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Utility of Preoperative Positron Emission Tomography (pet) in Localizing Perforator Vessels of Anterolateral Thigh Free Flap

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第4期13卷 275-284页

作者： Alexandra McMillan Sameer A. Alvi Zaid Al-Qurayshi Zachary Fleishacker Nitin A. Pagedar Marisa r. Buchakjian Department of Otolaryngology University of Iowa Hospitals and Clinics Iowa City IA USA Division of Otolaryngology-Head & Neck Surgery North Shore University Health System Evanston IL USA Pritzker School of Medicine The University of Chicago Chicago IL USA Holden Comprehensive Cancer Center University of Iowa Iowa City IA USA

Objectives: The anterolateral thigh (ALT) flap is often considered the workhorse in soft tissue reconstruction of head and neck defects secondary to trauma, infection, or tumor resection. Despite its many advantages, ALT flaps have been criticized due to variability in vasculature, which may result in inadequate or non-existent perforators. This retrospective study aims to investigate the utility and validity of positron emission tomography (pet) scan to identify the location and characteristics of perforators to the ALT flap. Methods: we performed a 10-year retrospective review of ALT flaps at our institution to identify patients with preoperative pet scans available for analysis. Three reviewers (attending physician, fellow, and resident) were asked to identify the number, location, and characteristics (myocutaneous versus septocutaneous) of ALT perforators on imaging, and reviewer agreement was assessed. results were then compared to available operative data. results: One hundred twenty-one patients were identified who underwent ALT free flap surgery. Thirty-eight preoperative pet scans were identified for review. At least one perforator was identified in 92.1% of scans. Agreement percentages regarding the number of perforators ranged from 53% - 61% whereas agreement regarding the location of a single perforator ranged from 79% - 90%. However, reviewers did not agree regarding the type of perforator, with agreement ranging from 34% - 53%. Poor agreement was observed when compared to intraoperative data, with the number of perforators ranging from 26% - 34% and the type of perforator 11% - 24%. These findings are likely due to insufficient data available in operative reports. Conclusion: Although initial studies suggest that pet scan shows promising evidence to support the capacity to preoperatively identify ALT perforators, future prospective studies are warranted to fully validate these findings.

关键词： Anterolateral Thigh Flaps Positron Emission Tomography Head and Neck Defects Perforator Mapping

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Association between lifestyle factors and thyroid function in young euthyroid adults

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Food Science and Human wellness 2024年第1期13卷 265-275页

作者： Elisa Merchan-ramirez Guillermo Sanchez-Delgado Lucas Jurado-Fasoli Francisco M Acosta Manuel Munoz-Torres Jose M.Llamas-Elvira Jonatan r ruiz Sport and Health University research Institute(iMUDS) Faculty of Sports ScienceUniversity of GranadaGranada 18016Spain Pennington Biomedical research Center Baton Rouge 70808USA Faculty of Medicine University of GranadaGranada 18071Spain Turku pet Centre University of TurkuTurku 20500Finland Turku pet Centre Turku University HospitalTurku 20520Finland Biosanitary research Institute of Granada(Ibs.Granada) Granada 18012Spain CIBErFES Instituto de Salud CarlosⅢMadrid 28029Spain Endocrinology and Nutrition Service University Hospital San CecilioGranada 18016Spain Nuclear Medicine Service "Virgen de las Nieves"University HospitalGranada 18014Spain

