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High-resolution short-term prediction of the COVID-19 epidemic based on spatial-temporal model modified by historical meteorological data

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Fundamental Research 2024年第3期4卷 527-539页

作者： Bin chen Ruming chen lin Zhao Yuxiang Ren li Zhang Yingjie Zhao Xinbo lian wei yan Shuoyuan gao College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Collaborative Innovation Center of Western Ecological Security Lanzhou UniversityLanzhou 730000China

In the global challenge of Coronavirus disease 2019(COVID-19)pandemic,accurate prediction of daily new cases is crucial for epidemic prevention and socioeconomic *** contrast to traditional local,one-dimensional time-series data-based infection models,the study introduces an innovative approach by formulating the short-term prediction problem of new cases in a region as multidimensional,gridded time series for both input and prediction targets.A spatial-temporal depth prediction model for COVID-19(ConvLSTM)is presented,and further ConvLSTM by integrating historical meteorological factors(Meteor-ConvLSTM)is refined,considering the influence of meteorological factors on the propagation of *** correlation between 10 meteorological factors and the dynamic progression of COVID-19 was evaluated,employing spatial analysis techniques(spatial autocorrelation analysis,trend surface analysis,etc.)to describe the spatial and temporal characteristics of the *** the original ConvLSTM,an artificial neural network layer is introduced to learn how meteorological factors impact the infection spread,providing a 5-day forecast at a 0.01°×0.01°pixel *** results using real dataset from the 3.15 outbreak in Shanghai demonstrate the efficacy of Meteor-ConvLSTM,with reduced RMSE of 0.110 and increased R^(2) of 0.125(original ConvLSTM:RMSE=0.702,R^(2)=0.567;Meteor-ConvLSTM:RMSE=0.592,R^(2)=0.692),showcasing its utility for investigating the epidemiological characteristics,transmission dynamics,and epidemic development.

关键词： COVID-19 Prediction ConvLSTM Refined prediction Meteorological factors Spatial-temporal analysis

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Gas microchannel plate-pixel detector for X-ray polarimetry

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Nuclear Science and Techniques 2024年第5期35卷 60-73页

作者： Huan-Bo Feng Hong-bang liu Dong Wang Zi-li li Shu-lin liu Qian liu Hang-Zhou li Bin-Long Wang yan-Jun Xie Zong-Wang Fan Hui Wang Ran chen Di-Fan Yi Rui-Ting Ma Fei Xie Bo peng Xiang-Ming Sun Jin li En-wei liang Present Address:Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Science Huzhou UniversityHuzhou 313000China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Physical Science University of Chinese Academy of SciencesBeijing 100049China The 13th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050057China

POLAR-2 is a gamma-ray burst(GRB)polarimeter that is designed to study the polarization in GRB radiation emissions,aiming to improve our knowledge of related ***-2 is expected to utilize an on-board polarimeter that is sensitive to soft X-rays(2-10 keV),called low-energy polarization *** have developed a new soft X-ray polari-zation detector prototype based on gas microchannel plates(GMCPs)and pixel chips(Topmetal).The GMCPs have bulk resistance,which prevents charging-up effects and ensures gain stability during *** detector is composed of low outgassing materials and is gas-sealed using a laser welding technique,ensuring long-term stability.A modulation factor of 41.28%±0.64% is obtained for a 4.5 keV polarized X-ray beam.A residual modulation of 1.96%±0.58% at 5.9 keV is observed for the entire sensitive area.

关键词： X-ray polarimetry Gas microchannel plate-pixel detector Gamma-ray bursts

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Clinical significance of upregulated Rho GTPase activating protein 12 causing resistance to tyrosine kinase inhibitors in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4244-4263页

作者： Xiao-wei Wang Yu-Xing Tang Fu-Xi li Jia-Le Wang gao-peng Yao da-Tong Zeng Yu-Lu Tang bang-Teng Chi Qin-yan Su lin-Qing Huang Di-Yuan Qin Gang chen Zhen-Bo Feng Rong-Quan He Department of Pathology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Pathology Red Cross Hospital of Yulin CityYulin 537000Guangxi Zhuang Autonomous RegionChi Department of Medical Oncology The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Computer Science and Technology School of Computer and Electronic InformationGuangxi UniversityNanning 530004Guangxi Zhuang Autonomous RegionChina

