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Satisfaction of the Service Provider with the Organization of the Timely Cervical Cancer Detection Program

Health 2017年第2期9卷 289-298页

作者： Gutierrez-Enriquez Sandra Olimpia Teran-Figueroa Yolanda Gaytan-Hernandez Dario Diaz-Oviedo Aracely Zuniga-Martinez Ma.de Lourdes Hernandez-Nava Nereyda Cruz Ortiz Maribel perez rodriguez maria del carmen Ramirez-Ramirez Rocio Faculty of Nursing and Nutrition Autonomous University of San Luis PotosiSan Luis PotosiMexico Academic Coordination Altiplano Region Autonomous University of San Luis PotosiSan Luis PotosiMexico

Cervical cancer is a priority health problem in Mexico. The objective of this work was to know the degree of satisfaction of the service provider with the organization of the program of Timely Detection of Cervical Cancer, specifically in taking of the cervical cytology. The study design was observational, transversal and prospective conducted from January to May 2015 in Jurisdiction 1 of the Health Services of San Luis Potosí, Mexico, in 20 health centers. Participants were 87 service providers whose function is to take cervical cytology (Pap smears). A 32-question questionnaire was applied, with Likert scale with 5 levels of response: 1 (dissatisfied), 2 (little satisfied), 3 (indifferent), 4 (satisfied) and 5 (very satisfied). The score range was 32 points (minimum job satisfaction) up to 160 points (Maximum job satisfaction). We analyzed 2 dimensions: 1) intrinsic factors that have to do with motivation and professional recognition, and 2) extrinsic factors related to infrastructure, materials, remuneration and labor policies. Each factor consisted of four categories. Descriptive statistics and linear correlation of Pearson were applied for the analysis of data. Participants signed an informed consent letter. Of 4 categories, in the intrinsic dimension, the one with the highest percentage of satisfaction was “delegation of activities” with 28.8%. In the extrinsic dimension, the category with the highest percentage of satisfaction was “infrastructure and materials” with 49.4%;while satisfaction increase in intrinsic dimensions also does in extrinsic dimensions, such correlations are significant (p delegation of activities and remuneration (r = 0.074 and p = 0.497). The higher hierarchical level, the men, the bachelor academic level and older people showed the highest level of satisfaction.

关键词： Job Satisfaction Cervical Cancer Health Providers

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HVEM,a cosignaling molecular switch,and its interactions with BTLA,CD160 and LIGHT

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Cellular & Molecular Immunology 2019年第7期16卷 679-682页

作者： Jose Ignacio rodriguez-Barbosa Pascal Schneider Andreas Weigert Kyung-Mi Lee Tae-Jin Kim Jose-Antonio perez-Simon maria-Luisa del Rio Transplantation Immunobiology Section Research Institutes of the University of LeonCampus of Vegazana s/n24071 LeonSpain Leon Regional Transplantation Coordination Center Leon University HospitalLeonSpain Acción Estratégica en Salud Consorcio CIBER-ONCSevilleSpain Department of Biochemistry University of Lausanne1066 EpalingesSwitzerland Institute of Biochemistry I Faculty of MedicineGoethe-University Frankfurt60590 FrankfurtGermany Department of Biochemistry and Molecular Biology Korea University College of MedicineSeoul 02841Republic of Korea Department of Biomedical Engineering Center for Bio-Integrated ElectronicsSimpson Querrey Institute for BioNanotechnologyNorthwestern UniversityEvanstonIL 60208USA Department of Hematology Virgen del Rocio University HospitalBiomedical Institute of SevillaSevillaSpain

Temporal and spatial expression of cosignaling receptors and their ligands regulates the early stages of T-cell activation(signal 1,T-cell receptor(TCR)signaling and signal 2,costimulation/coinhibition),clonal expansion and T-cell survival during their differentiation towards effector T *** the inflammatory stimulus is eliminated,effector T cells return to homeostasis after undergoing a contraction phase by activation-induced cell death and the intervention of ligands for coinhibitory receptors,leaving a population of long-term memory T *** expression of ligands for coinhibitory receptors on hematopoietic cells and,more importantly,on non-hematopoietic cells of peripheral tissues is a key process in tuning the functional activity of effector T cells to prevent excess tissue inflammation that may lead to immunopathology and subsequent tissue dysfunction.

