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金属介导的免疫调控与干预:金属免疫学的兴起与展望

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中国科学：化学 2019年第8期49卷 1037-1046页

作者：李劼郑鹏赵劲陈鹏郭子建南京大学化学化工学院配位化学国家重点实验室南京210023 北京大学化学与分子工程学院北京分子科学国家研究中心北京100871

金属元素是生命体的重要组成部分,金属离子及金属蛋白在包括物质存储运输、能量转化传递、信号转导调控、分子合成降解等在内的几乎所有生命过程中都发挥着重要作用.金属在免疫系统,尤其是免疫应答的调控过程中也扮演关键角色,其调控的... 详细信息

金属元素是生命体的重要组成部分,金属离子及金属蛋白在包括物质存储运输、能量转化传递、信号转导调控、分子合成降解等在内的几乎所有生命过程中都发挥着重要作用.金属在免疫系统,尤其是免疫应答的调控过程中也扮演关键角色,其调控的异常往往导致疾病的发生.近年来,免疫相关的肿瘤治疗方案让人们看到了治愈癌症的希望.金属元素在免疫应答和肿瘤治疗中的重要作用正逐渐受到关注,是未来发展的重要方向;然而,目前大多数研究仅仅停留在现象描述阶段,难以在分子层面阐明机制.本文简要介绍了金属元素在免疫应答过程中的关键作用以及在癌症免疫治疗中的重要应用,阐述了"金属免疫学"(Metalloimmunology)这一正在兴起的前沿交叉领域的研究范畴、科学价值和发展趋势.

关键词：金属免疫学金属离子金属药物肿瘤免疫宿主-病原菌相互作用

r. doping tr.gger.ng r.constr.ction of cobalt phosphide for.coupling glycer.l electr.oxidation with seawater.electr.lysis

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Jour.al of Ener.y Chemistr. 2025年第1期100卷 317-326页

作者： Binglu Deng Jie Shen Jinxing Lu Chuqiang Huang Zhuoyuan chen Feng peng Yunpeng Liu School of Mater.als Science and Hydr.gen Ener.y Foshan University School of Chemistr. and Chemical Engineer.ng Guangzhou University Guangdong Key Labor.tor. for.Hydr.gen Ener.y Technologies

Seawater.electr.lysis is a pr.mising appr.ach for.sustainable ener.y without r.lying on pr.cious ***,the lar.e-scale seawater.electr.lysis is hinder.d by low catalytic efficiency and sever. anode cor.osion caused by the har.ful *** contr.st to the oxygen evolution r.action （OEr.and chlor.n ion oxidation r.action （ClOr.,glycer.l oxidation r.action （GOr. is mor. ther.odynamically and kinetically favor.ble ***,a r. doping cobalt phosphide （r.-CoP2） is pr.posed as a r.bust bifunctional electr.catalyst for.seawater.electr.lysis and GOr.for.the concur.ent pr.ductions of hydr.gen and value-added *** in situ and ex situ char.cter.zation analyses demonstr.ted that r. doping featur.d in the dynamic r.constr.ction pr.cess fr.m r.-CoP2to r.-CoOOH,accounting for.the super.or.GOr.*** coupling GOr.with hydr.gen evolution was r.alized by employing r.-CoP2as both anode and cathode,r.quir.ng only a low voltage of 1.43 V at 100 mA cm-2,which was 250 m V lower.than that in alkaline *** wor. guides the design of bifunctional electr.catalysts for.ener.y-efficient seawater.electr.lysis coupled with biomass r.sour.e upcycling.