BACKGROUND Hepatocellular carcinoma(HCC)is a major health challenge with high incidence and poor survival rates in *** therapies,particularly tyrosine kinase inhibitors(TKIs),are the first-line treatment for advanced HCC,but resistance is *** Rho GTPase family member Rho GTPase activating protein 12(ARHGAP12),which regulates cell adhesion and invasion,is a potential therapeutic target for overcoming TKI resistance in ***,no studies on the expression of ARHGAP12 in HCC and its role in resistance to TKIs have been *** To unveil the expression of ARHGAP12 in HCC,its role in TKI resistance and its potential associated *** This study used single-cell RNA sequencing(scRNA-seq)to evaluate ARHGAP12 mRNA levels and explored its mechanisms through enrichment *** was used to investigate focal adhesion(FA)pathway *** integrated bulk RNA data(RNA-seq and microarray),immunohistochemistry and proteomics to analyze ARHGAP12 mRNA and protein levels,correlating with clinical *** assessed ARHGAP12 expression in TKI-resistant HCC,integrated conventional HCC to explore its mechanism,identified intersecting FA pathway genes with scRNA-seq data and evaluated its response to TKI and *** ARHGAP12 mRNA was found to be highly expressed in malignant hepatocytes and to regulate *** malignant hepatocytes in high-score FA groups,MDK-[integrin alpha 6(ITGA6)+integrinβ-1(ITGB1)]showed specificity in ligand-receptor ***12 mRNA and protein were upregulated in bulk RNA,immunohistochemistry and proteomics,and higher expression was associated with a worse ***12 was also found to be a TKI resistance gene that regulated the FA ***1 was identified as a crossover gene in the FA pathway in both scRNA-seq and bulk *** expression of ARHGAP12 was associated with adverse reactions to sorafenib,cabozantinib and regorafenib,but not to *** ARHGAP12 expre

关键词： Hepatocellular carcinoma Focal adhesion Tyrosine kinase inhibitor Rho GTPase activating protein 12 Drug resistance Molecular mechanism Biomarker

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High-fat diet impairs gut barrier through intestinal microbiota-derived reactive oxygen species

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Science China(life Sciences) 2024年第5期67卷 879-891页

作者： Nianyi Zeng Fan Wu Junqi Lu Xiang li Shaomei lin Lang Zhou Zhongwei Wang Guangyan Wu Qingfa Huang daowen Zheng Jie gao Shan Wu Xiaojiao chen Muxuan chen Fanguo Meng Haitao Shang yan He peng chen Hong wei Zhuang li Hongwei Zhou Microbiome Medicine Center Department of Laboratory MedicineZhujiang HospitalSouthern Medical UniversityGuangzhou 510282China Department of Environmental Health Guangdong Provincial Key Laboratory of Tropical Disease ResearchSchool of Public Health and Tropical MedicineSouthern Medical UniversityGuangzhou 510515China Redox Medical Center for Public Health Soochow UniversitySuzhou 215301China Precision Medicine Institute The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pathophysiology Guangdong Provincial Key Laboratory of ProteomicsSchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China

Gut barrier disruption is a key event in bridging gut microbiota dysbiosis and high-fat diet(HFD)-associated metabolic ***,the underlying mechanism remains *** the present study,by comparing HFD-and normal diet(ND)-treated mice,we found that the HFD instantly altered the composition of the gut microbiota and subsequently damaged the integrity of the gut *** sequencing revealed that the HFD upregulates gut microbial functions related to redox reactions,as confirmed by the increased reactive oxygen species(ROS)levels in fecal microbiota incubation in vitro and in the lumen,which were detected using in vivo fluorescence *** microbial ROS-producing capability induced by HFD can be transferred through fecal microbiota transplantation(FMT)into germ-free(GF)mice,downregulating the gut barrier tight ***,mono-colonizing GF mice with an Enterococcus strain excelled in ROS production,damaged the gut barrier,induced mitochondrial malfunction and apoptosis of the intestinal epithelial cells,and exacerbated fatty liver,compared with other low-ROS-producing Enterococcus *** administration of recombinant high-stability-superoxide dismutase(SOD)significantly reduced intestinal ROS,protected the gut barrier,and improved fatty liver against the *** conclusion,our study suggests that extracellular ROS derived from gut microbiota play a pivotal role in HFD-induced gut barrier disruption and is a potential therapeutic target for HFD-associated metabolic diseases.

