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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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Neural Regeneration Research 2025年第7期20卷 2116-2128页

作者： Yuxue Mu ning Zhang Dongyu Wei Guoqing Yang Lilingxuan Yao Xinyue Xu Yang Li Junhui Xue Zuoming Zhang Tao Chen Aerospace Clinical Medical Center School of Aerospace MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Aviation Medicine Xijing HospitalAir Force Medical UniversityXi’anShaanxi ProvinceChina Department of Emergency Medicine Wuhan No.1 HospitalWuhanHubei ProvinceChina Third Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina Fourth Regiment School of Basic MedicineAir Force Medical UniversityXi’anShaanxi ProvinceChina

A microgravity environment has been shown to cause ocular damage and affect visual acuity,but the underlying mechanisms remain ***,we established an animal model of weightlessness via tail suspension to examine the pathological changes and molecular mechanisms of retinal damage under *** 4 weeks of tail suspension,there were no notable alterations in retinal function and morphology,while after 8 weeks of tail suspension,significant reductions in retinal function were observed,and the outer nuclear layer was thinner,with abundant apoptotic *** investigate the mechanism underlying the degenerative changes that occurred in the outer nuclear layer of the retina,proteomics was used to analyze differentially expressed proteins in rat retinas after 8 weeks of tail *** results showed that the expression levels of fibroblast growth factor 2(also known as basic fibroblast growth factor)and glial fibrillary acidic protein,which are closely related to Müller cell activation,were significantly *** addition,Müller cell regeneration and Müller cell gliosis were observed after 4 and 8 weeks,respectively,of simulated *** findings indicate that Müller cells play an important regulatory role in retinal outer nuclear layer degeneration during weightlessness.

关键词： glial fibrous acidic protein gliosis Müller cells nerve growth factor neural differentiation neurodegeneration proteomic retinal degeneration retinal outer nuclear layer simulated weightlessness

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新工科背景下“遗传学”在线课程建设探索

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科教导刊 2019年第31期 128-129页

作者：宁蓬勃龚小程张瑞丽余杰石莎西安电子科技大学生命科学技术学院

遗传学是生物技术专业重要的必修课,在高等院校生命科学及相关学科的课程设置中占有重要地位.当前现代遗传学相关研究的深入,使得遗传学知识理论得以进一步丰富并绳愆纠缪,以及信息化时代学生的学习特点,都对遗传学课程的设置提出了新... 详细信息

遗传学是生物技术专业重要的必修课,在高等院校生命科学及相关学科的课程设置中占有重要地位.当前现代遗传学相关研究的深入,使得遗传学知识理论得以进一步丰富并绳愆纠缪,以及信息化时代学生的学习特点,都对遗传学课程的设置提出了新的要求.在新工科教学背景之下,学生对于遗传学知识的掌握程度,将影响其以后在生物相关领域内深造和就业的能力.本校就建设"遗传学"课程在线教育的必要性以及建设模式展开深入探讨,探索"遗传学"如何针对工科学科特点进行有特色的在线课程建设.

关键词：新工科背景遗传学在线课程

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Design of Solid Electrolytes with Fast Ion Transport:Computation-Driven and Practical Approaches

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Energy Material Advances 2023年第1期4卷 77-111页

作者： Muhammad Khurram Tufail pengbo Zhai Mengyang Jia ning Zhao Xiangxin Guo College of Physics Qingdao University266071 QingdaoChina College of Materials Science and Engineering Qingdao University266071 QingdaoChina

For next-generation all-solid-state metal batteries,the computation can lead to the discovery of new solid electrolytes with increased ionic conductivity and excellent *** on computational predictions,a new proposed solid electrolyte with a flat energy landscape and fast ion migration is synthesized using traditional synthesis *** the promise of the predicted solid electrolyte candidates,conventional synthetic methods are frequently hampered by extensive optimization procedures and overpriced raw *** is impossible to rationally develop novel superionic conductors without a comprehensive understanding of ion migration *** this review,we cover ion migration mechanisms and all emerging computational approaches that can be applied to explore ion conduction in inorganic *** general illustrations of sulfide and oxide electrolyte structures as well as their fundamental features,including ion migration paths,dimensionalities,defects,and ion occupancies,are systematically *** major challenges to designing the solid electrolyte and their solving strategies are highlighted,such as lattice softness,polarizability,and structural *** addition to an overview of recent findings,we propose a computational and experimental approach for designing high-performance solid *** review article will contribute to a practical understanding of ion conduction,designing,rapid optimization,and screening of advanced solid electrolytes in order to eliminate liquid electrolytes.