关键词： Glycer.l electr.oxidation Hydr.gen evolution r. doping Cobalt phosphide Bifunctional electr.catalysts

Constr.ction of 3D por.us Cu_(1.81)S/nitr.gen-doped car.on fr.mewor.s for.ultr.fast and long-cycle life sodium-ion stor.ge

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Inter.ational Jour.al of Miner.ls,Metallur.y and Mater.als 2025年第1期32卷 191-200页

作者： chen chen Hongyu Xue Qilin Hu Mengfan Wang Pan Shang Ziyan Liu Tao peng Deyang Zhang Yongsong Luo Key Labor.tor. of Micr.electr.nics and Ener.y of Henan Pr.vince Henan Joint International Research Laboratory of New Energy Storage TechnologyCollege of Physics and Electronic EngineeringXinyang Normal UniversityXinyang 464000China School of Physics and Electr.nic Engineer.ng Nanyang Normal UniversityNanyang 473061China

Tr.nsition metal sulfides have gr.at potential as anode mter.als for.sodium-ion batter.es(SIBs)due to their.high theor.tical specific ***,the infer.or.intr.nsic conductivity and lar.e volume var.ation dur.ng sodiation-desodiation pr.cesses ser.ously affect its high-r.te and long-cyde per.or.ance,unbeneficial for.the application as fast-char.ing and long-cycling SIBs ***,the thr.e-dimensional por.us Cu_(1.81)S/nitr.gen-doped car.on fr.mewor.s(Cu_(1.81)S/NC)ar. synthesized by the simple and facile sol-gel and annealing pr.cesses,which can accommodate the volumetr.c expansion of Cu_(1.81)S nanopar.icles and acceler.te the tr.nsmission of ions and electr.ns dur.ng Na^(+)inser.ion/extr.ction pr.cesses,exhibiting the excellent r.te capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity r.tention for.6000 cycles at 10.0 A·g^(-1))for.***,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/C cathode also demonstr.te the satisfactor. r.ver.ible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle per.or.ance with the 86.9% capacity r.tention at 2.0 A·g^(-1)after.750 *** wor. pr.poses a pr.mising way for.the conver.ionbased metal sulfides for.the applications as fast-char.ing sodium-ion batter. anode.

关键词： copper.sulfide nanopar.icles por.us car.on fr.mewor. fast char.ing long-cycle per.or.ance sodium-ion full batter.es

Effects of Bifidobacter.um lactis BLa80 on fecal and mucosal flor. and stem cell factor.c-kit signaling pathway in simulated micr.gr.vity r.ts

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Wor.d Jour.al of Gastr.enter.logy 2025年第1期31卷 93-109页

作者： Ping Zhang Ying Zhu Pu chen Tong Zhou Zhe-Yi Han Jun Xiao Jian-Feng Ma Wen Ma peng Zang Ying chen Gr.duate School Hebei North UniversityZhangjiakou 075000Hebei ProvinceChina Key Labor.tor. of Aer.space Nutr.tion and Food Engineer.ng China Astronaut Research and Training CenterBeijing 100094China Depar.ment of Gastr.enter.logy The Air Force Medical CenterBeijing 100142China Depar.ment of Blood Tr.nsfusion Air Force Medical CenterBeijing 100142China

BACKGr.UND Simulated micr.gr.vity envir.nment can lead to gastr.intestinal motility *** pathogenesis of gastr.intestinal motility disor.er. is closely r.lated to the stem cell factor.SCF)/c-kit signaling pathway associated with intestinal flor. and Cajal str.mal ***,intestinal flor. can also affect the r.gulation of SCF/c-kit signaling pathway,thus affecting the expr.ssion of Cajal str.mal *** cells ar. the pacemaker. of gastr.intestinal *** To investigate the effects of Bifidobacter.um lactis(***)BLa80 on the intestinal flor. of r.ts in simulated micr.gr.vity and on the gastr.intestinal motility-r.lated SCF/c-kit *** The inter.ationally r.cognized tail suspension animal model was used to simulate the micr.gr.vity envir.nment,and 30 r.ts wer. r.ndomly divided into contr.l gr.up,tail suspension gr.up and dr.g administr.tion tail suspension gr.up with 10 r.ts in each gr.up for.a total of 28 *** tail gr.up was given *** BLa80 by intr.gastr.c administr.tion,and the other.two gr.ups wer. given water.intr.gastr.c administr.tion,the concentr.tion of intr.gastr.c administr.tion was 0.1 g/mL,and each r.t was 1 mL/***&eosin staining was used to obser.e the histopathological changes in each segment of the intestine of each gr.up,and the expr.ssion levels of SCF,c-kit,extr.cellular.signal-r.gulated kinase(Er.)and p-Er. in the gastr.c antr.m of each gr.up wer. detected by Wester. blotting and *** fecal flor. and mucosal flor. of r.ts in each gr.up wer. detected by 16S *** Simulated micr.gr.vity r.sulted in sever. exfoliation of villi of duodenum,jejunum and ileum in r.ts,mar.ed damage,incr.ased space between villi,loose ar.angement,shor.ened columnar.epithelium of colon,less folds,nar.ower.mucosal thickness,r.duced goblet cell number.and cr.pts,and significant impr.vement after.pr.biotic *** micr.gr.vity r.duced the expr.ssions of SCF and c-kit,and incr.ased the expr.ss

