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Diagnostic value of matrix metalloproteinases 2, 7 and 9 in urine for early detection of colorectal cancer

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 931-939页

作者： Liu peng Xin zhang Man-Li zhang Tao Jiang peng-jun zhang Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Interventional TherapyPeking University Cancer Hospital&InstituteBeijing 100142China Division of Medicine Innovation Research Chinese PLA General HospitalBeijing 100853China

BACKGROUND A noninvasive biomarker with high diagnostic performance is urgently needed for the early diagnosis of colorectal cancer(CRC).AIM To evaluate the diagnostic value of matrix metalloproteinases(MMPs)2,7 and 9 in urine for *** Of 59 healthy controls,47 patients with colon polyps and 82 patients with CRC were included in this *** antigen(CEA)in serum and MMP2,MMP7,and MMP9 in urine were *** combined diagnostic model of the indicators was established by binary logistic *** receiver operating characteristic curve(ROC)of the subjects was used to evaluate the independent and combined diagnostic value of the *** The MMP2,MMP7,MMP9,and CEA levels in the CRC group differed significantly from levels in the healthy controls(P<0.05).The levels of MMP7,MMP9,and CEA also differed significantly between the CRC group and the colon polyps group(P<0.05).The area under the curve(AUC)distinguishing between the healthy control and the CRC patients using the joint model with CEA,MMP2,MMP7 and MMP9 was 0.977,and the sensitivity and specificity were 95.10%and 91.50%,*** early-stage CRC,the AUC was 0.975,and the sensitivity and specificity were 94.30%and 98.30%,*** advanced stage CRC,the AUC was 0.979,and the sensitivity and specificity were 95.70%and 91.50%,*** CEA,MMP7 and MMP9 to jointly established a model distinguishing the colorectal polyp group from the CRC group,the AUC was 0.849,and the sensitivity and specificity were 84.10%and 70.20%,*** early-stage CRC,the AUC was 0.818,and the sensitivity and specificity were 76.30%and 72.30%,*** advanced stage CRC,the AUC was 0.875,and the sensitivity and specificity were 81.80%and 72.30%,*** MMP2,MMP7 and MMP 9 may exhibit diagnostic value for the early detection of CRC and may serve as auxiliary diagnostic markers for CRC.

关键词： Colorectal cancer Early detection Matrix metalloproteinases Urine Biomarker

Evaluation of the value of multiparameter combined analysis of serum markers in the early diagnosis of gastric cancer

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World Journal of Gastrointestinal Oncology 2020年第4期12卷 483-491页

作者： Zhi-Guo zhang Liang Xu peng-jun zhang Lei Han Department of Oncology Beijing Daxing District People’s HospitalBeijing 102600China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Interventional Therapy DepartmentPeking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND In early gastric cancer(GC),tumor markers are increased in the *** levels of these markers have been used as important indexes for GC screening,early diagnosis and prognostic ***,specific tumor markers have not yet been *** based on a single tumor marker has limited *** detection rate of GC is still very *** To improve the diagnostic value of blood markers for *** We used a multiparameter joint analysis of 77 indexes of malignant GC and gastric polyp(GP),64 indexes of GC and healthy controls(Ctrls).RESULTS By analyzing the data,there are 27 indexes in the final Ctrls vs GC with P values<0.01,the area under the curve(AUC)of albumin is the largest in Ctrls vs GC,and the AUC was 0.907.30 indexes in GP vs GC have P values<*** them,the D-dimer showed an AUC of *** 27 indexes in Ctrls vs GC and 30 indexes in GP vs GC were used for binary logistic regression,discriminant analysis,classification tree analysis and artificial neural network analysis *** the ability to distinguish between Ctrls vs GC,GP vs GC,artificial neural networks had better diagnostic value when compared with classification tree,binary logistic regression,and discriminant *** compared Ctrl and GC,the overall prediction accuracy was 92.9%,and the AUC was 0.992(0.980,1.000).When compared GP and GC,the overall prediction accuracy was 77.9%,and the AUC was 0.969(0.948,0.990).CONCLUSION The diagnostic effect of multi-parameter joint artificial neural networks analysis is significantly better than the single-index test diagnosis,and it may provide an assistant method for the detection of GC.

