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Neuronal effects of SP600125 pretreatment in a rat model of cerebral ischemia/reperfusion injury Inhibited down-regulation of DNA repair protein

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Neural Regeneration Research 2009年第12期4卷 1055-1061页

作者： Ning Wang Rongliang Xue Fengzhen Yao Jiaxuan He Jianrui Lu pengbo zhang Gang Wu Department of Anesthesiology Second Affiliated Hospital Xi'an Jiaotong University Xi'an 710004 Shaanxi province China Department of Anesthesiology Jiangsu Province Hospital of Traditional Chinese Medicine Nanjing 210002 Jiangsu province China

BACKGROUND： Recent studies have shown that the selective inhibitor of c-Jun N-terminal kinases （JNKs） signaling pathway, SP600125, exhibits neuronal protective effects in a rat model of brain ischemia/reperfusion. OBJECTIVE： To determine the mechanisms of neuroprotective effects of SP600125 in a rat model of brain ischemia/reperfusion, and determine the role of the JNK signaling pathway in SP600125-induced effects. DESIGN, TIME AND SETTING： A randomized, controlled, animal experiment was performed at the Animal Experiment Center, Medical School of Xi＇an Jiaotong University from June 2007 to September 2008. MATERIALS： SP600125 was provided by Biosource, USA; rabbit anti-phospho-JNK （Thr183/Tyr185） polyclonal antibody from Cell Signaling Technology, USA; rabbit anti-X-ray repair cross-complementing protein 1 （XRCC1） and anti-Ku70 polyclonal antibodies from Santa Cruz Biotechnology, USA; and TUNEL kit from Beijing Huamei Biology, China. METHODS： A total of 108 male, 4-month-old, Sprague Dawley rats were randomly assigned to three groups, with 36 rats per group. The sham operation group and ischemia/reperfusion group （I/R group） were intracerebroventricularly injected with 10 μL 1% DMSO. The SP600125-treated group （pre-SP group） was given 10 μL SP600125 （3 μg/μL）. Thirty minutes later, brain ischemia was induced in the I/R and pre-SP groups using the four-vessel occlusion method. Specifically, whole brain ischemia was induced for 6 minutes, and the clips were released to restore carotid artery blood flow. Rats from each group were observed at 2, 6, 12, 24, 48, and 72 hours, with 6 rats for each time point. The sham operation group was treated with the same surgical exposure procedures, with exception of occlusion of the carotid artery. MAIN OUTCOME MEASURES： Hematoxylin-eosin staining was used to observe neuronal survival in the hippocampal CA1 region, TUNEL was used to detect apoptosis in the hippocampal CA1 region, and immunohistochemistry was used to detect expressio

关键词： ischemia/reperfusion injury apoptosis c-Jun N-terminal kinases DNA repair protein X-ray repair cross-complementing protein 1 Ku70

Reducing surficial and interfacial defects by thiocyanate ionic liquid additive and ammonium formate passivator for efficient and stable perovskite solar cells

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Nano Research 2023年第5期16卷 6849-6858页

作者： Mengfei Zhu Yuren Xia Lina Qin Kaiqiang zhang Junchuan Liang Cheng Zhao Daocheng Hong Minghang Jiang Xinmei Song Jie Wei pengbo zhang Yuxi Tian Zhong Jin State Key Laboratory of Coordination Chemistry MOE Key Laboratory of Mesoscopic ChemistryMOE Key Laboratory of High Performance Polymer Materials and TechnologyJiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu 210023China