Purpose:The present work examines the associations of dietary habits,sedentarism,physical activity(PA)levels and sleep habits,with thyroid function in young euthyroid ***:A total of 105 young euthyroid adults participated in this cross-sectional *** function was determined in fasting conditions(>6 h).Dietary habits were measured by a food frequency questionnaire and three non-consecutive 24 h recalls,and different dietary intake and patterns were then *** time spent in sedentary,PA levels and sleep habits were objectively measured using a wrist-worn ***:Energy and carbohydrate intake were positively associated with thyroid stimulating hormone(TSH)(β=0.222;r^(2)=0.102;P=0.022 andβ=0.425;r^(2)=0.129;P=0.007,respectively)whereas fat intake was negatively associated with TSH(β=-0.428;r^(2)=0.137;P=0.004).Energy intake was also positively associated with free triiodothyronine(β=0.277;r^(2)=0.137;P=0.004).Further,adherence to the Mediterranean diet was negatively related to TSH and free thyroxine(FT4)(β=-0.221;r^(2)=0.113;P=0.020 andβ=-0.268;r^(2)=0.071;P=0.007,respectively).Vigorous-intensity and overall PA were negatively associated with FT4(β=-0.227;r^(2)=0.052;P=0.022 andβ=-0.204;r^(2)=0.042;P=0.041,respectively).In contrast,no associations were found between sleep parameters and thyroid ***:Lifestyle factors such as dietary intake and PA levels seems to be related to thyroid function even in young euthyroid adults.

关键词： Thyroid hormones Dietary intake Sleep Physical activity Euthyroid

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Oxidized organic molecules in the tropical free troposphere over Amazonia

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National Science review 2024年第1期11卷 174-184页

作者： Qiaozhi Zha Diego Aliaga radovan Krejci Victoria A.Sinclair Cheng wu Giancarlo Ciarelli wiebke Scholz Liine Heikkinen Eva Partoll Yvette Gramlich wei Huang Markus Leiminger Joonas Enroth Otso Per?kyl? runlong Cai Xuemeng Chen Alkuin Maximilian Koenig Fernando Velarde Isabel Moreno Tuukka pet?j? Paulo Artaxo Paolo Laj Armin Hansel Samara Carbone Markku Kulmala Marcos Andrade Douglas worsnop Claudia Mohr Federico Bianchi Institute for Atmospheric and Earth System research/Physics University of Helsinki Joint International research Laboratory of Atmospheric and Earth System Sciences Nanjing University Department of Environmental Science & Bolin Centre for Climate research Stockholm University Department of Chemistry and Molecular Biology University of Gothenburg Institute for Ion and Applied Physics University of Innsbruck Ionicon Analytik GmbH Laboratory for Atmospheric Physics Institute for Physics Research Universidad Mayor de San Andrés Institute of Physics University of Sao Paulo Institute for Geosciences and Environmental research (IGE) University of Grenoble Alpes Agrarian Sciences Institute Federal University of Uberl?ndia Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Department of Atmospheric and Oceanic Sciences University of Maryland Aerodyne research Inc. Department of Environmental System Science ETH Zürich Switzerland and Laboratory of Atmospheric Chemistry Paul Scherrer Institute

New particle formation(NPF) in the tropical free troposphere(FT) is a globally important source of cloud condensation nuclei, affecting cloud properties and climate. Oxidized organic molecules(OOMs)produced from biogenic volatile organic compounds are believed to contribute to aerosol formation in the tropical FT, but without direct chemical observations. we performed in situ molecular-level OOMs measurements at the Bolivian station Chacaltaya at 5240 m above sea level, on the western edge of Amazonia. For the first time, we demonstrate the presence of OOMs, mainly with 4–5 carbon atoms, in both gas-phase and particle-phase(in terms of mass contribution) measurements in tropical FT air from Amazonia. These observations, combined with air mass history analyses, indicate that the observed OOMs are linked to isoprene emitted from the rainforests hundreds of kilometers away. Based on particle-phase measurements, we find that these compounds can contribute to NPF, at least the growth of newly formed nanoparticles, in the tropical FT on a continental scale. Thus, our study is a fundamental and significant step in understanding the aerosol formation process in the tropical FT.