关键词： designing electrolyte conduction

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Impacts of the annual cycle of background SST in the tropical Pacific on the phase and amplitude of ENSO

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 12-17页

作者： Song Jiang Congwen Zhu ning Jiang State Key Laboratory of Severe Weather(LASW) Chinese Academy of Meteorological SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina

The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of *** on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual *** magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity *** reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.

关键词： Annual cycle SST anomaly Antisymmetric mode ENSO

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大数据平台在市域治安风险防控中的设计与应用

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河南师范大学学报（自然科学版） 2025年第1期53卷 100-105,I0006页

作者：罗宁中国人民公安大学侦查学院北京100038 河南警察学院侦查系郑州450046

通过对大数据技术在市域治安风险防控应用中的现状与不足进行剖析,深度挖掘市域治安风险源头和应对方法.探讨了适用于市域治安风险防范的大数据平台设计的要素基础与设计基础,对市域治安风险防控大数据平台进行结构设计、流程设计和功... 详细信息

通过对大数据技术在市域治安风险防控应用中的现状与不足进行剖析,深度挖掘市域治安风险源头和应对方法.探讨了适用于市域治安风险防范的大数据平台设计的要素基础与设计基础,对市域治安风险防控大数据平台进行结构设计、流程设计和功能设计,给出了矛盾纠纷风险防控、平安校园风险防控、重点关注人员时空轨迹分析等功能的实现方法,深度分析了由矛盾纠纷引起刑事案的内在因素(变量)及各因素的特征.为大数据在市域治安风险防控中的应用提供支撑.

关键词：大数据治安风险防控平台设计

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Catalytic atroposelective synthesis of indolyl quinazolinones bearing N-N/C-C diaxes

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Science China Chemistry 2025年

作者： ning-Yi Wang Shuo Gao Zhu-Di Shu Bei-Bei Cheng Chun Ma Yu-Chen Zhang Feng Shi Research Center of Chiral Functional Heterocycles School of Chemistry and Materials Science Jiangsu Normal University School of Petrochemical Engineering Changzhou University School of Chemistry and Chemical Engineering Henan Normal University

The first catalytic atroposelective synthesis of indole derivatives bearing N-N/C-C diaxes has been established by the strategy of de novo ring formation. By this strategy, various indolyl quinazolinones bearing vicinal N-N/C-C diaxes were synthesized in high yields with overall good diastereoselectivities and excellent enantioselectivities via chiral phosphoric acid-catalyzed onepot asymmetric formal (5+1) cycloaddition/oxidation reaction. Moreover, such indolyl quinazolinones bearing vicinal N-N/CC diaxes have good configurational stability and could be converted into new chiral ligands with applications in asymmetric catalysis. Therefore, this work not only offered a new member for the family of diaxial atropisomers, but also provided a powerful strategy for catalytic asymmetric synthesis of atropisomers bearing N-N/C-C diaxes.

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Neuronal effects of SP600125 pretreatment in a rat model of cerebral ischemia/reperfusion injury Inhibited down-regulation of DNA repair protein

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Neural Regeneration Research 2009年第12期4卷 1055-1061页

作者： ning Wang Rongliang Xue Fengzhen Yao Jiaxuan He Jianrui Lu pengbo Zhang Gang Wu Department of Anesthesiology Second Affiliated Hospital Xi'an Jiaotong University Xi'an 710004 Shaanxi province China Department of Anesthesiology Jiangsu Province Hospital of Traditional Chinese Medicine Nanjing 210002 Jiangsu province China

