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Crohn’s disease as the intestinal manifestation of pan-lymphatic dysfunction:An exploratory proposal based on basic and clinical data

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World Journal of Gastroenterology 2024年第1期30卷 34-49页

作者： Yu-Wei Zhou Yue Ren Miao-Miao Lu Ling-Ling Xu Wei-Xin Cheng Meng-Meng Zhang Lin-Ping Ding Dong Chen Jian-Guo Gao Juan Du Ci-Liang Jin Chun-Xiao Chen Yun-Fei Li Tao Cheng peng-lei jiang Yi-Da Yang peng-Xu Qian peng-Fei Xu Xi Jin Department of Gastroenterology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second Hospital of JiaxingJiaxing 314000Zhejiang ProvinceChina Endoscopy Center Children’s Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second People’s Hospital of Yuhang DistrictHangzhou 310000Zhejiang ProvinceChina Department of Gastroenterology Hangzhou Shangcheng District People’s HospitalHangzhou 310003Zhejiang ProvinceChina Department of Colorectal Surgery The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Women’s Hospital and Institute of Genetics Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Center of Stem Cell and Regenerative Medicine and Bone Marrow Transplantation CenterThe First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Infectious Disease The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

Crohn’s disease(CD)is caused by immune,environmental,and genetic *** can involve the entire gastrointestinal tract,and although its prevalence is rapidly increasing its etiology remains *** biological and small-molecule drugs have advanced the treatment of CD;however,a considerable proportion of patients are non-responsive to all known *** achieve a breakthrough in this field,innovations that could guide the further development of effective therapies are of utmost *** this review,we first propose the innovative concept of pan-lymphatic dysfunction for the general distribution of lymphatic dysfunction in various diseases,and suggest that CD is the intestinal manifestation of pan-lymphatic dysfunction based on basic and clinical preliminary *** supporting evidence is fully summarized,including the existence of lymphatic system dysfunction,recognition of the inside-out model,disorders of immune cells,changes in cell plasticity,partial overlap of the underlying mechanisms,and common gut-derived fatty and bile acid *** benefit of this novel concept is that it proposes adopting the zebrafish model for studying intestinal diseases,especially CD,as this model is good at presenting and mimicking lymphatic *** importantly,the ensuing focus on improving lymphatic function may lead to novel and promising therapeutic strategies for CD.

关键词： Inflammatory bowel disease Crohn’s disease Lymphatic system Inside-out model Immune cells Zebrafish

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Pore shrinkage capacity of Shajiang black soils(Vertisols)on the North China Plain and its influencing factors

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Pedosphere 2024年第3期34卷 620-630页

作者： Yueming CHEN Zhongbin ZHANG lei GAO Zichun GUO peng XIONG Fahui jiang Xinhua peng State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008(China) University of Chinese Academy of Sciences Beijing 100049(China) jiangxi Agricultural University Nanchang 330045(China)

Different pore sizes present different pore shrinkage capacities in a nonrigid ***,the shrinkage capacities of different pore sizes and their influencing factors are not *** aimed to quantify the shrinkage capacities of different pore sizes(large pores,>50μm;medium pores,0.2-50μm;fine pores,jiang black soil)region of the North China *** results showed that soil total shrinkage capacity,indicated by the coefficient of linear extensibility(COLE),had a mean value of 0.041-0.051 in the west-east and north-south *** pores had higher pore shrinkage index(PSI)values(0.103-0.109)than medium(0.077-0.096)and fine(0.087-0.091)*** PSI of fine pores showed a fluctuating increasing trend from northwest to southeast,and the fine pore shrinkage capacity determined the COLE(r^(2)=0.789,P<0.001).The PSI of large pores had a significant relationship with soil bulk density(r=0.281,P<0.05)and organic carbon(r=-0.311,P<0.05),whereas those of medium and fine pores were correlated with soil clay content(r=0.381 and 0.687,respectively,P<0.001).In addition,the PSI of fine pores was also correlated with montmorillonite content(r=0.387,P<0.01).It can be concluded that the PSI of large pores is related to anthropogenically influenced soil properties with low stability,whereas those of medium and fine pores are related to pedogenic *** high variability in anthropogenic and pedogenic factors explains the spatial pattern of Vertisol shrinkage capacity on the North China Plain.