关键词： oxidized organic molecules tropical aerosol formation Amazon free troposphere

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Towards seamless environmental prediction-development of Pan-Eurasian EXperiment(PEEX)modelling platform

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Big Earth Data 2024年第2期8卷 189-230页

作者： Alexander Mahura Alexander Baklanov risto Makkonen Michael Boy Tuukka petäjä Hanna KLappalainen roman Nuterman Veli-Matti Kerminen Stephen r.Arnold Markus Jochum Anatoly Shvidenko Igor Esau Mikhail Sofiev Andreas Stohl Tuula Aalto Jianhui Bai Chuchu Chen Yafang Cheng Oxana Drofa Mei Huang Leena Järvi Harri Kokkola rostislav Kouznetsov Tingting Li Piero Malguzzi Sarah Monks Mads Bruun Poulsen Steffen M.Noe Yuliia Palamarchuk Benjamin Foreback petri Clusiu Till Andreas Soya rasmussen Jun She Jens Havskov Sørensen Dominick Spracklen Hang Su Juha Tonttila Siwen wang Jiandong wang Tobias wolf-Grosse Yongqiang Yu Qing Zhang wei Zhang wen Zhang Xunhua Zheng Siqi Li Yong Li Putian Zhou Markku Kulmala Faculty of Science Institute for Atmospheric and Earth System Research(INAR)/PhysicsUniversity of Helsinki(UHEL)HelsinkiFinland Science and Innovation Department World Meteorological Organization(WMO)GenevaSwitzerland Niels Bohr Institute University of CopenhagenCopenhagenDenmark Climate System research Finnish Meteorological Institute(CSR-FMI)HelsinkiFinland School of Engineering Sciences Lappeenranta University of TechnologyLappeenrantaFinland Institute for Climate and Atmospheric Science School of Earth and EnvironmentUniversity of LeedsLeedsUK Biodiversity and Natural resources Program International Institute for Applied Systems Analysis(IIASA)LaxenburgAustria Department of Physics and Technology UiT-The Arctic University of NorwayTromsoNorway Nansen Environmental and remote Sensing Center(NErSC) BergenNorway Atmospheric Composition Finnish Meteorological Institute(AC-FMI)HelsinkiFinland Norwegian Institute for Air research(NILU) KjellerNorway LAGEO Institute of Atmospheric PhysicsChinese Academy of Sciences(IAP-CAS)BeijingChina Max Planck Institute for Chemistry(MPI-Chem) MainzGermany Institute of Atmospheric Sciences and Climate National Research Council of Italy(CNR-15SAC)BolognaItaly Institute of Geographic Sciences and Natural resources research(IGSNrr) Chinese Academy of Sciences(CAS)BeijingChina Faculty of Science Helsinki Institute of Sustainability Science(HELSUS)University of Helsinki(UHEL)HelsinkiFinland Atmospheric research Centre of Eastern Finland Finnish Meteorological Institute(ARCEF-FMI)KuopioFinland Institute of Atmospheric Physics Chinese Academy of Sciences(IAP-CAS)BeijingChina Department of Plant Physiology Estonian University of Life Sciences(EULS)Institute of Agricultural and Environmental Sciences(IAES)TartuEstonia Danish Meteorological Institute(DMI) CopenhagenDenmark State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry LAPC) Institute of Atmospheric Physics(IAP)Chinese Academy of Sciences(CAS)BeijingChina Uni

The Pan-Eurasian Experiment Modelling Platform(PEEX-MP)is one of the key blocks of the PEEX research *** PEEX MP has more than 30 models and is directed towards seamless envir-onmental *** main focus area is the Arctic-boreal regions and *** models used in PEEX-MP cover several main components of the Earth’s system,such as the atmosphere,hydrosphere,pedosphere and biosphere,and resolve the physicalchemicalbiological processes at different spatial and temporal scales and *** paper introduces and discusses PEEX MP multi-scale modelling concept for the Earth system,online integrated,forward/inverse,and socioeconomical modelling,and other approaches with a particular focus on applications in the PEEX geographical *** employed high-performance com-puting facilities,capabilities,and PEEX dataflow for modelling results are *** virtual research platforms(PEEXView,Virtual research Environment,web-based Atlas)for handling PEEX modelling and observational results are *** over-all approach allows us to understand better physical-chemicalbiological processes,Earth’s system interactions and feedbacks and to provide valuable information for assessment studies on evaluating risks,impact,consequences,*** population,envir-onment and climate in the PEEX *** work was also one of the last projects of *** Zilitinkevich,who passed away on 15 February *** the finalization took time,the paper was actually submitted in 2023 and we could not argue that the final paper text was agreed with him.