关键词： Simulated micr.gr.vity r.t Intestinal flor. Gastr.intestinal motility Stem cell factor.c-kit signaling pathway

Utilizing engineer.d extr.cellular.vesicles as deliver. vector. in the management of ischemic str.ke:a special outlook on mitochondr.al deliver.

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Neur.l r.gener.tion r.sear.h 2025年第8期20卷 2181-2198页

作者： Jiali chen Yiyang Li Xingping Quan Jinfen chen Yan Han Li Yang Manfei Zhou Gr.ta Seng peng Mok r.ibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Depar.ment of Phar.acy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Depar.ment of Electr.cal and Computer.Engineer.ng University of MacaoTaipaMacao Special Administrative RegionChina Depar.ment of Phar.aceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic str.ke is a secondar. cause of mor.ality wor.dwide,imposing consider.ble medical and economic bur.ens on *** vesicles,ser.ing as natur.l nanocar.ier. for.dr.g deliver.,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncer.ain distr.bution and r.pid clear.nce of extr.cellular.vesicles impede their.deliver. *** utilizing membr.ne decor.tion or.by encapsulating ther.peutic car.o within extr.cellular.vesicles,their.deliver. efficacy may be gr.atly ***,pr.vious studies have indicated that micr.vesicles,a subset of lar.e-sized extr.cellular.vesicles,can tr.nspor. mitochondr.a to neighbor.ng cells,ther.by aiding in the r.stor.tion of mitochondr.al function post-ischemic *** extr.cellular.vesicles have also demonstr.ted the capability to tr.nsfer.mitochondr.al components,such as pr.teins or.deoxyr.bonucleic acid,or.their.sub-components,for.extr.cellular.vesicle-based ischemic str.ke *** this r.view,we under.ake a compar.tive analysis of the isolation techniques employed for.extr.cellular.vesicles and pr.sent an over.iew of the cur.ent dominant extr.cellular.vesicle modification *** the complex facets of tr.ating ischemic str.ke,we also delineate var.ous extr.cellular.vesicle modification appr.aches which ar. suited to differ.nt facets of the tr.atment ***,given the bur.eoning inter.st in mitochondr.al deliver.,we delved into the feasibility and existing r.sear.h findings on the tr.nspor.ation of mitochondr.al fr.ctions or.intact mitochondr.a thr.ugh small extr.cellular.vesicles and micr.vesicles to offer.a fr.sh per.pective on ischemic str.ke ther.py.

关键词： deliver. engineer.ng extr.cellular.vesicles identification ischemic str.ke isolation mitochondr.a tar.eting str.tegy ther.peutic effects

Per.pher.l mitochondr.al DNA as a neur.inflammator. biomar.er.for.major.depr.ssive disor.er

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Neur.l r.gener.tion r.sear.h 2025年第6期20卷 1541-1554页

作者： Jinmei Ye Cong Duan Jiaxin Han Jinr.ng chen Ning Sun Yuan Li Tifei Yuan Daihui peng Division of Mood Disor.er Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Depar.ment of Psychiatr. First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Shanghai Key Labor.tor. of Psychotic Disor.er. Brain Health InstituteNational Center for Mental DisordersShanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghaiChina Co-Innovation Center.of Neur.r.gener.tion Nantong UniversityNantongJiangsu ProvinceChina

