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Pyrroloquinoline quinone:a potential neuroprotective compound for neurodegenerative diseases targeting metabolism

Neural Regeneration Research 2025年第1期20卷 41-53页

作者： Alessio Canovai pete a.willia.s Department of Biology University of PisaPisaItaly Department of Clinical Neuroscience Division of Eye and VisionSt.Erik Eye HospitalKarolinska InstitutetStockholmSweden

Pyrroloquinoline quinone is a quinone described as a cofactor for many bacterial dehydrogenases and is reported to exert an effect on metabolism in mammalian cells/*** quinone is present in the diet being available in foodstuffs,conferring the potential of this compound to be supplemented by dietary *** quinone’s nutritional role in mammalian health is supported by the extensive deficits in reproduction,growth,and immunity resulting from the dietary absence of pyrroloquinoline quinone,and as such,pyrroloquinoline quinone has been considered as a“new vitamin.”Although the classification of pyrroloquinoline quinone as a vitamin needs to be properly established,the wide range of benefits for health provided has been reported in many *** this respect,pyrroloquinoline quinone seems to be particularly involved in regulating cell signaling pathways that promote metabolic and mitochondrial processes in many experimental contexts,thus dictating the rationale to consider pyrroloquinoline quinone as a vital compound for mammalian *** the regulation of different metabolic mechanisms,pyrroloquinoline quinone may improve clinical deficits where dysfunctional metabolism and mitochondrial activity contribute to induce cell damage and *** quinone has been demonstrated to have neuroprotective properties in different experimental models of neurodegeneration,although the link between pyrroloquinoline quinone-promoted metabolism and improved neuronal viability in some of such contexts is still to be fully ***,we review the general properties of pyrroloquinoline quinone and its capacity to modulate metabolic and mitochondrial mechanisms in physiological *** addition,we analyze the neuroprotective properties of pyrroloquinoline quinone in different neurodegenerative conditions and consider future perspectives for pyrroloquinoline quinone’s potential in health and disease.

关键词： metabolism mitochondria neurodegenerative disease neuroprotection pyrroloquinoline quinone retinal diseases

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Isotope Tracking of surface Water Groundwater Interaction in the Beninese Part of the Iullemeden Aquifer system

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Journal of Water Resource and Protection 2024年第7期16卷 489-501页

作者： Houégnon Géraud Vinel Gbewezoun samuel Yao Ganyaglo Abdoukarim Alassane samuel Boakye Dampare Gaya salifou Orou pete Alou Moussa Boukari Daouda Mama Laboratoire dHydrologie Applique (LHA) of Institut National de lEau (INE) Universit dAbomey-Calavi Abomey-Calavi Benin International Chair in Mathematical Physics and Applications (ICMPA-UNEsCO Chair) Universit dAbomey-Calavi Abomey-Calavi Benin school of Nuclear and Allied sciences (sNAs) University of Ghana-Atomic Campus Accra Ghana Ghana Atomic Energy Commission (GAEC) Accra Ghana

The Kandi basin is located in northeast Benin (West Africa). This study is focused on the estimation of water fluxes exchanged between the river Niger (and its tributaries) and the transboundary Iullemeden Aquifer system. In that framework, an innovative approach based on the application of the Bayesian Mixing Model (MixsIAR) analysis on water isotopes (oxygen-18, deuterium and tritium) was performed. Moreover, to assess the relevance of the model outputs, Pearson’s correlation and Principal Component Analysis (PCA) have been done. A complex relationship between surface water and groundwater has been found. sixty percent (60%) of groundwater samples are made of more than 70% river water and rainwater;while 31.25% of surface water samples are made of about 84% groundwater. To safeguard sustainable water resources for the well-being of the local communities, surface water and groundwater must be managed as a unique component in the Kandi basin.

关键词： Benin West Africa Kandi basin Iullemeden Aquifer system surface Water Groundwater Interaction

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Guanidinoamidized Linear Polyethyleneimine for Gene Delivery

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Chinese Journal of Polymer science 2015年第6期33卷 908-919页

作者： Bo Zhang Xin-peng Ma Mei-hua sui Edward Van Kirk willia m J.Murdoch Maciej Radosz 林能明申有青 Institute for Individualized Medicine Hangzhou First People’s Hospital Laboratory of Clinical Pharmacy Zhejiang Cancer Hospital Department of Chemical and Petroleum Engineering University of Wyoming Center for Bionanoengineering and the state Key Laboratory for Chemical Engineering Department of Chemical and Biological EngineeringZhejiang University Department of Animal science University of Wyoming

Guanidine was introduced to low molecular weight linear polyethyleneimine （LPEI） via amide groups, to explore the effect of both guanidine degree and pendant chain length on its transfection behavior. The resulting guanidinoamidized LPEIs （GLPEIs） could dramatically reduce LPEI＇s toxicity, enhance its DNA-packaging capability, cellular uptake and therefore transfection efficiency. These polyplexes were taken up very efficiently via caveolae-mediated endocytosis and their transfection efficiencies in ovarian cancer cells were significantly improved compared to native LPEIlok polyplexes. Among these GLPEIs, LPEI-C3-G100 showed higher DNA affinity even than LPEI25k and the highest transfection efficiency, probably due to the optimization of polymer chain flexibility. Of notice, LPEI-C3-G100 polyplexes could more effectively accumulate into cytoplasm than LPEI25k, although the transfection efficiency of LPEI-C3-G100 polyplexes was not superior to that of LPEI25k polyplexes, which would be probably attributed to the more efficient release of LPEI25k polyplexes than LPEI-C3-G100 polyplexes in the cytoplasm.

关键词： Polyethyleneimine Guanidine Gene delivery Cellular uptake.