关键词： clay content coefficient of linear extensibility pore shrinkage index soil structure spatial distribution swelling

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Response of maize growth and soil biological characteristics to planting density under fertigation in a semi-arid region

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 186-192页

作者： peng jiang lei Li Dejia Xu Rui Wang Quan Sun School of Forestry and Prataculture Ningxia UniversityYinchuan 750021China Institute of Agricultural Resources and Environment Ningxia Academy of Agriculture and Forestry SciencesYinchuan 750002China School of Agriculture Ningxia UniversityYinchuan 750021China

Increasing the planting density can exacerbate crop competition for water,nutrients and space which results in a decline in the crop ***,the effect of increasing planting density on crop growth and soil biological characteristics in barren sandy land in the semi-arid regions are still *** this study,we investigated the effects of six planting densities(5.4×10^(4),6.45×10^(4),7.95×10^(4),9.5×10^(4),9.75×10^(4) and 10.5×10^(4) plants/hm^(2))on maize growth,photosynthesis characteristics,yield and soil biological characteristics in barren sandy soil in the semi-arid region of Ningxia,*** results indicated that the stem diameter and spike length decreased linearly with increasing planting *** plant height,spike weight,grain weight and 100-grain weight decreased with increasing plating ***,the root length increased with increasing planting *** diameter,volume and activity increased and then decreased with increasing planting *** was no significant difference(p>0.05)in the effect of planting density on transpiration rate intercellular CO_(2) *** well,the soil microbial biomass carbon and microbial biomass nitrogen decreased with increasing planting *** soil catalase activities increased and then decreased with increasing planting *** alkaline phosphatase activity,the amounts of soil bacteria and actinomycetes increased with increasing planting ***,a moderately increasing planting density can improve maize yield when water and nutrients are *** optimal planting density was 8.29×10^(4) plants/hm^(2) and the highest yield was 15.84 t/hm^(2) in barren sandy soil in semi-arid region of Ningxia,*** study provides a theoretical basis for high yield and high efficiency of maize.

关键词： maize growth planting density yield fertigation soil enzyme activity

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Porous garnet as filler of solid polymer electrolytes to enhance the performance of solid-state lithium batteries

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Nano Research 2024年第4期17卷 2663-2670页

作者： Yang Zhang lei Zhang peng Guo Chaoyan Zhang Xiaochuan Ren Zhen jiang Jianjun Song Chuan Shi College of Physics Qingdao UniversityQingdao 266071China Industrial Research Institute of Nonwovens and Technical Textiles College of Textiles and ClothingQingdao UniversityQingdao 266071China Department of Chemistry University of PennsylvaniaPhiladelphiaPA 19104USA

In order to enhance the ionic conductivity of solid polymer electrolytes(SPEs)and their structural rigidity against lithium dendrite during lithium-ion battery(LIB)cycling,we propose porous garnet Li6.4La3Zr2Al0.2O12(LLZO),as the filler to *** porous LLZO with interlinked grains was synthesized via a resol-assisted cationic coordinative co-assembly *** porous structure of LLZO with high specific surface area facilitates the interaction between polymer and filler and provides sufficient entrance for Li^(+)migration into the LLZO ***,the interconnection of LLZO grains forms continuous inorganic pathways for fast Li^(+)migration,which avoid the multiple diffusion for Li^(+)in *** a result,the SPEs with porous LLZO(SPE-PL)show a high ionic conductive of 0.73 mS·cm^(-1) at 30℃ and lithium-ion transference number of *** porous LLZO with uniformly dispersed pores also acts as an ion distributor to regulate ionic *** lithium-symmetrical batteries assembled with SPE-PL show a highly stable Li plating/stripping cycling for nearly 3000 h at 0.1 mA·cm^(-2).The corresponding Li/LiFePO_(4) batteries also exhibit excellent cyclic performance with capacity retention of 75%after nearly 500 *** work brings new insights into the design of conductive fillers and the optimization of SPEs.

