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Diagnosis and treatment experience of atypical hepatic cystic echinococcosis type 1 at a tertiary center in China

World Journal of Gastroenterology 2024年第5期30卷 462-470页

作者： yu-peng li Jie Zhang Zhi-De li Chao Ma Guang-Lei Tian yuan Meng Xiong Chen Zhi-Gang Ma Department of Hepatobiliary Surgery People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830000Xinjiang Uygur Autonomous RegionChina

BACKGROUND Some hydatid cysts of cystic echinococcosis type 1(CE1)lack well-defined cyst walls or distinctive endocysts,making them difficult to differentiate from simple hepatic *** To investigate the diagnostic methods for atypical hepatic CE1 and the clinical efficacy of laparoscopic *** The clinical data of 93 patients who had a history of visiting endemic areas of CE and were diagnosed with cystic liver lesions for the first time at the People's Hospital of Xinjiang Uygur Autonomous Region(China)from January 2018 to September 2023 were retrospectively *** diagnoses were made based on findings from serum immunoglobulin tests for echinococcosis,routine abdominal ultrasound,high-frequency ultrasound,abdominal computed tomography(CT)scan,and *** to the treatments,these patients underwent reexaminations at the outpatient clinic until October *** evaluations included the diagnostic precision of diverse examinations,the efficacy of surgical approaches,and the incidence of CE *** All 93 patients were diagnosed with simple hepatic cysts by conventional abdominal ultrasound and abdominal CT *** them,16 patients were preoperatively diagnosed with atypical CE1,and 77 were diagnosed with simple hepatic cysts by high-frequency *** the 16 patients preoperatively diagnosed with atypical CE1 underwent laparoscopy,of whom 14 patients were intraoperatively confirmed to have CE1,which was consistent with the postoperative pathological diagnosis,one patient was diagnosed with a mesothelial cyst of the liver,and the other was diagnosed with a hepatic cyst combined with local *** the 77 patients who were preoperatively diagnosed with simple hepatic cysts,4 received aspiration sclerotherapy of hepatic cysts,and 19 received laparoscopic *** patients were intraoperatively diagnosed with simple hepatic *** the followup period,none of the 14 patients with CE1 expe

关键词： Hepatic echinococcosis Hepatic cystic echinococcosis type 1 Hepatic cyst Color Doppler ultrasound Laparoscopy

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Deep learning characterization of rock conditions based on tunnel boring machine data

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Underground Space 2023年第5期12卷 89-101页

作者： Xu li Min Yao Ji-dong yuan yu-jie Wang peng-yu li Key Laboratory of Urban Underground Engineering of Ministry of Education Beijing Jiaotong UniversityBeijing 100044China School of Computer and Information Technology Beijing Jiaotong UniversityBeijing 100044China China Institute of Water Resources and Hydropower Research Beijing 100048China China Railway Engineering Equipment Group Co. Ltd.Zhengzhou 450000China

Rock condition perception based on tunnel boring machine(TBM)data is of great importance for not only ensuring tunnel boring safety but also improving construction *** prediction of TBM boring responses(i.e.,torque and total thrust of the cutterhead)largely determines the reliability of rock condition *** this paper,a new architecture of a two-dimensional convolutional neural network(2D-CNN)with a dual-input strategy is proposed to predict the TBM *** TBM Lot 3 of the Yinsong project in Jilin province,China,is taken as the case study in this *** types of models that follow different learning strategies are compared:one is defined as the point model,which only learns data of the stable phase,and the other is defined as the line model,which learns data from both the loading and stable boring *** line model is further improved by the weighted loss function *** results indicate that the strategy of learning data from both the loading phase and stable boring phase and increasing the weight of samples from the stable phase is shown to be optimal in predicting TBM boring *** terms of learning strategies,the line model can learn the influence of active control parameters on passive response parameters,but the point model *** terms of machine learning algorithms,2D-CNN has the best performance,with R2 values of 0.865 and 0.923 for torque and total thrust,*** proposed line model can overcome the problem that the traditional model failed to learn the influence of control *** a model can provide a solid base for the timely optimization of the control parameters in TBM boring process.

