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阿替普酶静脉溶栓后替罗非班治疗急性脑梗死患者的效果

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中国药物应用与监测 2025年第1期22卷 139-143页

作者：王倩彭晓邯郸市第一医院神经内一科邯郸056000

目的探究阿替普酶静脉溶栓后替罗非班治疗急性脑梗死患者的效果。方法纳入2021年5月至2024年1月邯郸市第一医院接收的急性脑梗死患者,根据治疗方案不同分为溶栓组与替罗非班组,倾向性匹配排除基线资料,两组各105例。溶栓组给予阿替普酶... 详细信息

目的探究阿替普酶静脉溶栓后替罗非班治疗急性脑梗死患者的效果。方法纳入2021年5月至2024年1月邯郸市第一医院接收的急性脑梗死患者,根据治疗方案不同分为溶栓组与替罗非班组,倾向性匹配排除基线资料,两组各105例。溶栓组给予阿替普酶静脉溶栓治疗,替罗非班组在静脉溶栓基础上加用替罗非班治疗,治疗时间持续2周。对比溶栓组与替罗非班组临床疗效,治疗前后神经功能[卒中量表(national.institute of health stroke scale,NiHSS)、Barthel指数]、凝血指标[纤维蛋白原(fibrinogen,FiB)、凝血酶原时间(prothrombin time,PT)]、脑血流指标[脑动脉平均血流速度(mean flow velocity,Vm)、收缩期血流峰值(peak systolic velocity,Vs)、舒张期血流峰值(peak diastolic velocity,Vd)]、血清相关因子[胰岛素样生长因子1(iinsulin-like growth factor 1,iGF-1)、脑源性神经营养因子(brain-derived neurotrophic factor,BDNF)、血管内皮生长因子(vascular endothelial growth factor,VEGF)]、氧化应激因子[谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)、丙二醛(malonaldehyde,MDA)、超氧化物歧化酶(superoxi dedismutase,SOD)]药物不良反应及出血转化情况。结果替罗非班组总疗效96.19%(101/105)高于溶栓组88.57%(93/105)(χ^(2)=4.330,P=0.037);治疗后,替罗非班组与溶栓组NiHSS下降[分别为(7.63±1.10)分、(8.71±1.20)分],Barthel指数上升[分别为(73.92±6.58)分、(68.54±6.01)分],差异均有统计学意义(均PiHSS低于溶栓组,Barthel指数高于溶栓组,差异有统计学意义(均PiB下降[分别为(2.79±0.52)g·l^(-1)、(3.45±0.62)g·l^(-1)],PT上升[分别为(15.59±3.01)s、(13.89±2.91)s],差异有统计学意义(均PiB低于溶栓组,PT高于溶栓组,差异有统计学意义(均PiGF-1、BDNF、VEGF上升[分别为(145.95±24.10)μg·l^(-1)、(134.37±22.21)μg·l^(-1),(9.21±1.51)μg·l^(-1)、(7.89±1.36)μg·l^(-1)、(74.52±6.30)μg·l^(-1)、(71.26±5.27)μg·l^(-1)],差异有统计学意义(均Pl·l^(-1)、(6.55±0.82)mmol·l^(-1),(125.52±20.11)U·ml^(-1)、(106.83±16.84)U·ml^(-1)],GSHPx、SOD上升[分别为(71.35±4.36)μmol·l^(-1),(64.93±5.04)μmol·l^(-1)],差异有统计学意义(均P<0.05),且替罗非班组MDA低于溶栓组(P<0.05),GSH-Px、SOD高于溶栓组,差异有统计学意义(均P<0.05);替罗非班组药物不良反应发生率为9.52%(10/105),溶栓组药物不良反应发生率为5.71%(6/105),差异无统计学意义(χ^(2)=1.082,P=0.398)。替罗非班组出血转化率为8.57%(9/105),溶栓组药物出血转化率为5.71%(6/105),差异无统计学意义(χ^(2)=0.646,P=0.421)。结论阿替普酶静脉溶栓后替罗非班可有效治疗急性脑梗死,提高神经功能,改善血清指标,安全性高,值得应用。

关键词：急性脑梗死替罗非班阿替普酶神经功能溶栓治疗

Synergetic deformation mechanisms in an Mg-Zn-Y-Zr alloy with intragranular lPSO structures

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Journal of Magnesium and Alloys 2023年第5期11卷 1754-1768页

作者： Z.Z.peng X.H.Shao Z.M.liang D.l.Wang l.W.Wang X.l.Ma Hebei Key laboratory of Material Near-Net Forming Technology School of Materials Science and EngineeringHebei University of Science and TechnologyShijiazhuang 050018China Shenyang National laboratory for Materials Science Institute of Metal ResearchChinese Academy of Sciences72 Whenua RoadShenyang 110016China

