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Research and development of advanced structured packing in a rotating packed bed

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Chinese Journal of Chemical Engineering 2022年第9期35卷 178-186页

作者： Zhi-Guo Yuan Yu-Xia Wang You-Zhi Liu Dan Wang Wei-Zhou Jiao peng-fei liang Shanxi Province Key Laboratory of Higee-Oriented Chemical Engineering North University of ChinaTaiyuan 030051China

As the core component of the rotating packing bed,packing is a place for efficient gas–liquid mixing and mass *** this paper,a 3D structured packing composed of a mesh structure and a support structure was *** mesh structure is a ring-shaped mesh surrounded by triangular meshes,which is stable in structure and can achieve a high degree of dispersion and aggregation of the liquid *** support structure is composed of ring-shaped structural units arranged at a certain angle along the axial direction,which can enhance the turbulence of the airflow while constructing regular gas-phase *** steel meshes of different diameters and supporting structures are alternately combined to form 3D packing,which is loaded in a layered cross-flow rotating packing *** results show that under the same operating conditions,the mass transfer performance of 3D packing and wire mesh packing are equivalent,and both are better than pall ring ***,the pressure drop of 3D packing is significantly lower than that of pall ring packing and wire mesh *** design and implementation of packing the development presented in this paper can be used to develop special structured packing for rotating bed,which can further improve the performance of rotating packed bed(RPB).

关键词： Rotating packed bed 3D printed packing 3D modeling Mass transfer Pressure drop Gas–liquid channel

A novel mutation of LIM2 causes autosomal dominant membranous cataract in a Chinese family

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1512-1520页

作者： Rui Pei peng-fei liang Wei Ye Ji Li Ji-Yuan Ma Jian Zhou Department of Ophthalmology Xijing HospitalFourth Military Medical UniversityXi’an 710032Shaanxi ProvinceChina Department of Otolaryngology Xijing HospitalFourth Military Medical UniversityXi'an 710032Shaanxi ProvinceChina

AIM:To identify mutations in the genes of a fourgeneration Chinese family with congenital membranous cataracts and investigate the morphologic changes and possible functional damage underlying the role of the mutant ***:Whole exome analysis of thirteen members of a four-generation pedigree affected with congenital membranous cataracts was performed;co-segregation analysis of identified variants was validated by Sanger *** members underwent detailed physical and complete eye *** physical changes caused by the mutation were analyzed in silico through homology *** lens fiber block from a patient was observed under a scanning electron microscope(SEM).Cell membrane proteins and cytoplasmic proteins from the human lenses donated by one patient with cataract in this family and from the dislocated lens resulted from the penetrating ocular trauma of a patient unrelated with this family were extracted,and the expression and localization of MP20 and Cx46 were detected by Western blot(WB)assay in these ***:A novel LIM2 heterozygous mutation(c.388 C>T,p.R130 C)was identified with congenital membranous cataracts inherited by an autosomal dominant(AD)*** and amblyopia were observed in all patients of this family,and exotropia and long axial length were observed in most patients.A/B ultrasound scan and ultrasound biomicroscopy revealed obvious thin crystalline lenses from 1.7 to 2.7 mm in central thickness in all cataract *** bioinformatic analysis showed that the mutation was deleterious to the physiological function of LIM2-encoded ***,by SEM,ultrastructure of the cataract nucleus showed that lens fiber cells(LFCs)remained morphologic characteristics of immature fiber cells,including flap cell surface with straight edges and lacking normal ball-and-socket joint boundaries,which implied that the differentiation of LFCs might be *** of MP20 and Cx46 in the cytoplasm was observe

关键词： LIM2 MP20 congenital cataract missense mutation differentiation

Efficacy of combination of localized closure,ethacridine lactate dressing,and phototherapy in treatment of severe extravasation injuries:A case series

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World Journal of Clinical Cases 2021年第18期9卷 4599-4606页