关键词： fatty liver disease gut microbiota gut barrier high-fat diet oxidative stress reactive oxygen species

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Neomicrocoleus ***.(Microcoleaceae,Oscillatoriales),a novel cyanobacterial genus from benthic mats in a water channel

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Journal of Oceanology and limnology 2024年第1期42卷 263-276页

作者： Ruozhen GENG Zhongshi HE Kaihui gao peng XIAO He ZHANG Si chen Hua li Gongliang YU Renhui li College of life and Environmental Sciences Wenzhou UniversityWenzhou 325035China Key Laboratory of Algal Biology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of Sciences Beijing 100049China Hubei Institution of Land Surveying and Mapping Wuhan 430072China

A new filamentous cyanobacterial strain(CHAB 4127)was successfully isolated from the algal mat during the field investigation of the open channel from Luanhe River to Tianjin,*** polyphasic approach combining morphological,ultrastructural,ecological,and molecular features was used to characterize this studied *** strain is morphologically similar to the Microcoleus-like cyanobacterial taxa under light microscopy,and the radial arrangement of thylakoids is also consistent with that of Microcoleus-like *** phylogenetic position of CHAB 4127 based on 16S rRNA gene sequences,is shown to be clearly clustered into an independent clade with the newly established genus *** maximum similarity of 16S r RNA gene of the studied strain with other existing related cyanobacterial taxa is 93.97%,and the ITS secondary structures is also obviously different from other members of *** on all the above evidence,we proposed the establishment of this novel cyanobacterial genus as Neomicrocoleus,with its type species,Neomicrocoleus tianjinensis.

关键词： Neomicrocoleus tianjinensis morphology 16S rRNA taxonomy polyphasic approach

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Cascaded four-wave mixing all-optical wavelength converter based on highly nonlinear fiber deposited graphene oxide

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Journal of Materials Science & Technology 2024年第4期171卷 10-15页

作者： Yuanhongliu gao Xiaoyu chen Tonglei cheng Fang Wang Xin yan College of Information Science and Engineering State Key Laboratory of Synthetical Automation for Process IndustriesNortheastern UniversityShenyang 110819China

The all-optical wavelength conversion using cascaded four-wave mixing(FWM)phenomena with graphene oxide(GO)and a highly nonlinear fiber(HNLF)device is demonstrated *** has a strong third-order nonlinear effect and is an excellent nonlinear optical material for nonlinear optical wavelength *** group velocity matching of pump and signal,HNLF,and GO amplification promote the cascaded nonlinear frequency mixing *** the experimental and analytical results,the maximum spacing between signal and pump is 21 nm,and specifically,the order of cascaded FWM light increases from order 1 to order 2 with increasing GO,and the first-order FWM conversion effi-ciency increases to a maximum of−14.5 *** the best of our knowledge,this is the first time that cascaded FWM-based all-optical wavelength conversion in HNLF-GO with wide wavelength selectivity is investigated with combined pump and signal *** findings not only provide an effective method for achieving all-optical wavelength conversion in cascaded FWM but also offer the possibility of fabricating high-performance nonlinear optical devices.

