CEWH.

关键词： miR-184 Corneal epithelial wound healing Proliferation Migration CDC25A CARM1 LAsP1

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Robotic-assisted retroperitoneal lymph node dissection for stage II testicular cancer

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Asian Journal of Urology 2024年第1期11卷 121-127页

作者： George McClintock Ahmed s.Goolam Don Perera Ryan Downey scott Leslie peter Grimison Henry Woo peter Ferguson Nariman Ahmadi Department of Urology Chris O'Brien LifehouseSydneyNSWAustralia Department of Anaesthesia Chris O'Brien LifehouseSydneyNSWAustralia The University of sydney SydneyNSW2006Australia Department of Medical Oncology Chris O'Brien LifehouseSydneyNSWAustralia

Objective:To evaluate the perioperative as well as early oncological outcomes of patients undergoing robotic retroperitoneal lymph node dissection for treatment of testicular ***:We conducted a prospective consecutive case series of patients undergoing robotic assisted retroperitoneal lymph node dissection for metastatic testicular cancer between May 2018 and July 2021 at our *** were collected on patient and tumour characteristics,intraoperative and postoperative parameters,and functional and oncological *** statistics are ***:Nineteen patients were identified;18(94.7%)completed the procedure robotically and one was converted to open surgery;78.9%of patients had stage≥IIB and 12(63.2%)patients had undergone prior *** median operative time was 300(interquartile range[IQR]240-315)*** blood loss was 100(IQR 50-175)*** length of stay was 2(range 1-11)*** robotically completed patients commenced diet and passed flatus on Day 1 and were discharged by Day *** median lymph node yield was 40.5(IQR 38-51)*** patients undergoing nerve-sparing procedures recovered antegrade ejaculatory *** patient had a Clavien-Dindo III complication(chylous ascites requiring drainage).At a median follow-up of 22.3(IQR 16.3-24.9)months,one patient developed retroperitoneal recurrence,which was successfully treated with second-line chemotherapy;no other patients have had ***:Robotic retroperitoneal lymph node dissection is a safe and feasible alternative to open surgery in appropriately selected patients,offering low *** oncological outcomes are *** cohorts and longer follow-ups are required to validate our institution's findings.

关键词： Retroperitoneal lymph node dissection Robotic surgery Testicular cancer Retroperitoneal node dissection

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A Population Dynamics Approach to the Distribution of space Debris in Low Earth Orbit

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Communications on Applied Mathematics and Computation 2024年第1期6卷 340-353页

作者： John Jurkiewicz peter Hinow Department of Mathematical sciences University of Wisconsin-MilwaukeeMilwaukeeWI53201USA

The presence of the debris in the Earth’s orbit poses a significant risk to human activity in outer *** debris population continues to grow due to ground launches,the loss of external parts from space ships,and uncontrollable collisions between objects.A computationally feasible continuum model for the growth of the debris population and its spatial distribution is therefore *** we propose a diffusion-collision model for the evolution of the debris density in the low-Earth orbit and its dependence on the ground-launch *** parametrize this model and test it against data from publicly available object catalogs to examine timescales for the uncontrolled ***,we consider sensible launch policies and cleanup strategies and how they reduce the future risk of collisions with active satellites or space ships.

关键词： Population dynamics space debris Kessler syndrome Diffusion Low-Earth orbit

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Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

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Journal of Molecular Cell Biology 2024年第1期16卷 54-65页

作者： peter Zorn Jaime Calvo sánchez Tala Alakhras Barbara schreier Michael Gekle stefan Hüttelmaier Marcel Köhn Junior Group‘Non-coding RNAs and RBPs in Human Diseases’ Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany Julius Bernstein Institute of Physiology Medical FacultyUniversity of Halle–Wittenberg06112 Halle(Saale)Germany Institute of Molecular Medicine Medical FacultyUniversity of Halle–Wittenberg06120 Halle(Saale)Germany

Alternative splicing is one of the major cellular processes that determine the tissue-specific expression of protein ***,it remains challenging to identify physiologically relevant and tissue-selective proteins that are generated by alternative ***,we investigated the target spectrum of the splicing factor Rbfox1 in the cardiac muscle context in more *** using a combination of in silico target prediction and in-cell validation,we identified several focal adhesion proteins as alternative splicing targets of *** focused on the alternative splicing patterns of vinculin(metavinculin isoform)and paxillin(extended paxillin isoform)and identified both as potential Rbfox1 *** analyses suggested that both isoforms are promoted by Rbfox1 due to binding in the *** adhesions play an important role in the cardiac muscle context,since they mainly influence cell shape,cytoskeletal organization,and cell–matrix *** data confirmed that depletion of Rbfox1 changed cardiomyoblast morphology,cytoskeletal organization,and multinuclearity after differentiation,which might be due to changes in alternative splicing of focal adhesion ***,our results indicate that Rbfox1 promotes alternative splicing of focal adhesion genes in cardiac muscle cells,which might contribute to heart disease progression,where downregulation of Rbfox1 is frequently observed.