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InGaAs／AlAs双势垒RTD单片高速逻辑IC的研制

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微电子学与计算机 1996年第2期13卷 1-5页

作者：雷培明 willia,W 美国Notre Dame大学电机工程系

本文叙述一种新型的基于ＩｎＧａＡｓ／ＡｌＡＳ双势垒ＲＴＤ单片高速逻辑集成电路的设计和制造技术。由该技术产主的Ｓｃｈｏｔ－ｔｋｙ／ＲＴＤ集成双稳开关已工作到３ＧＨＺ的振荡频率。

关键词： InGaAs AlAs 双势垒RTD 逻辑集成电路

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soil inorganic carbon sequestration through alkalinity regeneration using biologically induced weathering of rock powder and biochar

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soil Ecology Letters 2022年第4期4卷 293-306页

作者： Muhammad Azeem sajjad Raza Gang Li pete smith Yong-Guan Zhu Key Laboratory of Urban Environment and Health Ningbo Observation and Research Station Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Zhejiang Key Lab of Urban Environmental Processes and Pollution Control CAS Haixi Industrial Technology Innovation Center in BeilunNingbo 315830China Institute of soil and Environmental science Pir Mehr Ali Shah Arid Agriculture University RawalpindiPunjab 46300Pakistan school of Geographical sciences Nanjing University of Information Science and TechnologyNanjing 21000China Institute of Biological&Environmental sciences University of Aberdeen23 St Machar DriveAberdeen AB243UUUK

soil inorganic carbon(sIC)accounts for about half of the C reserves worldwide and is considered more stable than soil organic carbon(sOC).However,soil acidification,driven mainly by nitrogen(N)fertilization can accelerate sIC losses,possibly leading to complete loss under continuous and intensive N ***-free soils are less fertile,productive,and more prone to ***,minimizing carbonate losses is essential for soil health and climate change ***/mineral residues or powder have been suggested as a cheaper source of amendments to increase soil ***,slow mineral dissolution limits its efficient *** microorganisms play a vital role in the weathering of rocks and their inoculation with mineral residues can enhance dissolution *** is an alternative material for soil amendments,in particular,bone biochar(BBC)contains higher Ca and Mg that can induce even higher *** review covers i)the contribution and mechanism of rock residues in alkalinity generation,ii)the role of biochar or BBC to soil alkalinity,and iii)the role of microbial inoculation for accelerating alkalinity generation through enhanced mineral *** conclude that using rock residues/BBC combined with microbial agents could mitigate soil acidification and sIC losses and also improve agricultural circularity.

关键词： soil acidity Climate change Valorizing of waste Biological weathering

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No Longer Left Behind Journey to the West

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China International Business 2008年第12期 61-62页

作者： pete sWEENEY

sichuan and Yunnan have benefited from massive investment since the 1960s, and this looks set to continue with the government＇s recently announced stimulus package.

关键词：投资西部地区开发利用

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English Christmas Pantomime： Theatre or Community Activism

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Journal of Literature and Art studies 2016年第7期6卷 804-810页

作者： pete Reader, MFA seton Hall University South Orange N J USA

How is English Christmas panto community activism？ The structure of pantomime has not changed in a hundred years, but allows for local creativity to work within its framework to be both family entertainment and social satire This basic structure is founded on a children＇s story like Puss ＇n ＇boots or Cinderella. The story and character types remain the same; but the community can add their own jokes and commentary to make the play relevant to themselves and their community. What is added by the community says a lot about who they are and what they care about. The company Price-Waterhouse-Coopers produces their pantomime as management training and team building while engaging the community. The Basel swiss panto raises money for African Charities. The Maplewood, NJ panto raises money for the homeless and the Jaguar Charity panto in Birmingham performs to disadvantaged children and adults. The productions can be extravagant or threadbare, but share the same goal of raising cheer and goodwill to the benefit of the community. What is it, then, about panto that brings a community together in such civic mindedness？

关键词： English Christmas pantomine community engagement theatre activism

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Chengdu Renaissance

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China International Business 2008年第12期 63-64页

作者： pete sWEENEY

sichuaffs provincial capital has become one of China＇s business and investment hotspots, despite the disruption caused by last May＇s earthquake.

关键词：对外贸易经济开发中国商品贸易

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Measuring Cities with software-Defined sensors

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Journal of social Computing 2020年第1期1卷 14-27页

作者： Charlie Catlett pete Beckman Nicola Ferrier Howard Nusbaum Michael E.Papka Marc G.Berman Rajesh sankaran University of Illinois Discovery Partners Institute ChicagoIL 60606USA Northwestern University EvanstonIL 60208USA University of Chicago ChicagoIL 60637USA Northern Illinois University DeKalbIL 60115USA Argonne National Laboratory

The Chicago Array of Things(AoT)project,funded by the Us National science Foundation,created an experimental,urban-scale measurement capability to support diverse scientific *** conceived as a traditional sensor network,collaborations with many science communities guided the project to design a system that is remotely programmable to implement Artificial Intelligence(AI)within the devices—at the“edge”of the network—as a means for measuring urban factors that heretofore had only been possible with human observers,such as human behavior including social *** concept of“software-defined sensors”emerged from these design discussions,opening new possibilities,such as stronger privacy protections and autonomous,adaptive measurements triggered by events or *** provide examples of current and planned social and behavioral science investigations uniquely enabled by software-defined sensors as part of the sAGE project,an expanded follow-on effort that includes AoT.

关键词： sensors edge computing computer vision urban science

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Going Home

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语言教育 1995年第2期 32-34页

作者： pete Hamill 李波

I first heard this story a few years ago from a girl I had metin New York’s Greenwich *** the story is one of thosemysterious bits of folklore that reappear every few years,to he toldanew in one form or ***,I still l... 详细信息

关键词： think story happen young night morning Going Home looking perhaps doing

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