Organic–inorganic metal halide perovskites have attained extensive attention owing to their outstanding photovoltaic performances,but the existence of numerous defects in crystalline perovskites is still a serious constraint for the further development of perovskite solar cells(PSCs).In particular,the rapid crystallization guided by anti-solvents leads to plenty of surficial and interfacial defects in perovskite ***,we report the adoption of a pseudo-halide anion based ionic liquid additive,1-butyl-3-methylimidazolium thiocyanate(BMIMSCN)for growing ternary cation(CsFAMA,where FA=formamidinium and MA=methylammonium)perovskites with large-scale crystal grains and strong preferential orientation via the enhanced Ostwald ***,a novel halide-free passivator,benzylammonium formate(BAFa),was employed as a buffering layer on the perovskite films to suppress surface-dominated charge *** a result,the cooperative effects of BMIMSCN additive and BAFa passivator lead to significant enhancements on fluorescence lifetime(from 79.41 to 201.01 ns),open-circuit voltage(from 1.13 to 1.19 V),photoelectric conversion efficiency(from 18.90%to 22.33%).Moreover,the BMIMSCN/BAFa-CsFAMA PSCs demonstrated greatly improved stability against moisture and *** work suggests a promising strategy to improve the quality of perovskite materials via reducing the surficial and interfacial defects by the synergistic effects of lattice doping and interface engineering.

关键词： organic–inorganic perovskite solar cells pseudo-halide ion liquid additive non-halide ammonium formate passivator crystalline and interface engineering efficiency and stability improvements

Neural substrates for regulating self-grooming behavior in rodents

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第10期25卷 841-856页

作者： Guanqing LI Chanyi LU Miaomiao YIN Peng WANG pengbo zhang Jialiang WU Wenqiang WANG Ding WANG Mengyue WANG Jiahan LIU Xinghan LIN Jian-Xu zhang Zhenshan WANG Yiqun YU Yun-Feng zhang State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100101China School of Life Sciences Hebei UniversityBaoding 071002China State Key Laboratory of Molecular Development Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China Department of Rehabilitation Medicine Tianjin Huanhu HospitalTianjin 300350China Medical Center for Human Reproduction Beijing Chao-Yang HospitalCapital Medical UniversityBeijing 100101China Department of Gastrointestinal Surgery the People’s Hospital of Zhaoyuan CityZhaoyuan 265400China School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China Department of Otolaryngology EyeEarNose&Throat HospitalFudan UniversityShanghai 200031China Ear Nose&Throat InstituteEyeEarNose&Throat HospitalFudan UniversityShanghai 200031China Clinical and Research Center for Olfactory Disorders EyeEarNose&Throat HospitalFudan UniversityShanghai 200031China

Grooming,as an evolutionarily conserved repetitive behavior,is common in various animals,including humans,and serves essential functions including,but not limited to,hygiene maintenance,thermoregulation,de-arousal,stress reduction,and social *** rodents,grooming involves a patterned and sequenced structure,known as the syntactic chain with four phases that comprise repeated stereotyped movements happening in a cephalocaudal progression style,beginning from the nose to the face,to the head,and finally ending with body *** context-dependent occurrence of grooming behavior indicates its adaptive *** review briefly summarizes the neural substrates responsible for rodent grooming behavior and explores its relevance in rodent models of neuropsychiatric disorders and neurodegenerative diseases with aberrant grooming *** further emphasize the utility of rodent grooming as a reliable measure of repetitive behavior in neuropsychiatric models,holding promise for translational ***,we mainly focus on rodent ***(grooming being applied on one animal by its conspecifics via licking or carefully nibbling)and heterogrooming(a form of grooming behavior directing towards another animal,which occurs in other contexts,such as maternal,sexual,aggressive,or social behaviors)are not covered due to space constraints.

