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performance of Dexcom G5 and FreeStyle Libre sensors tested simultaneously in people with type 1 or 2 diabetes and advanced chronic kidney disease

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World Journal of Clinical Cases 2022年第22期10卷 7794-7807页

作者： Arndís FinnaÓlafsdóttir Mervi Andelin Aso Saeed Sheyda Sofizadeh Hussein Hamoodi per-anders jansson Marcus Lind Department of Medicine NU-Hospital GroupUddevallaSweden Department of Molecular and Clinical Medicine Institute of MedicineSahlgrenska AcademyUniversity of GothenburgGöteborgSweden Department of Nephrology Gothenburg UniversitySahlgrenska AcademyInstitute Internal MedicineGöteborgSweden Statistiska Konsultgruppen GöteborgSweden Wallenberg Laboratory Department of Molecular and Clinical MedicineInstitute of MedicineSahlgrenska AcademyUniversity of GothenburgGöteborgSweden

BACKGROUND Advanced chronic kidney disease(CKD) is a common complication for people with type 1 and 2 diabetes and can often lead to glucose instability. Continuous glucose monitoring(CGM) helps users monitor and stabilize their glucose levels. To date, CGM and intermittent scanning CGM are only approved for people with diabetes but not for those with advanced *** To compare the performance of Dexcom G5 and FreeStyle Libre sensors in adults with type 1 or 2 diabetes and advanced *** This was a non-randomized clinical trial that took place in two outpatient clinics in western Sweden. All patients with type 1 or 2 diabetes and an estimated glomerular filtration rate(eGFR) of per 1.73 m^(2) were invited to participate. Forty patients(full analysis set = 33) carried the Dexcom G5 sensor for 7 d and FreeStyle Libre sensor for 14 d simultaneously. For referencing capillary blood glucose(SMBG) was measured with a high accuracy glucose meter(HemoCue®) during the study period. At the end of the study, all patients were asked to answer a questionnaire on their experience using the *** The mean age was 64.1(range 41-77) years, hemoglobin A1 c was 7.0% [standard deviation(SD) 3.2], and diabetes duration was 28.5(SD 14.7) years. A total of 27.5% of the study population was on hemodialysis and 22.5% on peritoneal dialysis. The mean absolute relative difference for Dexcom G5 vs SMBG was significantly lower than that for FreeStyle Libre vs SMBG [15.2%(SD 12.2) vs 20.9%(SD 8.6)], with a mean difference of 5.72 [95% confidence interval(CI): 2.11-9.32;P = 0.0036]. The mean absolute difference was also significantly lower for Dexcom G5 than for FreeStyle Libre, 1.21 mmol/L(SD 0.78) and 1.76 mmol/L(SD 0.78), with a mean diffrenec of 0.55(95%CI: 0.27-0.83;P = 0.0004).The mean difference(MD) was-0.107 mmol/L and-1.10 mmol/L(P = 0.0002), respectively. In all, 66% of FreeStyle Libre values were in the no risk zone on the surveillance error grid compared t

关键词： Type 1 diabetes Type 2 diabetes Chronic kidney disease Continuous glucose monitoring Accuracy Mean absolute relative difference

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On the potential of using ensemble learning algorithm to approach the partitioning coefficient(k)value in Scheil-Gulliver equation

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Materials Genome Engineering Advances 2024年第3期2卷 48-58页

作者： Ziyu Li He Tan anders E.W.Jarfors Jacob Steggo Lucia Lattanzi per jansson Comptech i Skillingaryd AB SkillingarydSweden Department of Materials and Manufacturing School of EngineeringJönköping UniversityJönköpingSweden Department of Computing School of EngineeringJönköping UniversityJönköpingSweden

The Scheil-Gulliver equation is essential for assessing solid fractions during alloy solidification in materials *** the prevalent use of the Calculation of Phase Diagrams(CALPHAD)method,its computational intensity and time are limiting the simulation ***,Artificial Intelligence has emerged as a potent tool in materials science,offering robust and reliable predictive modeling *** study introduces an ensemble-based method that has the potential to enhance the prediction of the partitioning coefficient(k)in the Scheil equation by inputting various alloy *** findings demonstrate that this approach can predict the temperature and solid fraction at the eutectic temperature with an accuracy exceeding 90%,while the accuracy for k prediction surpasses 70%.Additionally,a case study on a commercial alloy revealed that the model's predictions are within a 5℃deviation from experimental results,and the predicted solid fraction at the eutectic temperature is within a 15%difference of the values obtained from the CALPHAD model.