关键词： Multi-scale and-processes modelling concept seamless coupling high-performance computing data infrastructure virtual research platforms

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Physical activity and amyloid beta in middle-aged and older adults:A systematic review and meta-analysis

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Journal of Sport and Health Science 2024年第2期13卷 133-144页

作者： María rodriguez-Ayllon Patricio Solis-Urra Cristina Arroyo-ávila Miriam álvarez-Ortega Pablo Molina-García Cristina Molina-Hidalgo Manuel Gómez-río Belinda Brown Kirk I.Erickson Irene Esteban-Cornejo Department of Epidemiology Erasmus University Medical Center RotterdamRotterdamGD 3015the Netherlands Department of Physical Education and Sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18071Spain Faculty of Education and Social Sciences Universidad Andres BelloVina del Mar 2531015Chile Department of Nuclear Medicine Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Physical Medicine and rehabilitation Service Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Department of Psychology University of PittsburghPittsburghPA 15260USA Centre for Healthy Ageing Health Futures InstituteMurdoch UniversityMurdochWA 6150Australia School of Medical and Health Sciences Edith Cowan UniversityJoondalupWA 6027Australia Advent Health research Institute Neuroscience Institute OrlandoOrlandoFL 32803USA Physiopathology of Obesity and Nutrition research Center(CIBErobn) Institute of Health Carlos Ⅲ(ISCⅢ)Madrid 28029Spain

Background:One of the pathological hallmarks distinguishing Alzheimer’s disease from other dementias is the accumulation of amyloid beta(Aβ).Higher physical activity is associated with decreased dementia risk,and one potential path could be through Aβlevels *** aimed to explore the relationship between physical activity and Aβin middle-aged and older ***:A systematic search of PubMed,web of Science,PsycINFO,Cochrane Central register of Controlled Trials,and SPOrTDiscus was performed from inception to April 28,*** were eligible if they included physical activity and Aβdata in adults aged 45 years or ***-level metaanalyses of intervention and observational studies were performed to examine the role of physical activity in modulating Aβ***:In total,37 articles were included(8 randomized controlled trials,3 non-randomized controlled trials,4 prospective longitudinal studies,and 22 cross-sectional studies).The overall effect size of physical activity interventions on changes in blood Aβwas medium(pooled standardized mean difference=-0.69,95%confidence interval(95%CI):-1.41 to 0.03;I^(2)=74.6%).However,these results were not statistically significant,and there were not enough studies to explore the effects of physical activity on cerebrospinal fluid(CSF)and brain Aβ.Data from observational studies were examined based on measurements of Aβin the brain using positron emission tomography scans,CSF,and *** physical activity was positively associated with Aβonly in the CSF(Estimate r=0.12;95%CI:0.05-0.18;I^(2)=38.00%).Conclusion:Physical activity might moderately reduce blood Aβin middle-aged and older ***,results were only near statistical significance and might be interpreted with caution given the methodological limitations observed in some of the included *** observational studies,higher levels of physical activity were positively associated with Aβonly in ***,further research is needed t

关键词： Aging Cognitive impairment Dementia Exercise pet

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Magnetic Properties and Structure of Nanocrystalline Nd_(4.5)Fe_(76)Co_(1)B_(18.5) Alloys

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Journal of Materials Science & Technology 2001年第2期17卷 285-286页

作者： wenli pet Fazeng LIAN Guiqin ZHOU Department of Materials Science and Engineering Northeastern UniversityShenyang 110006China