关键词： stimulation homeostasis inflammation

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Cardiovascular impact of COVID-19 with a focus on children: A systematic review

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World Journal of Clinical Cases 2020年第21期8卷 5250-5283页

作者： Moises rodriguez-Gonzalez Ana Castellano-Martinez Helena maria Cascales-Poyatos Alvaro Antonio perez-Reviriego Pediatric Cardiology Division Puerta del Mar University HospitalCadiz 11009Spain Biomedical Research and Innovation Institute of Cadiz Puerta del Mar University HospitalCadiz 11009Spain Pediatric Nephrology Division Puerta del Mar University HospitalCadiz 11009Spain Pediatrics Division Motril-San Antonio Primary Care CenterMotril 18600Spain Pediatrics Division UGC Pediatria AG Sur GranadaSanta Ana HospitalMotril 18600Spain

BACKGROUND Since the beginning of the pandemic,coronavirus disease-2019(COVID-19)in children has shown milder cases and a better prognosis than *** the respiratory tract is the primary target for severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),cardiovascular involvement is emerging as one of the most significant and life-threatening complications of SARS-CoV-2 infection in *** To summarize the current knowledge about the potential cardiovascular involvement in pediatric COVID-19 in order to give a perspective on how to take care of them during the current pandemic *** Multiple searches in MEDLINE,PubMed were performed using the search terms“COVID-19”or“SARS-CoV-2"were used in combination with“myocardial injury”or"arrhythmia"or“cardiovascular involvement”or"heart disease"or"congenital heart disease"or“pulmonary hypertension”or"long QT"or“cardiomyopathies”or“channelopathies”or"Multisystem inflammatory system"or"PMIS"or“MIS-C”or”Pediatric multisystem inflammatory syndrome"or"myocarditis"or"thromboembolism to identify articles published in English language from January 1st,2020 until July 31st,*** websites of World Health Organization,Centers for Disease control and Prevention,and the Johns Hopkins Coronavirus Resource Center were reviewed to provide up to date numbers and infection control *** lists from the articles were reviewed to identify additional pertinent *** manuscripts concerning the subject were reviewed by the authors,and the data were extracted using a standardized collection *** were subsequently analyzed with descriptive *** Pediatric multisystemic inflammatory syndrome temporally associated with COVID-19(PMIS),multiple meta-analyses were conducted to summarize the pooled mean proportion of different cardiovascular variables in this population in pseudo-cohorts of observed *** A total of 193 articles were *** publications used in

关键词： COVID-19 SARS-CoV-2 Congenital heart diseases Myocardial dysfunction Pediatric Multisystem Inflammatory Syndrome Cardiac Biomarkers

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Preliminary Studies on Composition, Quality and Oxidative Stability of Commercial Avocado Oil Produced in Chile

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Journal of Food Science and Engineering 2014年第1期4卷 21-26页

作者： Marcos Alexis Flores maria del carmen perez-Camino Jose Troca Basic Science Department Faculty of Science University of Santo Tom6s Avda. Carlos Schorr 255 Talca 3473620 Chile Instituto de la Grasa (CSIC) Avda. Padre Tejero 4 Seville 41012 Spain

Avocado oil is a relatively new oil in the market and is highly appreciated by the consumers because of its fine aroma, pleasant taste and health benefits. A study on the characterization of commercial avocado oils produced in Chile was conducted in order to discuss their quality parameters. The study was applied to two marketed avocado oils. The main analytical parameters evaluated to the oils were： fatty acid composition, total chlorophylls, total carotenoids, tocopherols, acid value, peroxide value, total phenolic compounds, polar compounds, oil stability, UV absorption and 3.5-stigmastadiene content. The fatty acid compositions of the studied oils were according with oil composition of pulp pure of avocado fruit. The analysis of tocopherols by high performance liquid chromatography （HPLC） revealed significant differences between the avocado oils studied. Total phenolic compounds, oil stability, UV Absorption characteristics, peroxide value, acid value, tocopherols content, total chlorophylls, total carotenoids and polar compounds were also significantly different between the commercial studied oils. All the above results show a different quality between both commercial avocado oils, showing that the sample C has worse values for the parameters of quality as those required by legislation in many countries. Also, 3.5-stigmastadiene content shows high concentration for one of the commercial avocado oil evaluated which demonstrates the presence of refined oil or that the oil has been submitted to high temperatures. On the other hand it is remarkable that despite the fact that there are many differences in quality parameters, both oils are labeled and marketed as extra virgin quality oils, demonstrating the need to regulate the classification of appreciated oils by the consumers.