Deformation kink is one of the important strengthening mechanisms of the long-period-stacking-ordered(lPSO)phase containing magnesium(Mg)alloys,while the deformation twin is generally *** optimize the mechanical properties of lPSO containing Mg alloy by simultaneously exciting kink and twin,we successfully prepared the Mg-Zn-Y-Zr alloy featuring intragranular lPSO phase and free grain boundary lPSO phase by *** unraveled the corresponding strengthening and toughening mechanisms through transmission electron microscopy characterization and theoretical *** high strength and good plasticity of the homogenized alloy benefit from the synergistic deformation mechanism of mul.iple kinking and twining in the *** the activation of kinking and twinning depends on the thicknesses of lPSO lamellae and their relative *** results may shed light on optimizing the design of Mg alloys regulating the microstructure of lPSO phases.

关键词： Mg alloy lPSO distribution Kink Twin Transmission electron microscopy

Electronic energy loss and ion velocity correlation effects in track production in swift-ion-irradiated liNbO_(3):A quantitative assessment between structural damage morphology and energy deposition

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Journal of Materials Science & Technology 2022年第21期116卷 30-40页

作者： Xinqing Han Qing Huang Miguel l.Crespillo Eva Zarkadoula Yong liu Xuelin Wang peng liu institute of Frontier and interdisciplinary Science and Key laboratory of Particle Physics and Particle irradiation(MOE) Shandong UniversityQingdao 266237China Shanghai institute of Applied Physics Chinese Academy of Sciences(CAS)Shanghai 201800China Centro de Micro-Análisis de Materiales(CMAM) Universidad Autónoma de MadridMadrid E-28049Spain Materials Science&Technology Division Oak Ridge National LaboratoryOak RidgeTennessee 37831USA

The primary motivation for studying how irradiation modifies the structures and properties of solid materials involves the understanding of undesirable phenomena,including irradiation-induced degradation of components in nuclear reactors and space exploration,and beneficial applications,including material performance tailoring through ion beam modification and defect *** this work,the formation mechanism of latent tracks with different damage morphologies in liNbO_(3)crystals under 0.09-6.17 Me V/u ion irradiation with an electronic energy loss from 2.6-13.2 ke V/nm is analyzed by experimental characterizations and numerical ***-induced damage is preliminarily evaluated via the prism coupling technique to analyze the correlation between the dark-mode spectra and energy loss profiles of irradiated *** the irradiation conditions of different ion velocities and electronic energy losses,different damage morphologies,from individual spherical defects to discontinuous and continuous tracks,are experimentally *** ion penetration process,the ion velocity determines the spatiotemporal distribution of deposited irradiation energy induced by electronic energy loss,meaning that the two essential factors including electronic energy loss and ion velocity coaffect the track *** inelastic thermal spike model.is used to numerically calculate the spatiotemporal evolutions of energy deposition and the corresponding atomic temperature under different irradiation conditions,and a quantitative relationship is proposed by comparison with corresponding experimentally observed track damage *** obtained quantitative relationship between irradiation conditions and track damage provides deep insight and guidance for understanding the damage behavior of crystal materials in extreme radiation environments and selecting irradiation parameters,including ion species and energies,for ion beam technique application in atom

关键词： latent track damage Thermal spike model Electronic energy loss Velocity effect ion modification

Structural damage response of lanthanum and yttrium aluminate crystals to nuclear col.isions and electronic excitation:Threshold assessment of irradiation damage

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Journal of Materials Science & Technology 2021年第31期90卷 95-107页

作者： Yong liu Xinqing Han Qing Huang Miguel l.Crespillo peng liu Eva Zarkadoula Xuelin Wang institute of Frontier and interdisciplinary Science and Key laboratory of Particle Physics and Particle irradiation(MOE) Shandong UniversityQingdao 266237China Shanghai institute of Applied Physics Chinese Academy of Sciences(CAS)Shanghai 201800China Department of Materials Science&Engineering University of TennesseeKnoxvilleTN 37996United States Materials Science&Technology Division Oak Ridge National LaboratoryOak RidgeTN 37831United States