The technology, structures and magnetic properties of Nd4.5Fe76Co1B18.5 nanocomposite magnets were investigated. The effect of crystallizing treatment temperature and time on structures and magnetic properties of Nd4.5Fe76Co1B18.5 amorphous ribbons was studied. The results show that Nd4.5Fe76Co1B18.5 containing more analogue metals is easy to form amorphous. The magnetic properties of 16 m/s quenched ribbon for 710°C × 900 s crystallizing treatment are as follows: iHc=242.1 kA/m, Br=0.9410 T and (BH)max=59.64 kJ/m3. The even grain size is as follows: D(Fe3B)=34 nm and D (Nd2Fe14B)=23 nm.

关键词： Nanostructured materials

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Design and construction of super-long span bridges in China: review and future perspectives

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Frontiers of Structural and Civil Engineering 2020年第4期14卷 803-838页

作者： wei HUANG Minshan pet Xiaodong LIU Ya wEI Intelligent Transportation System research Center Southeast UniversityNanjing 211189China China Communications Construction Company Ltd. Beijing 100088China Department of Civil Engineering Tsinghua UniversiyBeijing 100084China

Super-long span bridges demand high design requirements and involve many difficulties when constructed,which is an important indicator to reflect the bridge technical level of a *** the past three decades,a large percentage of the new long-span bridges around the world were built in China,and thus,abundant technological innovations and experience have been accumulated during the design and *** paper aims to review and summarize the design and construction practices of the superstructure,the substructure,and the steel deck paving of the long-span bridges during the past decades as well as the current operation status of the existing long-span bridges in China.A future perspective was given on the developing trend of high-speed railway bridge,bridge over deep-sea,health monitoring and maintenance,intellectualization,standard system,and information technology,which is expected to guide the development direction for the construction of future super long-span bridges and promote China to become a strong bridge construction country.

关键词： long-span bridges steel box girder design technology construction technology,review and future perspectives

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The Use of Insulin Negatively Impacts the Mortality of Severe COVID-19 in Patients with Type 2 Diabetes—A Systematic review

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Journal of Diabetes Mellitus 2024年第3期14卷 166-176页

作者： Caio F. Biolcatti Marcela r. Simoes Thais P. Prado Milena Monfort-Pires Licio A. Velloso Obesity and Comorbidities research Center Campinas Brazil Turku pet Centre University of Turku Turku Finland National Institute of Science and Technology on Neuroimmunomodulation Campinas Brazil

Obesity and type 2 diabetes are among the most important risk factors for severe coronavirus disease-19. Some studies have suggested that the use of insulin as a therapeutic agent to treat hyperglycemia and the metabolic abnormalities associated with type 2 diabetes during the acute phase of severe coronavirus disease-19 could have a negative impact on the disease’s progression;however, there is no consensus on this issue. Here, we performed a systematic review in an attempt to answer this important question. we included 29 articles published from December 2019 to August 2023, which reported the outcomes of 3,070,657 patients with severe coronavirus disease-19 that had the diagnosis of diabetes and were treated with either insulin or other glucose-reducing agents. The results show that using insulin as a pharmacological intervention to treat type 2 diabetes in patients with severe coronavirus disease-19 increases the likelihood of mortality by 193%.

关键词： SArS-CoV2 Obesity Inflammation Metabolism Glucose

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High-performance portable grating-based surface plasmon resonance sensor using a tunable laser at normal incidence

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Photonics research 2024年第5期12卷 947-958页

作者： DUC LE ANNI rANTA-LASSILA TEEMU SIPOLA MIKKO KArPPINEN JArNO petAJA MINNA KEHUSMAA SANNA AIKIO TIAN-LONG GUO MATTHIEU rOUSSEY JUSSI HILTUNEN ALEXEY POPOV VTT Technical research Centre of Finland 90570 OuluFinland Department of Physics and Mathematics University of Eastern FinlandFI-80101 JoensuuFinland