关键词： Four-wave mixing Graphene oxide Highly nonlinear fiber Optical wavelength conversion

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LncRNA LOC103694972 promotes fibrosis of NRK-49F cells by regulating STAT3-dependent Smad/CTGF pathway via targeting miR-29c-3p

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BIOCELL 2024年第3期48卷 501-511页

作者： yan li HUZHI CAI XIAOliNG peng YOUHUI liU QINGyanG chen XIANGDONG liN XINYU chen Department of Vascular and Tumor Intervention The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Intensive Care Unit The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Nursing Research The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Intensivie Care Unit The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Endocrinology The First Hospital of Hunan University of Chinese MedicineChangsha410007China Department of Preventive Treatment Center The First Hospital of Hunan University of Chinese MedicineChangsha410007China

Background:Renalﬁbrosis is an important process in the development of chronic kidney *** the pathogenesis andﬁnding effective treatments for renalﬁbrosis is *** study aims to investigate whether a newly discovered long non-coding RNA(lncRNA)called LOC103694972 could be a potential target for treatingﬁbrosis of NRK-49F ***:LncRNA Chip was used to identify differentially expressed lncRNAs between TGF-β1-induced NRK-49F cells and normal *** dual-luciferase assay conﬁrmed the binding between miR-29c-3p and signal transducer and activator of transcription(STAT3),as well as between miR-29c-3p and lncRNA ***-LOC103694972 and miR-29c-3p mimic were then transfected into TGF-β1-induced NRK-49F ***:The study found that LOC103694972 was highly expressed in TGF-β1-induced NRK-49F *** cells exhibited increased cell length and activity compared to the control *** expression levels of Collagen I,α-Smooth muscle actin(α-SMA),and tissue inhibitor of metalloproteinase(TIMP-1)were increased,while matrix Metalloproteinase 2(MMP2)and matrix Metalloproteinase 9(MMP9)expression was ***,transfection with si-LOC103694972 and miR-29c-3p mimics restored cell morphology and reduced cell *** led to a decrease in the levels of Collagen I,α-SMA,and TIMP-1,as well as an increase in MMP2 and MMP9 ***,TGF-β1-induced NRK-49F cells transfected with miR-29c-3p mimics activated the STAT3-Smad3/CTGF ***:Based on theseﬁndings,lncRNA LOC103694972 shows promise as a target for treating renalﬁ*** negatively regulates miR-29c-3p and activates the STAT3-Smad3/CTGF pathway.

关键词： Renal fibrosis lncRNA LOC103694972 lncRNA Chip miR-29c-3p STAT3-Smad3/CTGF

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Loss of SHROOM3 affects neuroepithelial cell shape through regulating cytoskeleton proteins in cynomolgus monkey organoids

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Zoological Research 2024年第2期45卷 233-241页

作者： peng li Ting Zhang Ruo Wu Jun-Yu Zhang yan Zhuo Shan-Gang li Jiao-Jian Wang Wen-Ting guo Zheng-Bo Wang Yong-Chang chen State Key Laboratory of Primate Biomedical Research Institute of Primate Translational MedicineKunming University of Science and TechnologyKunmingYunnan 650500China Yunnan Key Laboratory of Primate Biomedical Research KunmingYunnan 650500China

Neural tube defects(NTDs)are severe congenital neurodevelopmental disorders arising from incomplete neural tube *** folate supplementation has been shown to mitigate the incidence of NTDs,some cases,often attributable to genetic factors,remain *** SHROOM3 gene has been implicated in NTD cases that are unresponsive to folate supplementation;at present,however,the underlying mechanism remains *** tube morphogenesis is a complex process involving the folding of the planar epithelium of the neural *** determine the role of SHROOM3 in early developmental morphogenesis,we established a neuroepithelial organoid culture system derived from cynomolgus monkeys to closely mimic the in vivo neural plate *** of SHROOM3 resulted in shorter neuroepithelial cells and smaller *** morphological changes were attributed to the insufficient recruitment of cytoskeletal proteins,namely fibrous actin(F-actin),myosin II,and phospho-myosin light chain(PMLC),to the apical side of the neuroepithelial ***,these defects were not rescued by folate *** sequencing revealed that differentially expressed genes were enriched in biological processes associated with cellular and organ *** summary,we established an authentic in vitro system to study NTDs and identified a novel mechanism for NTDs that are unresponsive to folate supplementation.