A comparative analysis is performed on the structural damage response and associated mechanisms in lanthanum aluminate and yttrium aluminate crystals under various irradiation conditions by a combination of experimental and theoretical *** low-energy Au~+irradiation,the damage accumulation curve shows a higher damage rate for laAlO_(3)crystals than YAlO_(3)*** relatively low irradiation tolerance of laAlO_(3)to the action of nuclear col.isions is ascribed to the large amorphization cross-section and effective cross-section for defect-stimulated *** swift Ar^(12+),Ni^(19+)and Kr^(17+)irradiation with different ion energies and velocities,the formed highly-disordered/amorphous latent tracks with different morphologies in pristine and predamaged crystals are discussed,and the corresponding electronic energy loss and lattice temperature thresholds are quantitatively *** to YAlO_(3),laAlO_(3)exhibits lower sensitivity and higher damage tolerance to the electronic energy loss process,attributing to its relatively high recrystal.ization efficiency during the rapid quenching ***,the introduction of lattice defects into laAlO_(3)and YAlO_(3)crystals considerably enhances the sensitivity and intensity of thermal spike response to the electronic energy loss,and the induced effective modification of track morphologies demonstrates the synergistic effect between the electronic energy loss and pre-existing defects created by nuclear *** this case,even under the action of electronic energy loss below the threshold,the lattice temperature in the nuclear-col.ision damaged crystal.ine system could still meet the criterion for track *** irradiation energy deposited to atoms and induced lattice temperature evolution discussed in this work provide a deeper insight into the complex processes involved in irradiation-induced latent track behaviors.

关键词： Nuclear energy loss Electronic energy loss Synergistic effect irradiation damage latent ion track

The synergistic effect of micro structure/nanofiller/superhydrophobicity on the surface flashover

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High Voltage 2022年第6期7卷 1091-1098页

作者： Qing Xie Guoshuang Ma peng Wang Xuesong Zhang Jiyuan Yan Zhaochen liu Fangcheng lü School of Electrical and Electronic Engineering North China Electric Power UniversityBaodingChina School of Energy Power and Mechanical EngineeringNorth China Electric Power UniversityBaodingChina

The surface flashover is affected by many factors,such as surface roughness,nanofillers and chemical functional *** this research study,polyamide mesh was utilised as a scaffold to systematically study the synergistic effect of micro structure/nanofiller/superhydrophobicity on the surface *** on the dissolution and resolidification method,nanofillers were partially embedded into the mesh ***,Al_(2)O_(3)nanoparticles were used as a typical non-conductive nanofiller,and carbon nanotubes were used as a typical conductive ***,the micro structure was determined by altering the mesh size,and chemical fluorination was utilised to change the surface chemical *** was found that the polyamide mesh with 300#demonstrated best anti-flashover *** fluorination could effectively improve the flashover *** further adjusting the ratio of Al_(2)O_(3)to carbon nanotubes,the flashover voltage can be increased by up to 30%.

关键词： filler surface structure

NONliNEAR EXPECTATiONS AND NONliNEAR MARKOV CHAiNS

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Chinese Annals of Mathematics,Series B 2005年第2期26卷 159-184页

作者： peng Shige School of Mathematics and System Science Shandong UniversityJinan 250100China

This paper deals with nonlinear expectations. The author obtains a nonlinear gen- eralization of the well-known Kolmogorov’s consistent theorem and then use it to con- struct ?ltration-consistent nonlinear expectations via nonlinear Markov chains. Com- pared to the author’s previous results, i.e., the theory of g-expectations introduced via BSDE on a probability space, the present framework is not based on a given probabil- ity measure. Many fully nonlinear and singular situations are covered. The induced topology is a natural generalization of lp-norms and l∞-norm in linear situations. The author also obtains the existence and uniqueness result of BSDE under this new framework and develops a nonlinear type of von Neumann-Morgenstern representation theorem to utilities and present dynamic risk measures.

关键词： Backward stochastic differential equations Nonlinear expectation Non-linear expected utilities Measure of risk g-expectation Nonlinear Mar-kov chain g-martingale Nonlinear martingale Nonlinear Kolmogorov’s consistent theorem Doob-Meyer decomposition

用于动态场景高动态范围成像的局部熵引导的双分支网络

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计算机应用 2025年第1期45卷 204-213页

作者：黄颖李昌盛彭慧刘苏重庆邮电大学计算机科学与技术学院重庆400065 重庆邮电大学软件工程学院重庆400065

针对基于多张曝光图像序列的高动态范围(HDR)成像任务在相机抖动或拍摄主体移动时出现运动伪影以及曝光失真的问题,提出一个用于动态场景HDR成像的局部熵引导的双分支网络。首先,利用离散小波变换(DWT)分离出输入图像的低频光照相关信... 详细信息

针对基于多张曝光图像序列的高动态范围(HDR)成像任务在相机抖动或拍摄主体移动时出现运动伪影以及曝光失真的问题,提出一个用于动态场景HDR成像的局部熵引导的双分支网络。首先,利用离散小波变换(DWT)分离出输入图像的低频光照相关信息以及高频运动相关信息,以便于网络有针对性地处理曝光以及主体移动;其次,对于低频光照相关信息分支,设计一个利用图像局部熵计算注意力的模块来引导网络减少细节不足的曝光特征的提取;对于高频运动相关信息分支,引入一个轻量级的特征对齐模块来进行场景的一致性对齐,从而减少运动特征的提取;最后,结合通道注意力构建时域自注意力模块,从而加强曝光图像序列在时间域之间的相互依赖关系,以进一步提高结果质量。在公开数据集Kalantari、Sen、Tursun上进行评估。在Kalantari数据集上的实验结果表明,与最新的一些方法对比,所提网络以PSNR-l为42.20 dB的成绩取得第一,SSiM-l为0.988 9的成绩取得第三。结合其余数据集上的实验结果可知,所提网络可以有效减少曝光失真以及运动伪影,并生成细节多、视觉效果佳的图像。