关键词： Gastric cancer Gastric polyp Serum Artificial neural network Detection

Clinical value evaluation of serum markers for early diagnosis of colorectal cancer

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World Journal of Gastrointestinal Oncology 2020年第2期12卷 219-227页

作者： Wen-Yue Song Xin zhang Qi zhang peng-jun zhang Rong zhang School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016Liaoning ProvinceChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Interventional Therapy DepartmentPeking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND Early screening for colorectal cancer(CRC)is important in clinical ***,the currently methods are inadequate because of high cost and low diagnostic *** To develop a new examination method based on the serum biomarker panel for the early detection of *** Three hundred and fifty cases of CRC,300 cases of colorectal polyps and 360 cases of normal *** with the results of area under curve(AUC)and correlation analysis,the binary Logistic regression analysis of the remaining indexes which is in accordance with the requirements was carried out,and discriminant analysis,classification tree and artificial neural network analysis were used to analyze the remaining indexes at the same *** By comparison of these methods,we obtained the ability to distinguish CRC from healthy control group,malignant disease group and benign disease *** neural network had the best diagnostic value when compared with binary logistic regression,discriminant analysis,and classification *** AUC of CRC and the control group was 0.992(0.987,0.997),sensitivity and specificity were 98.9%and 95.6%.The AUC of the malignant disease group and benign group was 0.996(0.992,0.999),sensitivity and specificity were 97.4%and 96.7%.CONCLUSION Artificial neural network diagnosis method can improve the sensitivity and specificity of the diagnosis of CRC,and a novel assistant diagnostic method was built for the early detection of CRC.

关键词： Colorectal cancer Serum Index Biomarker Artificial neural network

Different headspace profiles in wild crucifer species in response to Plutella xylostella herbivory and exogenous jasmonic acid application

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Insect Science 2010年第1期17卷 29-37页

作者： peng-jun zhang Jin-Ping Shu Marcel Dicke Shu-Sheng Liu Institute of Insect Sciences Zhejiang University Hangzhou China Laboratory of Entomology Wageningen University Wageningen The Netherlands

Although exogenous treatment of plants withjasmonic acid （JA） may result in induced responses similar to plant defences induced by herbivory, few studies have compared the details of insect herbivory and JA-mimicked responses. We compared volatiles of two crucifer species, Cardamine impatiens and Lepidium virginicum, in response to Plutella xylostella larval feeding and exogenous application of JA, over the entire period of time when induced changes were detectable. Significant differences in the composition and timing of volatiles occurred between herbivory and JA treatments in both plants. The quantity ofnitrile and isothiocyanate released in response to herbivory was significantly larger than that upon JA treatment. In each of the two plant species, most volatile components were emitted immediately upon larval feeding and their quantity dropped rapidly once feeding ceased. In contrast, the emission of volatiles in response to JA treatment lasted for a longer period of time, and the maximum emission rate was recorded 2 and 3 days after JA treatment in L. virginicum and C. impatiens respectively. These findings are discussed in the context of signal-transduction pathways and mechanisms involved in induced emissions of plant volatiles, as well as induced defences mediated by plant volatiles.

关键词： Brassicaceae herbivory induced response jasmonic acid Plutella xylostella volatile emission

Synthesis and Crystal Structure of Rctt-1-(2-benzoxazolyl)-2-(4-chlorophenyl)-4-phenyl-3-(4-pyridinyl)cyclobutane

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Chinese Journal of Structural Chemistry 2003年第1期22卷 65-69页

作者： ZHUANG jun-peng zhang Wen-Qin② (Department of Chemistry, Tianjin University, Tianjin 300072, China) Tianjin Univ Dept Chem Tianjin 300072 Peoples R China