Surface plasmon resonance(SPr)sensors are among the most sensitive *** such devices,a grating is a compelling alternative to a prism for the excitation of a surface plasmon,especially in the development of sensors for point-of-care applications due to their compactness and ***,we demonstrate the use of a tunable laser in a grating-based SPr system for further miniaturization and *** tunable laser working at normal incidence replaces spectral and moving components,while also simplifying the optical *** incidence is conventionally avoided due to the complexity of the control of degenerated SPr *** investigate,both computationally and experimentally,the splitting of the SPr modes at small nonzero incidences,which is lacking in previously reported *** optimizing the grating configuration,we were able to diminish the SPr mode splitting phenomenon when the excitation was feasible with the normal incidence *** fabricated sensor showed a high sensitivity of 1101.6 nm/***,the figure of merit of the sensor,defined as the ratio between the sensitivity and bandwidth of the SPr dip,was *** experimental results were consistent with the simulation *** also demonstrate its capability for detecting low concentrations of glucose and creatinine with the limit of detection of 14.2 and 19.1 mmol/L,respectively.

关键词： tunable splitting excitation

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real-world performance analysis of a novel computational method in the precision oncology of pediatric tumors

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world Journal of Pediatrics 2023年第10期19卷 992-1008页

作者： Barbara Vodicska Júlia Déri Dóra Tihanyi Edit Várkondi EnikőKispéter róbert Dóczi Dóra Lakatos Anna Dirner Mátyás Vidermann Péter Filotás réka Szalkai-Dénes István Szegedi Katalin Bartyik Krisztina Míta Gábor réka Simon Péter Hauser György Péter Csongor Kiss Miklós Garami István peták Oncompass Medicine Hungary Kft Retek Str.34Budapest 1024Hungary Division of Pediatric Hematology-Oncology Department of PediatricsFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Pediatrics Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Onco-Hematology Department Velkey LászlóPaediatric Health CentreMiskolcHungary Department of Paediatrics Semmelweis UniversityBudapestHungary Onco-Hematology Department Heim Pál Children’s HospitalBudapestHungary Department of Pharmacology and Pharmacotherapy Semmelweis UniversityBudapestHungary Department of Pharmaceutical Sciences University of Illinois at ChicagoChicagoUSA Genomate Health CambridgeMAUSA

Background The utility of routine extensive molecular profiling of pediatric tumors is a matter of debate due to the high number of genetic alterations of unknown significance or low evidence and the lack of standardized and personalized decision support *** drug assignment(DDA)is a novel computational method to prioritize treatment options by aggregating numerous evidence-based associations between multiple drivers,targets,and targeted *** has been validated to improve personalized treatment decisions based on the outcome data of adult patients treated in the SHIVA01 clinical *** aim of this study was to evaluate the utility of DDA in pediatric *** Between 2017 and 2020,103 high-risk pediatric cancer patients(rs)were involved in our precision oncology program,and samples from 100 patients were eligible for further *** or blood samples were analyzed by whole-exome(wES)or targeted panel sequencing and other molecular diagnostic modalities and processed by a software system using the DDA algorithm for therapeutic decision ***,a molecular tumor board(MTB)evaluated the results to provide therapy *** Of the 100 cases with comprehensive molecular diagnostic data,88 yielded wES and 12 panel sequencing *** identified matching off-label targeted treatment options(actionability)in 72/100 cases(72%),while 57/100(57%)showed potential drug *** reached 88%(29/33)by 2020 due to the continuous updates of the evidence *** approved the clinical use of a DDA-top-listed treatment in 56 of 72 actionable cases(78%).The approved therapies had significantly higher aggregated evidence levels(AELs)than dismissed *** of wES results for targeted panels missed important mutations affecting therapy *** DDA is a promising approach to overcome challenges associated with the interpretation of extensive molecular profiling in the routine car

关键词： Computational decision support Pediatric tumors Precision oncology Tumor board

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