关键词： TBM Rock condition perception 2D-CNN Weighted loss function line model

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Fourth-order phase-field modeling for brittle fracture in piezoelectric materials

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 837-856页

作者： yu TAN Fan peng Chang liU Daiming peng Xiangyu li State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China College of Science Chang'an UniversityXi'an 710064China Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province School of Mechanics and Aerospace EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Failure analyses of piezoelectric structures and devices are of engineering and scientific *** this paper,a fourth-order phase-field fracture model for piezoelectric solids is developed based on the Hamilton *** typical electric boundary conditions are involved in the present model to characterize the fracture behaviors in various physical situations.A staggered algorithm is used to simulate the crack *** polynomial splines over hierarchical T-meshes(PHT-splines)are adopted as the basis function,which owns the *** numerical simulations are performed to study the influence of the electric boundary conditions and the applied electric field on the fracture behaviors of piezoelectric *** electric boundary conditions may influence crack paths and fracture loads *** present research may be helpful for the reliability evaluation of the piezoelectric structure in the future applications.

关键词： isogeometric analysis(IGA) brittle fracture fourth-order phase-field model piezoelectric solid

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Ionizable drug delivery systems for efficient and selective gene therapy

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Military Medical Research 2023年第6期10卷 818-847页

作者： yu-Qi Zhang Ran-Ran Guo Yong-Hu Chen Tian-Cheng li Wen-Zhen Du Rong-Wu Xiang Ji-Bin Guan yu-peng li yuan-yu Huang Zhi-Qiang yu Yin Cai peng Zhang Gui-Xia ling Faculty of Medical Device Shenyang Pharmaceutical UniversityShenyang 110016LiaoningChina Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016LiaoningChina School of Pharmacy Yanbian UniversityYanji 133002JilinChina School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016LiaoningChina Masonic Cancer Center University of MinnesotaMinneapolisMN 55455USA Masonic Cancer Center and Department of Medicinal Chemistry University of MinnesotaMinneapolisMN 55455USA Advanced Research Institute of Multidisciplinary Science School of Life ScienceSchool of Medical TechnologyKey Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer ResearchAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523018GuangdongChina Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong KongHong Kong SARChina

Gene therapy has shown great potential to treat various diseases by repairing the abnormal gene ***,a great challenge in bringing the nucleic acid formulations to the market is the safe and effective delivery to the specific tissues and *** be excited,the development of ionizable drug delivery systems(IDDSs)has promoted a great breakthrough as evidenced by the approval of the BNT162b2 vaccine for prevention of coronavirus disease 2019(COVID-19)in *** with conventional cationic gene vectors,IDDSs can decrease the toxicity of carriers to cell membranes,and increase cellular uptake and endosomal escape of nucleic acids by their unique pH-responsive *** the progress,there remain necessary requirements for designing more efficient IDDSs for precise gene ***,we systematically classify the IDDSs and summarize the characteristics and advantages of IDDSs in order to explore the underlying design *** delivery mechanisms and therapeutic applications of IDDSs are comprehensively reviewed for the delivery of plasmid DNA(pDNA)and four kinds of *** particular,organ selecting considerations and high-throughput screening are highlighted to explore efficiently multifunctional ionizable nanomaterials with superior gene delivery *** anticipate providing references for researchers to rationally design more efficient and accurate targeted gene delivery systems in the future,and indicate ideas for developing next generation gene vectors.

关键词： Ionizable nanomaterials Ionizable drug delivery systems(IDDSs) Nucleic acids Gene therapy

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Polydopamine modified CuS@HKUST for rapid sterilization through enhanced photothermal property and photocatalytic ability

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Rare Metals 2022年第2期41卷 663-672页

作者： Dong-lin Han peng-li yu Xiang-Mei liu Ying-De Xu Shui-lin Wu College of Materials Science and Engineering Jilin Institute of Chemical TechnologyJilin 132022China School of Materials Science and Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjin 300072China Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei Key Laboratory of Polymer MaterialsSchool of Materials Science and EngineeringHubei UniversityWuhan 430062China