The title compound (C28H21ClN2O, Mr = 436.92) was synthesized by the cross- photodimerization of (E)-2-(2-phenylethenyl)benzoxazole and (E)-4-[2-(4-chlorophenyl)ethenyl]- pyridine in sulfuric acid solution. Its molecular structure has been unequivocally determined by X-ray crystallography. The title compound belongs to triclinic system, space group P?with cell parameters: a = 9.648(3), b = 10.458(4), c = 12.106(4) , a = 89.089(7), b = 75.644(6), g = 68.441(7)? V = 1096.7(7) 3, Z = 2, Dc = 1.323 g/cm3, F(000) = 456 and m(MoKa) = 0.198 mm-1. The final R and wR are 0.0627 and 0.1285, respectively for 1737 observed reflections with I > 2s(I). S = 0.921 and (/s)max = 0.001. The cyclobutane ring has a puckered conformation with four different aryl groups substituted on each carbon atom. The dihedral angles of the cyclobutane ring are 20.2 and 20.6? The bond distances of the cyclobutane ring are 1.541, 1.555, 1.560 and 1.563 ? respectively, which are slightly longer than that of the normal CC single bond. The title compound is the only cross-dimer and its two heteroaryl groups are situated at the trans-1,3 position of the cyclobutane ring, revealing that the cross-photodimerization proceeds in a head-to-tail pattern with high stereo-selectivity.

关键词： cyclobutane photodimerization crystal structure

Evaluation of the diagnostic value of serum-based proteomics for colorectal cancer

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1562-1573页

作者： Hui-Juan Wang Yi-Bin Xie peng-jun zhang Tao Jiang Department of Respiratory and Critical Care Medicine Beijing Chao-Yang HospitalBeijing Institute of Respiratory MedicineCapital Medical UniversityBeijing 100020China Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Interventional Therapy DepartmentPeking University Cancer Hospital and InstituteBeijing 100142China Medical Innovation Research Division of Chinese PLA General Hospital Beijing 100853China

BACKGROUND Colorectal cancer(CRC)is a highly malignant cancer with a high incidence and mortality in *** is urgent to find a diagnostic marker with higher sensitivity and specificity than the traditional approaches for CRC *** To provide new ideas for the diagnosis of CRC based on serum *** Specimens from 83 healthy people,62 colon polyp(CRP)patients,and 101 CRC patients were analyzed by matrix-assisted laser desorption/ionization time-offlight mass *** diagnostic value of the profiles of differentially expressed proteins was then *** Compared with the healthy control group,CRC patients had elevated expression of 5 proteins and reduced expression of 14 *** area under the curve(AUC)for a differentially expressed protein with a mass-to-charge ratio of 2022.34 was the largest;the AUC was 0.843,which was higher than the AUC of 0.717 observed with carcinoembryonic antigen(CEA),and the sensitivity and specificity of this identified marker were 75.3%and 79.5%,*** cross-validation,the accuracy of diagnosis using levels of this differentially expressed protein was 82.37%.Compared with the CRP group,the expression of 3 proteins in the serum of CRC patients was elevated and 11 proteins were expressed at reduced *** possessing mass-to-charge ratio values of 2899.38 and 877.3 were selected to establish a classification tree *** results showed that the accuracy of CRC diagnosis was 89.5%,the accuracy of CRP diagnosis was 81.6%,and the overall accuracy of this approach was 86.3%.The overall sensitivity and specificity of diagnosis using the proteomics approach were 81.8%and 66.75%,*** sensitivities and specificities of diagnoses based on CEA and carbohydrate antigen 19-9 expression were 55.6%and 91.3%and 65.4%and 65.2%,*** We demonstrated that serum proteomics may be helpful for the detection of CRC,and it may assist clinical practice for CRC diagnosis

关键词： Colorectal cancer Colorectal polyps Serum Proteomics Diagnostic value

Potential microRNA panel for the diagnosis and prediction of overall survival of hepatocellular carcinoma with hepatitis B virus infection

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World Journal of Gastrointestinal Oncology 2020年第4期12卷 383-393页