关键词： Rbfox1 alternative splicing focal adhesion cardiac muscle cells Topic:cardiac myocytesalternative splicingfocal adhesionsgenesintronsprotein isoformsrna splicing

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Chinese Medicine,Acupuncture and science

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Chinese Medicine and Culture 2024年第1期7卷 77-85页

作者： peter Eckman Private practitioner San Francisco 94131USA

Ever since the introduction of Western biomedicine into China, there has been friction between proponents of this new approach, and proponents of the traditional medical practices that had evolved over thousands of years in China. For the most part, this friction has been couched in the unexamined assumption that Western medicine is based on science, while Chinese medicine is not. This article will examine that assumption, which in this author’s opinion is unjustified and incorrect. Having practiced acupuncture for the past 50 years, after receiving my doctoral degrees in medicine and physiology, my thinking on this topic has also evolved over time. I will begin this article with some historical information that bears on the topic under discussion, followed by my personal ideas about how to resolve the confiicts that have arisen.

关键词： science Chinese medicine Western medicine Resonance Constitution

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Primary lateral sclerosis:more than just an upper motor neuron disease

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Neural Regeneration Research 2024年第9期19卷 1881-1882页

作者： Ee Ling Tan Jasmin Lope peter Bede Computational Neuroimaging Group(CNG) School of MedicineTrinity College DublinIreland Department of Neurology St James’s HospitalDublinIreland

Advances in clinical care and recent research achievements:Primary lateral sclerosis(PLs)has traditionally been regarded as a pure upper motor neuron condition,a view perpetuated by most medical textbooks.

关键词： sclerosis clinical traditionally

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Benchmarking visual sLAM methods in mirror environments

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Computational Visual Media 2024年第2期10卷 215-241页

作者： peter Herbert Jing Wu Ze Ji Yu-Kun Lai school of Computer science and Informatics Cardiff UniversityAbacws BuildingSenghennydd RdCardiff CF244AGUK school of Engineering Cardiff UniversityQueen’s BuildingsThe ParadeCardiff CF243AAUK

Visual simultaneous localisation and mapping(vsLAM)finds applications for indoor and outdoor navigation that routinely subjects it to visual complexities,particularly mirror *** effect of mirror presence(time visible and its average size in the frame)was hypothesised to impact localisation and mapping performance,with systems using direct techniques expected to perform ***,a dataset,MirrEnv,of image sequences recorded in mirror environments,was collected,and used to evaluate the performance of existing representative *** ORB-sLAM3 and BundleFusion appear to show moderate degradation of absolute trajectory error with increasing mirror duration,whilst the remaining results did not show significantly degraded localisation *** mesh maps generated proved to be very inaccurate,with real and virtual reflections colliding in the reconstructions.A discussion is given of the likely sources of error and robustness in mirror environments,outlining future directions for validating and improving vsLAM performance in the presence of planar *** MirrEnv dataset is available at https://***/10.17035/d.2023.0292477898.

关键词： visual simultaneous localisation and mapping(vsLAM) mirror localisation mapping reflection datase

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Researching Forms of shadow Education:Methodological Challenges and Complexities of Private supplementary Tutoring in Myanmar

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ECNU Review of Education 2024年第1期7卷 89-110页

作者： peter Kamtungtuang suante Mark Bray The University of Hong Kong East China Normal University&The University of Hong Kong

Purpose:The growing literature on private supplementary tutoring,widely known as shadow education,addresses multiple dimensions and ***,many studies inadequately capture the diversity and implications of different forms of *** paper examines these matters in Myanmar,highlighting complexities and ambiguities in descriptors and in the nature of ***/Approach/Methods:Using a mixed-methods design,this study was conducted in Mandalay Region and Chin *** data were obtained from interviews with I10 Grade II students,34 high school teachers,30 parents,29 private tutoring providers,and two private school ***:The article categorizes tutoring forms based on their styles and orientations,particularly lecture-type teaching and homework supervision by guides,class sizes,durations of fee-charging(e.g,annually),the number of subjects taught per tutor,and tutoring *** study brings the topic out of the shadows for clearer analysis of the phenomenon and thus for assessment of its ***:The study makes a methodological contribution to the wider picture by demonstrating the need for greater clarity and precision in the national and international comparative *** also underscores shortcomings of predetermined categories in questionnaires and the value of qualitative interviews.