作者： Yan-Xu Lu Ying Wu peng-fei liang Rong-Chan Wu Ling-Yun Tian Hui-Ying Mo Xiangya Stomatological Hospital&School of Stomatology Central South UniversityChangsha 410000Hunan ProvinceChina Teaching and Research Section of Clinical Nursing Department of Burn and Reconstructive SurgeryXiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina Department of Burn and Reconstructive Surgery Xiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina Phase 1 Clinical Trial Center Xiangya Hospital of Central South UniversityChangsha 410008Hunan ProvinceChina School of Nursing Anhui University of Chinese MedicineHefei 230012Anhui ProvinceChina

BACKGROUND The management of severe extravasation injuries is still *** injuries can be treated in many *** To present a series of patients with severe extravasation injuries due to infusion who were managed with ethacridine lactate dressing combined with localized closure and *** In this study,we evaluated the data of eight patients,including six from the Department of Burn,one(with colorectal carcinoma)from the Veteran Cadre Department,and one(with leukemia)from the Hematology *** these,three patients were male and five were *** of the patients ranged from 10 mo to 72 years,including two children(10 and 19 mo of age).In this study,the infusion was stopped immediately when the extravasation was *** extravasation event was managed routinely using a blocking solution.A ring-shaped localized closure was performed using the blocking ***,ethacridine lactate dressing and phototherapy were applied for 3-5 *** In this study,the drugs contained in the infusates were iodixanol,norepinephrine,alprostadil,amino acids,fat emulsion,cefoselis,cefoxitin,and potassium chloride+concentrated sodium *** of the patients achieved complete healing after treatment and no obvious adverse reactions were *** The treatment of severe extravasation injuries using a combination of localized closure,ethacridine lactate dressing,and phototherapy resulted in satisfactory outcomes in patients.

关键词： Extravasation Closure Ethacridine lactate Dressing Phototherapy Treatment

Characterization of CIAE developed double-sided silicon strip detector for charged particles

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Nuclear Science and Techniques 2018年第5期29卷 98-103页

作者： Xin-Xing Xu Fanurs C.E.Teh Cheng-Jian Lin Jenny Lee Feng Yang Zhao-Qiao Guo Tian-Shu Guo Li-Jie Sun Xin-Zhi Teng Jia-Jian Liu peng-Jie Li peng-fei liang Lei Yang Nan-Ru Ma Hui-Ming Jia Dong-Xi Wang Sylvain Leblond Taras Lokotko Qing-Qing Zhao Huan-Qiao Zhang China Institute of Atomic Energy Beijing 102413China Department of Physics The University of Hong KongPokfulam RoadHong KongChina College of Physics and Technology Guangxi Normal UniversityGuilin 541004China Beijing Kelixing Photoelectric Technology Co. Ltd.Beijing 102413China

A double-sided silicon strip detector(DSSD)with active area of 48 mm x 48 mm and thickness of300μm has been developed. Each side of DSSD consists of48 strips, each with width of 0.9 mm and inter-strip separation of 0.1 mm. Electrical properties and detection performances including full depletion bias voltage, reverse leakage current, rise time, energy resolution and cross talk have been studied. At a bias of 80 V, leakage current in each strip is less than 15 nA, and rise time for alpha particle at 5157 keV is approximately 15 ns on both *** energy resolutions have been achieved with0.65-0.80% for the junction strips and 0.85-1.00% for the ohmic strips. The cross talk is found to be negligible on both sides. The overall good performance of DSSD indicates its readiness for various nuclear physics experiments.

关键词： Double-sided silicon strip detector P-stop Detection performance Cross talk

Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang fei Yang Zixiao Li Qian Li School of Basic Medical Sciences Capital Medical UniversityBeijingChina Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer Invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

Prognostic model for esophagogastric variceal rebleeding after endoscopic treatment in liver cirrhosis: A Chinese multicenter study

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World Journal of Gastroenterology 2025年第2期31卷 85-101页