关键词：高动态范围成像局部熵注意力机制离散小波变换图像信息分离

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14种市售麻椒鸡的品质及风味分析

食品工业科技 2025年第1期46卷 302-316页

作者：刘聪刘欣王鹏徐幸莲王寅李建超南京农业大学肉品质量控制与新资源创制全国重点实验室江苏南京210095 江苏立华食品有限公司江苏常州213200

为明确麻椒鸡产品的品质特性及风味特征,本研究以14种不同品牌的市售麻椒鸡(以A~N字母表示)作为研究对象,测定了其色泽、质构、剪切力、电子鼻、挥发性风味物质和电子舌,并结合感官评价进一步探究感官评价指标与仪器分析指标之间的相关... 详细信息

为明确麻椒鸡产品的品质特性及风味特征,本研究以14种不同品牌的市售麻椒鸡(以A~N字母表示)作为研究对象,测定了其色泽、质构、剪切力、电子鼻、挥发性风味物质和电子舌,并结合感官评价进一步探究感官评价指标与仪器分析指标之间的相关性。结果表明:14种麻椒鸡鸡胸的硬度范围为1742.81~4587.54 g,剪切力范围为14.41~35.07 N;鸡腿的硬度范围为797.09~3389.61 g,剪切力范围为7.70~26.34 N。电子鼻评价结果显示,14种麻椒鸡的主要挥发性气味成分为氮氧化合物、无机硫化物、有机硫化物和短链烷烃。气相色谱-离子迁移谱(GCiMS)显示,麻椒鸡风味的形成是鸡肉本身带有的香气和香辛料赋予香气整体协调的结果,14种麻椒鸡中共鉴定出77种挥发性化合物,结合正交偏最小二乘判别分析(OPlS-DA)发现,丁醛、芳樟醇、α-蒎烯、丙烯酸乙酯、α-松油醇、2-庚酮、1-辛烯-3-醇等26种物质为麻椒鸡产品的特征风味物质。电子舌评价结果显示,鲜味和咸味对麻椒鸡的滋味贡献较突出。相关性分析结果表明,感官评价中的总体喜爱度与丁醛、芳樟醇、α-蒎烯、丙烯酸乙酯、α-松油醇、2-庚酮、1-辛烯-3-醇、W5S、W1W、W2W、W1S、咸味、l^(*)和b^(*)值等指标呈现极显著正相关(P<0.01)。本研究可以为麻椒鸡产品风味品质的研究与调控、原辅料的选择、麻椒鸡产品工业化水平的提升提供参考。

关键词：麻椒鸡风味特征气相色谱-离子迁移谱品质特性相关性

基于气基直接还原工艺的球团配矿研究及性能评价

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烧结球团 2025年第1期50卷 78-84页

作者：李晓兵路鹏林林唐珏北京科技大学机械工程学院河钢张宣高科科技有限责任公司东北大学冶金学院

发展气基直接还原工艺可促进企业能源结构转型。为了保障该工艺的顺利实施，本文采用焦炉煤气作为还原介质，开展球团优化配矿研究。研究4种铁精粉基础性能，优选3种铁精粉进行单种矿的造球、焙烧试验。综合铁精粉成分、基础性能及单烧... 详细信息

发展气基直接还原工艺可促进企业能源结构转型。为了保障该工艺的顺利实施，本文采用焦炉煤气作为还原介质，开展球团优化配矿研究。研究4种铁精粉基础性能，优选3种铁精粉进行单种矿的造球、焙烧试验。综合铁精粉成分、基础性能及单烧球团抗压强度，制定优化了5种配矿方案，并对各球团矿冶金性能进行了综合评价。结果表明，60%山西+10%内蒙+30%河北配矿方案性能最优。因此，采用该配矿结构的球团矿和直接还原所用球团进行竖炉投笼对比试验。试验结果表明，该配矿结构球团矿金属化率、碳含量、粒级指标均符合直接还原铁产品要求，可以满足气基直接还原工艺的需求，证实优化配矿和球团冶金性能综合评价方法的可靠性，为推动我国焦炉煤气零重整直接还原工艺发展奠定了理论基础。

关键词：气基竖炉直接还原球团矿优化配矿冶金性能

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