关键词： solid polymer electrolytes lithium metal battery porous conductive filler solid state battery

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Reliability evaluation of IGBT power module on electric vehicle using big data

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Journal of Semiconductors 2024年第5期45卷 50-60页

作者： Li Liu lei Tang Huaping jiang Fanyi Wei Zonghua Li Changhong Du Qianlei peng Guocheng Lu The School of Electrical Engineering Chongqing UniversityChongqing 400044China The Deepal Automobile Technology Co. Ltd.Chongqing 400023China

There are challenges to the reliability evaluation for insulated gate bipolar transistors(IGBT)on electric vehicles,such as junction temperature measurement,computational and storage *** this paper,a junction temperature estimation approach based on neural network without additional cost is proposed and the lifetime calculation for IGBT using electric vehicle big data is *** direct current(DC)voltage,operation current,switching frequency,negative thermal coefficient thermistor(NTC)temperature and IGBT lifetime are *** the junction temperature(T_(j))is *** the rain flow counting method,the classified irregular temperatures are brought into the life model for the failure *** fatigue accumulation method is then used to calculate the IGBT *** solve the limited computational and storage resources of electric vehicle controllers,the operation of IGBT lifetime calculation is running on a big data *** lifetime is then transmitted wirelessly to electric vehicles as input for neural *** the junction temperature of IGBT under long-term operating conditions can be accurately estimated.A test platform of the motor controller combined with the vehicle big data server is built for the IGBT accelerated aging ***,the IGBT lifetime predictions are derived from the junction temperature estimation by the neural network method and the thermal network *** experiment shows that the lifetime prediction based on a neural network with big data demonstrates a higher accuracy than that of the thermal network,which improves the reliability evaluation of system.

关键词： IGBT junction temperature neural network electric vehicles big data

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Covalent Organic Framework with 3D Ordered Channel and Multi-Functional Groups Endows Zn Anode with Superior Stability

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Nano-Micro Letters 2024年第4期16卷 350-363页

作者： Bin Li pengchao Ruan Xieyu Xu Zhangxing He Xinyan Zhu Liang Pan Ziyu peng Yangyang Liu peng Zhou Bingan Lu lei Dai jiang Zhou School of Chemical Engineering North China University of Science and TechnologyTangshan 063009People’s Republic of China School of Materials Science and Engineering Central South UniversityChangsha 410083People’s Republic of China State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an 710049People’s Republic of China Hunan Provincial Key Defense Laboratory of High Temperature Wear‑Resisting Materials and Preparation Technology Hunan University of Science and TechnologyXiangtan 411201People’s Republic of China School of Physics and Electronics Hunan UniversityChangsha 410082People’s Republic of China

Achieving a highly robust zinc(Zn)metal anode is extremely important for improving the performance of aqueous Zn-ion batteries(AZIBs)for advancing“carbon neutrality”society,which is hampered by the uncontrollable growth of Zn dendrite and severe side reactions including hydrogen evolution reaction,corrosion,and passivation,***,an interlayer containing fluorinated zincophilic covalent organic framework with sulfonic acid groups(COF-S-F)is developed on Zn metal(Zn@COF-S-F)as the artificial solid electrolyte interface(SEI).Sulfonic acid group(-SO_(3)H)in COF-S-F can effectively ameliorate the desolvation process of hydrated Zn ions,and the three-dimensional channel with fluoride group(-F)can provide interconnected channels for the favorable transport of Zn ions with ion-confinement effects,endowing Zn@COF-S-F with dendrite-free morphology and suppressed side ***,Zn@COF-S-F symmetric cell can stably cycle for 1,000 h with low average hysteresis voltage(50.5 m V)at the current density of 1.5 m A cm^(-2).Zn@COF-S-F|Mn O_(2)cell delivers the discharge specific capacity of 206.8 m Ah g^(-1)at the current density of 1.2 A g^(-1)after 800 cycles with high-capacity retention(87.9%).Enlightening,building artificial SEI on metallic Zn surface with targeted design has been proved as the effective strategy to foster the practical application of high-performance AZIBs.