BACKGROUND： Recent studies have shown that the selective inhibitor of c-Jun N-terminal kinases （JNKs） signaling pathway, SP600125, exhibits neuronal protective effects in a rat model of brain ischemia/reperfusion. OBJECTIVE： To determine the mechanisms of neuroprotective effects of SP600125 in a rat model of brain ischemia/reperfusion, and determine the role of the JNK signaling pathway in SP600125-induced effects. DESIGN, TIME AND SETTING： A randomized, controlled, animal experiment was performed at the Animal Experiment Center, Medical School of Xi＇an Jiaotong University from June 2007 to September 2008. MATERIALS： SP600125 was provided by Biosource, USA; rabbit anti-phospho-JNK （Thr183/Tyr185） polyclonal antibody from Cell Signaling Technology, USA; rabbit anti-X-ray repair cross-complementing protein 1 （XRCC1） and anti-Ku70 polyclonal antibodies from Santa Cruz Biotechnology, USA; and TUNEL kit from Beijing Huamei Biology, China. METHODS： A total of 108 male, 4-month-old, Sprague Dawley rats were randomly assigned to three groups, with 36 rats per group. The sham operation group and ischemia/reperfusion group （I/R group） were intracerebroventricularly injected with 10 μL 1% DMSO. The SP600125-treated group （pre-SP group） was given 10 μL SP600125 （3 μg/μL）. Thirty minutes later, brain ischemia was induced in the I/R and pre-SP groups using the four-vessel occlusion method. Specifically, whole brain ischemia was induced for 6 minutes, and the clips were released to restore carotid artery blood flow. Rats from each group were observed at 2, 6, 12, 24, 48, and 72 hours, with 6 rats for each time point. The sham operation group was treated with the same surgical exposure procedures, with exception of occlusion of the carotid artery. MAIN OUTCOME MEASURES： Hematoxylin-eosin staining was used to observe neuronal survival in the hippocampal CA1 region, TUNEL was used to detect apoptosis in the hippocampal CA1 region, and immunohistochemistry was used to detect expressio

关键词： ischemia/reperfusion injury apoptosis c-Jun N-terminal kinases DNA repair protein X-ray repair cross-complementing protein 1 Ku70

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Evaluation of solid electrolytes: Development of conventional and interdisciplinary approaches

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Interdisciplinary Materials 2023年第4期2卷 529-568页

作者： Muhammad Khurram Tufail pengbo Zhai Waquar Khokar Mengyang Jia ning Zhao Xiangxin Guo College of Physics Qingdao UniversityQingdaoChina College of Materials Science and Engineering Qingdao UniversityQingdaoChina

Solid-state lithium batteries(SSLBs)have received considerable attention due to their advantages in thermal stability,energy density,and *** electrolyte(SE)is a key component in developing high-performance *** in-depth understanding of the intrinsic bulk and interfacial properties is imperative to achieve SEs with competitive *** review first introduces the traditional electrochemical approaches to evaluating the fundamental parameters of SEs,including the ionic and electronic conductivities,activation barrier,electrochemical stability,and diffusion *** that,the characterization techniques to evaluate the structural and chemical stability of SEs are ***,emerging interdisciplinary visualization techniques for SEs and interfaces are highlighted,including synchrotron X-ray tomography,ultrasonic scanning imaging,time-of-flight secondary-ion mass spectrometry,and three-dimensional stress mapping,which improve the understanding of electrochemical performance and failure *** addition,the application of machine learning to accelerate the screening and development of novel SEs is *** review article aims to provide an overview of advanced characterization from a broad physical chemistry view,inspiring innovative and interdisciplinary studies in solid-state batteries.

关键词： advanced characterization interdisciplinary techniques machine learning solid electrolytes solid-state batteries

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A breakthrough of printable mesoscopic perovskite solar cells

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Science China Materials 2025年第1期 307-308页

作者： Zhiyi Yao Zhijun ning School of Physical Science and Technology Shanghai Tech University

High-performance solar cells based on low-cost wet coating methods are the much-anticipated technology for the next generation of photovoltaics. Perovskite solar cells (PSCs) provide a fascinating choice because their...

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Palladium installed copper-organic framework for C–C coupling reactions

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Science China Chemistry 2025年

作者： Yu-Mei Wang Mei-Xia Tao Kai-Ming Mo Xu Chen Shu-Hua Zhong Elena S Shubina Guo-Hong ning Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Supramolecular Coordination ChemistryJinan University A.N.Nesmeyanov Institute of Organoelement Compounds Russian Academy of Sciences

The formation of C–C bonds is a crucial aspect of organic synthesis. Synthesists' long-term objective is to identify novel catalysts to optimize reaction systems based on traditional transition metal catalysis. This study explores the synthesis and catalytic potential of palladium-installed covalent metal-organic frameworks(CMOFs) based on copper cyclic trinuclear units(Cu-CTUs). By incorporating palladium ions into the imine-based framework JNM-7 through a straightforward immersion method, we achieved a notable enhancement in catalytic activity for critical C–C coupling reactions, including C–H arylation and Sonogashira cross-coupling. The resulting JNM-7-Pd demonstrated remarkable stability and recyclability, maintaining its efficiency over at least three cycles without any decline in efficiency.

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