作者： Jun-Yi Zhan Jie Chen Jin-Zhong Yu fei-peng Xu fei-fei Xing De-Xin Wang Ming-Yan Yang Feng Xing Jian Wang Yong-Ping Mu Cell Biology Laboratory Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Liver Diseases Shanghai Academy of Chinese MedicineShanghai 201203China Clinical Key Laboratory of Traditional Chinese Medicine of Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Key Laboratory of Liver and Kidney Disease of the Ministry of Education Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Gastroenterology and Hepatology Zhongshan Hospital Affiliated to Fudan UniversityShanghai 200032China Shanghai Institute of Liver Disease Fudan UniversityShanghai 200032China Evidence-Based Medicine Center Fudan UniversityShanghai 200032China Department of Gastrointestinal Endoscopy Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Hepatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

BACKGROUND Rebleeding after recovery from esophagogastric variceal bleeding(EGVB)is a severe complication that is associated with high rates of both incidence and *** its clinical importance,recognized prognostic models that can effectively predict esophagogastric variceal rebleeding in patients with liver cirrhosis are *** To construct and externally validate a reliable prognostic model for predicting the occurrence of esophagogastric variceal *** This study included 477 EGVB patients across 2 cohorts:The derivation cohort(n=322)and the validation cohort(n=155).The primary outcome was rebleeding events within 1 *** least absolute shrinkage and selection operator was applied for predictor selection,and multivariate Cox regression analysis was used to construct the prognostic *** validation was performed with bootstrap *** assessed the discrimination,calibration and accuracy of the model,and performed patient risk *** Six predictors,including albumin and aspartate aminotransferase concentrations,white blood cell count,and the presence of ascites,portal vein thrombosis,and bleeding signs,were selected for the rebleeding event prediction following endoscopic treatment(REPET)*** predicting rebleeding within 1 year,the REPET model ex-hibited a concordance index of 0.775 and a Brier score of 0.143 in the derivation cohort,alongside 0.862 and 0.127 in the validation ***,the REPET model revealed a significant difference in rebleeding rates(P<0.01)between low-risk patients and intermediate-to high-risk patients in both *** We constructed and validated a new prognostic model for variceal rebleeding with excellent predictive per-formance,which will improve the clinical management of rebleeding in EGVB patients.

关键词： Esophagogastric variceal bleeding Variceal rebleeding Liver cirrhosis Prognostic model Risk stratification Secondary prophylaxis

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光伏含氟废水实验研究及工程实例

环境科技 2017年第2期30卷 55-57页

作者：李鹏飞陈良江苏南大环保科技有限公司江苏南京210046

以光伏废水为研究对象,采用两级混凝沉淀法对含氟废水进行处理。通过小试实验研究了p H值对两级除氟效果的影响,同时研究了硫酸铝的投加量对除氟效果的影响,并根据实验结果应用于工程实例中。实验结果表明:一级钙盐除氟法最佳反应p H值... 详细信息

以光伏废水为研究对象,采用两级混凝沉淀法对含氟废水进行处理。通过小试实验研究了p H值对两级除氟效果的影响,同时研究了硫酸铝的投加量对除氟效果的影响,并根据实验结果应用于工程实例中。实验结果表明:一级钙盐除氟法最佳反应p H值为8.0,二级铝盐除氟法最佳反应p H值范围为6.0~7.5,硫酸铝最佳投药量为ρ(Al_2(SO_4)_3):ρ(F-)=20∶1。工程实例表明,通过两级混凝沉淀处理后,出水F-质量浓度可以稳定达到8 mg/L,满足废水排放标准。

关键词：光伏废水氟混凝沉淀铝盐除氟

Activation of adult endogenous neurogenesis by a hyaluronic acid collagen gel containing basic fibroblast growth factor promotes remodeling and functional recovery of the injured cerebral cortex

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Neural Regeneration Research 2025年第10期20卷 2923-2937页