关键词： AI application partitioning coefficient scheil-gulliver equation solidification

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Androgen deprivation therapy and side effects:are GnRH antagonists safer?

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Asian Journal of Andrology 2021年第1期23卷 3-10页

作者： Stephen J Freedland per-anders Abrahamsson Division of Urology Department of SurgeryCedars-Sinai Medical CenterLos AngelesCA 90048USA Section of Urology Durham VA Medical CenterDurhamNC 27705USA Department of Urology SkSne University HospitalLund UniversityMalmo 20502Sweden.

Androgen deprivation therapy(ADT)with gonadotropin-releasing hormone(GnRH)agonists and antagonists is the mainstay of advanced prostate cancer *** drug classes decrease levels of luteinizing hormone and follicle-stimulating hormones(FSH),thereby lowering testosterone to castrate *** is associated with adverse events(AEs),including cardiovascular(CV)disorders,bone fractures,metabolic dysfunction,and impaired cognitive *** literature review discusses these AEs,with a focus on CV and bone-related events.A hypothesis-generating meta-analysis of six clinical trials showed a potentially increased risk for CV disorders with GnRH agonists versus the GnRH antagonist *** no study has directly compared GnRH agonists versus antagonists with a primary CV outcome,one hypothesis for this observation is that GnRH agonists lead to initial surges in FSH that may negatively impact CV health,whereas antagonists do *** agonists are associated with metabolic and cognitive AEs and while data are lacking for GnRH antagonists,no differences in risk are *** common AEs with ADT include injection site reactions,which are much more common with degarelix than with GnRH agonists,which may reflect differing administration and injection *** studies are needed to further evaluate and compare the safety profiles of GnRH agonists and antagonists,especially in patients with pre-existing CV disease and other *** should carefully evaluate benefits and risks when prescribing ADT and ensure that side effects are well managed.

关键词： androgen antagonists metabolic syndrome prostate cancer safety

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Intermittent androgen deprivation therapy in patients with prostate cancer: Connecting the dots

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Asian Journal of Urology 2017年第4期4卷 208-222页

作者： per-anders Abrahamsson Department of Urology Skane University HospitalLund UniversityMalmooSweden

Intermittent androgen deprivation therapy(IADT)is now being increasingly opted by the treating physicians and patients with prostate *** most common reason driving this is the availability of an off-treatment period to the patients that provides some relief from treatment-related side-effects,and reduced treatment *** may also delay the progression to castration-resistant prostate ***,the use of IADT in the setting of prostate cancer has not been strongly substantiated by data from clinical *** factors seem to contribute towards this inadequacy of supportive data for the use of IADT in patients with prostate cancer,e.g.,population characteristics(both demographic and clinical),study design,treatment regimen,on-and off-treatment criteria,duration of active treatment,endpoints,and *** present review article focuses on seven clinical trials that evaluated the efficacy of IADT *** androgen deprivation therapy for the treatment of prostate *** results from these clinical trials have been discussed in light of the factors that may impact the treatment outcomes,especially the disease(tumor)*** on evidence,potential candidate population for IADT has been suggested along with recommendations for the use of IADT in patients with prostate cancer.

关键词： Continuous androgen deprivation therapy Intermittent androgen deprivation therapy Prostate cancer Study designs and outcomes Tumor burden

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In Situ/Operando(Soft) X-ray Spectroscopy Study of Beyond Lithium-ion Batteries

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Energy & Environmental Materials 2021年第2期4卷 139-157页

作者： Feipeng Yang Xuefei Feng Yi-Sheng Liu Li Cheng Kao per-anders Glans Wanli Yang Jinghua Guo Joint Center for Energy Storage Research Lemont IL 60439USA Advanced Light Source Lawrence Berkeley National LaboratoryBerkeley CA 94720USA Department of Chemistry and Biochemistry University of California Santa CruzSanta Cruz CA 95064USA