关键词： Classification methodology Myanmar private tutoring shadow education

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Cost burden following esophagectomy:A single centre observational study

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World Journal of Gastrointestinal surgery 2024年第7期16卷 2255-2269页

作者： Vered Buchholz Dong Kyu Lee David s Liu Ahmad Aly stephen A Barnett Riley Hazard peter Le Benjamin Kioussis Vijayaragavan Muralidharan Laurence Weinberg Department of surgery Austin HealthMelbourne 3084VictoriaAustralia Department of Anesthesiology and Pain Medicine Dongguk University Ilsan HospitalSeoul 14566GoyangSouth Korea Department of surgery Austin HealthThe University of MelbourneMelbourne 3084VictoriaAustralia Department of Anesthesia Austin HealthMelbourne 3084VictoriaAustralia Department of Anesthesia Austin HospitalHeidelberg 3084VictoriaAustralia Department of Critical Care The University of MelbourneMelbourne 3084VictoriaAustralia

BACKGROUND Cost analyses of patients undergoing esophagectomy is valuable for identifying modifiable expenditure drivers to target and curtail costs while improving the quality of *** aimed to define the cost-complication relationship after esophagectomy and delineate the incremental contributions to *** To assess the relationship between the hospital costs and potential cost drivers post esophagectomy and investigate the relationship between the cost-driving variables(predicting variables)and hospital costs(dependent variable).METHODs In this retrospective single center study,the severity of complications was graded using the Clavien-Dindo(CD)classification *** esophagectomy complications were categorized and defined according to consensus *** costing data included the in-hospital costs of the index admission and any unplanned admission within 30 postoperative *** used correlation analysis to assess the relationship between key clinical variables and hospital costs(in United states dollars)to identify cost drivers.A mediation model was used to investigate the relationship between these variables and hospital *** A total of 110 patients underwent primary esophageal *** median admission cost was $47822.7(interquartile range:35670.2-68214.0).The total effects on costs were $13593.9(95%CI:10187.1-17000.8,Pse in CD severity grade,$4781(95%CI:3772.7-5789.3,Pse in the number of complications,and $42552.2(95%CI:8309-76795.4,P=0.015)if a key esophagectomy complication *** esophagectomy complications drove the costs directly by $11415.7(95%CI:992.5-21838.9,P=0.032).CONCLUsION The severity and number of complications,and the development of key esophagectomy complications significantly contributed to total hospital *** institutional initiatives and strategies are needed to enhance patient outcomes and minimize costs.

关键词： Anesthesia Esophagectomy Complications Cancer surgery

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A survey on sensor-and Communication-Based Issues of Autonomous UAVs

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Computer Modeling in Engineering & sciences 2024年第2期138卷 1019-1050页

作者： Pavlo Mykytyn Marcin Brzozowski Zoya Dyka peter Langendoerfer IHP-Leibniz-Institut für Innovative Mikroelektronik Wireless SystemsFrankfurt(Oder)15236Germany BTU Cottbus-senftenberg Faculty 1:MINTCottbus03046German

The application field for Unmanned Aerial Vehicle (UAV) technology and its adoption rate have been increasingsteadily in the past years. Decreasing cost of commercial drones has enabled their use at a scale broader thanever before. However, increasing the complexity of UAVs and decreasing the cost, both contribute to a lack ofimplemented securitymeasures and raise new security and safety concerns. For instance, the issue of implausible ortampered UAV sensor measurements is barely addressed in the current research literature and thus, requires moreattention from the research community. The goal of this survey is to extensively review state-of-the-art literatureregarding common sensor- and communication-based vulnerabilities, existing threats, and active or passive cyberattacksagainst UAVs, as well as shed light on the research gaps in the literature. In this work, we describe theUnmanned Aerial system (UAs) architecture to point out the origination sources for security and safety *** the coverage and completeness of each related research work in a comprehensive comparison table as wellas classify the threats, vulnerabilities and cyber-attacks into sensor-based and communication-based ***, for each individual cyber-attack, we describe existing countermeasures or detectionmechanisms andprovide a list of requirements to ensureUAV’s security and *** also address the problem of implausible sensormeasurements and introduce the idea of a plausibility check for sensor data. By doing so, we discover additionalmeasures to improve security and safety and report on a research niche that is not well represented in the currentresearch literature.

关键词： Unmanned aerial vehicle unmanned aerial system cyber security and privacy drone swarm security vulnerabilities cyber-threats cyber-attacks plausibility check

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