作者： Qi zhang Hai-Feng Xu Wen-Yue Song peng-jun zhang Yong-Bo Song School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016Liaoning ProvinceChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Interventional Therapy DepartmentPeking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND In hepatocellular carcinoma(HCC),abnormal expression of multiple micro RNAs(miRNAs)has been shown to be involved in the malignant biological behavior of liver *** vast majority of liver cancer cases in China are closely related to hepatitis B virus(HBV)infection,but there are few studies on the changes of miRNA expression in the progression from HBV infection to *** To explore the role of miRNAs in the progression of HBV infection to cirrhosis and even to liver *** We screened differentially expressed miRNAs in 40 HBV cirrhosis,40 normal and15 HCC tissues by using a Taq Man Low Density Array and real time quantitative polymerase chain *** evaluate the power of the selected miRNAs to predict disease,we calculated the area under the receiver-operating-characteristic *** overall survival of HBV cirrhosis patients was analyzed via KaplanMeier *** The levels of miR-375,miR-122 and miR-143 were significantly lower in HBV cirrhosis tissues,while miR-224 was significantly higher than in the controls(P<0.0001).The area under the curves of the receiver-operating-characteristic curve for the 4-miRNA panel was 0.991(95%CI:0.974-1).Patients with a lower expression level of miR-224 or higher expression levels of miR-375,miR-122 and miR-143 had longer overall *** four miRNAs(miR-375,miR-122,miR-143 and miR-224)may be helpful for early diagnosis of HBV infection,HBV cirrhosis,and prediction of its overall survival.

关键词： Hepatitis B virus infection Hepatocellular carcinoma MicroRNAs Cirrhosis Biomarker Tissue

Accelerating CFD simulation with high order finite difference method on curvilinear coordinates for modern GPU clusters

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Advances in Aerodynamics 2022年第1期4卷 115-146页

作者： Chuang-Chao Ye peng-jun-Yi zhang Zhen-Hua Wan Rui Yan De-jun Sun Department of Modern Mechanics University of Science and Technology of ChinaHefeiChina

A high fidelity flow simulation for complex geometries for high Reynolds number(Re)flow is still very challenging,requiring a more powerful HPC ***,the development of HPC with traditional CPU architecture suffers bottlenecks due to its high power consumption and technical *** architecture computation is raised to be a promising solution to the challenges of HPC *** accelerating technology has been utilized in low order scheme CFD solvers on the structured grid and high order scheme solvers on unstructured *** high-order finite difference methods on structured grids possess many advantages,e.g.,high efficiency,robustness,and low ***,the strong dependence among points for a high-order finite difference scheme still limits its application on the GPU *** the present work,we propose a set of hardware-aware technology to optimize data transfer efficiency between CPU and GPU,as well as communication efficiency among *** in-house multi-block structured CFD solver with high order finite difference methods on curvilinear coordinates is ported onto the GPU platform and obtains satisfying performance with a speedup maximum of around 2000x over a single CPU *** work provides an efficient solution to apply GPU computing in CFD simulation with specific high order finite difference methods on current GPU heterogeneous *** test shows that significant accelerating effects can be achieved for different GPUs.

关键词： Hardware-aware High order Finite difference methods Curvilinear coordinates GPU

Blood index panel for gastric cancer detection

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World Journal of Gastrointestinal Surgery 2022年第9期14卷 1026-1036页

作者： Guang-Hong Guo Yi-Bin Xie peng-jun zhang Tao Jiang Department of Laboratory Medicine The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Interventional Therapy DepartmentPeking University Cancer Hospital and InstituteBeijing 100142China Medicine Innovation Research Division of Chinese PLA General Hospital Beijing 100853China

BACKGROUND Gastric cancer is a common malignant *** detection and diagnosis are crucial for the prevention and treatment of gastric *** To develop a blood index panel that may improve the diagnostic value for discriminating gastric cancer and gastric *** Thirteen tumor-related detection indices,38 clinical biochemical indices and 10 cytokine indices were examined in 139 gastric cancer patients and 40 gastric polyp patients to build the *** additional 68 gastric cancer patients and 22 gastric polyp patients were enrolled for *** area under the curve evaluation and univariate and multivariate *** Five tumor-related detection indices,12 clinical biochemical indices and 1 cytokine index showed significant differences between the gastric cancer and gastric polyp *** antigen(CA)724,phosphorus(P)and ischemia-modified albumin(IMA)were included in the blood index panel,and the area under the curve(AUC)of the index panel was 0.829(0.754,0.905).After validation,the AUC was 0.811(0.700,0.923).Compared to the conventional index CA724,the blood index panel showed significantly increased diagnostic *** We developed an index model that included CA724,P and IMA to discriminate the gastric cancer and gastric polyp groups,which may be a potential diagnostic method for clinical practice.

关键词： Gastric cancer Gastric polyp Blood Index Panel