The lightweight,rechargeable lithium-ion battery is one of the dominant energy storage devices globally in portable electronics due to its high energy density,no memory effect,wide operating voltage,lightweight,and good charge ***,due to safety concerns,the depletion of lithium reserves,and the corresponding increase of cost,an alternative battery system becomes more and more *** develop alternative battery systems with low cost and high material abundance,for example,sodium,magnesium,zinc,and calcium,it is important to understand the chemical and electronic structure of *** X-ray spectroscopy,for example,X-ray absorption spectroscopy(XAS),X-ray emission spectroscopy(XES),and resonant inelastic soft X-ray scattering(RIXS),is an element-specific technique with sensitivity to the local chemical environment and structural order of the element of *** soft X-ray systems enable operando experiments that can be applied to amorphous and crystalline samples,making it a powerful tool for studying the electronic and structural changes in electrode and electrolyte *** this article,the application of in situ/operando(soft)X-ray spectroscopy in beyond lithium-ion batteries is reviewed to demonstrate how such spectroscopic characterizations could facilitate the interpretation of interfacial phenomena under in situ/operando condition and subsequent development of the beyond lithium-ion batteries.

关键词： (soft)X-ray spectroscopy beyond lithium-ion battery in situ/operando interface

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Catquest-9SF functioning over a decade–a study from the Swedish National Cataract Register

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Eye and Vision 2020年第1期7卷 553-562页

作者： Mats Lundström Maria Kugelberg per Montan Ingela Nilsson Madeleine Zetterberg Konrad Pesudovs anders Behndig Department of Clinical Sciences/Ophthalmology Faculty of MedicineLund UniversityTrossögatan 437137 KarlskronaLundSweden Department of Clinical Neuroscience Division of Ophthalmology and VisionKarolinska InstitutetStockholmSweden St Erik Eye Hospital StockholmSweden Capio Medocular LundSweden Department of Clinical Neuroscience Institute of Neuroscience and PhysiologySahlgrenska Academy at the University of GothenburgGothenburgSweden University of New South Wales AdelaideSAAustralia Department of Clinical Sciences/Ophthalmology UmeåUniversityUmeåSweden

Background:The Swedish National Cataract Register(NCR)collects data on cataract surgery outcomes during March,including patient-reported outcomes using the Catquest-9SF questionnaire for over 11 *** studies from NCR have shown that the preoperative visual acuity has improved over *** main purpose of this study was to evaluate the Catquest-9SF Rasch scoring performance in this changing environment.A second purpose was to describe clinical data over the same period for those who completed the ***:The performance of the Catquest-9SF was analysed by a separate Rasch analysis for each year,resulting in a preoperative and postoperative score for each participating patient in the annual *** clinical data and questionnaire scoring were analysed for each year in the period 2008-2018 ***:Data were available for 42,023 eyes for 11 annual cohorts(2008-2018).The psychometric properties of the questionnaire were stable during the study *** separation(precision)for the whole period was 2.58 and varied between 2.45 and *** person reliability was 0.87 and varied between 0.86 and *** targeting of question difficulty to person ability became less accurate over time meaning that the item activities became easier to carry out without *** average targeting for the whole period was−2.06 and changed from−1.92 in 2008 to−2.31 in *** person score improved both before surgery and after surgery,indicating that patients are undergoing surgery at a more able level and getting better *** average improvement by surgery decreased from 3.41 logits in 2008 to 3.21 logits in 2018(p=0.003).Over time,patient age decreased from 75 to 74 years(pperative visual acuity in both the operated eye and the better eye improved over time(0.47 to 0.40 logMAR,p<0.001 and 0.22 to 0.19 logMAR,p<0.001,respectively),as did the mean post

关键词： Cataract extraction Outcomes Questionnaire Patient-reported outcomes Rasch analysis

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Direct generation of linearly polarized photon emission with designated orientations from site-controlled InGaN quantum dots

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Light(Science & Applications) 2014年第1期3卷 323-329页

作者： anders Lundskog Chih-Wei Hsu K Fredrik Karlsson Supaluck Amloy Daniel Nilsson Urban Forsberg per Olof Holtz Erik Janzen Department of Physics Chemistry and Biology(IFM) Linkoping UniversitySE-58183 LinkopingSweden Department of Physics Faculty of ScienceThaksin UniversityPhattalung 93110Thailand