关键词： Grooming Repetitive behavior Syntactic chain Cephalocaudal progression Neuropsychiatric disorders

东北地区旧石器时代野生动物资源的获取及其与自然环境的关系

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农业考古 2024年第4期 43-53页

作者：张鹏卜复旦大学历史地理研究中心

东北地区旧石器时代种类丰富的野生动物资源是当地人们持续生存发展的重要保障。综合利用统计分析、种类构成、自然环境复原等方法对野生动物资源分布、自然环境演变、人类狩猎策略等方面进行考察,可以发现,旧石器时代早中期较低纬度地... 详细信息

东北地区旧石器时代种类丰富的野生动物资源是当地人们持续生存发展的重要保障。综合利用统计分析、种类构成、自然环境复原等方法对野生动物资源分布、自然环境演变、人类狩猎策略等方面进行考察,可以发现,旧石器时代早中期较低纬度地区、岗丘台地型、山地丘陵型的野生动物资源相对较多,旧石器时代晚期较高纬度地区、河湖阶地型、岗丘台地型的野生动物资源相对较多。从自然环境变迁对人类野生动物资源获取方式的影响看,整体温暖湿润的旧石器时代早期人类倾向于狩猎大中型哺乳动物,利用效率较低;寒冷干燥的旧石器时代中期人类改变狩猎策略,利用效率提高;冷暖波动频繁的旧石器时代晚期人类通过强化利用大型哺乳动物、创新石器技术、狩猎对象广谱化等策略来应对气候危机背景下野生动物资源减少的问题,同时这也加速了东北地区大型哺乳动物群的绝灭进程。

关键词：东北地区旧石器时代动物资源自然环境

Effect of interstitial impurities on grain boundary strength in vanadium

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Effect of interstitial impurities on grain boundary strength...

Synthesis of Di/Triarylmethanes via Pd-Catalyzed Coupling of Benzylic Phosphates with Arylsilanes

中国晶体学会第六届学术年会暨会员代表大会（极端条件晶体材料分会）

作者： Yaochun Yang pengbo zhang Jianhua,Ding Jijun Zhao Keylaboratory of Materials Modification by laser ion and electron beams (Ministry of Education)Dalian university of technology Department of physics Dalian Maritime University

Grain boundary(GB)energy plays a significant role in controlling grain morphology and mechanical properties of polycrystalline alloys[1].Small amounts of interstitial impurities can significantly change the fracture t...

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Synthesis of Di/Triarylmethanes via Pd-Catalyzed Coupling of...

螺栓连接薄壁带肋中型预制混凝土墙板结构研究简述

中国化学会第29届学术年会

作者： pengbo zhang Jian XU Guo TANG Yufen ZHAO College of Chemistry and Chemical Engineering Xiamen University

Diarylmethanes are regarded as an important class of compounds both in pharmaceutical chemistry and supramolecular structures. Recently, great efforts have been made to develop the transition-metal-catalyzed synthesis of diarylmethanes involving the Pd-catalyzed coupling of benzyl halides or aryl halides with organoboron,1a organotin1b or organozinc.1c Several Cu（I）-catalyzed cross-coupling reactions between Grignard reagents and alkyl or benzyl halides2 have also been reported. However, to the best of our knoeledge, no benzylic phosphates, which are readily obtained from corresponding alcohols and are highly stable, have been involved in Hiyama cross-coupling to prepare diarymethanes. Our ongoing interest in phosphate reactivity has led us to explore the possibility of the formation of various unsymmetrical diarylmethanes from the reaction of benzyl phosphates with aryltrialkoxysilane using Pd as a *** shown in Scheme 1, we have developed the Hiyama-type cross-coupling reactions of benzylic phosphates with arylsilane. This is the frist example that benzylic phosphates function as electrophilic substrates in Pd-catalyzed Hiyama-type crosscoupling reactions. The reaction can tolerate either electron-donating or electronwithdrawing functional groups.