关键词： Avocado oil 3.5-estigmastadiene polar compounds quality parameters.

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Determination of Mercuric Ion in Water Samples with a LED Exciting and CCD Based Portable Spectrofluorimeter

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American Journal of Analytical Chemistry 2011年第5期2卷 605-611页

作者： Arsenio Munoz de la Pena maria Isabel rodriguez-Caceres Diego Bohoyo Gil maria del carmen Mahedero maria del carmen Hurtado-Sanchez Reyes Babiano Department of Analytical Chemistry University of ExtremaduraBadajozSpain Department of Organic and Inorganic Chemistry University of ExtremaduraBadajozSpain

The fluorescent characteristics of a fluorimetric chemosensor for mercuric ion, Hg2+, employing a synthesized Rhodamine 6G derivative, have been analyzed. For that, a portable spectrofluorimeter composed of a 515 nm LED as excitation source, two fiber-optics and a CCD camera as detector, has been used, intended for “in situ” analysis. A highly selective Rhodamine based probe for Hg2+, that is water soluble and gives a positive response upon analyte binding, is reported. The reagent is bearing a monothiospirolactone group in a Rhodamine 6G architecture and the thiol atom served for the direct attack of thiophilic Hg2+. The fluorescence enhancement is attributed to the spirolactone ring opening and the coordination of two sulphur atoms to Hg2+ giving a 2:1 reagent: Hg2+ stoichiometry complex.

关键词： Chemosensor LED Mercuric Ion Water Analysis

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Ammonium Thiosulfate Ecological Viable Alternative to Replace Sodium Cyanide in Gold and Silver Dissolution Ores

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Journal of Environmental Science and Engineering(A) 2016年第5期5卷 223-229页

作者： maria del carmen Hernandez maria del carmen Avitia Heriberto Pena Irma Leticia Gonzalez Nancy Veronica Torres Abdiel Rosaldo Felix[ Luis Miguel rodriguez Laura Bibiana Hernandez Department of Chemical and Biochemical Engineering Technological Institute of Parral Chihuahua 33850 Mexico Department of Economic Administrative Department Technological Institute of Parral Chihuahua 33850 Mexico Department of Industrial Engineering Technological Institute of Parral Chihuahua 33850 Mexico Engineering and Independent Consultant Palma Triangular 108 San Jose de Pozo Bravo Aguascalientes 20126 Mexico

The southern region of the state of Chihuahua is mining by origin, as this has been proved ghost towns of Minas Nuevas, it is also called Villa Escobedo, Emerald and Blue. Minerals are nonrenewable resources. There are only reserves and waste deposited in tailings ponds of low-rade precious metals （gold and silver）. A conventional method for recovering gold and silver ore is low-grade cyanidation and the solvent consider toxic and highly dangerous for the flora, fauna, humans and the environment. The mechanism of cyanide poisoning is inhibition of cytochrome oxidase--an enzyme needed for cell respiration. Without compromising efficiency, sensitivity and cost of the process, the toxic solvent is replaced by a less aggressive one, which helps the environment, public and occupational health. （NH4）2S203 has no appreciable damage to conservative amounts, is a selective aqueous solvent for leaching gold and silver, easy to get and manipulate. This work is done in the Technological Institute of Parral in a low-grade ore from the southern region of the state of Chihuahua. This document has been enriched presented in the IMEC 2014, with the increase of series Ⅴ and Ⅵ.

关键词： Leaching cyanide ammonium thiosulfate.

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Contamination of Water for Domestic Use and Human Consumption by Heavy Metals Derived from Mining Activity in Parral, Chihuahua, Mexico

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Journal of Environmental Science and Engineering(A) 2012年第3期1卷 286-294页

作者： Luis Miguel rodriguez Ever Torres Luis Saenz maria del carmen Avitia Guillermo rodriguez Eduardo Herrera carmen Julia Navarro Guillermo Gonzalez Luis Lozoya Damaris Acosta Technological Institute of Parral Parral Chihuahua 33850 Mexico Research Center for Advanced Materials （CIMA V） Chihuahua 31109 Mexico