Semiconductor quantum dots(QDs)have been demonstrated viable for efficient light emission applications,in particular for the emission of single photons on ***,the preparation of QDs emitting photons with predefined and deterministic polarization vectors has proven *** to linearly polarized photons is essential for various *** this report,a novel concept to directly generate linearly-polarized photons is *** concept is based on InGaN QDs grown on top of elongated GaN hexagonal pyramids,by which the predefined elongation determines the polarization vectors of the emitted photons from the *** growth scheme should allow fabrication of ultracompact arrays of photon emitters,with a controlled polarization direction for each individual emitter.

关键词： GaN InGaN photoluminescence polarized emission quantum dot

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理论研究晶体场效应和电荷转移效应对Co^(2+)的2p电子X射线L2,3吸收边光谱的影响

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高等学校化学学报 2021年第7期42卷 2197-2209页

作者：程效 BORA Debajeet K. GLANS per-anders GUO Jinghua 罗毅中国科学技术大学合肥微尺度物质科学国家研究中心合肥230026 Advanced Light Source Lawrence Berkeley National LaboratoryBerkeley CA 94720USA

运用多重态计算方法研究了在正八面体对称性的晶体场中Co^(2+)离子的2p电子X射线L2,3吸收边光谱,研究了Co^(2+)离子和周围的配位离子之间的正八面体(Oh)晶体场效应和相应的电荷转移效应对于吸收光谱的影响.系统讨论了在多重态计算中起... 详细信息

运用多重态计算方法研究了在正八面体对称性的晶体场中Co^(2+)离子的2p电子X射线L2,3吸收边光谱,研究了Co^(2+)离子和周围的配位离子之间的正八面体(Oh)晶体场效应和相应的电荷转移效应对于吸收光谱的影响.系统讨论了在多重态计算中起作用的所有物理参数对CoO和CoCl_(2)的X射线吸收光谱特性的特定影响及其物理机制.将计算得出的光谱数据和同样具有Oh对称性结构Co^(2+)离子的CoO和CoCl_(2)实验光谱数据进行了对比,在实验光谱数据中发现的特征被确定为来自不同自旋态,并且光谱强度的变化与晶体场的强度相关,揭示了其中包含的电荷转移效应.本文为低对称性复杂系统的多重态计算提供了一个基础的参考标准,可以适用于含有钴元素或其它过渡金属的复杂体系的X射线吸收光谱的理论计算.

关键词：多重态计算 X射线吸收光谱钴元素晶体场效应电荷转移效应

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Utilizing the full capacity of carbon black as anode for Na-ion batteries via solvent co-intercalation

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Nano Research 2017年第12期10卷 4378-4387页

作者： Wei Xiao Qian Sun Jian Liu Biwei Xiao per-anders Glans Jun Li Ruying Li Jinghua Guo Wanli Yang Tsun-Kong Sham Xueliang Sun Department of Mechanical & Materials Engineering University of Western Ontario London Ontario N6ASB9 Canada Department of Chemistry University of Western Ontario London Ontario N6ASB7 Canada Advanced Light Source Lawrence Berkeley National Laboratory Berkeley California 94720 USA

Carbonaceous materials have long been considered promising anode materials for Na-ion batteries. However, the electrochemical performance of conventional carbon anodes is generally poor because the sodium ion storage solely relies on the disordered region of the carbon materials in a carbonate-based electrolyte. The solvent co-intercalation mechanism for Na ions has been recently reported in natural graphite anodes for Na-ion batteries with ether-based electrolytes, but their capacities are still unsatisfactory. We show here for the first time that by combining regular Na ion storage in the disordered carbon layer and solvent co-intercalation mechanism in the graphitized layer of a commercial N330 carbon black as an anode material for Na-ion batteries in ether-based electrolyte, the reversible capacity could be fully realized and doubled in magnitude. This unique sodium intercalation process resulted in a significantly improved electrochemical performance for the N330 electrode with an initial reversible capacity of 234 mAh.g-1 at 50 mA.g-1 and a superior rate capability of 105 mAh.g-1 at 3,200 mA-g-1. When cycled at 3,200 mA.g-1 over 2,000 cycles, the electrode still exhibited a highly reversible capacity of 72 mAh.g-1 with a negligible capacity loss per cycle （0.0167%）. Additionally, surface-sensitive C K-edge X-ray absorption spectroscopy, with the assistance of electrochemical and physicochemical characterizations, helped in identifying the controlled formation and evolution of a thin and robust solid electrolyte interphase film. This film not only reduced the resistance for sodium ion diffusion, but also maintained the structural stability of the electrode for extended cycle reversibility. The superior electrochemical performance of N330 carbon black strongly demonstrated the potential of applying ether-based electrolytes for a wide range of carbon anodes apart from natural graphite.