作者： Yan Li peng Hao Hongmei Duan fei Hao Wen Zhao Yudan Gao Zhaoyang Yang Kwok-Fai So Xiaoguang Li Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina China Rehabilitation Science Institute China Rehabilitation Research CenterBeijing Key Laboratory of Neural Injury and RehabilitationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Beijing Key Laboratory for Biomaterials and Neural Regeneration School of Engineering MedicineBeihang UniversityBeijingChina Guangdong-HongKong-Macao Institute of CNS Regeneration Ministry of Education CNS Regeneration Collaborative Joint LaboratoryJinan UniversityGuangzhouGuangdong ProvinceChina Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) GuangzhouGuangdong ProvinceChina Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongHong Kong Special Administration RegionChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-HongKong-Macao Greater Bay AreaGuangzhouGuangdong ProvinceChina Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Biomedical Engineering School of Biological Science and Medical EngineeringBeihang UniversityBeijingChina

The presence of endogenous neural stem/progenitor cells in the adult mammalian brain suggests that the central nervous system can be repaired and regenerated after ***,whether it is possible to stimulate neurogenesis and reconstruct cortical layers II to VI in non-neurogenic regions,such as the cortex,remains *** this study,we implanted a hyaluronic acid collagen gel loaded with basic fibroblast growth factor into the motor cortex immediately following traumatic *** findings reveal that this gel effectively stimulated the proliferation and migration of endogenous neural stem/progenitor cells,as well as their differentiation into mature and functionally integrated ***,these new neurons reconstructed the architecture of cortical layers II to VI,integrated into the existing neural circuitry,and ultimately led to improved brain *** findings offer novel insight into potential clinical treatments for traumatic cerebral cortex injuries.

关键词： adult endogenous neurogenesis basic fibroblast growth factor-hyaluronic acid collagen gel cortical remodeling functional recovery migration motor cortex injury neural circuits neural stem cells newborn neurons proliferation

Association between autoimmune gastritis and gastric polyps:Clinical characteristics and risk factors

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 73-87页

作者： Jing-Zheng Jin Xiao liang Shu-peng Liu Rui-Lan Wang Qing-Wei Zhang Yu-Feng Shen Xiao-Bo Li Division of Gastroenterology and Hepatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Shanghai Institute of Digestive DiseasesShanghai 200001China Division of Gastroenterology and Hepatology Renji Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200127China Division of Gastroenterology and Hepatology Sichuan Armed Police Corps HospitalLeshan 610041Sichuan ProvinceChina Division of Gastroenterology and Hepatology NHC Key Laboratory of Digestive DiseasesRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Gastroenterology Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai Institute of Digestive DiseasesShanghai 200127China

BACKGROUND The relationship between autoimmune gastritis(AIG)and gastric polyps(GPs)is not well *** To explore the clinical characteristics and risk factors of AIG with GPs in *** This double center retrospective study included 530 patients diagnosed with AIG from July 2019 to July *** collected clinical,biochemical,serological,and demographic data were of each *** regression analyses,both multivariate and univariate,were conducted to pinpoint independent risk factors for GPs in patients with AIG *** operating characteristic curves were utilized to establish the optimal cutoff values,sensitivity,and specificity of these risk factors for predicting GPs in patients with *** Patients with GPs had a higher median age than those without GPs[61(52.25-69)years vs 58(47-66)years,P=0.006].The gastrin-17 levels were significantly elevated in patients with GPs compared with those without GPs[91.9(34.2-138.9)pmol/mL vs 60.9(12.6-98.4)pmol/mL,P<0.001].Additionally,the positive rate of parietal cell antibody(PCA)antibody was higher in these patients than in those without GPs(88.6%vs 73.6%,P<0.001).Multivariate and univariate analyses revealed that PCA positivity[odds ratio(OR)=2.003,P=0.017],pepsinogen II(OR=1.053,P=0.015),and enterochromaffin like cells hyperplasia(OR=3.116,P<0.001)were significant risk factors for GPs,while pepsinogen I was identified as a protective *** PCA positivity and enterochromaffin like cells hyperplasia are significant risk factor for the development of GPs in patients with *** gastrin-17 levels may also play a role in this *** findings suggest potential targets for further research and therapeutic intervention in managing GPs in patients with AIG.

关键词： Autoimmune gastritis Gastric polyps Neuroendocrine tumor Risk factors Nomogram