In the pathogenesis of major.depr.ssive disor.er. chr.nic str.ss-r.lated neur.inflammation hinder. favor.ble pr.gnosis and antidepr.ssant r.sponse. Mitochondr.al DNA may be an inflammator. tr.gger. after.its r.lease fr.m str.ss-induced dysfunctional centr.l ner.ous system mitochondr.a into per.pher.l cir.ulation. This evidence suppor.s the potential use of per.pher.l mitochondr.al DNA as a neur.inflammator. biomar.er.for.the diagnosis and tr.atment of major.depr.ssive disor.er. Her.in, we cr.tically r.view the neur.inflammation theor. in major.depr.ssive disor.er. pr.viding compelling evidence that mitochondr.al DNA r.lease acts as a cr.tical biological substr.te, and that it constitutes the neur.inflammator. disease pathway. After.its r.lease, mitochondr.al DNA can be car.ied in the exosomes and tr.nspor.ed to extr.cellular.spaces in the centr.l ner.ous system and per.pher.l cir.ulation. Detectable exosomes r.nder.encaged mitochondr.al DNA r.latively stable. This mitochondr.al DNA in per.pher.l cir.ulation can thus be dir.ctly detected in clinical pr.ctice. These char.cter.stics illustr.te the potential for.mitochondr.al DNA to ser.e as an innovative clinical biomar.er.and molecular.tr.atment tar.et for.major.depr.ssive disor.er. This r.view also highlights the futur. potential value of clinical applications combining mitochondr.al DNA with a panel of other.biomar.er., to impr.ve diagnostic pr.cision in major.depr.ssive disor.er.

关键词： biomar.er cytokine exosomes inflammasome major.depr.ssive disor.er micr.glia mitochondr.al DNA mitochondr.al dysfunction neur.inflammation Toll-like r.ceptor

Maintaining moder.te levels of hypochlor.us acid pr.motes neur.l stem cell pr.lifer.tion and differ.ntiation in the r.cover. phase of str.ke

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Neur.l r.gener.tion r.sear.h 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-De Zhang Jie chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma peng-peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Phar.acy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Depar.ment of Labor.tor. Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Depar.ment of Labor.tor. Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous r.moval of ischemia/r.per.usion-induced r.active oxygen species is not conducive to the r.cover. of late ***,pr.vious studies have shown that excessive incr.ases in hypochlor.us acid after.str.ke can cause sever. damage to br.in *** pr.vious studies have found that a small amount of hypochlor.us acid still exists in the later.stage of str.ke,but its specific r.le and mechanism ar. cur.ently *** simulate str.ke in vivo,a middle cer.br.l ar.er. occlusion r.t model was established,with an oxygen-glucose depr.vation/r.oxygenation model established in vitr. to mimic *** found that in the ear.y stage(within 24 hour.)of ischemic str.ke,neutr.phils pr.duced a lar.e amount of hypochlor.us acid,while in the r.cover. phase(10 days after.str.ke),micr.glia wer. activated and pr.duced a small amount of hypochlor.us ***,in acute str.ke in r.ts,hypochlor.us acid pr.duction was pr.vented using a hypochlor.us acid scavenger.taur.ne,or.myeloper.xidase inhibitor.4-aminobenzoic acid *** r.sults showed that high levels of hypochlor.us acid(200μM)induced neur.nal apoptosis after.oxygen/glucose depr.vation/***,in the r.cover. phase of the middle cer.br.l ar.er. occlusion model,a moder.te level of hypochlor.us acid pr.moted the pr.lifer.tion and differ.ntiation of neur.l stem cells into neur.ns and *** suggests that hypochlor.us acid plays differ.nt r.les at differ.nt phases of cer.br.l ischemia/r.per.usion *** levels of hypochlor.us acid(5 and 100μM)pr.moted nuclear.tr.nslocation ofβ-*** tr.nsfection of single-site mutation plasmids,we found that hypochlor.us acid induced chlor.nation of theβ-catenin tyr.sine 30 r.sidue,which pr.moted nuclear.***,our.study indicates that maintaining low levels of hypochlor.us acid plays a key r.le in the r.cover. of neur.logical function.