Because of the impressive evolution of the drugresistant bacteria,the development of efficient,antibioticfree agent is in great ***,an efficient antibacterial agent,CuS@HKUST-polydopamine(PDA),was exquisitely designed,where the Cu-based metal-organic framework(MOF)—HKUST nanoparticles served as the porous frame,and the CuS was synthesized within the structure of the MOF through the process of in situ sulfuration,followed with polydopamine(PDA)covering the *** structure of the HKUST preventing the aggregation of the CuS nanoparticles,which improved their photothermal and photocatalytic *** covering with PDA,the nanoparticles’abilities to produce heat and free radicals were further *** was because that the PDA itself could transform light into heat,which not only benefited the photothermal property,but also improved the photocatalytic property of the nanoparticles by accelerating the charge ***,the PDA could also transfer the photo-induced electrons fast and thus prevented the recombination of the photo-generated electron–hole pairs,which resulted in the enhanced ability to produce free *** a result,under light irradiation,the antibacterial efficiency of the CuS@HKUST-PDA against Staphylococcus aureus(***)and Escherichia coli(***)could reach 99.77%and 99.57%.Hence,the synthesized CuS@HKUST-PDA can be promising for anti-infection and sterilization application without using antibiotics.

关键词： Antibacterial CuS Polydopamine(PDA) Photothermal Photocatalytic Metal-organic framework(MOF)

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Machine Learning-based Identification of Contaminated Images in light Curve Data Preprocessing

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Research in Astronomy and Astrophysics 2024年第4期24卷 287-295页

作者： Hui li Rong-Wang li peng Shu yu-Qiang li yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Space Object and Debris Observation Chinese Academy of SciencesNanjing 210023China

Attitude is one of the crucial parameters for space objects and plays a vital role in collision prediction and debris *** light curves to determine attitude is the most commonly used *** photometric observations,outliers may exist in the obtained light curves due to various ***,preprocessing is required to remove these outliers to obtain high quality light *** statistical analysis,the reasons leading to outliers can be categorized into two main types:first,the brightness of the object significantly increases due to the passage of a star nearby,referred to as“stellar contamination,”and second,the brightness markedly decreases due to cloudy cover,referred to as“cloudy contamination.”The traditional approach of manually inspecting images for contamination is time-consuming and ***,we propose the utilization of machine learning methods as a *** Neural Networks and SVMs are employed to identify cases of stellar contamination and cloudy contamination,achieving F1 scores of 1.00 and 0.98 on a test set,*** also explore other machine learning methods such as ResNet-18 and light Gradient Boosting Machine,then conduct comparative analyses of the results.

关键词： techniques:image processing methods:data analysis light pollution

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Research on the mechanism of the two-dimensional ultrasonic surface burnishing process to enhance the wear resistance for aluminum alloy

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Friction 2024年第3期12卷 490-509页

作者： Zhen-yu ZHOU Qiu-Yang ZHENG yu li Cong DING Guang-Jian peng Zhong-yu PIAO College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China Key Laboratory of Special Purpose Equipment and Advanced Processing Technology Ministry of Education and Zhejiang ProvinceZhejiang University of TechnologyHangzhou 310014China

The gradient nanostructure is machined on the aluminum(Al)alloy by the two-dimensional ultrasonic surface burnishing process(2D-USBP).The mechanism of why the gradient nanostructure enhances wear resistance is *** mechanical properties and microstructure characterization for the gradient nanostructure are performed by operating a nanoindenter,transmission electron microscopy(TEM),and electron backscattered diffraction(EBSD).Dry wear tests are performed on the samples before and after machining to evaluate the wear resistance and *** effect of the gradient nanostructure on the wear resistance is explored by developing the crystal plasticity(CP)finite element and molecular dynamics(MD)*** characterization results show that the 2D-USBP sample prepared a gradient structure of~600μm thick on the aluminum surface,increasing the surface hardness from 1.13 to 1.71 GPa and reducing the elastic modulus from 78.84 to 70.14 *** optimization of the surface microstructure and the increase of the mechanical properties effectively enhance the wear resistance of the sample,with 41.20%,39.07%,and 54.58% of the wear scar areas for the 2D-USBP treated samples to the original samples under 5,10,and 15 N loads,*** gradient nanostructure hinders the slip of dislocations inside the sample during the wear process and reduces the size and scope of plastic deformation;meanwhile,the resistance to deformation,adhesion,and crack initiation and propagation of the sample surface is improved,resulting in enhanced wear resistance.