关键词： Aqueous Zn ion batteries Covalent organic framework Interfacial modification Zn ion flux regulation Desolvation effect

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A Multiscale Model of Mass-Functionally Graded Beam-Fluid System Under Bending and Vibration Responses

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Acta Mechanica Solida Sinica 2024年第2期37卷 327-340页

作者： lei Zhang Jianping Lin Jiaqing jiang Guannan Wang Department of Civil Engineering Zhejiang University866 Yuhangtang RoadHangzhou310058China Center for Balance Architecture Zhejiang UniversityHangzhou310007China College of Civil Engineering Huaqiao UniversityXiamen361021China Key Laboratory for Intelligent Infrastructure and Monitoring of Fujian Province Huaqiao UniversityXiamen361021China Department of Engineering Mechanics Zhejiang UniversityHangzhou310027China

In this paper,a multiscale model is developed for the mass functionally graded(FG)beam-fluid system to investigate its static and dynamic responses based on 3D printed porous beam free vibration tests,which are determined by two *** the microstructural level,the gradient variation is realized by arbitrary distribution of matrix pores,and the effective moduli under specific distribution are obtained using the micromechanics homogenization *** the meantime,at the structural level,the mechanical responses of FG porous beams subjected to mass loading are considered in a static fluid ***,the explicit expressions of local finite-element(FE)expressions corresponding to the static and dynamic responses are given in the *** present results are validated against numerical and experimental results from the literature and mechanical tests of 3D printed structures,with good agreement generally obtained,giving credence to the present *** this basis,a comprehensive parametric study is carried out,with a particular focus on the effects of boundary conditions,fluid density,and slenderness ratio on the bending and vibration of FG beams with several different gradations.

关键词： 3D printed test Mass functionally graded beam-fluid system Multiscale model Local finite-element expressions Static bending Free vibration

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Drug-Target Interactions Prediction Based on Signed Heterogeneous Graph Neural Networks

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Chinese Journal of Electronics 2024年第1期33卷 231-244页

作者： Ming CHEN Yajian jiang Xiujuan lei Yi PAN Chunyan JI Wei jiang College of Information Science and Engineering Hunan Normal University School of Computer Science Shaanxi Normal University Faculty of Computer Science and Control Engineering Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences Computer Science Department BNU-HKBU United International College

Drug-target interactions(DTIs) prediction plays an important role in the process of drug *** computational methods treat it as a binary prediction problem, determining whether there are connections between drugs and targets while ignoring relational types information. Considering the positive or negative effects of DTIs will facilitate the study on comprehensive mechanisms of multiple drugs on a common target, in this work, we model DTIs on signed heterogeneous networks, through categorizing interaction patterns of DTIs and additionally extracting interactions within drug pairs and target protein pairs. We propose signed heterogeneous graph neural networks(SHGNNs), further put forward an end-to-end framework for signed DTIs prediction, called SHGNN-DTI,which not only adapts to signed bipartite networks, but also could naturally incorporate auxiliary information from drug-drug interactions(DDIs) and protein-protein interactions(PPIs). For the framework, we solve the message passing and aggregation problem on signed DTI networks, and consider different training modes on the whole networks consisting of DTIs, DDIs and PPIs. Experiments are conducted on two datasets extracted from Drug Bank and related databases, under different settings of initial inputs, embedding dimensions and training modes. The prediction results show excellent performance in terms of metric indicators, and the feasibility is further verified by the case study with two drugs on breast cancer.

关键词： Drugs Training Proteins Measurement Message passing Prediction methods Graph neural networks

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New insights in nano-copper chromite catalyzing ultrafine AP:Evaluation of dispersity and mixing uniformity

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Defence Technology（防务技术） 2024年第2期32卷 120-133页

作者： Yong Kou peng Luo lei Xiao Yanping Xin Guangpu Zhang Yubing Hu Junqing Yang Hongxu Gao Fengqi Zhao Wei jiang Gazi Hao National Special Superfine Powder Engineering Research Center of China School of Chemistry and Chemical EngineeringNanjing University of Science and TechnologyNanjing210094China Xi'an North Huian Chemical Industry Co.Ltd Xi'an710302China Xi'an Modern Chemistry Research Institute Xi'an710065China