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建筑结构 2022年第S2期52卷 1509-1515页

作者：张蓬勃大连交通大学土木工程学院大连116028

我国低多层装配式建筑结构体系设计及施工技术成熟的类型有限,无法满足辽阔疆域内不同抗震设防烈度下的广泛的需求,介绍日本螺栓连接中型钢筋混凝土墙板结构体系,为我国低多层装配式建筑体系的研发提供参考。在查阅了大量资料的基础上,... 详细信息

我国低多层装配式建筑结构体系设计及施工技术成熟的类型有限,无法满足辽阔疆域内不同抗震设防烈度下的广泛的需求,介绍日本螺栓连接中型钢筋混凝土墙板结构体系,为我国低多层装配式建筑体系的研发提供参考。在查阅了大量资料的基础上,介绍了日本螺栓连接中型钢筋混凝土墙板结构体系最初发展起因、发展过程和应用现状,并简要说明主要构件和结构体系分类及建造特点。介绍了日本研究人员对带肋薄壁混凝土中型墙板结构的研究历程,归纳设计出发点、结构组成、力学试验结果、模拟分析结果、结构抗震评估方法。归纳振动台试验和震灾调查等方面的结果表明抗震效果较好,海啸作用下的抗冲击能力需要进一步研究。对现有研究进一步需要解决的问题提出个人观点。

关键词：带肋薄壁墙板装配式螺栓连接低多层建筑

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癫痫发作瞬态带宽特征自适应检测方法

仪器仪表学报 2016年第6期37卷 1390-1397页

作者：张鹏博王雪张蔚航戴逸翔清华大学精密仪器系精密测试技术及仪器国家重点实验室北京100084

癫痫是常见的神经系统疾病之一。癫痫发作的识别通常采用脑电测量记录中的癫痫发作起始点,以辅助医生进行诊断并对患者的发作状态报警。利用脑电信号的瞬态参数提出了一种自适应带宽特征,可用于提高癫痫发作检测精度。首先,利用经验模... 详细信息

癫痫是常见的神经系统疾病之一。癫痫发作的识别通常采用脑电测量记录中的癫痫发作起始点,以辅助医生进行诊断并对患者的发作状态报警。利用脑电信号的瞬态参数提出了一种自适应带宽特征,可用于提高癫痫发作检测精度。首先,利用经验模态分解(EMD)求得脑电信号的本征模态函数(IMF),并计算特定阶次IMF的解析信号;其次,利用该解析信号求解瞬时幅值与瞬时频率,对EEG信号的带宽特征添加权重,得到可用于癫痫检测的自适应带宽特征(Adaptive Bandwidth);最后,利用该特征完成癫痫发作检测。采用长达118 h 49 min的癫痫患者临床脑电数据进行实验,实验结果表明,自适应带宽特征的敏感性、特异性、准确性参数均比原特征取得明显提高。自适应带宽特征可提高癫痫发作检测精度并降低时间延迟,便于及时采取治疗措施,为临床检测提供了重要依据。

关键词：癫痫发作脑电经验模态分解本征模态函数带宽特征

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高速水润滑径向滑动轴承的壁面滑移设计

西安交通大学学报 2013年第9期47卷 72-76,99页

作者：张辉张朋波 MENG Hua 董光能西安交通大学机械工程学院西安710049 香港城市大学机械生物及医学工程学系中国香港999077

为了研究高速水润滑条件下具有不同边界滑移表面的径向滑动轴承的摩擦学特性,运用二元滑移理论建立了相应的数学模型。模型考虑了流体边界的滑移效应,对经典雷诺方程进行了修正,并将流量守恒边界条件应用于空化区。通过仿真对比不同滑... 详细信息

为了研究高速水润滑条件下具有不同边界滑移表面的径向滑动轴承的摩擦学特性,运用二元滑移理论建立了相应的数学模型。模型考虑了流体边界的滑移效应,对经典雷诺方程进行了修正,并将流量守恒边界条件应用于空化区。通过仿真对比不同滑移表面对轴承性能的影响,以大承载力和小摩擦阻力为设计目标,对轴承及滑移表面参数进行了优化设计。结果表明:对于偏心率较小、宽度较小和直径较大的轴承,滑移-非滑移间隔表面能显著地提高承载力,降低摩擦阻力和减小空化区面积;当滑移区域与非滑移区域的分界线在普通轴承压力峰值和最小膜厚位置之间时,承载力可达到最大值。

关键词：径向滑动轴承边界滑移摩擦学特性