关键词： carbon black anode sodium-ion batteries ether-based electrolyte co-intercalation

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Eosinophil associated genes in the inflammatory bowel disease 4 region:Correlation to inflammatory bowel disease revealed

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World Journal of Gastroenterology 2012年第44期18卷 6409-6419页

作者： Kristin Blom Jenny Rubin Jonas Halfvarson Leif Trkvist anders Rnnblom per Sangfelt Mikael Lrdal Ulla-Britt Jnsson Urban Sjqvist Lena Douhan Hkansson per Venge Marie Carlson Department of Medical Sciences Clinical ChemistryUppsala University HospitalSE-75185 UppsalaSweden Division of Gastroenterology Department of Intestinal Medicinerebro University HospitalSE-70185 rebroSweden School of Health and Medical Sciences rebro UniversitySE-70185 rebroSweden IBD Clinical research group Karolinska University HospitalSE-17177 StockholmSweden Department for Clinical Science Intervention and TechnologyKarolinska University HospitalSE-17177 StockholmSweden Department of Medical Sciences Gastroenterology Research GroupUppsala UniversitySE-75185 UppsalaSweden Department of Medicine Karolinska InstitutetSE-17177 StockholmSweden

AIM： To study the association between inflammatory bowel disease （IBD） and genetic variations in eosinophil protein X （EPX） and eosinophil cationic protein （ECP）. METHODS： DNA was extracted from ethylene diamine tetraacetic acid blood of 587 patients with Crohn＇s disease （CD）, 592 with ulcerative colitis （UC） and 300 healthy subjects. The EPX405 （G 〉 C, rs2013109）, ECP434 （G 〉 C, rs2073342） and ECP562 （G 〉 C, rs2233860） gene polymorphisms were analysed, by the 5＇-nuclease allelic discrimination assay. For de- termination of intracellular content of EPX and ECP in granulocytes, 39 blood samples was collected and extracted with a buffer containing cetyltrimethylam- monium bromide. The intracellular content of EPX was analysed using an enzyme-linked immunosorbent as- say. The intracellular content of ECP was analysed with the UniCAP system as described by the manufacturer. Statistical tests for calculations of results were χ2 test, Fisher＇s exact test, ANOVA, Student-Newman-Keuls test, and Kaplan-Meier survival curve with Log-rank test for trend, the probability values of P 〈 0.05 were considered statistically ***： The genotype frequency for males with UC and with an age of disease onset of ≥ 45 years （n = 57） was for ECP434 and ECP562, GG = 37%, GC = 60%, CC = 4% and GG = 51%, GC = 49%, CC = 0% respectively. This was significantly different from the healthy subject＇s genotype frequencies of ECP434 （GG = 57%, GC = 38%, CC = 5%; P = 0.010） and ECP562 （GG = 68%, GC = 29%,CC = 3%; P = 0.009）. The genotype frequencies for females, with an age of dis- ease onset of ≥ 45 years with CD （n = 62）, was for the ECP434 and ECP562 genotypes GG = 37%, GC =52%, CC = 11% and GG = 48%, GC = 47% and CC = 5% respectively. This was also statistically different from healthy controls for both ECP434 （P = 0.010） and ECP562 （P = 0.013）. The intracellular protein concen- tration of EPX and ECP was calculated in μg/10^6 eosi- nophils and then correlated to the EPX 405 genotypes

关键词： Eosinophil derived neurotoxin RNase 2 RNase 3 Single nucleotide polymorphism Inflamma-tion bowel disease Crohn's disease Ulcerative colitis

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