Improving the application of nanomaterials has always been a research hotspot in the field of energetic materials(EMs)due to their obvious catalytic effect on the EMs,especially the uniformly dispersed ***,few studies have reported the dispersion of *** this study,the dispersity and mixing uniformity of nano-CuCr_(2)O_(4)was evaluated based on the difference of solid UV light absorption between the nano-catalytic materials and *** nano-CuCr_(2)O_(4)/ultrafine AP composites with different dispersity of nano-CuCr_(2)O_(4)were prepared by manual grinding and mechanical grinding with different grinding strength and griding *** then,the absorbance of different samples at 212 nm was obtained by solid UV testing due to the high repeatability of the absorbance at 210-214 nm for three parallel experiments,and the dispersity of different samples was calculated through the established difference ***,the samples were characterized by XRD,IR,SEM,EDS,DSC and TG-MS,which confirmed that different mixing methods did not change the structure of the samples(XRD and IR),and the mixing uniformity improved with the increase of grinding strength and grinding time(SEM and EDS).The scientificity and feasibility of the difference equation were further verified by *** dispersity of nano-CuCr_(2)O_(4)exhibits a positive intrinsic relationship with its catalytic performance,and the uniformly dispersed nano-CuCr_(2)O_(4)significantly reduces the thermal decomposition temperature of ultrafine AP from 367.7 to 338.8℃.The TG-MS patterns show that the dispersed nano-CuCr_(2)O_(4)advanced the thermal decomposition process of ultrafine AP by about 700 s,especially in the high temperature decomposition stage,and the more concentrated energy release characteristic is beneficial to further enhance the energy performance of AP-based *** above conclusions show that the evaluation method of dispersity based on solid UV curves could pro

关键词： Nano-CuCr_(2)O_(4) Ultrafine AP Dispersity UVeVis diffuse reflectance spectroscopy Thermal decomposition

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Defective Nickel-Iron Layered Double Hydroxide for Enhanced Photocatalytic NO Oxidation with Significant Alleviation of NO2 Production

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Engineering 2024年第5期36卷 276-284页

作者： Xiaoyu Li Xiaoshu Lv Jian Pan peng Chen Huihui peng Yan jiang Haifeng Gong Guangming jiang Li’an Hou Engineering Research Center for Waste Oil Recovery Technology and Equipment Ministry of EducationChongqing Technology and Business UniversityChongqing 400067China State Key Laboratory of Water Environment Simulation School of EnvironmentBeijing Normal UniversityBeijing 100875China Environmental Technology Innovation Center of Jiande Hangzhou Bertzer Catalyst Co.Ltd.Hangzhou 310058China Chongqing Key Laboratory of Green Synthesis and Application College of ChemistryChongqing Normal UniversityChongqing 401331China

Photocatalysis offers a sustainable means for the oxidative removal of low concentrations of NOx(NO,NO2,N2O,N2O5,etc.)from the *** double hydroxides(LDHs)are promising candidate photocatalysts owing to their unique layered and tunable chemical structures and abundant surface hydroxide(OH)moieties,which are hydroxyl radical(OH)***,the practical applications of LDHs are limited by their poor charge-separation ability and insufficient active ***,we developed a facile N_(2)H_(4)-driven etching approach to introduce dual Ni^(2+)and OHvacancies(Niv and OHv,respectively)into NiFe-LDH nanosheets(hereafter referred to as NiFe-LDH-et)to facilitate improved charge-carrier separation and active Lewis acidic site(Fe^(3+)and Ni^(2+)exposed at OHv)*** contrast to inert pristine LDH,NiFe-LDH-et actively removed NO under visible-light ***,Ni_(76)Fe_(24)-LDH-et etched with 1.50 mmol·L^(-1)N_(2)H_(4)solution removed 32.8%of the NO in continuously flowing air(NO feed concentration:500 parts per billion(ppb))under visible-light illumination,thereby outperforming most reported *** and theoretical data revealed that the dual vacancies promoted the production of reactive oxygen species(O_(2)·^(-)andOH)and the adsorption of NO on the *** situ spectroscopy demonstrated that NO was preferentially adsorbed at Lewis acidic sites,particularly exposed Fe^(3+)sites,converted into NO+,and subsequently oxidized to NO3without the notable formation of the more toxic intermediate NO2,thereby alleviating risks associated with its production and emission.

关键词： Vacancie Layered double hydroxide NO+ Photocatalysis NO removal

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