Research was done with the objective of evaluating the quality of water supplied to the potable water system in Hidalgo del Parral, which comes from two main supply sources： wells from ＂Valle del Verano＂, which provide water to the east side of the city, and the Water Treatment Plant, which receives water from different mines and supplies the west side of the city. When this plant is overcome on its capacity of treatment, a part of the water from the mines is fed directly to the northwest part of the city. The metals lead （Pb）, chromium （Cr）, cadmium （Cd）, zinc （Zn）, and arsenic （As） were analyzed by atomic absorption （AA） technique, based on the United States Environmental Protection Agency （EPA） Method 7000B （Revision 2, February 2007）. The digestion process was done according to the guidelines established in Method NMX-AA-051-SCFI-2001, Analysis of Water-Determination of Metals by Atomic Absorption, developed by the National Standardization Technical Committee for Environmental Protection （Mexico）. The samples were collected from the following points： 13 wells and 2 re-pumping stations of ＂Valle del Verano＂, the inlet and outlet of the Water Treatment Plant, and domestic faucets. The east side of the city, supplied by the wells of ＂Valle del Verano＂, is metal-pollution free. The water that comes from the mines contains high concentrations of As, Zn, Cd and Pb, with levels that can get to 0.12, 32.6, 0.26 and 3.5 mg/L, respectively. This water pollution generated by mining can be concluded from the high levels found in the domestic samples in which, for several points, the concentrations exceed the parameters set by the current guideline. According to the results, it is vital to set a plan of remediation for the water that comes from the mines, because there is a great risk for health in the consumotion of this water.

关键词： Heavy metals mining water contamination.

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Effect of fosfomycin,Cynara scolymus extract,deoxynivalenol and their combinations on intestinal health of weaned piglets

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Animal Nutrition 2019年第4期5卷 386-395页

作者： Guadalupe Martinez Susana N.Dieguez maria B.Fernandez Paggi maria B.Riccio Denisa S.perez Gaudio Edgardo rodriguez Fabian A.Amanto maria O.Tapia Alejandro L.Soraci Area Toxicología Departamento de FisiopatologíaFacultad de Ciencias VeterinariasUniversidad Nacional del Centro de la Provincia de Buenos AiresTandilB7000Buenos AiresArgentina Centro de Investigación Veterinaria de Tandil(CIVETAN) UNCPBA-CICPBA-CONICETFacultad de Ciencias VeterinariasCampus UniversitarioTandilB7000Buenos AiresArgentina Consejo Nacional de Investigaciónes Científicas-CONICET Buenos AiresC1425FQBArgentina Comisión de Investigaciónes Científicas de la Provincia de Buenos Aires(CIC-PBA) La PlataB1900Buenos AiresArgentina Area Producción Porcina Departamento de Producción AnimalFacultad de Ciencias VeterinariasUniversidad Nacional del Centro de La Provincia de Buenos AiresTandilB7000Buenos AiresArgentina Area Estadística Sanidad Animal y Medicina PreventivaFacultad de Ciencias VeterinariasUniversiclacl Nacional del Centro de la Provincia de Buenos AiresTandilB7000Buenos AiresArgentina

Weaning is a challenging stage of pig *** undergo environmental,social and dietary changes leading to weaning stress *** order to compensate for the detrimental effects of weaning stress,antibiotics and natural extracts are used as feed additives,sometimes without fully understanding the interactions between them or even with low concentrations of mycotoxins that are frequently present in *** aim of this study was to evaluate the effect of fosfomycin(FOS),Cynara scolymus extract(CSE),deoxynivalenol(DON) and their combined administration on intestinal health of weaned *** experiment was designed as a 2×2×2 factorial arrangement with 3 factors(FOS,CSE and DON treatments),2 levels each(presence and absence) and 3 *** piglets(n=24)were randomly divided in groups to receive the different treatments,namely DON administered in diet(50 μg/kg BW),FOS administered into the drinking water(30 mg/kg BW),CSE administered in diet(15 mg/kg BW) and all their *** 15 d,the animals were euthanized and gastrointestinal tract samples were immediately taken to evaluate gastrointestinal pH,Enterobacteriaceae to lactic acid bacteria(E:L) ratio,volatile fatty acid(VFA) concentrations,disaccharidase(lactase,sucrase and maltase)activity,histology(intestinal absorptive area [IAA] and goblet cells count) and mucus ability to adhere pathogenic Escherichia *** our results,FOS and CSE treatments,individually or combined,produced a lower E:L ratio,an enhanced production of butyrate,increased disaccharidase activity(particularly maltase),and a greater IAA and goblet cells count along with an increase in pathogenic bacteria adherence to intestinal *** did not show interactions with the other factors and its administration produced decreases on VFA,disaccharidase activity and goblet cells *** conclusion,weaning piglets receiving diets containing FOS,CSE or both exhibited evident beneficial intestinal effects compared