关键词： structural superlubricity lattice registry elastic deformation strained solitons crystal plasticity molecular dynamics simulations

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Detecting bulk and edge exceptional points in non-Hermitian systems through generalized Petermann factors

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Frontiers of physics 2024年第2期19卷 169-177页

作者： yue-yu Zou Yao Zhou li-Mei Chen peng Ye School of Physics State Key Laboratory of Optoelectronic Materials and Technologiesand Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSun Yat-sen UniversityGuangzhou 510275China

Non-orthogonality in non-Hermitian quantum systems gives rise to tremendous exotic quantum phenomena,which can be fundamentally traced back to *** this paper,we introduce an interesting quantity(denoted asη)as a new variant of the Petermann factor to directly and efficiently measure non-unitarity and the associated non-Hermitian *** tuning the model parameters of underlying non-Hermitian systems,we find that the discontinuity of bothηand its first-order derivative(denoted as■η)pronouncedly captures rich physics that is fundamentally caused by *** concretely,in the 1D non-Hermitian topological systems,two mutually orthogonal edge states that are respectively localized on two boundaries become non-orthogonal in the vicinity of discontinuity ofηas a function of the model parameter,which is dubbed"edge state transition".Through theoretical analysis,we identify that the appearance of edge state transition indicates the existence of exceptional points(EPs)in topological edge *** the discontinuity of■η,we investigate a two-level non-Hermitian model and establish a connection between the points of discontinuity of■ηand EPs of bulk *** studying this connection in more general lattice models,we find that some models have discontinuity of■η,implying the existence of EPs in bulk states.

关键词： non-Hermitian Su−Schrieffer−Heeger(SSH)model exceptional point

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A Weighted Flow related to a Trudinger-Moser Functional on Closed Riemann Surface

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数学学报（英文版） 2024年第9期40卷 2244-2262页

作者： peng Xiu yu School of Mathematics Renmin University of ChinaBeijing 100872P.R.China

In this paper,with(∑,g)being a closed Riemann surface,we analyze the possible concen-tration behavior of a heat flow related to the Trudinger-Moser *** obtain a long time existence for the *** along some sequence of times tk →+∞,we can deduce the convergence of the flow in H2(∑).Furthermore,the limit function is a critical point of the Trudinger-Moser functional under certain constraint.

关键词： 58J05 58J32 58J35 global convergence heat flow Trudinger-Moser inequality

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Intestinal microecological transplantation for a patient with chronic radiation enteritis:A case report

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World Journal of Gastroenterology 2024年第19期30卷 2603-2611页

作者： lin Wang Yan li yu-Jing Zhang li-Hua peng Department of Gastroenterology and Hepatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Gastroenterology and Hepatology Chinese PLA Medical SchoolBeijing 100853China

BACKGROUND The gut microbiota is strongly associated with radiation-induced gut *** study aimed to assess the effectiveness and safety of intestinal microecological transplantation for treating patients with chronic radiation *** SUMMARY A 64-year-old female with cervical cancer developed abdominal pain,diarrhea,and blood in the stool 1 year after *** electronic colonoscopy was performed to diagnose chronic radiation *** courses of intestinal microecological transplantation and full-length 16S rRNA microbiological analysis were *** patient experienced short-and long-term relief from symptoms without adverse *** 16S rRNA sequencing revealed significant differences in the intestinal flora’s composition between patient and healthy *** bacteria,such as Escherichia fergusonii and Romboutsia timonensis,were more in the *** bacteria such as Faecalibacterium prausnitzii,Fusicatenibacter saccharivorans,Ruminococcus bromii,and Bifidobacterium longum were more in the healthy *** microbiota transplantation resulted in a significant change in the patient's intestinal flora *** composition converged with the donor's flora,with an increase in core beneficial intestinal bacteria,such as Eubacterium rectale,and a decrease in pathogenic *** in the intestinal flora corresponded with the patients'alleviating clinical *** Intestinal microecological transplantation is an effective treatment for relieving the clinical symptoms of chronic radiation enteritis by altering the composition of the intestinal *** study provides a new approach for treating patients with chronic radiation enteritis.

关键词： Chronic radiation enteritis Gut microbial transplantation Intestinal microecology Cancer Quality of life Case report

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