关键词： Neural tube defects SHROOM3 Neuroepithelial Organoids Cynomolgus monkey

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Analysis of vascular thrombus and clinicopathological factors in prognosis of gastric cancer:A retrospective cohort study

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3436-3444页

作者： guo-Yue chen Ping Ren Zhen gao Hao-Ming yang yan Jiao Department of Radiology Jinan Central HospitalJinan 250013Shandong ProvinceChina Department of Gastrointestinal Surgery Jiangsu Provincial People's HospitalNanjing 210029Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is one of the most common malignant tumors in the world,and its prognosis is closely related to many *** recent years,the incidence of vascular thrombosis in patients with GC has gradually attracted increasing attention,and studies have shown that it may have a significant impact on the survival rate and prognosis of ***,the specific mechanism underlying the association between vascular thrombosis and the prognosis of patients with GC remains *** To analyze the relationships between vascular cancer support and other clinicopathological factors and their influence on the prognosis of patients with *** This study retrospectively analyzed the clinicopathological data of 621 patients with GC and divided them into a positive group and a negative group according to the presence or absence of a vascular *** difference in the 5-year cumulative survival rate between the two groups was compared,and the relationships between vascular cancer thrombus and other clinicopathological factors and their influence on the prognosis of patients with GC were *** Among 621 patients with GC,the incidence of vascular thrombi was 31.7%(197 patients).Binary logistic regression analysis revealed that the degree of tumor differentiation,depth of invasion,and extent of lymph node metastasis were independent influencing factors for the occurrence of vascular thrombi in GC patients(Plinearly correlated with the percentage of vascular thrombi in GC patients(P<0.01),and the correlation between lymph node metastasis and vascular thrombi was more significant(r=0.387).Univariate analysis revealed that the 5-year cumulative survival rate of the positive group was significantly lower than that of the negative group(46.7%vs 73.3%,P<0.01).Multivariate analysis revealed that age,tumor diam

关键词： Vascular cancer thrombus Gastric cancer Survival prognosis TNM staging Retrospective study

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MOF-derived Cu embedded into N-doped mesoporous carbon as a robust support of Pdau nanocatalysts for ethanol electrooxidation

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Rare Metals 2024年第3期43卷 1083-1094页

作者： Yu-Fu Huang peng Wu Jun-Ping Tang Jian yang Jing li Shuai chen Xue-ling Zhao chengchen Bin-wei Zhang yan-Yun Ma wei-Heng Shi Dong-Hai lin Shi-Gang Sun School of Energy and Materials Shanghai Engineering Research Center of Advanced Thermal Functional MaterialsShanghai Key Laboratory of Engineering Materials Application and EvaluationShanghai Polytechnic UniversityShanghai201209China State Key Laboratory of Physical Chemistry of Solid Surfaces Department of ChemistryCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China School of Chemistry and Chemical Engineering Chongqing UniversityChongqing401331China Center of Advanced Energy Technology and Electrochemistry Institute of Advanced Interdisciplinary StudiesChongqing UniversityChongqing400044China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou215123China Department of Materials Science and Engineering Drexel UniversityPhiladelphiaPA19104USA

Metal-organic frameworks(MOFs)h ave attracted widespread attention due to their large surface area and porous *** designing the nanostructures of MOFs to promote their application in ethanol electrooxidation is still a ***,a novel Cu-NCNs(Cu-nitrogen-doped carbon nanotubes)support was synthesized by pyrolysis of melamine(MEL)and Cu-ZIF-8 together,and then,Pd-Au nanoalloys were loaded by sodium borohydride reduction method to prepare Pdau@Cu-NCNs *** generating mesoporous carbon with high specific surface area and favorable electron and mass transport can be used as a potential excellent carrier for Pdau *** addition,the balance of catalyst composition and surface structure was tuned by controlling the content of Pd and ***,the best-performed Pd_(2)Au_(2)@Cu-NCN-1000-2(where 1000 means the carrier calcination temperature,and 2 means the calcination constant temperature time)catalyst exhibits better long-term stability and electrochemical activity for ethanol oxidation in alkaline media(4.80 A·mg^(-1)),which is 5.05 times higher than that of commercial Pd/C(0.95 A·mg^(-1)).Therefore,this work is beneficial to further promoting the application of MOFs in direct ethanol fuel cells(DEFCs)and can be used as inspiration for the design of more efficient catalyst support structures.

关键词： Metal-organic frameworks(MOFs) N-doped Mesoporous carbon Pdau Ethanol electrooxidation

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