关键词： Fosfomycin Cynara scolymus extract Deoxynivalenol Intestinal health Weaned piglets

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Aggregation properties of a therapeutic peptide for rheumatoid arthritis:A spectroscopic and molecular dynamics study

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ChemPhysMater 2022年第1期1卷 62-70页

作者： Rita Cimino Marco Savioli Noemi Ferrante Carrante Ernesto Placidi Hilda Garay-perez Matilde López-Abad Alexis Musacchio Lasa maria del carmen Domínguez-Horta Emanuela Gatto Francesca Cavalieri Gianfranco Bocchinfuso mariano Venanzi PEPSA-LAB Department of Chemical Sciences and TechnologyUniversity of Rome Tor VergataVia della Ricerca Scientifica 100133RomeItaly Department of Physics University of Rome‘Sapienza’P.le A.Moro 500185 RomeItaly Centre for Genetic Engineering and Biotechnology PO Box 616210600HavanaCuba School of Science RMIT UniversityMelbourneVIC 3001Australia

The biological properties of therapeutic peptides,such as their pharmacokinetics and pharmacodynamics,are correlated with their structure and aggregation ***,we studied the aggregation properties of a therapeutic peptide(CIGB-814),currently in phase 2 clinical trial,for the treatment of rheumatoid arthritis over a wide range of concentrations(μM-mM).We applied spectroscopic techniques(fluorescence,circular dichro-ism,resonance,and dynamic light scattering),atomic force microscopy,and molecular dynamics simulations to determine the aggregation mechanism of *** found that the hierarchical aggregation of CIGB-814 at micromolar concentrations was initiated by the formation of peptide ***,the peptide oligomers trigger the nucleation and growth of peptide nanostructures(cac=123μM),ultimately leading to the fibrillization of CIGB-814(cac’=508μM).These results pave the way for a deeper understanding of the CIGB-814 therapeutic activity and may give important insights on its pharmacokinetics.

关键词： Molecular dynamics of peptide oligomers Peptide aggregation Peptide fibrils Peptide nanostructures Therapeutic peptides Treatment of rheumatoid arthritis

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An Unusual Presentation of Aortic Dissection and Aneurysmatic Disease in Marfan Syndrome: A Case Report

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World Journal of Cardiovascular Diseases 2022年第6期12卷 297-303页

作者： Adrian Espejel-Guzman Valente Fernandez-Badillo Javier Serrano-Roman Enrique Solorzano-Pinot Sergio Criales-Vera maria del carmen Lopez-rodriguez Candace Keirns Daniel Zagal-Cardoso Nilda Espinola-Zavaleta Department of Nuclear Cardiology National Institute of Cardiology Ignacio Chavez Mexico City Mexico Department of Computed Tomography National Institute of Cardiology Ignacio Chavez Mexico City Mexico Department of Clinical Cardiology National Institute of Cardiology Ignacio Chavez Mexico City Mexico Shelby County Health Department Memphis TN USA Department of Echocardiography ABC Medical Center I.A.P. Mexico City Mexico

Marfan’s syndrome (MFS) is an autosomal dominant disorder characterized by aortic root dilation, mitral valve prolapse and aortic regurgitation. The typical aneurysm location involves the thoracic aorta (60%). Thoracoabdominal aortic dissections are quite infrequent (10%). A type A aortic dissection can have fatal complications, such as aortic rupture and cardiac tamponade, and a prompt diagnosis is crucial. The present case involves a 46-year-old patient with Marfan’s syndrome who was admitted to the emergency department for dyspnea. The patient presented congestive signs and manifestations suggesting acute heart failure. An initial transthoracic echocardiogram (TTE) showed ventricular hypertrophy and diastolic dysfunction. Additionally, TTE showed plurivalvular regurgitation, pulmonary hypertension (42 mmHg), aortic dilatation, and a dissection flap. Coronary computed tomography angiography (CCTA) was performed, confirming the suspicion of ascending aortic dissection. The patient underwent a three-stage intervention for the repair of all the defects, with adequate recovery. This was a rare presentation of aortic dissection in MFS, which was a diagnostic challenge for the heart team.

关键词： Marfan-Syndrome Aortic-Dissection Heart-Failure

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