关键词： cell differ.ntiation cer.br.l ischemia/r.per.usion injur. chlor.nation hypochlor.us acid micr.glia neur.l stem cell neur.genesis nuclear.tr.nslocation str.ke β-catenin

Pr.tein photocr.sslinking r.veals dimer.of dimer. for.ation on Mar. pr.tein in Escher.chia coli

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Science China Chemistr. 2012年第1期55卷 106-111页

作者： chen Xing HAO ZiYang chen peng r. Beijing National Labor.tor. for.Molecular.Sciences(BNLMS) Department of Chemical BiologyCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

The multiple antibiotic r.sistance r.gulator. pr.tein(Mar.) binds to two pr.moter.sites on the mar. oper.tor.in Escher.chia *** study showed that mor. than one Mar. dimer.pr.teins bound to either.of its two pr.moter.sites(Site I and Site II),suggesting that Mar. might for. higher.complexes than homodimer. when bound to DNA inside *** *** fur.her.ver.fy this hypothesis,we site-specifically incor.or.ted a photocr.sslinking pr.be at the inter.ace between two Mar. dimer.*** in living *** cells r.vealed a covalent linkage between the two inter.imer.subunits of Mar.,suggesting that Mar. for.s dimer.of dimer. in vivo.

关键词： Mar. pr.tein antibiotic r.sistance pr.tein photocr.sslinking DNA binding site dimer.zation

Liter.tur. study on tr.ditional Chinese medicine syndr.mes after.r.nal tr.nsplantation

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Wor.d Jour.al of Tr.nsplantation 2025年第1期15卷 150-155页

作者： Yun-peng Guo Ling-Xue Bao Yu-Yang Wang Quan Wen Gai Hang Bo chen Tongliao Clinical Medical College Inner Mongolia Medical UniversityTongliao 028000Inner Mongolia Autonomous RegionChina Depar.ment of Ur.logy Tongliao People's HospitalTongliao 028000Inner Mongolia Autonomous RegionChina

BACKGr.UND Kidney tr.nsplantation is the most effective means to tr.at patients with r.nal failur.,but its postoper.tive pr.blems such as r.jection r.actions,immunosuppr.ssant poisoning,chr.nic tr.nsplant kidney nephr.pathy,*** have not been effectively *** study sear.hed for.liter.tur. on tr.ditional Chinese medicine(TCM)syndr.mes after.kidney tr.nsplantation in China,conducted statistical analysis of the r.sults,and sought to identify the under.ying *** To under.tand the TCM syndr.mes after.r.nal tr.nsplantation and associated r.les and pr.vide a theor.tical basis for.fur.her.clinical *** The liter.tur. per.aining to TCM syndr.mes in r.nal tr.nsplantation,published in the China National Knowledge Infr.str.ctur.,Wanfang database,and WIP database fr.m 1970 to 2021,was meticulously sear.hed and compr.hensively and statistically *** Following the established inclusion and exclusion cr.ter.a,13 studies wer. selected for.***-r.nal tr.nsplantation,no significant discr.pancy was noted among the gr.ups based on the location of TCM ***,when categor.zed accor.ing to TCM pathogenic factor.,the gr.ups with spleen and kidney yang deficiency,as well as liver.and kidney yin deficiency,exhibited a statistically significant differ.nce in the *** Cur.ently,the r.sear.h on TCM syndr.mes per.aining to r.nal tr.nsplantation is in its nascent *** is imper.tive to conduct a multicentr.c,lar.e-scale sur.ey of TCM syndr.mes subsequent to r.nal tr.nsplantation in the ensuing year..

关键词： Kidney tr.nsplantation Syndr.me Liter.tur. analysis Tr.ditional Chinese medicine Systematic r.view