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A comprehensive review on anti-diabetic property of rice bran

Asian Pacific Journal of Tropical Biomedicine 2018年第1期8卷 79-84页

作者： Bhagavathi Sundaram Sivamaruthi periyanaina kesika Chaiyavat Chaiyasut Innovation Center for Holistic Health Nutraceuticals and Cosmeceuticals Faculty of Pharmacy Chiang Mai University

Rice bran(RB) is one of the nutrient-rich agricultural byproducts. It is a composite of carbohydrates, lipids, proteins, fibers, minerals, and trace elements such as phosphorus, potassium, magnesium, calcium and manganese. The extraction and purification process influences the quality and quantity of rice bran oil, which is rich in tocopherols, tocotrienols, 毭-oryzanol, and unsaturated fatty acids. The bioactive components of RB have been reported for exhibiting antioxidant, anti-inflammatory, hypocholesterolemic, anti-cancer, anti-colitis, and antidiabetic properties. In vitro and in vivo studies, and clinical trials in human volunteers revealed the anti-hyperglycemic activity of RB derived compounds. An updated comprehensive review on the antidiabetic property of RB and its derivative is required to appraise the current knowledge in the particular field. Thus, the present paper covered the composition and bioactivities of RB, and influence of extraction methods on the biological property of rice bran oil and rice bran extract. And the current review also focused on the reported antihyperglycemia activity of rice bran derivatives, and its probable mechanism.

关键词： Anti-diabetic Anthocyanins Rice bran Rice bran oil Rice bran extract γ-oryzanol

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Beneficial effects of anthocyanins against diabetes mellitus associated consequences——A mini review

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Asian Pacific Journal of Tropical Biomedicine 2018年第10期8卷 471-477页

作者： Bhagavathi Sundaram Sivamaruthi periyanaina kesika Kumaresan Subasankari Chaiyavat Chaiyasut Innovation Center for Holistic Health Nutraceuticalsand CosmeceuticalsFaculty of PharmacyChiang Mai University Centre of Advanced Study in Marine Biology Annamalai University

Anthocyanins(ACN) are water-soluble pigments, belonging to flavonoids, and are present in almost all fruits, and vegetables at varying concentration. About 635 ACN were distinguished based on the position and number of methoxyl and hydroxyl moieties in the basic structure of ACN. Pelargonidin, cyanidin, delphinidin, malvidin, peonidin, and petunidin are extensively studied anthocyanidins. The absorption, bioavailability, metabolism, pharmacokinetics, molecular mechanism, and analytical techniques of several phytochemicals were described. The biological benefits(antidiabetic, anti-neuro-disorder, anti-cardiovascular diseases, antigastrointestinal diseases, and disorders) of flavonoids and ACN have been reported. Several in vitro, and in vivo reports demonstrated that ACN-rich plant extracts ameliorate the diabetesassociated consequences by reducing the glucose absorption, ROS production, oxidative stress, glomerular angiogenesis, lipid synthesis, and FoxO1 and adipose triglyceride lipase expressions, and improve the insulin secretion, insulin sensitivity, glucose tolerance, glucose uptake, glucose consumption, antioxidant activity. The literature search was made in Scopus, Google Scholar, PubMed using the keywords "anthocyanin" and "diabetes". The documents were carefully checked for the relevance to the current manuscript and the selection was made without any chronological restriction. The present manuscript summarizes the updated reports on antihyperglycemic properties of ACN.

关键词： Anthocyanins Flavonoids Diabetes Cyanidin 3-O-β-D-glucoside Insulin sensitivity

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Lactic acid bacteria mediated fermented soybean as a potent nutraceutical candidate

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Asian Pacific Journal of Tropical Biomedicine 2017年第10期7卷 930-936页

作者： Sasithorn Sirilun Bhagavathi Sundaram Sivamaruthi periyanaina kesika Sartjin Peerajan Chaiyavat Chaiyasut Innovation Center for Holistic Health Nutraceuticalsand CosmeceuticalsFaculty of PharmacyChiang Mai University Chiang Mai 50200Thailand Health Innovation Institute Chiang Mai 50230Thailand

Objective: To study some soybean cultivars commonly used in Northern Thailand that exhibit high nutritional profile and to investigate the changes in bioactive principles and antioxidant capacity of the fermented soy broth that was prepared using the selected soybean cultivar and Lactobacillus paracasei HII02 mediated fermentation ***: The best soybean cultivar was subjected to fermentation, and then analyzed the phytochemical, antioxidant and nutritional changes by high performance liquid chromatography and spectrophotometric ***: Sor Jor 2 soybean cultivar showed rich nutritional profile and was subjected to fermentation process. Lactobacillus paracasei HII02 mediated fermentation of Sor Jor 2 soybean exhibited stable physical and chemical characteristics. Lactic acid bacteria mediated fermentation also increased the aglycone forms of isoflavone content, exhibited antioxidant capacity and thereby enhanced the quality of the fermented soy broth. It also prevented the growth of coliforms in fermented ***: The study results suggest that fermented soybean is rich in nutrition and considered to be safe for consumption for the improvement of health and to treat the malnutrition.

关键词： Lactic acid bacteria Fermentation Lactobacillus paracasei HII02 Soybean Northern Thailand

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